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Dr

Gawain McColl

Research Fellow
Florey Department of Neuroscience and Mental Health
science & technology
life sciences & biomedicine
animals
caenorhabditis elegans
biochemistry & molecular biology
chemistry
physical sciences
humans
caenorhabditis-elegans
Gawain McColl's Profile Picture
Dr

Gawain McColl

 
Division
Medicine, Dentistry and Health Sciences
Gawain McColl's Profile Picture
Dr

Gawain McColl

 
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Gawain's  Short Profile
 

Projects

Displaying the 7 most recent projects by Gawain McColl.

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UNDERSTANDING HOW CELLS STORE AND USE IRON

2020 - 2022
Active
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UNDERSTANDING HOW CELLS STORE AND USE IRON

2020 - 2022
Active
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Iron, ferroptosis and the biology of ageing

This project aims to determine how and when regulation of iron is lost. Failing iron metabolism during life may dictate the rate of ageing b..

2018 - 2021
Active
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Defining the capacity of cells to keep the proteome folded over space and time

2017 - 2021
Active
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The life cycle of iron

2016 - 2016
Completed
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Iron accumulation in C.elegans: a model of ageing

This project will investigate the role of biological metals in the process of ageing, the causes of which remain unresolved. The practical o..

2013 - 2016
Completed
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New High Thoughput Animal Models to Investigate Amyloid Beta Toxicity

Amyloid-beta is widely considered to cause Alzheimer’s disease. The majority of amyloid-beta in Alzheimer's disease brains is found as short..

2013 - 2015
Completed

7

Projects

Project Types

6

Research Grant

1

Internal Research Grant

Scholarly Works

Displaying the 10 most recent scholarly works by Gawain McColl.

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Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology

Shalini S Rao, Larissa Lago, Irene Volitakis, Jay J Shukla, Gawain McColl, David I Finkelstein, Paul A Adlard

Journal article  |  2021  |  Neurotherapeutics

The accumulation of neurofibrillary tangles (NFTs), which is composed of abnormally hyperphosphorylated tau aggregates, is the cla..

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Re-examining ferritin-bound iron: current and developing clinical tools.

Erin S Grant, Danielle B Clucas, Gawain McColl, Liam T Hall, David A Simpson

Journal article  |  2020  |  Clinical Chemistry and Laboratory Medicine

Iron is a highly important metal ion cofactor within the human body, necessary for haemoglobin synthesis, and required by a wide r..

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Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

Nicole L Jenkins, Simon A James, Agus Salim, Fransisca Sumardy, Terence P Speed, Marcus Conrad, Des R Richardson, Ashley Bush, Gawain McColl

Journal article  |  2020  |  eLife

All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis,..

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Late Life Iron Accumulation, Cell Death and Frailty

Nicole Jenkins, Simon James, Ashley Bush, Gawain McColl

Conference Proceedings  |  2019  |  Free Radical Biology and Medicine

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IMPACT OF COMORBID CONDITIONS ON HEALTH CARE EXPENDITURE AND WORK-RELATED OUTCOMES IN PATIENTS WITH RHEUMATOID ARTHRITIS: A RETROSPECTIVE ANALYSIS USING THE MEDICAL EXPENDITURE PANEL SURVEY IN THE PERIOD 2006-2015

MV Vu, N Carvalho, R Buchbinder, G McColl, PM Clarke, A Tran-Duy

Conference Proceedings  |  2019  |  Value in Health

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Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model

Satish N Dighe, Eugenio De la Mora, Stephen Chan, Srinivas Kantham, Gawain McColl, Jared A Miles, Suresh Kumar Veliyath, B Yogi Sreenivas, Zeyad D Nassar, Israel Silman, Joel L Sussman, Martin Weik, Ross P McGeary, Marie-Odile Parat, Xavier Brazzolotto, Benjamin P Ross

Journal article  |  2019  |  Communications Chemistry

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Simultaneous nanostructure and chemical imaging of intact whole nematodes

Michael WM Jones, Nicholas W Phillips, Brian Abbey, Dominic J Hare, Grant A van Riessen, David J Vine, Martin D de Jonge, Gawain McColl

Journal article  |  2019  |  Chemical Communications

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"To Treat or not To Treat": Informing the Decision for Disease-Modifying Therapy in Late-Stage Alzheimer's Disease

Andrew D Watt, Nicole L Jenkins, Gawain McColl, Steven Collins, Patricia M Desmond

Journal article  |  2019  |  Journal of Alzheimer's Disease

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Ethical Issues in the Treatment of Late-Stage Alzheimer's Disease

Andrew D Watt, Nicole L Jenkins, Gawain McColl, Steven Collins, Patricia M Desmond

Journal article  |  2019  |  Journal of Alzheimer's Disease

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Multifunctional Analogs of Kynurenic Acid for the Treatment of Alzheimer's Disease: Synthesis, Pharmacology, and Molecular Modeling Studies

Girdhar Singh Deora, Srinivas Kantham, Stephen Chan, Satish N Dighe, Suresh K Veliyath, Gawain McColl, Marie-Odile Parat, Ross P McGeary, Benjamin P Ross

Journal article  |  2017  |  ACS Chemical Neuroscience

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Scholarly Works

Keyword Analysis

Expanding Knowledge
Clinical Health (organs, Diseases and Abnormal Conditions)
Neurosciences
Biochemistry and Cell Biology
Analytical Chemistry
Specific Population Health (excl. Indigenous Health)
Genetics
Pharmacology and Pharmaceutical Sciences
Applied Economics
Chemical Engineering

Credentials

Positions

Research Fellow

Florey Department of Neuroscience and Mental Health

Honorary

Biosciences

Education

Doctorate

Monash University

Links