Fleur Sernee

Evolution and function of carbohydrate reserve biosynthesis in parasitic protists

Julie E Ralton, M Fleur Sernee, Malcolm J McConville

Journal article  |  2021  |  TRENDS IN PARASITOLOGY

Nearly all eukaryotic cells synthesize carbohydrate reserves, such as glycogen, starch, or low-molecular-weight oligosaccharides. ..

Metabolic stringent response in intracellular stages of Leishmania

Eleanor C Saunders, Marijke F Sernee, Julie E Ralton, Malcolm J McConville

Journal article  |  2021  |  CURRENT OPINION IN MICROBIOLOGY

Leishmania are unusual in being able to survive long-term in the mature phagolysosome compartment of macrophages and other phagocy..

The Structure and Biosynthesis of Glycans in the Parasitic Protists

MF Sernee, JE Ralton, MJ McConville

Book Chapter  |  2021

Leishmania Encodes a Bacterium-like 2,4-Dienoyl-Coenzyme A Reductase That Is Required for Fatty Acid beta-Oxidation and Intracellular Parasite Survival

Geo Semini, Daniel Paape, Martin Blume, M Fleur Sernee, Diego Peres-Alonso, Sebastien Calvignac-Spencer, Joerg Doellinger, Stefan Jehle, Eleanor Saunders, Malcolm J McConville, Toni Aebischer

Journal article  |  2020  |  MBIO

Leishmania spp. are protozoan parasites that cause a spectrum of important diseases in humans. These parasites develop as extracel..

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites

M Fleur Sernee, Julie E Ralton, Tracy L Nero, Lukasz F Sobala, Joachim Kloehn, Marcel A Vieira-Lara, Simon A Cobbold, Lauren Stanton, Douglas EV Pires, Eric Hanssen, Alexandra Males, Tom Ward, Laurence M Bastidas, Phillip L van der Peet, Michael W Parker, David B Ascher, Spencer J Williams, Gideon J Davies, Malcolm J McConville

Journal article  |  2019  |  CELL HOST & MICROBE

Parasitic protists belonging to the genus Leishmania synthesize the non-canonical carbohydrate reserve, mannogen, which is compose..

Golgi-Located NTPDase1 of Leishmania major Is Required for Lipophosphoglycan Elongation and Normal Lesion Development whereas Secreted NTPDase2 Is Dispensable for Virulence

Fiona M Sansom, Julie E Ralton, M Fleur Sernee, Alice M Cohen, David J Hooker, Elizabeth L Hartland, Thomas Naderer, Malcolm J McConville

Journal article  |  2014  |  PLOS NEGLECTED TROPICAL DISEASES

Parasitic protozoa, such as Leishmania species, are thought to express a number of surface and secreted nucleoside triphosphate di..

Central carbon metabolism of Leishmania parasites

Eleanor C Saunders, David P de Souza, Thomas Naderer, Marijke F Sernee, Julie E Ralton, Maria A Doyle, James I MacRae, Jenny L Chambers, Joanne Heng, Amsha Nahid, Vladimir A Likic, Malcolm J McConville

Journal article  |  2010  |  PARASITOLOGY

Leishmania spp. are sandfly-transmitted protozoa parasites that cause a spectrum of diseases in humans. Many enzymes involved in L..

Analysis of the Leishmania Metabolome

M MCCONVILLE, D DE SOUZA, E SAUNDERS, J PYKE, T NADERER, undefined Ellis, M SERNEE, J RALTON, V LIKIC

Book Chapter  |  2008

PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria

Yasu S Morita, Chubert BC Sena, Ross F Waller, Ken Kurokawa, M Fleur Sernee, Fumiki Nakatani, Ruth E Haites, Helen Billman-Jacobe, Malcolm J McConville, Yusuke Maeda, Taroh Kinoshita

Journal article  |  2006  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol mannosides (PIMs) are a major class of glycolipids in all mycobacteria. AcPIM2, a dimannosyl PIM, is both an ..

Leishmania beta-1,2-mannan is assembled on a mannose-cyclic phosphate primer

M Fleur Sernee, Julie E Ralton, Zoran Dinev, George N Khairallah, Richard A O'Hair, Spencer J Williams, Malcolm J McConville

Journal article  |  2006  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infective stages of the protozoan parasite Leishmania spp. accumulate a class of beta-1,2-mannan oligosaccharides as their major c..