Natalie Gunn

Stage-based Variation in the Effect of Primary Tumor Side on All Stages of Colorectal Cancer Recurrence and Survival

Margaret M Lee, Andrew MacKinlay, Christine Semira, Christine Schieber, Antonio Jose Jimeno Yepes, Belinda Lee, Rachel Wong, Chathurika KH Hettiarachchige, Natalie Gunn, Jeanne Tie, Hui-Li Wong, Iain Skinner, Ian T Jones, James Keck, Suzanne Kosmider, Ben Tran, Kathryn Field, Peter Gibbs

Journal article  |  2018  |  CLINICAL COLORECTAL CANCER

BACKGROUND: Multiple studies have defined the prognostic and potential predictive significance of the primary tumor side in metast..

Optimization and (CH3)-C-13 methionine labeling of a signaling competent neurotensin receptor 1 variant for NMR studies

Fabian Bumbak, Alastair C Keen, Natalie J Gunn, Paul R Gooley, Ross AD Bathgate, Daniel J Scott

Journal article  |  2018  |  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Neurotensin is a 13-residue peptide that acts as a neuromodulator of classical neurotransmitters such as dopamine and glutamate in..

A Novel Ultra-Stable, Monomeric Green Fluorescent Protein For Direct Volumetric Imaging of Whole Organs Using CLARITY

Daniel J Scott, Natalie J Gunn, Kelvin J Yong, Verena C Wimmer, Nicholas A Veldhuis, Leesa M Challis, Mouna Haidar, Steven Petrou, Ross AD Bathgate, Michael DW Griffin

Journal article  |  2018  |  SCIENTIFIC REPORTS

Recent advances in thick tissue clearing are enabling high resolution, volumetric fluorescence imaging of complex cellular network..

A hybrid approach for automated mutation annotation of the extended human mutation landscape in scientific literature.

Antonio Jimeno Yepes, Andrew MacKinlay, Natalie Gunn, Christine Schieber, Noel Faux, Matthew Downton, Benjamin Goudey, Richard L Martin

Journal article  |  2018  |  AMIA Annu Symp Proc

As the cost of DNA sequencing continues to fall, an increasing amount of information on human genetic variation is being produced ..

Label-free screening of single biomolecules through resistive pulse sensing technology for precision medicine applications

S Harrer, SC Kim, C Schieber, S Kannam, N Gunn, S Moore, D Scott, R Bathgate, S Skafidas, JM Wagner

Journal article  |  2015  |  NANOTECHNOLOGY

Employing integrated nano- and microfluidic circuits for detecting and characterizing biological compounds through resistive pulse..

Sensing of protein molecules through nanopores: a molecular dynamics study

Sridhar Kumar Kannam, Sung Cheol Kim, Priscilla R Rogers, Natalie Gunn, John Wagner, Stefan Harrer, Matthew T Downton

Journal article  |  2014  |  NANOTECHNOLOGY

Solid-state nanopores have been shown to be suitable for single molecule detection. While numerous modeling investigations exist f..

Nanosensors for next generation drug screening

Sridhar K Kannam, Matthew T Downton, Natalie Gunn, Sung Cheol Kim, Priscilla R Rogers, Christine Schieber, Julia S Baldauf, John M Wagner, Daniel Scott, Ross Bathgate, Stan Skafidas, Stefan Harrer

Conference Proceedings  |  2013  |  MICRO/NANO MATERIALS, DEVICES, AND SYSTEMS

One promising path for future drug screening technologies is to examine the binding of ligands to target proteins at the single mo..

Targeting Lyn tyrosine kinase through protein fusions encompassing motifs of Cbp (Csk-binding protein) and the SOCS box of SOCS1 (Biochemical Journal (2012) 442 (611-620))

RJ Whiting, CJ Payne, J Satiaputra, N Kucera, TW Qiu, S Irtegun, NJ Gunn, NS Slavova-Azmanova, TD Mulhern, E Ingley

Journal article  |  2012  |  Biochemical Journal

Targeting Lyn tyrosine kinase through protein fusions encompassing motifs of Cbp (Csk-binding protein) and the SOCS box of SOCS1

Rhiannon J Whiting, Christine J Payne, Jiulia Satiaputra, Nicole Kucera, Theresa W Qiu, Sevgi Irtegun, Natalie J Gunn, Neli S Lavova-Azmanova, Terrence D Mulhern, Evan Ingley

Journal article  |  2012  |  BIOCHEMICAL JOURNAL

The tyrosine kinase Lyn is involved in oncogenic signalling in several leukaemias and solid tumours, and we have previously identi..

Bacterial expression and purification of active hematopoietic cell kinase

Romana Kristelly, Theresa Wenli Qiu, Natalie J Gunn, Denis B Scanlon, Terrence D Mulhern

Journal article  |  2011  |  PROTEIN EXPRESSION AND PURIFICATION

Src family kinases (SFKs) are traditionally purified from eukaryotic expression systems. These expression systems can be costly, y..