Ching-Seng Ang

Phosphomatics: interactive interrogation of substrate-kinase networks in global phosphoproteomics datasets.

Michael G Leeming, Sean O'Callaghan, Luana Licata, Marta Iannuccelli, Prisca Lo Surdo, Elisa Micarelli, Ching-Seng Ang, Shuai Nie, Swati Varshney, Sadia Ameen, Heung-Chin Cheng, Nicholas A Williamson

Journal article  |  2021  |  Bioinformatics

MOTIVATION: Mass spectrometry-based phosphoproteomics can routinely identify and quantify thousands of phosphorylated peptides fro..

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

Monisha Samuel, Pamali Fonseka, Rahul Sanwlani, Lahiru Gangoda, Sing Ho Chee, Shivakumar Keerthikumar, Alex Spurling, Sai V Chitti, Damien Zanker, Ching-Seng Ang, Ishara Atukorala, Taeyoung Kang, Sanjay Shahi, Akbar L Marzan, Christina Nedeva, Claire Vennin, Morghan C Lucas, Lesley Cheng, David Herrmann, Mohashin Pathan, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The concept that extracellular vesicles (EVs) from the diet can be absorbed by the intestinal tract of the consuming organism, be ..

Influence of Poly(ethylene glycol) Molecular Architecture on Particle Assembly and Ex Vivo Particle-Immune Cell Interactions in Human Blood

Jiaying Song, Yi Ju, Thakshila H Amarasena, Zhixing Lin, Srinivas Mettu, Jiajing Zhou, Md Arifur Rahim, Ching-Seng Ang, Christina Cortez-Jugo, Stephen J Kent, Frank Caruso

Journal article  |  2021  |  ACS NANO

Poly(ethylene glycol) (PEG) is widely used in particle assembly to impart biocompatibility and stealth-like properties in vivo for..

A New Turn in Peptide-Based Imaging Agents: Foldamers Afford Improved Theranostics Targeting Cholecystokinin-2 Receptor-Positive Cancer

Alicia Corlett, Marc-Antoine Sani, Jessica Van Zuylekom, Ching-Seng Ang, Elisabeth von Guggenberg, Carleen Cullinane, Benjamin Blyth, Rodney J Hicks, Peter D Roselt, Philip E Thompson, Craig A Hutton, Mohammad B Haskali

Journal article  |  2021  |  JOURNAL OF MEDICINAL CHEMISTRY

Proteins adopt unique folded secondary and tertiary structures that are responsible for their remarkable biological properties. Th..

Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size

Thanh Kha Phan, Pamali Fonseka, Rochelle Tixeira, Mohashin Pathan, Ching-Seng Ang, Dilara Ceyda Ozkocak, Suresh Mathivanan, Ivan Ka Ho Poon

Journal article  |  2021  |  PROTEOMICS

Apoptotic bodies (ApoBDs), which are large extracellular vesicles exclusively released by apoptotic cells, possess therapeutically..

Temporal Quantitative Proteomics Analysis of Neuroblastoma Cells Treated with Bovine Milk-Derived Extracellular Vesicles Highlights the Anti-Proliferative Properties of Milk-Derived Extracellular Vesicles

Pamali Fonseka, Taeyoung Kang, Sing Chee, Sai V Chitti, Rahul Sanwlani, Ching-Seng Ang, Suresh Mathivanan

Journal article  |  2021  |  CELLS

Neuroblastoma (NBL) is a pediatric cancer that accounts for 15% of childhood cancer mortality. Amplification of the oncogene N-Myc..

The TIM22 complex mediates the import of sideroflexins and is required for efficient mitochondrial one-carbon metabolism

Thomas D Jackson, Daniella H Hock, Kenji M Fujihara, Catherine S Palmer, Ann E Frazier, Yau C Low, Yilin Kang, Ching-Seng Ang, Nicholas J Clemons, David R Thorburn, David A Stroud, Diana Stojanovski

Journal article  |  2021  |  MOLECULAR BIOLOGY OF THE CELL

Acylglycerol kinase (AGK) is a mitochondrial lipid kinase that contributes to protein biogenesis as a subunit of the TIM22 complex..

Hidden information on protein function in censuses of proteome foldedness

Dezerae Cox, Ching-Seng Ang, Nadinath Nillegoda, Gavin Reid, Danny Hatters

Journal article  |  2021

Methods: that assay protein foldedness with proteomics have generated censuses of protein folding stabilities in biological milie..

What Are We Missing by Using Hydrophilic Enrichment? Improving Bacterial Glycoproteome Coverage Using Total Proteome and FAIMS Analyses

Ameera Raudah Ahmad Izaham, Ching-Seng Ang, Shuai Nie, Lauren E Bird, Nicholas A Williamson, Nichollas E Scott

Journal article  |  2021  |  JOURNAL OF PROTEOME RESEARCH

Hydrophilic interaction liquid chromatography (HILIC) glycopeptide enrichment is an indispensable tool for the high-throughput cha..

Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression

Hon Yan K Yip, Annabel Chee, Ching-Seng Ang, Sung-Young Shin, Lisa M Ooms, Zainab Mohammadi, Wayne A Phillips, Roger J Daly, Timothy J Cole, Roderick T Bronson, Lan K Nguyen, Tony Tiganis, Robin M Hobbs, Catriona A McLean, Christina A Mitchell, Antonella Papa

Journal article  |  2020  |  MOLECULAR CELL

The PTEN tumor suppressor controls cell death and survival by regulating functions of various molecular targets. While the role of..