Sidonia Eckle

Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens

Hamish EG McWilliam, Jeffrey YW Mak, Wael Awad, Matthew Zorkau, Sebastian Cruz-Gomez, Hui Jing Lim, Yuting Yan, Sam Wormald, Laura F Dagley, Sidonia BG Eckle, Alexandra J Corbett, Haiyin Liu, Shihan Li, Scott JJ Reddiex, Justine D Mintern, Ligong Liu, James McCluskey, Jamie Rossjohn, David P Fairlie, Jose A Villadangos

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B2..

Peripheral Blood Mucosal-Associated Invariant T Cells in Tuberculosis Patients and Healthy Mycobacterium tuberculosis-Exposed Controls

Sara Suliman, Anele Gela, Simon C Mendelsohn, Sarah K Iwany, Kattya Lopez Tamara, Simbarashe Mabwe, Nicole Bilek, Fatoumatta Darboe, Michelle Fisher, Alexandra J Corbett, Lars Kjer-Nielsen, Sidonia BG Eckle, Chuan-Chin Huang, Zibiao Zhang, David M Lewinsohn, James McCluskey, Jamie Rossjohn, Mark Hatherill, Segundo R Leon, Roger Calderon, et al.

Journal article  |  2020  |  The Journal of Infectious Diseases

BACKGROUND: In human blood, mucosal-associated invariant T (MAIT) cells are abundant T cells that recognize antigens presented on ..

Biased MAIT TCR Usage Poised for Limited Antigen Diversity?

Michael NT Souter, Sidonia BG Eckle

Journal article  |  2020  |  Frontiers in Immunology

Hypersensitivities following allergen antigen recognition by unconventional T cells

Marcela de Lima Moreira, Michael NT Souter, Zhenjun Chen, Liyen Loh, James McCluskey, Daniel G Pellicci, Sidonia BG Eckle

Journal article  |  2020  |  Allergy

Conventional T cells recognise protein-derived antigens in the context of major histocompatibility complex (MHC) class Ia and clas..

The murine CD94/NKG2 ligand, Qa-1(b), is a high-affinity, functional ligand for the CD8?? homodimer

Katharine Jennifer Goodall, Angela Nguyen, Craig McKenzie, Sidonia Barbara Guiomar Eckle, Lucy Catherine Sullivan, Daniel Mark Andrews

Journal article  |  2020  |  Journal of Biological Chemistry

The immune co-receptor CD8 molecule (CD8) has two subunits, CD8α and CD8β, which can assemble into homo or heterodimers. Nonclassi..

The molecular basis underpinning the potency and specificity of MAIT cell antigens

Wael Awad, Geraldine JM Ler, Weijun Xu, Andrew N Keller, Jeffrey YW Mak, Xin Yi Lim, Ligong Liu, Sidonia BG Eckle, Jerome Le Nours, James McCluskey, Alexandra J Corbett, David P Fairlie, Jamie Rossjohn

Journal article  |  2020  |  Nature Immunology

Mucosal-associated invariant T (MAIT) cells are activated by microbial riboflavin-based metabolite antigens when presented by MR1...

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCR alpha beta Clonotypes with Potent Antimicrobial Responses

Liyen Loh, Nicholas A Gherardin, Sneha Sant, Ludivine Grzelak, Jeremy Chase Crawford, Nicola L Bird, Hui-Fern Koay, Carolien E van de Sandt, Marcela L Moreira, Martha Lappas, E Kaitlynn Allen, Jane Crowe, Thomas Loudovaris, Katie L Flanagan, Kylie M Quinn, Jamie Rossjohn, Paul G Thomas, Sidonia BG Eckle, James McCluskey, Dale I Godfrey, et al.

Journal article  |  2020  |  The Journal of Immunology

Mucosal-associated invariant T (MAIT) cells are important for immune responses against microbial infections. Although known to und..

A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1

Jerome Le Nours, Nicholas A Gherardin, Sri H Ramarathinam, Wael Awad, Florian Wiede, Benjamin S Gully, Yogesh Khandokar, T Praveena, Jacinta M Wubben, Jarrod J Sandow, Andrew I Webb, Anouk von Borstel, Michael T Rice, Samuel J Redmond, Rebecca Seneviratna, Maria L Sandoval-Romero, Shihan Li, Michael NT Souter, Sidonia BG Eckle, Alexandra J Corbett, et al.

Journal article  |  2019  |  Science

T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We ..

Characterization and Purification of Mouse Mucosal-Associated Invariant T (MAIT) Cells.

Zhenjun Chen, Huimeng Wang, Criselle D'Souza, Hui-Fern Koay, Bronwyn Meehan, Zhe Zhao, Troi Pediongco, Mai Shi, Tianyuan Zhu, Bingjie Wang, Lars Kjer-Nielsen, Sidonia BG Eckle, Jamie Rossjohn, David P Fairlie, Dale I Godfrey, Richard A Strugnell, James McCluskey, Alexandra J Corbett

Journal article  |  2019  |  Current Protocols in Immunology

This unit describes the utility of various mouse models of infection and immunization for studying mucosal-associated invariant T ..

Characterization of Human Mucosal-associated Invariant T (MAIT) Cells.

Michael NT Souter, Liyen Loh, Shihan Li, Bronwyn S Meehan, Nicholas A Gherardin, Dale I Godfrey, Jamie Rossjohn, David P Fairlie, Katherine Kedzierska, Daniel G Pellicci, Zhenjun Chen, Lars Kjer-Nielsen, Alexandra J Corbett, James McCluskey, Sidonia BG Eckle

Journal article  |  2019  |  Current Protocols in Immunology

Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells restricted by the major histocompatibility comp..