Gawain McColl

Nonmonotonic Superparamagnetic Behavior of the Ferritin Iron Core Revealed via Quantum Spin Relaxometry

Erin S Grant, Liam T Hall, Lloyd CL Hollenberg, Gawain McColl, David A Simpson

Journal article  |  2022  |  ACS NANO

Ferritin is the primary storage protein in our body and is of significant interest in biochemistry, nanotechnology, and condensed ..

A biosensor of protein foldedness identifies increased "holdase" activity of chaperones in the nucleus following increased cytosolic protein aggregation.

Candice B Raeburn, Angelique R Ormsby, Dezerae Cox, Chloe A Gerak, Christian Makhoul, Nagaraj S Moily, Simon Ebbinghaus, Alex Dickson, Gawain McColl, Danny M Hatters

Journal article  |  2022  |  J Biol Chem

Chaperones and other quality control machinery guard proteins from inappropriate aggregation, which is a hallmark of neurodegenera..

Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology (vol 18, pg 1081, 2021)

Shalini S Rao, Larissa Lago, Irene Volitakis, Jay J Shukla, Gawain McColl, David I Finkelstein, Paul A Adlard

Journal article  |  2021  |  NEUROTHERAPEUTICS

In this article Figs. 3, 4, and 5 have been updated.

Acoustomicrofluidic Concentration and Signal Enhancement of Fluorescent Nanodiamond Sensors

Asma Akther, Ella P Walsh, Philipp Reineck, Brant C Gibson, Takeshi Ohshima, Hiroshi Abe, Gawain McColl, Nicole L Jenkins, Liam T Hall, David A Simpson, Amgad R Rezk, Leslie Y Yeo

Journal article  |  2021  |  ANALYTICAL CHEMISTRY

Diamond nitrogen-vacancy (NV) centers constitute a promising class of quantum nanosensors owing to the unique magneto-optic proper..

Therapeutic potential of iron modulating drugs in a mouse model of multiple system atrophy

Jay J Shukla, Nadia Stefanova, Ashley Bush, Gawain McColl, David Finkelstein, Erin J McAllum

Journal article  |  2021  |  NEUROBIOLOGY OF DISEASE

Multiple System Atrophy (MSA) is a rare neurodegenerative synucleinopathy which leads to severe disability followed by death withi..

Structural insights into the ferroxidase and iron sequestration mechanisms of ferritin from Caenorhabditis elegans

Tess R Malcolm, Sanjeedha Mohamed Mubarak, Eric Hanssen, Hamish G Brown, Gawain McColl, Megan J Maher, Guy NL Jameson

Journal article  |  2021  |  Acta Crystallographica Section A Foundations and Advances

Re-examining ferritin-bound iron: current and developing clinical tools

Erin S Grant, Danielle B Clucas, Gawain McColl, Liam T Hall, David A Simpson

Journal article  |  2021  |  CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Iron is a highly important metal ion cofactor within the human body, necessary for haemoglobin synthesis, and required by a wide r..

Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology

Shalini S Rao, Larissa Lago, Irene Volitakis, Jay J Shukla, Gawain McColl, David I Finkelstein, Paul A Adlard

Journal article  |  2021  |  NEUROTHERAPEUTICS

The accumulation of neurofibrillary tangles (NFTs), which is composed of abnormally hyperphosphorylated tau aggregates, is the cla..

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

Nicole L Jenkins, Simon A James, Agus Salim, Fransisca Sumardy, Terence P Speed, Marcus Conrad, Des R Richardson, Ashley Bush, Gawain McColl

Journal article  |  2020  |  ELIFE

All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis,..

The Iron Chelator Deferiprone Improves the Phenotype in a Mouse Model of Tauopathy

Shalini S Rao, Stuart D Portbury, Larissa Lago, Ashley Bush, Paul A Adlard

Journal article  |  2020  |  JOURNAL OF ALZHEIMERS DISEASE

BACKGROUND: Abnormally hyperphosphorylated tau is a defining pathological feature of tauopathies, such as Alzheimer's disease (AD)..