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High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot..
Displaying the 14 most recent projects by Ygal Haupt.
Displaying the 87 most recent scholarly works by Ygal Haupt.
TP53 Status, Patient Sex, and the Immune Response as Determinants of Lung Cancer Patient Survival.
Donald Freudenstein, Cassandra Litchfield, Franco Caramia, Gavin Wright, Benjamin J Solomon, David Ball, Simon P Keam, Paul Neeson, Ygal Haupt, Sue Haupt
Journal article | 2020 | Cancers
Lung cancer poses the greatest cancer-related death risk and males have poorer outcomes than females, for unknown reasons. Patient..
High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot.
Simon P Keam, Heloise Halse, Thu Nguyen, Minyu Wang, Nicolas Van Kooten Losio, Catherine Mitchell, Franco Caramia, David J Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Shahneen Sandhu, Piers Blombery, Ygal Haupt, Scott G Williams, Paul J Neeson
Journal article | 2020 | Journal for ImmunoTherapy of Cancer
BACKGROUND: Prostate cancer (PCa) has a profoundly immunosuppressive microenvironment and is commonly immune excluded with few inf..
P53: A Guardian of Immunity Becomes Its Saboteur through Mutation
Arjelle Decasa Agupitan, Paul Neeson, Scott Williams, Jason Howitt, Sue Haupt, Ygal Haupt
Journal article | 2020 | International Journal of Molecular Sciences
Awareness of the importance of immunity in controlling cancer development triggered research into the impact of its key oncogenic ..
The tumor immune microenvironment of germline BRCA1/2 and sporadic prostate cancer
Anna S Trigos, Anupama Pasam, Patricia Diana Banks, Roslyn Wallace, Simon P Keam, Heather Thorne, Catherine Mitchell, David Clouston, Declan G Murphy, Nathan Lawrentschuk, Damien M Bolton, Daniel Moon, Elena Castro, David Olmos, Phillip K Darcy, Ygal Haupt, Scott Williams, David L Goode, Paul J Neeson, Shahneen Kaur Sandhu
Conference Proceedings | 2020 | JOURNAL OF CLINICAL ONCOLOGY
Predicting radiation-induced immune trafficking and activation in localized prostate cancer
Scott Williams, Simon P Keam, Heloise Halse, Nguyen Thu, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Shahneen Kaur Sandhu, Piers Blombery, Ygal Haupt, Paul J Neeson
Conference Proceedings | 2020 | JOURNAL OF CLINICAL ONCOLOGY
E6AP Promotes a Metastatic Phenotype in Prostate Cancer
Cristina Gamell, Ivona Bandilovska, Twishi Gulati, Arielle Kogan, Syer Choon Lim, Zaklina Kovacevic, Elena A Takano, Clelia Timpone, Arjelle D Agupitan, Cassandra Litchfield, Giovanni Blandino, Lisa G Horvath, Stephen B Fox, Scott G Williams, Andrea Russo, Enzo Gallo, Piotr J Paul, Catherine Mitchell, Shahneen Sandhu, Simon P Keam, et al.
Journal article | 2019 | iScience
Although primary prostate cancer is largely curable, progression to metastatic disease is associated with very poor prognosis. E6A..
Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network
Sue Haupt, Franco Caramia, Alan Herschtal, Thierry Soussi, Guillermina Lozano, Hu Chen, Han Liang, Terence P Speed, Ygal Haupt
Journal article | 2019 | Nature Communications
The disproportionately high prevalence of male cancer is poorly understood. We tested for sex-disparity in the functional integrit..
Predicting radiation-induced immune trafficking and activation in localized prostate cancer
Simon Keam, Heloise Halse, Nguyen ThuNgoc, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip Darcy, Shahneen Sandhu, Piers Blombery, Ygal Haupt, Scott Williams, Paul Neeson
Conference Proceedings | 2019 | JOURNAL FOR IMMUNOTHERAPY OF CANCER
Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma
Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Huiqin Chen, Alison Slater, Kerry Ardley, Laura Kirby, Keefe T Chan, Natalie Brajanovski, Lorey K Smith, Aparna D Rao, Emily J Lelliott, Margarete Kleinschmidt, Ismael A Vergara, Anthony T Papenfuss, Peter Lau, Prerana Ghosh, Sue Haupt, et al.
Journal article | 2019 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Immune Profiling of Primary Prostate Cancer Arising in Men with and Without Germline DNA Repair Defects
Shahneen Sandhu, Anna Trigos, Anu Pasam, Patricia Banks, Simon Keam, Heather Thorn, Catherine Mitchell, David Clouston, Declan Murphy, Damien Bolton, Phil Darcy, Ygal Haupt, Scot Williams, David Goode, Paul Neeson
Conference Proceedings | 2019 | ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
E6AP goes viral: the role of E6AP in viral- and non-viral-related cancers
Ivona Bandilovska, Simon P Keam, Cristina Gamell, Claudia Machicado, Sue Haupt, Ygal Haupt
Journal article | 2019 | Carcinogenesis
Since its discovery, the E3 ubiquitin ligase E6-associated protein (E6AP) has been studied extensively in two pathological context..
A quantitative model to predict pathogenicity of missense variants in the TP53 gene
Cristina Fortuno, Arcadi Cipponi, Mandy L Ballinger, Sean Tavtigian, Magali Olivier, Vatsal Ruparel, Ygal Haupt, Sue Haupt, Kathy Tucker, Amanda B Spurdle, David M Thomas, Paul A James
Journal article | 2019 | Human Mutation
Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects
Alex RD Delbridge, Andrew J Kueh, Francine Ke, Natasha M Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J Herold, Ygal Haupt, Gordon K Smyth, Tim Thomas, Marnie E Blewitt, et al.
Journal article | 2019 | Cell Reports
Direct evidence of a clonal and tumor-directed T cell response to prostate cancer brachytherapy.
Scott Williams, Simon Keam, Heloise Halse, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phil Darcy, Shahneen Kaur Sandhu, Piers Blombery, Ygal Haupt, Paul J Neeson
Conference Proceedings | 2019 | Journal of Clinical Oncology
Copy number analysis identifies ESR1 and MDM4 as drivers of progression in invasive lobular breast carcinoma
JM Atkinson, L Cao, A Basudan, MJ Sikora, A Bahreini, N Tasdemir, RC Jankowitz, PF McAuliffe, D Dabbs, S Haupt, Y Haupt, PC Peter Lucas, AV Lee, S Oesterreich
Conference Proceedings | 2019 | Poster Session Abstracts
Frequent amplifications of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma
Lan Cao, Ahmed Basudan, Matthew J Sikora, Amir Bahreini, Nilgun Tasdemir, Kevin M Levine, Rachel C Jankowitz, Priscilla F McAuliffe, David Dabbs, Sue Haupt, Ygal Haupt, Peter C Lucas, Adrian Lee, Steffi Oesterreich, Jennifer M Atkinson
Journal article | 2019 | Cancer Letters
Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast cancer following invasive ductal carcino..
Biodosimetric transcriptional and proteomic changes are conserved in irradiated human tissue
Simon P Keam, Twishi Gulati, Cristina Gamell, Franco Caramia, Gisela Mir Arnau, Cheng Huang, Ralf B Schittenhelm, Oded Kleifeld, Paul J Neeson, Scott G Williams, Ygal Haupt
Journal article | 2018 | Radiation and Environmental Biophysics
An Analysis of Multiple Biomarkers to Better Predict Prostate Cancer Metastasis after Radical Prostatectomy
A Zhang, K Chiam, Y Haupt, S Fox, S Birch, W Tilley, L Butler, K Knudsen, C Cornstock, K Rasiah, J Grogan, K Mahon, T Bianco-Miotto, M Bohm, S Henshall, W Delprado, P Stricker, L Horvath, J Kench
Conference Proceedings | 2018 | ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
Exploring the oncoproteomic response of human prostate cancer to therapeutic radiation using data-independent acquisition (DIA) mass spectrometry
Simon P Keam, Twishi Gulati, Cristina Gamell, Franco Caramia, Cheng Huang, Ralf B Schittenhelm, Oded Kleifeld, Paul J Neeson, Ygal Haupt, Scott G Williams
Journal article | 2018 | The Prostate
Proteotranscriptomic Measurements of E6-Associated Protein (E6AP) Targets in DU145 Prostate Cancer Cells
Twishi Gulati, Cheng Huang, Franco Caramia, Dinesh Raghu, Piotr J Paul, Robert JA Goode, Simon P Keam, Scott G Williams, Sue Haupt, Oded Kleifeld, Ralf B Schittenhelm, Cristina Gamell, Ygal Haupt
Journal article | 2018 | Molecular & Cellular Proteomics
Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis
Shashank Masaldan, Sharnel AS Clatworthy, Cristina Gamell, Peter M Meggyesy, Antonia-Tonia Rigopoulos, Sue Haupt, Ygal Haupt, Delphine Denoyer, Paul A Adlard, Ashley I Bush, Michael A Cater
Journal article | 2018 | REDOX BIOLOGY
An analysis of multiple biomarkers to better predict prostate cancer metastasis and death after radical prostatectomy.
Alison Yan Zhang, Karen Chiam, Ygal Haupt, Stephen B Fox, Simone Birch, Wayne Tilley, Lisa Butler, Karen E Knudsen, Christopher Cornstock, Krishan Rasiah, Judith Grogan, Kate Lynette Mahon, Tina Bianco-Miotto, Maret Bohm, Susan M Henshall, Warick Delprado, Phillip Stricker, Lisa Horvath, James Kench
Conference Proceedings | 2018 | Journal of Clinical Oncology
The Transcriptional Landscape of Radiation-Treated Human Prostate Cancer: Analysis of a Prospective Tissue Cohort
Simon P Keam, Franco Caramia, Cristina Gamell, Piotr J Paul, Gisela Mir Arnau, Paul J Neeson, Scott G Williams, Ygal Haupt
Journal article | 2018 | International Journal of Radiation Oncology*Biology*Physics
E6AP promotes prostate cancer by reducing p27 expression
Dinesh Raghu, Piotr Jan Paul, Twishi Gulati, Siddhartha Deb, Christine Khoo, Andrea Russo, Enzo Gallo, Giovanni Blandino, Ai-Leen Chan, Elena Takano, Shahneen K Sandhu, Stephen B Fox, Scott Williams, Sue Haupt, Cristina Gamell, Ygal Haupt
Journal article | 2017 | Oncotarget
MDM4 is a rational target for treating breast cancers with mutant p53
Panimaya Jeffreena Miranda, Daniel Buckley, Dinesh Raghu, Jia-Min B Pang, Elena A Takano, Reshma Vijayakumaran, Amina FAS Teunisse, Atara Posner, Tahlia Procter, Marco J Herold, Cristina Gamell, Jean-Christophe Marine, Stephen B Fox, Aart Jochemsen, Sue Haupt, Ygal Haupt
Journal article | 2017 | The Journal of Pathology
Inhibiting the system x((C)over-bar)/glutathione axis selectively targets cancers with mutant-p53 accumulation
David S Liu, Cuong P Duong, Sue Haupt, Karen G Montgomery, Colin M House, Walid J Azar, Helen B Pearson, Oliver M Fisher, Matthew Read, Glen R Guerra, Ygal Haupt, Carleen Cullinane, Klas G Wiman, Lars Abrahmsen, Wayne A Phillips, Nicholas J Clemons
Journal article | 2017 | Nature Communications
Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer
Cristina Gamell, Twishi Gulati, Yaara Levav-Cohen, Richard J Young, Hongdo Do, Pat Pilling, Elena Takano, Neil Watkins, Stephen B Fox, Prudence Russell, Doron Ginsberg, Brendon J Monahan, Gavin Wright, Alex Dobrovic, Sue Haupt, Ben Solomon, Ygal Haupt
Journal article | 2017 | Science Signaling
WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma
Yuting Sun, Jessica L Bell, Daniel Carter, Samuele Gherardi, Rebecca C Poulos, Giorgio Milazzo, Jason WH Wong, Rima Al-Awar, Andrew E Tee, Pei Y Liu, Bing Liu, Bernard Atmadibrata, Matthew Wong, Toby Trahair, Quan Zhao, Jason M Shohet, Ygal Haupt, Johannes H Schulte, Peter J Brown, Cheryl H Arrowsmith, et al.
Journal article | 2015 | Cancer Research
APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma
David SH Liu, Matthew Read, Carleen Cullinane, Walid J Azar, Christina M Fennell, Karen G Montgomery, Sue Haupt, Ygal Haupt, Klas G Wiman, Cuong P Duong, Nicholas J Clemons, Wayne A Phillips
Journal article | 2015 | GUT
Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities
Madhusudhan Kollareddy, Elizabeth Dimitrova, Krishna C Vallabhaneni, Adriano Chan, Thuc Le, Krishna M Chauhan, Zunamys I Carrero, Gopalakrishnan Ramakrishnan, Kounosuke Watabe, Ygal Haupt, Sue Haupt, Radhika Pochampally, Gerard R Boss, Damian G Romero, Caius G Radu, Luis A Martinez
Journal article | 2015 | Nature Communications
Role of p53 in the progression of gastric cancer
Rita A Busuttil, Giada V Zapparoli, Sue Haupt, Christina Fennell, Stephen Q Wong, Jia-Min B Pang, Elena A Takeno, Catherine Mitchell, Natasha Di Costanzo, Stephen Fox, Ygal Haupt, Alexander Dobrovic, Alex Boussioutas
Journal article | 2014 | ONCOTARGET
Co-targeting Deoxyribonucleic Acide-Dependent Protein Kinase and Poly(Adenosine Diphosphate-Ribose) Polymerase-1 Promotes Accelerated Senescence of Irradiated Cancer Cells
Arun Azad, Patricia Bukczynska, Susan Jackson, Ygal Haput, Carleen Cullinane, Grant A McArthur, Benjamin Solomon
Journal article | 2014 | International Journal of Radiation: Oncology - Biology - Physics
The p53-Mdm2 loop: a critical juncture of stress response.
Yaara Levav-Cohen, Zehavit Goldberg, Kah Hin Tan, Osnat Alsheich-Bartok, Valentina Zuckerman, Sue Haupt, Ygal Haupt
Book Chapter | 2014 | Sub-cellular biochemistry
The presence of a functional p53 protein is a key factor for the proper suppression of cancer development. A loss of p53 activity,..
Increasing Intracellular Bioavailable Copper Selectively Targets Prostate Cancer Cells
Michael A Cater, Helen B Pearson, Kamil Wolyniec, Paul Klaver, Maree Bilandzic, Brett M Paterson, Ashley I Bush, Patrick O Humbert, Sharon La Fontaine, Paul S Donnelly, Ygal Haupt
Journal article | 2013 | ACS CHEMICAL BIOLOGY
Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner
Sue Haupt, Catherine Mitchell, Vincent Corneille, Jake Shortt, Stephen Fox, Pier Paolo Pandolfi, Mireia Castillo-Martin, Dennis M Bonal, Carlos Cordon-Cardo, Guillermina Lozano, Ygal Haupt
Journal article | 2013 | CELL CYCLE
c-Abl Phosphorylates E6AP and Regulates Its E3 Ubiquitin Ligase Activity
Ai-Leen Chan, Tamar Grossman, Valentina Zuckerman, Dafne Campigli Di Giammartino, Ofra Moshe, Martin Scheffner, Brendon Monahan, Pat Pilling, Yong-Hui Jiang, Sue Haupt, Ora Schueler-Furman, Ygal Haupt
Journal article | 2013 | Biochemistry
New Strategies to Direct Therapeutic Targeting of PML to Treat Cancers.
Kamil Wolyniec, Dennis A Carney, Sue Haupt, Ygal Haupt
Journal article | 2013 | Frontiers in Oncology
The tumor suppressor function of the promyelocytic leukemia (PML) protein was first identified as a result of its dysregulation in..
MDM4 is a key therapeutic target in cutaneous melanoma
Agnieszka Gembarska, Flavie Luciani, Clare Fedele, Elisabeth A Russell, Michael Dewaele, Stephanie Villar, Aleksandra Zwolinska, Sue Haupt, Job de Lange, Dana Yip, James Goydos, Jody J Haigh, Ygal Haupt, Lionel Larue, Aart Jochemsen, Hubing Shi, Gatien Moriceau, Roger S Lo, Ghanem Ghanem, Mark Shackleton, et al.
Journal article | 2012 | NATURE MEDICINE
E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis
Kamil Wolyniec, Jake Shortt, Elisa de Stanchina, Yaara Levav-Cohen, Osnat Alsheich-Bartok, Igal Louria-Hayon, Vincent Corneille, Beena Kumar, Simone J Woods, Stephen Opat, Ricky W Johnstone, Clare L Scott, David Segal, Pier Paolo Pandolfi, Stephen Fox, Andreas Strasser, Yong-Hui Jiang, Scott W Lowe, Sue Haupt, Ygal Haupt
Journal article | 2012 | BLOOD
Synchronized release of Doxil and Nutlin-3 by remote degradation of polysaccharide matrices and its possible use in the local treatment of colorectal cancer
Mirela Nadler-Milbauer, Lior Apter, Ygal Haupt, Sue Haupt, Yechezkel Barenholz, Tamara Minko, Abraham Rubinstein
Journal article | 2011 | Journal of Drug Targeting
Luminal delivery and dosing considerations of local celecoxib administration to colorectal cancer.
Sue Haupt, Tamar Zioni, Irith Gati, Jackie Kleinstern, Abraham Rubinstein
Journal article | 2006 | European Journal of Pharmaceutical Sciences
The purpose of this study was to develop a biodegradable drug platform composed of chitosan and guar gum and to explore the possib..
C-Abl as a modulator of p53.
Yaara Levav-Cohen, Zehavit Goldberg, Valentina Zuckerman, Tamar Grossman, Sue Haupt, Ygal Haupt
Journal article | 2005 | Biochemical and Biophysical Research Communications
P53 is renowned as a cellular tumor suppressor poised to instigate remedial responses to various stress insults that threaten DNA ..
Local prevention of oxidative stress in the intestinal epithelium of the rat by adhesive liposomes of superoxide dismutase and tempamine.
Tareq Taha Jubeh, Sivan Antler, Susan Haupt, Yechezkel Barenholz, Abraham Rubinstein
Journal article | 2005 | Molecular Pharmaceutics
The purpose of the present study was to investigate whether the local prevention of luminal superoxide-mediated biological damage ..
Regional peptide uptake study in the rat intestinal mucosa: glatiramer acetate as a model drug.
Susan Haupt, Efrat Gil, Regin Tirosh, Ety Klinger, Alexander Gad, Abraham Rubinstein
Journal article | 2002 | Pharmaceutical Research
PURPOSE: To identify regions of the rat intestine that are able to internalize from the lumen oligopeptides, using the model drug ..
The colon as a possible target for orally administered peptide and protein drugs.
Susan Haupt, Abraham Rubinstein
Journal article | 2002 | Critical Reviews in Therapeutic Drug Carrier Systems
Oral administration offers a potential portal to the superficial layers of the gastrointestinal (GI) tract (local delivery) and to..
Honours, Awards and Fellowships
The Sir Peter Maccallum Department Of Oncology
Doctor of Philosophy
Walter and Eliza Hall Institute of Medical Research
Bachelor of Science with Honours
Australian National University