Rene Koopman

Functional electrical stimulation in-bed cycle ergometry in mechanically ventilated patients: a multicentre randomised controlled trial

Sue Berney, Ramona O Hopkins, Joleen Wyn Rose, Rene Koopman, Zudin Puthucheary, Amy Pastva, Ian Gordon, Elizabeth Colantuoni, Selina M Parry, Dale M Needham, Linda Denehy

Journal article  |  2021  |  THORAX

PURPOSE: To investigate the effect of functional electrical stimulation-assisted cycle ergometry (FES-cycling) on muscle strength,..

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

K Watt, DC Henstridge, M Ziemann, CB Sim, MK Montgomery, D Samocha-Bonet, BL Parker, GT Dodd, ST Bond, TM Salmi, RS Lee, RE Thomson, A Hagg, JR Davey, H Qian, R Koopman, A El-Osta, JR Greenfield, MJ Watt, MA Febbraio, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strat..

Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia-reperfusion damage

Francesca M Alves, Kai Kysenius, Marissa K Caldow, Justin P Hardee, Peter J Crouch, Scott Ayton, Ashley I Bush, Gordon S Lynch, Rene Koopman

Journal article  |  2021  |  JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

BACKGROUND: Oxidative stress is implicated in the insidious loss of muscle mass and strength that occurs with age. However, few st..

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity

Justin P Hardee, Karen JB Martins, Paula M Miotto, James G Ryall, Stefan M Gehrig, Boris Reljic, Timur Naim, Jin D Chung, Jen Trieu, Kristy Swiderski, Ashleigh M Philp, Andrew Philp, Matthew J Watt, David A Stroud, Rene Koopman, Gregory R Steinberg, Gordon S Lynch

Journal article  |  2021  |  MOLECULAR METABOLISM

OBJECTIVES: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscul..

Distinct roles for dietary protein and amino acids in health and disease

Rene Koopman, Rajavel Elango

Journal article  |  2021  |  CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Protein Type, Protein Dose, and Age Modulate Dietary Protein Digestion and Phenylalanine Absorption Kinetics and Plasma Phenylalanine Availability in Humans

Stefan HM Gorissen, Jorn Trommelen, Imre WK Kouw, Andrew M Holwerda, Bart Pennings, Bart BL Groen, Benjamin T Wall, Tyler A Churchward-Venne, Astrid MH Horstman, Rene Koopman, Nicholas A Burd, Cas J Fuchs, Marlou L Dirks, Peter T Res, Joan MG Senden, Jan MJM Steijns, Lisette CPGM de Groot, Lex B Verdijk, Luc JC van Loon

Journal article  |  2020  |  JOURNAL OF NUTRITION

BACKGROUND: Dietary protein ingestion stimulates muscle protein synthesis by providing amino acids to the muscle. The magnitude an..

Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation

Kristy Swiderski, Rebecka Bindon, Jennifer Trieu, Timur Naim, Shana Schokman, Mathusi Swaminathan, Anita JL Leembruggen, Elisa L Hill-Yardin, Rene Koopman, Joel C Bornstein, Gordon S Lynch

Journal article  |  2020  |  JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY

Background/Aims: Patients with Duchenne muscular dystrophy exhibit significant, ongoing impairments in gastrointestinal (GI) funct..

Glycine Protects Muscle Cells From Wasting in vitro via mTORC1 Signaling

Marissa K Caldow, Daniel J Ham, Jennifer Trieu, Jin Dylan Chung, Gordon S Lynch, Rene Koopman

Journal article  |  2019  |  FRONTIERS IN NUTRITION

Glycine supplementation can protect skeletal muscles of mice from cancer-induced wasting, but the mechanisms underlying this prote..

Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice

Daniel J Ham, Anastasia Gardner, Tahnee L Kennedy, Jennifer Trieu, Timur Naim, Annabel Chee, Francesca M Alves, Marissa K Caldow, Gordon S Lynch, Rene Koopman

Journal article  |  2019  |  SCIENTIFIC REPORTS

Duchenne muscular dystrophy (DMD) is an X-linked genetic disease characterized by progressive muscle wasting and weakness and prem..

Choline administration attenuates aspects of the dystrophic pathology in mdx mice

FM Alves, MK Caldow, J Trieu, T Naim, MK Montgomery, MJ Watt, GS Lynch, R Koopman

Journal article  |  2019  |  Clinical Nutrition Experimental

Background & aims: Dystrophic muscle fibres are fragile and prone to breakage, leading to impaired Ca 2+ homeostasis and excessive..