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A/Prof

Oliver Sieber

Honorary
tumour biology
biomarkers
therapy
science & technology
life sciences & biomedicine
humans
oncology
colorectal neoplasms
mutation
Oliver Sieber's Profile Picture
A/Prof

Oliver Sieber

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Human Colorectal Cancer Genetics
Oliver Sieber's Profile Picture
A/Prof

Oliver Sieber

 

A/Prof Oliver Sieber is Laboratory Head at The Walter and Eliza Hall Institute of Medical Research (WEHI) and a NHMRC Senior Research Fellow. He received his PhD from University College London in 2004, and undertook 6 years postdoctoral training at Cancer Research UK, University of Oxford and the Ludwig Institute of Cancer Research (LICR).

He was Joint Laboratory Head at the LICR, Parkville, from 2009-12.


Lab focus: translational bowel cancer genomics


My research group aims to understand the genetic changes that contribute to bowel cancer. In particular, we are interested in the aberrant molecules that influence a person’s risk of developing bowel cancer, the course of disease in a bowel cancer patient, and the response of their cancer to therapy.

Bowel cancers vary greatly in the genes and proteins they express, and their clinical behaviour. We are working to define different subtypes of bowel cancer based on the molecules they express. Our goal is to link this to disease progression and sensitivity to anti-cancer treatments. We hope this will lead to significant new insights into fundamental tumour biology and open new avenues for diagnosis and treatment.


Research interest


We have a major focus on bowel cancer genomics, the application of high-throughput molecular profiling technologies to identify principal cancer genes and biomarkers of cancer risk and prognosis. We are conducting next-generation sequencing and microarray studies involving Australian and international patient cohorts to define molecular signatures associated with tumour characteristics and outcome.

Patient-focused investigations are being complemented with functional studies on cancer cell lines to distinguish driver from passenger mutations and to gain insights into molecular pathways of carcinogenesis. Molecularly-annotated cancer cell lines are further being used to explore the efficacy of novel drug therapies, both as single-agents and in combination with standard therapies.


www.wehi.edu.au/people/oliver-sieber

Scholarly Works

Displaying the 121 most recent scholarly works by Oliver Sieber.

Honours, Awards and Fellowships

2014

NHMRC Research Excellence Award: Top Ranked Application - CDF2 Biomedical 2013

NHMRC

2018

NHMRCF - NHMRC Fellowship


2014

NHMRCF - NHMRC Fellowship


3

Awards

Credentials

Positions


Honorary

Medical Biology (W.E.H.I.)

Honorary

Surgery - Royal Melbourne Hospital

Member

National Association of Research Fellows of NHMRC (NARF)

Steering Committee Member

Australian Living Organoid Alliance (ALOA)

Member

American Association for Cancer Research (AACR)

Member

Australasian Gastro-Intestinal Trials Group (AGITG)

Member

International Society for Gastrointestinal Hereditary Tumours (InSight)

Member

COGENT (COlorectal cancer GENeTics) Consortium

Education


Human Genetics

University College London

Genetics

University College London