Gawain McColl

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans.

Nicole L Jenkins, Simon A James, Agus Salim, Fransisca Sumardy, Terence P Speed, Marcus Conrad, Des R Richardson, Ashley I Bush, Gawain McColl

Journal article  |  2020  |  eLife

All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis,..

Late Life Iron Accumulation, Cell Death and Frailty

Nicole Jenkins, Simon James, Ashley Bush, Gawain McColl

Conference Proceedings  |  2019  |  Free Radical Biology and Medicine

IMPACT OF COMORBID CONDITIONS ON HEALTH CARE EXPENDITURE AND WORK-RELATED OUTCOMES IN PATIENTS WITH RHEUMATOID ARTHRITIS: A RETROSPECTIVE ANALYSIS USING THE MEDICAL EXPENDITURE PANEL SURVEY IN THE PERIOD 2006-2015

MV Vu, N Carvalho, R Buchbinder, G McColl, PM Clarke, A Tran-Duy

Conference Proceedings  |  2019  |  Value in Health

Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model

Satish N Dighe, Eugenio De la Mora, Stephen Chan, Srinivas Kantham, Gawain McColl, Jared A Miles, Suresh Kumar Veliyath, B Yogi Sreenivas, Zeyad D Nassar, Israel Silman, Joel L Sussman, Martin Weik, Ross P McGeary, Marie-Odile Parat, Xavier Brazzolotto, Benjamin P Ross

Journal article  |  2019  |  Communications Chemistry

Simultaneous nanostructure and chemical imaging of intact whole nematodes

Michael WM Jones, Nicholas W Phillips, Brian Abbey, Dominic J Hare, Grant A van Riessen, David J Vine, Martin D de Jonge, Gawain McColl

Journal article  |  2019  |  Chemical Communications

"To Treat or not To Treat": Informing the Decision for Disease-Modifying Therapy in Late-Stage Alzheimer's Disease

Andrew D Watt, Nicole L Jenkins, Gawain McColl, Steven Collins, Patricia M Desmond

Journal article  |  2019  |  Journal of Alzheimer's Disease

Ethical Issues in the Treatment of Late-Stage Alzheimer's Disease

Andrew D Watt, Nicole L Jenkins, Gawain McColl, Steven Collins, Patricia M Desmond

Journal article  |  2019  |  Journal of Alzheimer's Disease

Multifunctional Analogs of Kynurenic Acid for the Treatment of Alzheimer's Disease: Synthesis, Pharmacology, and Molecular Modeling Studies

Girdhar Singh Deora, Srinivas Kantham, Stephen Chan, Satish N Dighe, Suresh K Veliyath, Gawain McColl, Marie-Odile Parat, Ross P McGeary, Benjamin P Ross

Journal article  |  2017  |  ACS Chemical Neuroscience

Radiation Dose Limits for Bioanalytical X-ray Fluorescence Microscopy

Michael WM Jones, Dominic J Hare, Simon A James, Martin D de Jonge, Gawain McColl

Journal article  |  2017  |  Analytical Chemistry

Spiral scanning X-ray fluorescence computed tomography

Martin D de Jonge, Andrew M Kingston, Nader Afshar, Jan Garrevoet, Robin Kirkham, Gary Ruben, Glenn R Myers, Shane J Latham, Daryl L Howard, David J Paterson, Christopher G Ryan, Gawain McColl

Journal article  |  2017  |  Optics Express

Effect of the Biphenyl Neolignan Honokiol on A beta(42)-Induced Toxicity in Caenorhabditis elegans, A beta(42) Fibrillation, Cholinesterase Activity, DPPH Radicals, and Iron(II) Chelation

Srinivas Kantham, Stephen Chan, Gawain McColl, Jared A Miles, Suresh Kumar Veliyath, Girdhar Singh Deora, Satish N Dighe, Samira Khabbazi, Marie-Odile Parat, Benjamin P Ross

Journal article  |  2017  |  ACS Chemical Neuroscience

Imaging metals in biology: pictures of metals in health and disease

Dominic J Hare, Elizabeth J New, Gawain McColl

Journal article  |  2017  |  Metallomics

Iron, Copper, and Zinc Concentration in A beta Plaques in the APP/PS1 Mouse Model of Alzheimer's Disease Correlates with Metal Levels in the Surrounding Neuropil

Simon A James, Quentin I Churches, Martin D de Jonge, Ian E Birchall, Victor Streltsov, Gawain McColl, Paul A Adlard, Dominic J Hare

Journal article  |  2017  |  ACS Chemical Neuroscience

Amyloid-beta peptide protects against microbial infection in mouse and worm models of Alzheimer's disease

Deepak Kumar Vijaya Kumar, Se Hoon Choi, Kevin J Washicosky, William A Eimer, Stephanie Tucker, Jessica Ghofrani, Aaron Lefkowitz, Gawain McColl, Lee E Goldstein, Rudolph E Tanzi, Robert D Moir

Journal article  |  2016  |  Science Translational Medicine

phi XANES: In vivo imaging of metal-protein coordination environments (vol 6, 20350, 2016)

Simon A James, Dominic J Hare, Nicole L Jenkins, Martin D de Jonge, Ashley I Bush, Gawain McColl

Journal article  |  2016  |  SCIENTIFIC REPORTS

phi XANES: In vivo imaging of metal-protein coordination environments

Simon A James, Dominic J Hare, Nicole L Jenkins, Martin D de Jonge, Ashley I Bush, Gawain McColl

Journal article  |  2016  |  SCIENTIFIC REPORTS

Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake

Barbara R Cardoso, Alexandre L Busse, Dominic J Hare, Cristiane Cominetti, Maria A Horst, Gawain McColl, Regina M Magaldi, Wilson Jacob-Filho, Silvia MF Cozzolino

Journal article  |  2016  |  Food & Function

High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans

Dominic J Hare, Michael WM Jones, Verena C Wimmer, Nicole L Jenkins, Martin D de Jonge, Ashley I Bush, Gawain McColl

Journal article  |  2016  |  METALLOMICS

Profiling changes to natively-bound metals during Caenorhabditis elegans development

Dominic J Hare, Blaine R Roberts, Gawain McColl

Journal article  |  2016  |  RSC Advances

Accurate biometal quantification per individual Caenorhabditis elegans

Katherine Ganio, Simon A James, Dominic J Hare, Blaine R Roberts, Gawain McColl

Journal article  |  2016  |  The Analyst

Stabilization of Nontoxic A beta-Oligomers: Insights into the Mechanism of Action of Hydroxyquinolines in Alzheimer's Disease

Timothy M Ryan, Blaine R Roberts, Gawain McColl, Dominic J Hare, Philip A Doble, Qiao-Xin Li, Monica Lind, Anne M Roberts, Haydyn DT Mertens, Nigel Kirby, Chi LL Pham, Mark G Hinds, Paul A Adlard, Kevin J Barnham, Cyril C Curtain, Colin L Masters

Journal article  |  2015  |  JOURNAL OF NEUROSCIENCE

Imaging metals in biology: balancing sensitivity, selectivity and spatial resolution

Dominic J Hare, Elizabeth J New, Martin D de Jonge, Gawain McColl

Journal article  |  2015  |  Chemical Society Reviews

Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans

Simon A James, Blaine R Roberts, Dominic J Hare, Martin D de Jonge, Ian E Birchall, Nicole L Jenkins, Robert A Cherny, Ashley I Bush, Gawain McColl

Journal article  |  2015  |  CHEMICAL SCIENCE

Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging

Bence Paul, Dominic J Hare, David P Bishop, Chad Paton, Tran Nguyen Van, Nerida Cole, Megan M Niedwiecki, Erica Andreozzi, Angela Vais, Jessica L Billings, Lisa Bray, Ashley I Bush, Gawain McColl, Blaine R Roberts, Paul A Adlard, David I Finkelstein, John Hellstrom, Janet M Hergt, Jon D Woodhead, Philip A Doble

Journal article  |  2015  |  CHEMICAL SCIENCE

Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's disease

Patricia M Chege, Gawain McColl

Journal article  |  2014  |  Frontiers in Aging Neuroscience

An iron-dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

Dominic J Hare, Peng Lei, Scott Ayton, Blaine R Roberts, Rudolf Grimm, Jessica L George, David P Bishop, Alison D Beavis, Sarah J Donovan, Gawain McColl, Irene Volitakis, Colin L Masters, Paul A Adlard, Robert A Cherny, Ashley I Bush, David I Finkelstein, Philip A Doble

Journal article  |  2014  |  CHEMICAL SCIENCE

Direct in vivo imaging of essential bioinorganics in Caenorhabditis elegans

Simon A James, Martin D de Jonge, Daryl L Howard, Ashley I Bush, David Paterson, Gawain McColl

Journal article  |  2013  |  METALLOMICS

Utility of an improved model of amyloid-beta (A beta(1-42)) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease

Gawain McColl, Blaine R Roberts, Tara L Pukala, Vijaya B Kenche, Christine M Roberts, Christopher D Link, Timothy M Ryan, Colin L Masters, Kevin J Barnham, Ashley I Bush, Robert A Cherny

Journal article  |  2012  |  MOLECULAR NEURODEGENERATION

Caenorhabditis elegans Maintains Highly Compartmentalized Cellular Distribution of Metals and Steep Concentration Gradients of Manganese

Gawain McColl, Simon A James, Sheridan Mayo, Daryl L Howard, Christopher G Ryan, Robin Kirkham, Gareth F Moorhead, David Paterson, Martin D de Jonge, Ashley I Bush

Journal article  |  2012  |  PLOS ONE

PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease.

Robert A Cherny, Scott Ayton, David I Finkelstein, Ashley I Bush, Gawain McColl, Stephen M Massa

Journal article  |  2012  |  Journal of Huntington's Disease

BACKGROUND: There is evidence that interaction with biologically important metals, particularly copper and iron, contributes to th..

Life Span Extension via eIF4G Inhibition Is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans

Aric N Rogers, Di Chen, Gawain McColl, Gregg Czerwieniec, Krysta Felkey, Bradford W Gibson, Alan Hubbard, Simon Melov, Gordon J Lithgow, Pankaj Kapahi

Journal article  |  2011  |  Cell Metabolism

Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans

Gawain McColl, Aric N Rogers, Silvestre Alavez, Alan E Hubbard, Simon Melov, Christopher D Link, Ashley I Bush, Pankaj Kapahi, Gordon J Lithgow

Journal article  |  2010  |  Cell Metabolism

The Caenorhabditis elegans A beta(1-42) Model of Alzheimer Disease Predominantly Expresses A beta(3-42)

Gawain Mccoll, Blaine R Roberts, Adam P Gunn, Keyla A Perez, Deborah J Tew, Colin L Masters, Kevin J Barnham, Robert A Cherny, Ashley I Bush

Journal article  |  2009  |  Biological Chemistry

Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans

Gawain McColl, David W Killilea, Alan E Hubbard, Maithili C Vantipalli, Simon Melov, Gordon J Lithgow

Journal article  |  2008  |  Journal of Biological Chemistry

C-elegans ortholog of mammalian Ku70 interacts with insulin-like signaling to modulate stress resistance and life span

G McColl, MC Vantipalli, GJ Lithgow

Journal article  |  2005  |  The FASEB Journal

Fitness cost of extended lifespan in Caenorhabditis elegans

NL Jenkins, G McColl, GJ Lithgow

Journal article  |  2004  |  Proceedings of the Royal Society of London. Series B: Biological Sciences

Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans

GA Walker, TM White, G McColl, NL Jenkins, S Babich, EPM Candido, TE Johnson, GJ Lithgow

Journal article  |  2001  |  The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Natural selection - Evolution of lifespan in C-elegans

DW Walker, G McColl, NL Jenkins, J Harris, GJ Lithgow

Journal article  |  2000  |  Nature

Testing evolutionary theories of aging

G McColl, NL Jenkins, DW Walker, GJ Lithgow

Journal article  |  2000  |  Annals of the New York Academy of Sciences

The Drosophila heat shock hsr-omega gene: An allele frequency cline detected by quantitative PCR

G McColl, SW McKechnie

Journal article  |  1999  |  Molecular Biology and Evolution

The hsr-omega gene of Drosophila melanogaster produces RNA products both constitutively and at elevated levels in response to heat..

Both allelic variation and expression of nuclear and cytoplasmic transcripts of Hsr-omega are closely associated with thermal phenotype in Drosophila

SW McKechnie, MM Halford, G McColl, AA Hoffmann

Journal article  |  1998  |  Proceedings of the National Academy of Sciences

Response of two heat shock genes to selection for knockdown heat resistance in Drosophila melanogaster

G McColl, AA Hoffmann, SW McKechnie

Journal article  |  1996  |  Genetics