Gawain McColl

A biosensor to gauge protein homeostasis resilience differences in the nucleus compared to cytosol of mammalian cells

Candice Raeburn, Angelique Ormsby, Nagaraj Moily, Dezerae Cox, Simon Ebbinghaus, Alex Dickson, Gawain McColl, Danny Hatters

Journal article  |  2021

An extensive network of chaperones and other proteins maintain protein homeostasis and guard against inappropriate protein aggrega..

Re-examining ferritin-bound iron: current and developing clinical tools

Erin S Grant, Danielle B Clucas, Gawain McColl, Liam T Hall, David A Simpson

Journal article  |  2021  |  CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Iron is a highly important metal ion cofactor within the human body, necessary for haemoglobin synthesis, and required by a wide r..

Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology

Shalini S Rao, Larissa Lago, Irene Volitakis, Jay J Shukla, Gawain McColl, David I Finkelstein, Paul A Adlard

Journal article  |  2021  |  NEUROTHERAPEUTICS

The accumulation of neurofibrillary tangles (NFTs), which is composed of abnormally hyperphosphorylated tau aggregates, is the cla..

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

Nicole L Jenkins, Simon A James, Agus Salim, Fransisca Sumardy, Terence P Speed, Marcus Conrad, Des R Richardson, Ashley Bush, Gawain McColl

Journal article  |  2020  |  ELIFE

All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis,..

The Iron Chelator Deferiprone Improves the Phenotype in a Mouse Model of Tauopathy

Shalini S Rao, Stuart D Portbury, Larissa Lago, Ashley Bush, Paul A Adlard

Journal article  |  2020  |  JOURNAL OF ALZHEIMERS DISEASE

BACKGROUND: Abnormally hyperphosphorylated tau is a defining pathological feature of tauopathies, such as Alzheimer's disease (AD)..

Late Life Iron Accumulation, Cell Death and Frailty

Nicole Jenkins, Simon James, Ashley Bush, Gawain McColl

Conference Proceedings  |  2019  |  FREE RADICAL BIOLOGY AND MEDICINE

IMPACT OF COMORBID CONDITIONS ON HEALTH CARE EXPENDITURE AND WORK-RELATED OUTCOMES IN PATIENTS WITH RHEUMATOID ARTHRITIS: A RETROSPECTIVE ANALYSIS USING THE MEDICAL EXPENDITURE PANEL SURVEY IN THE PERIOD 2006-2015

MV Vu, N Carvalho, R Buchbinder, G McColl, PM Clarke, A Tran-Duy

Conference Proceedings  |  2019  |  VALUE IN HEALTH

Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model

Satish N Dighe, Eugenio De la Mora, Stephen Chan, Srinivas Kantham, Gawain McColl, Jared A Miles, Suresh Kumar Veliyath, B Yogi Sreenivas, Zeyad D Nassar, Israel Silman, Joel L Sussman, Martin Weik, Ross P McGeary, Marie-Odile Parat, Xavier Brazzolotto, Benjamin P Ross

Journal article  |  2019  |  COMMUNICATIONS CHEMISTRY

The development of polyphenols as drugs for Alzheimer’s disease (AD) is thwarted by their meagre brain availability due to instabi..

Simultaneous nanostructure and chemical imaging of intact whole nematodes

Michael WM Jones, Nicholas W Phillips, Brian Abbey, Dominic J Hare, Grant A van Riessen, David J Vine, Martin D de Jonge, Gawain McColl

Journal article  |  2019  |  CHEMICAL COMMUNICATIONS

Biological X-ray fluorescence microscopy (XFM) is an important tool for determining quantitative distributions of bioinorganics an..

"To Treat or not To Treat": Informing the Decision for Disease-Modifying Therapy in Late-Stage Alzheimer's Disease

Andrew D Watt, Nicole L Jenkins, Gawain McColl, Steven Collins, Patricia M Desmond

Journal article  |  2019  |  JOURNAL OF ALZHEIMERS DISEASE

Rosen et al. thoughtfully extend the ethical discussion surrounding disease-modifying therapies in late-stage Alzheimer's disease ..