Mike McGuckin

pH - Responsive colloidal carriers assembled from beta-lactoglobulin and Epsilon poly-L-lysine for oral drug delivery

Naisarg Pujara, Rabina Giri, Kuan Yau Wong, Zhi Qu, Prarthana Rewatkar, Md Moniruzzaman, Jakob Begun, Benjamin P Ross, Michael McGuckin, Amirali Popat

Journal article  |  2021  |  JOURNAL OF COLLOID AND INTERFACE SCIENCE

Site specific oral delivery of many biopharmaceutical classification system (BCS) class II and IV drugs is challenging due to thei..

Oral Delivery of beta-Lactoglobulin-Nanosphere-Encapsulated Resveratrol Alleviates Inflammation in Winnie Mice with Spontaneous Ulcerative Colitis

Naisarg Pujara, Kuan Yau Wong, Zhi Qu, Ran Wang, Md Moniruzzaman, Prarthana Rewatkar, Tushar Kumeria, Benjamin P Ross, Michael McGuckin, Amirali Popat

Journal article  |  2021  |  MOLECULAR PHARMACEUTICS

Resveratrol (RES) is a nutraceutical with promising anti-inflammatory properties for the treatment of inflammatory bowel diseases ..

Gut microbiota shape the inflammatory response in mice with an epithelial defect

Ran Wang, Md Moniruzzaman, Kuan Yau Wong, Percival Wiid, Alexa Harding, Rabina Giri, Wendy Hui Tong, Jackie Creagh, Jakob Begun, Michael A McGuckin, Sumaira Z Hasnain

Journal article  |  2021  |  GUT MICROBES

Intestinal epithelial cell endoplasmic reticulum (ER) stress has been implicated in intestinal inflammation. It remains unclear wh..

A Nucleotide Analog Prevents Colitis-Associated Cancer via Beta-Catenin Independently of Inflammation and Autophagy

Yong Hua Sheng, Rabina Giri, Julie Davies, Veronika Schreiber, Saleh Alabbas, Ramya Movva, Yaowu He, Andy Wu, John Hooper, Brett McWhinney, Iulia Oancea, Gregor Kijanka, Sumaira Hasnain, Andrew J Lucke, David P Fairlie, Michael A McGuckin, Timothy H Florin, Jakob Begun

Journal article  |  2021  |  CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY

BACKGROUND & AIMS: Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine trea..

Thioguanine prevents colitis-associated cancer via beta-catenin signaling in intestinal epithelial cells independently of immunosuppression and autophagy

Y Sheng, R Giri, J Davies, V Schreiber, S Alabbas, R Movva, Y He, A Wu, J Hooper, B Mcwhinney, I Oancea, G Kijanka, S Hasnain, M Mcguckin, T Florin, J Begun

Conference Proceedings  |  2020  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

One-Pot Synthesis of pH-Responsive Eudragit-Mesoporous Silica Nanocomposites Enable Colonic Delivery of Glucocorticoids for the Treatment of Inflammatory Bowel Disease

Zhi Qu, Kuan Yau Wong, Md Moniruzzaman, Jakob Begun, Helder A Santos, Sumaira Z Hasnain, Tushar Kumeria, Michael A McGuckin, Amirali Popat

Journal article  |  2020  |  ADVANCED THERAPEUTICS

Oral glucocorticoids are backbones for the acute management of inflammatory bowel disease (IBD). However, the clinical effectivene..

Influence of the MUC1 Cell Surface Mucin on Gastric Mucosal Gene Expression Profiles in Response toHelicobacter pyloriInfection in Mice

Yong H Sheng, Garrett Z Ng, Kim M Summers, Alison L Every, Gareth Price, Sumaira Z Hasnain, Philip Sutton, Michael A McGuckin

Journal article  |  2020  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

The cell surface mucin MUC1 is an important host factor limiting Helicobacter pylori (H. pylori) pathogenesis in both humans and m..

390 THIOGUANINE INHIBITS COLORECTAL TUMORIGENESIS VIA β-CATENIN SIGNALLING IN INTESTINAL EPITHELIAL CELLS INDEPENDENTLY OF IMMUNOSUPPRESSION OR AUTOPHAGY

Yong H Sheng, Rabina Giri, Julie Davies, veronika Schreiber, Saleh Y Alabbas, yaowu He, Andy Wu, John Hooper, Iulia Oancea, Gregor Kijanka, Sumaira Z Hasnain, Michael McGuckin, Timothy H Florin, Jakob Begun

Journal article  |  2020  |  Gastroenterology

Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis

Kathryn A Ramsey, Alice CH Chen, Giorgia Radicioni, Rohan Lourie, Megan Martin, Amy Broomfield, Yong H Sheng, Sumaira Z Hasnain, Graham Radford-Smith, Lisa A Simms, Lucy Burr, David J Thornton, Simon D Bowler, Stephanie Livengood, Agathe Ceppe, Michael R Knowles, Peadar G Noone, Scott H Donaldson, David B Hill, Camille Ehre, et al.

Journal article  |  2020  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rationale: Non-cystic fibrosis bronchiectasis is characterized by airway mucus accumulation and sputum production, but the role of..

Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial

Joyce S Ramos, Lance C Dalleck, Rebecca C Stennett, Gregore Mielke, Shelley E Keating, Lydia Murray, Sumaira Z Hasnain, Robert G Fassett, Michael McGuckin, Ilaria Croci, Jeff S Coombes

Journal article  |  2020  |  DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY

Introduction: IL-22 may have a role in the alleviation of the metabolic syndrome (MetS) via protection of pancreatic beta and endo..