Mike McGuckin

pH - Responsive colloidal carriers assembled from β-lactoglobulin and Epsilon poly-L-lysine for oral drug delivery.

Naisarg Pujara, Rabina Giri, Kuan Yau Wong, Zhi Qu, Prarthana Rewatkar, Md Moniruzzaman, Jakob Begun, Benjamin P Ross, Michael McGuckin, Amirali Popat

Journal article  |  2021  |  Journal of Colloid and Interface Science

Site specific oral delivery of many biopharmaceutical classification system (BCS) class II and IV drugs is challenging due to thei..

Oral Delivery of β-Lactoglobulin-Nanosphere-Encapsulated Resveratrol Alleviates Inflammation in Winnie Mice with Spontaneous Ulcerative Colitis.

Naisarg Pujara, Kuan Yau Wong, Zhi Qu, Ran Wang, Md Moniruzzaman, Prarthana Rewatkar, Tushar Kumeria, Benjamin P Ross, Michael McGuckin, Amirali Popat

Journal article  |  2021  |  Molecular Pharmaceutics

Resveratrol (RES) is a nutraceutical with promising anti-inflammatory properties for the treatment of inflammatory bowel diseases ..

A Nucleotide Analog Prevents Colitis-Associated Cancer via Beta-Catenin Independently of Inflammation and Autophagy

Yong Hua Sheng, Rabina Giri, Julie Davies, Veronika Schreiber, Saleh Alabbas, Ramya Movva, Yaowu He, Andy Wu, John Hooper, Brett McWhinney, Iulia Oancea, Gregor Kijanka, Sumaira Hasnain, Andrew J Lucke, David P Fairlie, Michael A McGuckin, Timothy H Florin, Jakob Begun

Journal article  |  2021  |  Cellular and Molecular Gastroenterology and Hepatology

BACKGROUND & AIMS: Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine trea..

One-Pot Synthesis of pH-Responsive Eudragit-Mesoporous Silica Nanocomposites Enable Colonic Delivery of Glucocorticoids for the Treatment of Inflammatory Bowel Disease

Zhi Qu, Kuan Yau Wong, Md Moniruzzaman, Jakob Begun, Helder A Santos, Sumaira Z Hasnain, Tushar Kumeria, Michael A McGuckin, Amirali Popat

Journal article  |  2020  |  Advanced Therapeutics

Influence of the MUC1 Cell Surface Mucin on Gastric Mucosal Gene Expression Profiles in Response toHelicobacter pyloriInfection in Mice

Yong H Sheng, Garrett Z Ng, Kim M Summers, Alison L Every, Gareth Price, Sumaira Z Hasnain, Philip Sutton, Michael A McGuckin

Journal article  |  2020  |  Frontiers in Cellular and Infection Microbiology

The cell surface mucin MUC1 is an important host factor limiting Helicobacter pylori (H. pylori) pathogenesis in both humans and m..

390 THIOGUANINE INHIBITS COLORECTAL TUMORIGENESIS VIA β-CATENIN SIGNALLING IN INTESTINAL EPITHELIAL CELLS INDEPENDENTLY OF IMMUNOSUPPRESSION OR AUTOPHAGY

Yong H Sheng, Rabina Giri, Julie Davies, veronika Schreiber, Saleh Y Alabbas, yaowu He, Andy Wu, John Hooper, Iulia Oancea, Gregor Kijanka, Sumaira Z Hasnain, Michael McGuckin, Timothy H Florin, Jakob Begun

Journal article  |  2020  |  Gastroenterology

Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis

Kathryn A Ramsey, Alice CH Chen, Giorgia Radicioni, Rohan Lourie, Megan Martin, Amy Broomfield, Yong H Sheng, Sumaira Z Hasnain, Graham Radford-Smith, Lisa A Simms, Lucy Burr, David J Thornton, Simon D Bowler, Stephanie Livengood, Agathe Ceppe, Michael R Knowles, Peadar G Noone, Scott H Donaldson, David B Hill, Camille Ehre, et al.

Journal article  |  2020  |  American Journal of Respiratory and Critical Care Medicine

Rationale: Non-cystic fibrosis bronchiectasis is characterized by airway mucus accumulation and sputum production, but the role of..

Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial

Joyce S Ramos, Lance C Dalleck, Rebecca C Stennett, Gregore Mielke, Shelley E Keating, Lydia Murray, Sumaira Z Hasnain, Robert G Fassett, Michael McGuckin, Ilaria Croci, Jeff S Coombes

Journal article  |  2020  |  Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of beta-catenin and E-cadherin

Yaowu He, Claire M Davies, Brittney S Harrington, Linh Hellmers, Yonghua Sheng, Amy Broomfield, Thomas McGann, Kate Bastick, Laurie Zhong, Andy Wu, Grace Maresh, Shannon McChesney, Kuan Yau Wong, Mark N Adams, Ryan C Sullivan, James S Palmer, Lez J Burke, Adam D Ewing, Xin Zhang, David Margolin, et al.

Journal article  |  2020  |  Oncogene

Elevated CUB-domain containing protein 1 (CDCP1) is predictive of colorectal cancer (CRC) recurrence and poor patient survival. Wh..

Efficient photoacoustic imaging using indocyanine green (ICG) loaded functionalized mesoporous silica nanoparticles

Zanib Chaudhary, Gul Majid Khan, Muhammad Mustafa Abeer, Naisarg Pujara, Brian Wan-Chi Tse, Michael A McGuckin, Amirali Popat, Tushar Kumeria

Journal article  |  2019  |  Biomaterials Science

Photoacoustic (PA) imaging is gaining momentum due to its greater depth of field, low background, and 3D imaging capabilities. How..