Mike McGuckin

Building a case for pancreas and liver targeted intereukin-22 therapy in fatty liver disease

Haressh Sajiir, Kuan Yau Wong, Alexandra Mueller, Sahar Keshvari, Ran Wang, Percival Wiid, Grant Ramm, Graeme Macdonald, John Prins, Michael McGuckin, Sumaira Hasnain

Journal article  |  2022  |  JOURNAL OF HEPATOLOGY

119-LB: Targeted IL-22 Improves Glucose Tolerance and Reduces Hepatic Steatosis and Hepatic Fibrosis in Murine Models of Diabetes and Liver Disease

JOHN B PRINS, HARESSH SAJIIR, SAHAR KESHVARI, KUAN YAU WONG, JACK LOCKETT, MICHAEL MCGUCKIN, SUMAIRA Z HASNAIN

Journal article  |  2022  |  Diabetes

The cytokine interleukin-22 (IL-22) is an inhibitor of cellular stress. In HFD murine models, systemic IL-22 is efficacious to res..

89: BUILDING A CASE FOR LIVER AND PANCREAS TARGETED INTERLEUKIN-22 THERAPY FOR USE IN NON-ALCOHOLIC FATTY LIVER DISEASE

Haressh Sajiir, Kuanyau Wong, Alexander Mueller, Sahar Keshvari, Ran Wang, Graeme A Macdonald, John Prins, Michael Mcguckin, Sumaira Z Hasnain

Journal article  |  2022  |  Gastroenterology

Secreted NF-κB suppressive microbial metabolites modulate gut inflammation.

Rabina Giri, Emily C Hoedt, Shamsunnahar Khushi, Angela A Salim, Anne-Sophie Bergot, Veronika Schreiber, Ranjeny Thomas, Michael A McGuckin, Timothy H Florin, Mark Morrison, Robert J Capon, Páraic Ó Cuív, Jakob Begun

Journal article  |  2022  |  Cell Rep

Emerging evidence suggests that microbiome-host crosstalk regulates intestinal immune activity and predisposition to inflammatory ..

MUC1-mediated Macrophage Activation Promotes Colitis-associated Colorectal Cancer via Activating the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Axis.

Yong H Sheng, Julie M Davies, Ran Wang, Kuan Yau Wong, Rabina Giri, Yuanhao Yang, Jakob Begun, Timothy H Florin, Sumaira Z Hasnain, Michael A McGuckin

Journal article  |  2022  |  Cell Mol Gastroenterol Hepatol

BACKGROUND & AIMS: MUC1 is abnormally expressed in colorectal cancer, including colitis-associated colorectal cancer (CAC), but it..

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

C Glenn Begley, Mark Ashton, Jonathan Baell, Michael Bettess, Michael P Brown, Brett Carter, William N Charman, Christopher Davis, Simon Fisher, Ian Frazer, Anand Gautam, Michael P Jennings, Philip Kearney, Eloise Keeffe, Darren Kelly, Angel F Lopez, Michael McGuckin, Michael W Parker, Craig Rayner, Brett Roberts, et al.

Journal article  |  2021  |  SCIENCE TRANSLATIONAL MEDICINE

Drug repurposing is promoted as a cost- and time-effective mechanism for providing new medicines. Often, however, there is insuffi..

Oral Delivery of beta-Lactoglobulin-Nanosphere-Encapsulated Resveratrol Alleviates Inflammation in Winnie Mice with Spontaneous Ulcerative Colitis

Naisarg Pujara, Kuan Yau Wong, Zhi Qu, Ran Wang, Md Moniruzzaman, Prarthana Rewatkar, Tushar Kumeria, Benjamin P Ross, Michael McGuckin, Amirali Popat

Journal article  |  2021  |  MOLECULAR PHARMACEUTICS

Resveratrol (RES) is a nutraceutical with promising anti-inflammatory properties for the treatment of inflammatory bowel diseases ..

pH - Responsive colloidal carriers assembled from beta-lactoglobulin and Epsilon poly-L-lysine for oral drug delivery

Naisarg Pujara, Rabina Giri, Kuan Yau Wong, Zhi Qu, Prarthana Rewatkar, Md Moniruzzaman, Jakob Begun, Benjamin P Ross, Michael McGuckin, Amirali Popat

Journal article  |  2021  |  JOURNAL OF COLLOID AND INTERFACE SCIENCE

Site specific oral delivery of many biopharmaceutical classification system (BCS) class II and IV drugs is challenging due to thei..

Gut microbiota shape the inflammatory response in mice with an epithelial defect

Ran Wang, Md Moniruzzaman, Kuan Yau Wong, Percival Wiid, Alexa Harding, Rabina Giri, Wendy Hui Tong, Jackie Creagh, Jakob Begun, Michael A McGuckin, Sumaira Z Hasnain

Journal article  |  2021  |  GUT MICROBES

Intestinal epithelial cell endoplasmic reticulum (ER) stress has been implicated in intestinal inflammation. It remains unclear wh..

A Nucleotide Analog Prevents Colitis-Associated Cancer via Beta-Catenin Independently of Inflammation and Autophagy

Yong Hua Sheng, Rabina Giri, Julie Davies, Veronika Schreiber, Saleh Alabbas, Ramya Movva, Yaowu He, Andy Wu, John Hooper, Brett McWhinney, Iulia Oancea, Gregor Kijanka, Sumaira Hasnain, Andrew J Lucke, David P Fairlie, Michael A McGuckin, Timothy H Florin, Jakob Begun

Journal article  |  2021  |  CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY

BACKGROUND & AIMS: Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine trea..