Sophie Valkenburg

Perturbed CD8( ) T cell immunity across universal influenza epitopes in the elderly

Thi HO Nguyen, Sneha Sant, Nicola L Bird, Emma J Grant, E Bridie Clemens, Marios Koutsakos, Sophie A Valkenburg, Stephanie Gras, Martha Lappas, Anthony Jaworowski, Jane Crowe, Liyen Loh, Katherine Kedzierska

Journal article  |  2018  |  JOURNAL OF LEUKOCYTE BIOLOGY

Influenza epidemics lead to severe illness, life-threatening complications, and deaths, especially in the elderly. As CD8+ T cells..

Lack of Heterologous Cross-reactivity toward HLA-A*02:01 Restricted Viral Epitopes Is Underpinned by Distinct alpha beta T Cell Receptor Signatures

Emma J Grant, Tracy M Josephs, Sophie A Valkenburg, Linda Wooldridge, Margaret Hellard, Jamie Rossjohn, Mandvi Bharadwaj, Katherine Kedzierska, Stephanie Gras

Journal article  |  2016  |  JOURNAL OF BIOLOGICAL CHEMISTRY

αβT cell receptor (TCR) genetic diversity is outnumbered by the quantity of pathogenic epitopes to be recognized. To provide effic..

Molecular basis for universal HLA-A(star)0201-restricted CD8( ) T-cell immunity against influenza viruses

Sophie A Valkenburg, Tracy M Josephs, E Bridie Clemens, Emma J Grant, Thi HO Nguyen, George C Wang, David A Price, Adrian Miller, Steven YC Tong, Paul G Thomas, Peter C Doherty, Jamie Rossjohn, Stephanie Gras, Katherine Kedzierska

Journal article  |  2016  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memory CD8(+)T lymphocytes (CTLs) specific for antigenic peptides derived from internal viral proteins confer broad protection aga..

Molecular Imprint of Exposure to Naturally Occurring Genetic Variants of Human Cytomegalovirus on the T cell Repertoire

Corey Smith, Stephanie Gras, Rebekah M Brennan, Nicola L Bird, Sophie A Valkenburg, Kelly-Anne Twist, Jacqueline M Burrows, John J Miles, Daniel Chambers, Scott Bell, Scott Campbell, Katherine Kedzierska, Scott R Burrows, Jamie Rossjohn, Rajiv Khanna

Journal article  |  2014  |  SCIENTIFIC REPORTS

Exposure to naturally occurring variants of herpesviruses in clinical settings can have a dramatic impact on anti-viral immunity. ..