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Bone Marrow Failure Syndromes In Australia: Improving Diagnosis To Inform Strategies For B..
Diagnostic evaluation and considerations in hypocellular bone marrow failure-A focus on ge..
Inhibiting Bcl-2 And Nk Cells Improves Stem Cell Transplant Outcomes In Acute Myeloid Leuk..
New advances in the management of cytomegalovirus in allogeneic haemopoietic stem cell tra..
Investigating The Safety And Efficacy, Quality Of Life, Cost-Efficiency And Immune Potenti..
Displaying the 7 most recent projects by David Ritchie.
Displaying the 193 most recent scholarly works by David Ritchie.
Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance
Robert Weinkove, Zoe K McQuilten, Jonathan Adler, Meera R Agar, Emily Blyth, Allen C Cheng, Rachel Conyers, Gabrielle M Haeusler, Claire Hardie, Christopher Jackson, Steven W Lane, Tom Middlemiss, Peter Mollee, Stephen P Mulligan, David Ritchie, Myra Ruka, Benjamin Solomon, Jeffrey Szer, Karin A Thursky, Erica M Wood, et al.
Journal article | 2020 | Medical Journal of Australia
INTRODUCTION: A pandemic coronavirus, SARS-CoV-2, causes COVID-19, a potentially life-threatening respiratory disease. Patients wi..
Diagnostic evaluation and considerations in hypocellular bone marrow failure-A focus on genomics
Lucy C Fox, Erica M Wood, David S Ritchie, Piers Blombery
Journal article | 2020 | International Journal of Laboratory Hematology
Hypocellular bone marrow failure (BMF) has myriad differential diagnoses, most simply considered as acquired and inherited disorde..
New advances in the management of cytomegalovirus in allogeneic haemopoietic stem cell transplantation
Michelle K Yong, David Gottlieb, Julian Lindsay, Jen Kok, William Rawlinson, Monica Slavin, David Ritchie, Ashish Bajel, Andrew Grigg
Journal article | 2020 | Internal Medicine Journal
Cytomegalovirus (CMV) viremia continues to be a frequent complication in the post haemopoietic stem cell transplant (HSCT) period ..
The QuantiFERON Monitor (R) assay is predictive of infection post allogeneic hematopoietic cell transplantation
Abby P Douglas, Lijia Yu, Vijaya Sundararajan, Jeff Szer, David Ritchie, Monica A Slavin, Joe Sasadeusz, Kumar Visvanathan
Journal article | 2020 | Transplant Infectious Disease
INTRODUCTION: Following allogeneic hematopoietic stem cell transplantation (alloHCT), excessive immunosuppression can be complicat..
Utility of clinical comprehensive genomic characterisation for diagnostic categorisation in patients presenting with hypocellular bone marrow failure syndromes.
Piers Blombery, Lucy Fox, Georgina L Ryland, Ella R Thompson, Jennifer Lickiss, Michelle McBean, Satwica Yerneni, David Hughes, Anthea Greenway, Francoise Mechinaud, Erica M Wood, Graham J Lieschke, Jeff Szer, Pasquale Barbaro, John Roy, Joel Wight, Elly Lynch, Melissa Martyn, Clara Gaff, David Ritchie
Journal article | 2020 | Haematologica
Bone marrow failure (BMF) related to hypoplasia of haematopoietic elements in the bone marrow is a heterogeneous clinical entity w..
Third-generation anti-CD19 chimeric antigen receptor T-cells incorporating a TLR2 domain for relapsed or refractory B-cell lymphoma: a phase I clinical trial protocol (ENABLE)
Philip George, Nathaniel Dasyam, Giulia Giunti, Brigitta Mester, Evelyn Bauer, Bethany Andrews, Travis Perera, Tess Ostapowicz, Chris Frampton, Peng Li, David Ritchie, Catherine M Bollard, Ian F Hermans, Robert Weinkove
Journal article | 2020 | BMJ Open
INTRODUCTION: Autologous T-cells transduced to express a chimeric antigen receptor (CAR) directed against CD19 elicit high respons..
Effects of chemotherapy agents used to treat pediatric acute lymphoblastic leukemia patients on bone parameters and longitudinal growth of juvenile mice
Lenny Straszkowski, Tanja Jovic, Wilson Castillo-Tandazo, David S Ritchie, Louise E Purton
Journal article | 2020 | Experimental Hematology
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Therapies for pediatric ALL have improved such that more t..
Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma
Thijs WH Flinsenberg, Charnelle C Tromedjo, Nan Hu, Ye Liu, Yin Guo, Kevin YT Thia, Tahereh Noori, Xiaomin Song, Han X Aw Yeang, Daniela G Tantalo, Sasanka Handunnetti, John F Seymour, Andrew W Roberts, David Ritchie, Rachel Koldej, Paul J Neeson, Lai Wang, Joseph A Trapani, Constantine S Tam, Ilia Voskoboinik
Journal article | 2020 | Haematologica
Severe chemotherapy toxicity in a 10-year-old with T-acute lymphoblastic lymphoma harboring biallelic FANCM variants
Georgina L Ryland, Lucy C Fox, Virginia Wootton, Ella R Thompson, Jennifer Lickiss, Alison H Trainer, Paddy Barbaro, Morag Whyte, David Ritchie, Piers Blombery
Journal article | 2020 | Leukemia & Lymphoma
Altitude exposure as a training & iron overload management strategy post leukemia
Benjamin G Serpell, Stephen Freeman, David Ritchie, Philip Choi, Julien D Periard, Avish P Sharma
Journal article | 2020 | Journal of Science and Medicine in Sport
OBJECTIVES: To examine iron stores, hemoglobin mass, and performance before, during and after intermittent altitude exposure in a ..
A Psychosexual Intervention for Couples within the First Year Post-Allogeneic Haematopoietic Stem Cell Transplantation: A Pilot Study
Brindha Pillay, Maria Ftanou, David Ritchie, Yvonne Panek-Hudson, Michael Jefford, Teresa Garcia, Cassandra Shields, Jo Gniel, Steve Ellen, Jo Phipps-Nelson, Allison Drosdowsky, Sarah Blaschke
Conference Proceedings | 2019 | ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
Time from autologous to allogeneic hematopoietic stem cell transplantation impacts post-transplant outcomes in multiple myeloma.
Salvatore Fiorenza, David Routledge, Jenny Collins, Michael Shipton, Simon Harrison, Ashish Bajel, James Cavet, Eleni Tholouli, Jordan Gauthier, David Ritchie
Journal article | 2019 | Bone Marrow Transplantation
A multicenter retrospective comparison of induction chemoimmunotherapy regimens on outcomes in transplant-eligible patients with previously untreated mantle cell lymphoma
Zi Yun Ng, Mark Bishton, David Ritchie, Robert Campbell, Michael Gilbertson, Kate Hill, Sumita Ratnasingam, Anthony Schwarer, Kate Manos, Sophie Shorten, Melissa Ng, Niles Nelson, Liu Xin, Sanjay De Mel Widanalage, Tenny Sunny, Duncan Purtill, Michelle Poon, Anna Johnston, Tara Cochrane, Hui-Peng Lee, et al.
Journal article | 2019 | Hematological Oncology
Mantle cell lymphoma (MCL) is an uncommon and typically aggressive form of lymphoma. Although often initially chemosensitive, rela..
Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes
Yuhao Jiao, Joanne E Davis, Jai Rautela, Emma M Carrington, Mandy J Ludford-Menting, Wilford Goh, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Rachel Koldej, Daniel Gray, David Huang, Ben T Kile, Andrew M Lew, David S Ritchie, Nicholas D Huntington
Journal article | 2019 | Cell Death & Differentiation
Allogeneic hematopoietic stem cell transplantation (alloSCT) is used to treat over 15,000 patients with acute myeloid leukemia (AM..
Lenalidomide maintenance treatment after imatinib discontinuation: results of a phase 1 clinical trial in chronic myeloid leukaemia
David M Ross, Ilaria S Pagani, Yazad D Irani, Jade Clarson, Tamara Leclercq, Dang Phuong, Jennifer McLean, Verity A Saunders, Lisa Carne, John Reynolds, David S Ritchie, Deborah L White, Susan Branford, Timothy P Hughes, Agnes SM Yong
Journal article | 2019 | British Journal of Haematology
Patterns of end-of-life hospital care for patients with non-Hodgkin lymphoma: exploring the landscape
Jennifer Philip, Anna Collins, David Ritchie, Brian Le, Jeremy Millar, Sue-Anne Mclachlan, Meinir Krishnasamy, Peter Hudson, Vijaya Sundararajan
Journal article | 2019 | Leukemia & Lymphoma
Rapid change, treatment responsiveness, and prognostication difficulties present challenges for palliative care integration for he..
Utilizing genomic analyses to investigate the first outbreak of vanA vancomycin-resistant Enterococcus in Australia with emergence of daptomycin non-susceptibility
Abby P Douglas, Caroline Marshall, Sarah L Baines, David Ritchie, Jeff Szer, Victoria Madigan, Hiu Tat Chan, Susan A Ballard, Benjamin P Howden, Kirsty Buising, Monica A Slavin
Journal article | 2019 | Journal of Medical Microbiology
The pharmacokinetics and pharmacodynamics of busulfan when combined with melphalan as conditioning in adult autologous stem cell transplant recipients
Abbey Willcox, Eric Wong, Christa Nath, Brett Janson, Simon J Harrison, Rosemary Hoyt, Ashish Bajel, Peter Shaw, David Ritchie, Andrew Grigg
Journal article | 2018 | Annals of Hematology
Nivolumab for Relapsed or Residual Haematological Malignancies after Allogeneic Haematopoietic Stem Cell Transplantation (NIVALLO)
Eric Wong, Emily Dawson, Joanne Davis, Rachel Koldej, Mandy Ludford-Menting, Matthew Lansdown, Heather Lambie, Jeffrey Szer, Andrew P Grigg, David Ritchie
Conference Proceedings | 2018 | Blood
The Impact of Vitamin D Replacement on Survival, Relapse and GvHD after Allogeneic Stem Cell Transplantation: A Matched Cohort Analysis
Sara Mastaglio, Eric Wong, Travis Perera, Andrew Lim, Kate Mason, Jenny Collins, Jeff Szer, Andrew Grigg, Rachel Koldej, David Ritchie
Conference Proceedings | 2018 | BONE MARROW TRANSPLANTATION
Prognostic markers in core-binding factor AML and improved survival with multiple consolidation cycles of intermediate-/high-dose cytarabine
Ashvind Prabahran, Mark Tacey, Shaun Fleming, Andrew Wei, Courtney Tate, Paula Marlton, Joel Wight, Andrew Grigg, Annabel Tuckfield, Jeff Szer, David Ritchie, Lynette Chee
Journal article | 2018 | European Journal of Haematology
Human blood MAIT cell subsets defined using MR1 tetramers
Nicholas A Gherardin, Michael NT Souter, Hui-Fern Koay, Kirstie M Mangas, Torsten Seemann, Timothy P Stinear, Sidonia BG Eckle, Stuart P Berzins, Yves d'Udekem, Igor E Konstantinov, David P Fairlie, David S Ritchie, Paul J Neeson, Daniel G Pellicci, Adam P Uldrich, James McCluskey, Dale I Godfrey
Journal article | 2018 | Immunology and Cell Biology
Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma
Nicholas A Gherardin, Liyen Loh, Lorenztino Admojo, Alexander J Davenport, Kelden Richardson, Amy Rogers, Phillip K Darcy, Misty R Jenkins, H Miles Prince, Simon J Harrison, Hang Quach, David P Fairlie, Katherine Kedzierska, James McCluskey, Adam P Uldrich, Paul J Neeson, David S Ritchie, Dale I Godfrey
Journal article | 2018 | Scientific Reports
Acute myeloid leukaemia relapsing after allogeneic haemopoietic stem cell transplantation: prognostic factors and impact of initial therapy of relapse
Andrew BM Lim, Cameron Curley, Chun Y Fong, Ian Bilmon, Ashanka Beligaswatte, Duncan Purtill, Bartlomiej Getta, Anne M Johnston, Tasman Armytage, Marnie Collins, Kate Mason, Katherine Fielding, Matthew Greenwood, John Gibson, Mark Hertzberg, Matthew Wright, Ian Lewis, John Moore, David Curtis, Jeff Szer, et al.
Journal article | 2018 | Internal Medicine Journal
Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity
AJ Davenport, RS Cross, KA Watson, Y Liao, W Shi, HM Prince, PA Beavis, JA Trapani, MH Kershaw, DS Ritchie, PK Darcy, PJ Neeson, MR Jenkins
Journal article | 2018 | Proceedings of the National Academy of Sciences
An International Multicenter Retrospective Comparison of Induction Chemoimmunotherapy Regimens on Outcomes in Patients with Transplant-Eligible Mantle Cell Lymphoma
Zi Yun Ng, Mark Bishton, David Ritchie, Robert Campbell, Michael P Gilbertson, Kate Hill, Sumita Ratnasingam, Anthony P Schwarer, Kate Manos, Sophie Shorten, Melissa Liet Hing Ng, Niles Elizabeth Nelson, Liu Xin, Sanjay De Mel, Tenny Sunny, Duncan Purtill, Michelle Poon, Anna M Johnston, Tara Cochrane, Hui-Peng Lee, et al.
Conference Proceedings | 2017 | BLOOD
Low T-Cell Responses to Mitogen Stimulation Predicts Poor Survival in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation
Michelle K Yong, Paul U Cameron, Monica A Slavin, Allen C Cheng, C Orla Morrissey, Krystal Bergin, Andrew Spencer, David Ritchie, Sharon R Lewin
Journal article | 2017 | Frontiers in Immunology
Cytomegalovirus Reactivation Is Associated with Increased Risk of Late-Onset Invasive Fungal Disease after Allogeneic Hematopoietic Stern Cell Transplantation: A Multicenter Study in the Current Era of Viral Load Monitoring
Michelle K Yong, Michelle Ananda-Rajah, Paul U Cameron, C Orla Morrissey, Andrew Spencer, David Ritchie, Allen C Cheng, Sharon R Lewin, Monica Slavin
Journal article | 2017 | Biology of Blood and Marrow Transplantation
Predicting Risk of Infection in Patients with Newly Diagnosed Multiple Myeloma: Utility of Immune Profiling
Benjamin W Teh, Simon J Harrison, Cody Charles Allison, Monica A Slavin, Tim Spelman, Leon J Worth, Karin A Thursky, David Ritchie, Marc Pellegrini
Journal article | 2017 | Frontiers in Immunology
Hematology oncology practice in the Asia-Pacific APHCON survey results from the 6th international hematologic malignancies conference: bridging the gap 2015, Beijing, China
Xiao Jun Huang, Kaiyan Liu, David Ritchie, Borje Andersson, Jin Lu, Jian Hou, Adolfo de la Fuente Burguera, JianXiang Wang, Allen Yeoh, Chenhua Yan, Daobin Zhou, Daryl Tan, Dong Wook Kim, Depei Wu, Elizabeth Shpall, Stephen Kornblau, Sattava Neelapu, Suradej Hongeng, Jianyong Li, Jiong Hu, et al.
Journal article | 2017 | Oncotarget
Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation
Michelle K Yong, Paul U Cameron, Monica Slavin, C Orla Morrissey, Krystal Bergin, Andrew Spencer, David Ritchie, Allen C Cheng, Assia Samri, Guislaine Carcelain, Brigitte Autran, Sharon R Lewin
Journal article | 2017 | The Journal of Infectious Diseases
Prognostic Limitations of Donor T Cell Chimerism after Myeloablative Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndromes
Eric Wong, Kate Mason, Jenny Collins, Barbara Hockridge, Janis Boyd, Alexandra Gorelik, Jeffrey Szer, David S Ritchie
Journal article | 2017 | Biology of Blood and Marrow Transplantation
Busulfan is effective second-line therapy for older patients with Philadelphia-negative myeloproliferative neoplasms intolerant of or unresponsive to hydroxyurea
Genevieve Douglas, Claire Harrison, Cecily Forsyth, Michael Bennett, William Stevenson, John Hounsell, Sumita Ratnasingam, David Ritchie, David M Ross, Andrew Grigg
Journal article | 2017 | Leukemia & Lymphoma
Safety, clinical effectiveness and trough plasma concentrations of intravenous posaconazole in patients with haematological malignancies and/or undergoing allogeneic haematopoietic stem cell transplantation: off-trial experience
Wirawan Jeong, Peter Haywood, Naranie Shanmuganathan, Julian Lindsay, Karen Urbancic, Michelle R Ananda-Rajah, Sharon CA Chen, Ashish Bajel, David Ritchie, Andrew Grigg, John F Seymour, Anton Y Peleg, David CM Kong, Monica A Slavin
Journal article | 2016 | Journal of Antimicrobial Chemotherapy
Spontaneous onset and transplant models of the Vk*MYC mouse show immunological sequelae comparable to human multiple myeloma
Rachel E Cooke, Nicholas A Gherardin, Simon J Harrison, Hang Quach, Dale I Godfrey, Miles Prince, Rachel Koldej, David S Ritchie
Journal article | 2016 | Journal of Translational Medicine
The impact of HLA class I and EBV latency-II antigen-specific CD8( ) T cells on the pathogenesis of EBV Hodgkin lymphoma
K Jones, L Wockner, RM Brennan, C Keane, PK Chattopadhyay, M Roederer, DA Price, DK Cole, B Hassan, K Beck, D Gottlieb, DS Ritchie, JF Seymour, F Vari, P Crooks, SR Burrows, MK Gandhi
Journal article | 2016 | Clinical & Experimental Immunology
Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition
Nicholas A Gherardin, Andrew N Keller, Rachel E Woolley, Jerome Le Nours, David S Ritchie, Paul J Neeson, Richard W Birkinshaw, Sidonia BG Eckle, John N Waddington, Ligong Liu, David P Fairlie, Adam P Uldrich, Daniel G Pellicci, James McCluskey, Dale I Godfrey, Jamie Rossjohn
Journal article | 2016 | Immunity
Asia-Pacific Hematology Consortium Report on approach to multiple myeloma. Survey results from the 6th International Hematologic Malignancies Conference: Bridging the Gap 2015, Beijing, China
Jin Lu, Jian Hou, Kai-Yan Liu, Simrit Parmar, Adolfo De La Fuente, Borje Andersson, ChenHua Yan, Daobin Zhou, Daryl Tan, David Ritchie, Deipei Wu, Elizabeth Shpall, Ginna G Laport, JianYong Li, Jiong Hu, Lian Sheng Zhang, Michael Wang, Pankaj Malhotra, Qian Jiang, Yazhen Qin, et al.
Journal article | 2016 | Leukemia & Lymphoma
Double umbilical cord blood transplant is effective therapy for relapsed or refractory Hodgkin lymphoma
Philip A Thompson, Travis Perera, David Marin, Betul Oran, Uday Popat, Muzaffar Qazilbash, Nina Shah, Simrit Parmar, Katayoun Rezvani, Amanda Olson, Partow Kebriaei, Paolo Anderlini, Gabriela Rondon, Amin Alousi, Stefan Ciurea, Richard E Champlin, Ashish Bajel, Jeffrey Szer, Elizabeth J Shpall, David Ritchie, et al.
Journal article | 2016 | Leukemia & Lymphoma
The Patient Remote Intervention and Symptom Management System (PRISMS) - a Telehealth-mediated intervention enabling real-time monitoring of chemotherapy side-effects in patients with haematological malignancies: study protocol for a randomised controlled trial
Sibilah Breen, David Ritchie, Penelope Schofield, Ya-seng Hsueh, Karla Gough, Nick Santamaria, Rose Kamateros, Roma Maguire, Nora Kearney, Sanchia Aranda
Journal article | 2015 | Trials
Allogeneic hematopoietic cell transplant for AML: no impact of pre-transplant extramedullary disease on outcome
SD Goyal, M-J Zhang, H-L Wang, G Akpek, EA Copelan, C Freytes, RP Gale, M Hamadani, Y Inamoto, RT Kamble, HM Lazarus, DI Marks, T Nishihori, RF Olsson, R Reshef, DS Ritchie, W Saber, BN Savani, A Seber, TC Shea, et al.
Journal article | 2015 | Bone Marrow Transplantation
Myelosuppressive Therapies Significantly Increase ProInflammatory Cytokines and Directly Cause Bone Loss
Julie M Quach, Maria Askmyr, Tanja Jovic, Emma K Baker, Nicole C Walsh, Simon J Harrison, Paul Neeson, David Ritchie, Peter R Ebeling, Louise E Purton
Journal article | 2015 | Journal of Bone and Mineral Research
Immunosurveillance and therapy of multiple myeloma are CD226 dependent
Camille Guillerey, Lucas Ferrari de Andrade, Slavica Vuckovic, Kim Miles, Shin Foong Ngiow, Michelle CR Yong, Michele WL Teng, Marco Colonna, David S Ritchie, Martha Chesi, P Leif Bergsagel, Geoffrey R Hil, Mark J Smyth, Ludovic Martinet
Journal article | 2015 | Journal of Clinical Investigation
A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia
Simon Z He, Samantha Busfield, David S Ritchie, Mark S Hertzberg, Simon Durrant, Ian D Lewis, Paula Marlton, Andrew J McLachlan, Ian Kerridge, Kenneth F Bradstock, Glen Kennedy, Andrew W Boyd, Trina M Yeadon, Angel F Lopez, Hayley S Ramshaw, Harry Iland, Simone Bamford, Megan Barnden, Mark DeWitte, Russell Basser, et al.
Journal article | 2015 | Leukemia & Lymphoma
Older recipient age is paradoxically associated with a lower incidence of chronic GVHD in Thymoglobulin recipients: a retrospective study exploring risk factors for GVHD in allogeneic transplantation with Thymoglobulin GVHD prophylaxis
ABM Lim, J Storek, A Beligaswatte, M Collins, M Tacey, T Williamson, K Mason, E Li, MA Chaudhry, JA Russell, A Daly, J Szer, I Lewis, D Ritchie
Journal article | 2015 | Bone Marrow Transplantation
A Radio-Resistant Perforin-Expressing Lymphoid Population Controls Allogeneic T Cell Engraftment, Activation, and Onset of Graft-versus-Host Disease in Mice
Joanne E Davis, Michael Harvey, Nicholas A Gherardin, Rachel Koldej, Nicholas Huntington, Paul Neeson, Joseph A Trapani, David S Ritchie
Journal article | 2015 | Biology of Blood and Marrow Transplantation
CD3(bright) signals on gamma delta T cells identify IL-17A-producing V gamma 6V delta 1( ) T cells
C Paget, MT Chow, NA Gherardin, PA Beavis, AP Uldrich, H Duret, M Hassane, F Souza-Fonseca-Guimaraes, DA Mogilenko, D Staumont-Salle, NK Escalante, GR Hill, P Neeson, DS Ritchie, D Dombrowicz, T Mallevaey, F Trottein, GT Belz, DI Godfrey, MJ Smyth
Journal article | 2015 | Immunology & Cell Biology
Induction of potent NK cell-dependent anti-myeloma cytotoxic T cells in response to combined mapatumumab and bortezomib
Paul J Neeson, Andy K Hsu, Yin R Chen, Heloise M Halse, Joanna Loh, Reece Cordy, Kate Fielding, Joanne Davis, Josh Noske, Alex J Davenport, Camilla A Lindqvist-Gigg, Robin Humphreys, Tsin Tai, H Miles Prince, Joseph A Trapani, Mark J Smyth, David S Ritchie
Journal article | 2015 | OncoImmunology
Lack of durable disease control with chemotherapy for mycosis fungoides and Sezary syndrome: a comparative study of systemic therapy
Charlotte FM Hughes, Amit Khot, Christopher McCormack, Stephen Lade, David A Westerman, Robert Twigger, Odette Buelens, Kate Newland, Constantine Tam, Michael Dickinson, Gail Ryan, David Ritchie, Colin Wood, H Miles Prince
Journal article | 2015 | Blood
The utility and limitations of F-18-fluorodeoxyglucose positron emission tomography with computed tomography in patients with primary mediastinal B-cell lymphoma: single institution experience and literature review
Chan Y Cheah, Michael S Hofman, John F Seymour, David S Ritchie, Michael Dickinson, Andrew Wirth, H Miles Prince, Max Wolf, Elchanan H Januszcewicz, Dennis A Carney, Kirsten E Herbert, Simon J Harrison, Kate L Burbury, Constantine S Tam
Journal article | 2015 | Leukemia & Lymphoma
A multicentre retrospective comparison of central nervous system prophylaxis strategies among patients with high-risk diffuse large B-cell lymphoma
CY Cheah, KE Herbert, K O'Rourke, GA Kennedy, A George, PL Fedele, M Gilbertson, SY Tan, DS Ritchie, SS Opat, HM Prince, M Dickinson, K Burbury, M Wolf, EH Januszewicz, CS Tam, DA Westerman, DA Carney, SJ Harrison, JF Seymour
Journal article | 2014 | British Journal of Cancer
The Choice of Multiple Myeloma Induction Therapy Affects the Frequency and Severity of Oral Mucositis After Melphalan-Based Autologous Stem Cell Transplantation
Shaun Fleming, Simon J Harrison, Piers Blombery, Trish Joyce, Kerrie Stokes, John F Seymour, H Miles Prince, David Ritchie
Journal article | 2014 | Clinical Lymphoma Myeloma and Leukemia
Sorafenib priming may augment salvage chemotherapy in relapsed and refractory FLT3-ITD-positive acute myeloid leukemia
KD Cummins, SM Jane, S Ninkovic, A Bazargan, R Filshie, G Sutrave, M Hertzberg, A Scott, S Lane, CK Yannakou, D Ritchie, J D'Rozario, J Black, K Bavishi, A Wei
Journal article | 2014 | Blood Cancer Journal
Plerixafor plus pegfilgrastim is a safe, effective mobilization regimen for poor or adequate mobilizers of hematopoietic stem and progenitor cells: a phase I clinical trial
KE Herbert, L Demosthenous, G Wiesner, E Link, DA Westerman, N Came, DS Ritchie, S Harrison, JF Seymour, HM Prince
Journal article | 2014 | Bone Marrow Transplantation
Limited clinical benefit for surveillance PET-CT scanning in patients with histologically transformed lymphoma in complete metabolic remission following primary therapy
Chan Y Cheah, Michael Dickinson, Michael S Hofman, Anupkumar George, David S Ritchie, H Miles Prince, David Westerman, Simon J Harrison, Kate Burbury, Max Wolf, Henry Januszewicz, Kirsten E Herbert, Dennis A Carney, Constantine Tam, John F Seymour
Journal article | 2014 | Annals of Hematology
Screening with Spirometry Is a Useful Predictor of Later Development of Noninfectious Pulmonary Syndromes in Patients Undergoing Allogeneic Stem Cell Transplantation
Philip A Thompson, Andrew Lim, Yvonne Panek-Hudson, Mark Tacey, Ramzi Hijazi, Ashley P Ng, Jeff Szer, David Ritchie, Ashish Bajel
Journal article | 2014 | Biology of Blood and Marrow Transplantation
The Drug Vehicle and Solvent N-Methylpyrrolidone Is an Immunomodulator and Antimyeloma Compound
Jake Shortt, Andy K Hsu, Benjamin P Martin, Karen Doggett, Geoffrey M Matthews, Maria A Doyle, Jason Ellul, Tina E Jockel, Daniel M Andrews, Simon J Hogg, Andrea Reitsma, David Faulkner, P Leif Bergsagel, Marta Chesi, Joan K Heath, William A Denny, Philip E Thompson, Paul J Neeson, David S Ritchie, Grant A McArthur, et al.
Journal article | 2014 | Cell Reports
Early thymus and activation-regulated chemokine (TARC) reduction and response following panobinostat treatment in patients with relapsed/refractory Hodgkin lymphoma following autologous stem cell transplant
Simon J Harrison, Andy K Hsu, Paul Neeson, Anas Younes, Anna Sureda, Andreas Engert, H Miles Prince, Martha Li, Paula Savage, Roberto Bugarini, Denise Williams, Margaret Squier, David S Ritchie
Journal article | 2014 | Leukemia & Lymphoma
The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions
Christopher J Chan, Ludovic Martinet, Susan Gilfillan, Fernando Souza-Fonseca-Guimaraes, Melvyn T Chow, Liam Town, David S Ritchie, Marco Colonna, Daniel M Andrews, Mark J Smyth
Journal article | 2014 | Nature Immunology
Fludarabine Melphalan reduced-intensity conditioning allotransplanation provides similar disease control in lymphoid and myeloid malignancies: analysis of 344 patients
A Bryant, I Nivison-Smith, ES Pillai, G Kennedy, A Kalff, D Ritchie, B George, M Hertzberg, S Patil, A Spencer, K Fay, P Cannell, L Berkahn, R Doocey, R Spearing, J Moore
Journal article | 2014 | Bone Marrow Transplantation
Persistence and Efficacy of Second Generation CAR T Cell Against the LeY Antigen in Acute Myeloid Leukemia
David S Ritchie, Paul J Neeson, Amit Khot, Stefan Peinert, Tsin Tai, Kellie Tainton, Karen Chen, Mandy Shin, Dominic M Wall, Dirk Hoenemann, Peter Gambell, David A Westerman, Javier Haurat, Jennifer A Westwood, Andrew M Scott, Lucy Kravets, Michael Dickinson, Joseph A Trapani, Mark J Smyth, Phillip K Darcy, et al.
Journal article | 2013 | Molecular Therapy
Central nervous system involvement in mantle cell lymphoma: clinical features, prognostic factors and outcomes from the European Mantle Cell Lymphoma Network
CY Cheah, A George, E Gine, A Chiappella, HC Kluin-Nelemans, W Jurczak, K Krawczyk, H Mocikova, P Klener, D Salek, J Walewski, M Szymczyk, L Smolej, RL Auer, DS Ritchie, L Arcaini, ME Williams, M Dreyling, JF Seymour
Journal article | 2013 | Annals of Oncology
Central nervous system multiple myeloma - potential roles for intrathecal therapy and measurement of cerebrospinal fluid light chains
Denise Lee, Anna Kalff, Michael Low, Shane Gangatharan, Prahlad Ho, Ashish Bajel, David Ritchie, Andrew Grigg, Andrew Spencer
Journal article | 2013 | British Journal of Haematology
Limited role for surveillance PET-CT scanning in patients with diffuse large B-cell lymphoma in complete metabolic remission following primary therapy
CY Cheah, MS Hofman, M Dickinson, A Wirth, D Westerman, SJ Harrison, K Burbury, M Wolf, H Januszewicz, K Herbert, HM Prince, DA Carney, DS Ritchie, RJ Hicks, JF Seymour
Journal article | 2013 | British Journal of Cancer
Bortezomib with high dose melphalan conditioning for autologous transplant is safe and effective in patients with heavily pretreated and high risk multiple myeloma
Nicole Wong Doo, Philip A Thompson, H Miles Prince, John F Seymour, David Ritchie, Kerrie Stokes, Kate Burbury, Max Wolf, Trish Joyce, Simon J Harrison
Journal article | 2013 | Leukemia and Lymphoma
IL15 levels on day 7 after hematopoietic cell transplantation predict chronic GVHD
LM Pratt, Y Liu, A Ugarte-Torres, M Hoegh-Petersen, PJ Podgorny, AW Lyon, TS Williamson, FM Khan, MA Chaudhry, A Daly, DA Stewart, JA Russell, A Grigg, D Ritchie, J Storek
Journal article | 2013 | Bone Marrow Transplantation
A Risk-Adapted Protocol for Delayed Administration of Filgrastim After High-Dose Chemotherapy and Autologous Stem Cell Transplantation
Amit Khot, Michael Dickinson, Kerrie Stokes, Simon Harrison, Kate Burbury, Shaun Fleming, Dominic Wall, Peter Gambell, H Miles Prince, John F Seymour, David Ritchie
Journal article | 2013 | Clinical Lymphoma & Myeloma
Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells
Saar Gill, Adrianne E Vasey, Alysha De Souza, Jeanette Baker, Aaron T Smith, Holbrook E Kohrt, Mareike Florek, Kenneth D Gibbs, Keri Tate, David S Ritchie, Robert S Negrin
Journal article | 2012 | Blood
A high rate of durable responses with romidepsin, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma
Simon J Harrison, Hang Quach, Emma Link, John F Seymour, David S Ritchie, Sam Ruell, Joanne Dean, Henry Januszewicz, Ricky Johnstone, Paul Neeson, Michael Dickinson, Jean Nichols, H Miles Prince
Journal article | 2011 | Blood
Strategies to optimize collection of hematopoietic stem cells in patients with mantle cell lymphoma receiving hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone combined with cytarabine and methotrexate (Hyper-CVAD) chemotherapy
Kirsten E Herbert, David S Ritchie, John F Seymour
Journal article | 2011 | Leukemia and Lymphoma
Ex vivo culture of chimeric antigen receptor T cells generates functional CD8( ) T cells with effector and central memory-like phenotype
P Neeson, A Shin, KM Tainton, P Guru, HM Prince, SJ Harrison, S Peinert, MJ Smyth, JA Trapani, MH Kershaw, PK Darcy, DS Ritchie
Journal article | 2010 | Gene Therapy
Improved survival for relapsed diffuse large B cell lymphoma is predicted by a negative pre-transplant FDG-PET scan following salvage chemotherapy
Michael Dickinson, Rosemary Hoyt, Andrew W Roberts, Andrew Grigg, John F Seymour, H Miles Prince, Jeff Szer, David Ritchie
Journal article | 2010 | British Journal of Haematology
Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen
S Peinert, HM Prince, PM Guru, MH Kershaw, MJ Smyth, JA Trapani, P Gambell, S Harrison, AM Scott, FE Smyth, PK Darcy, K Tainton, P Neeson, DS Ritchie, D Hoenemann
Journal article | 2010 | Gene Therapy
Reactivation of DNA viruses in association with histone deacetylase inhibitor therapy: a case series report
David Ritchie, Richard L Piekarz, Piers Blombery, Laszlo J Karai, Stefania Pittaluga, Elaine S Jaffe, Mark Raffeld, John E Janik, H Miles Prince, Susan E Bates
Journal article | 2009 | Haematologica
Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin Lymphoma
Michael Dickinson, David Ritchie, Daniel J DeAngelo, Andrew Spencer, Oliver G Ottmann, Thomas Fischer, Kapil N Bhalla, Angela Liu, Katie Parker, Jeffrey W Scott, Mark Bishton, H Miles Prince
Journal article | 2009 | British Journal of Haematology
Agonistic antibody to TRAIL-R1 (Mapatumumab) and low dose Bortezomib induce apoptosis in multiple myeloma while preserving dendritic cell function
Paul Neeson, Karen Chen, Tsin Tai, Amanda Shin, Kellie Tainton, Kate Fielding, Joanne Davis, H Prince, Robin Humphreys, David Ritchie
Journal article | 2009 | CANCER RESEARCH
Disease status at autologous stem cell transplantation and the cell of origin phenotype are important predictors of outcome in patients with neurologic (central nervous system) relapse of diffuse large B-cell lymphoma undergoing autologous stem cell transplantation
Sushrut Patil, Andrew Spencer, Anthony Schwarer, Sharon Avery, David Ritchie, Stephen Opat, Andrew Wei, Catriona McLean
Journal article | 2009 | Leukemia & Lymphoma
Dendritic cells treated with lipopolysaccharide up-regulate serine protease inhibitor 6 and remain sensitive to killing by cytotoxic T lymphocytes in vivo.
Kate A Andrew, Helen MA Simkins, Sabine Witzel, Rachel Perret, Jenny Hudson, Ian F Hermans, David S Ritchie, Jianping Yang, Franca Ronchese
Journal article | 2008 | The Journal of Immunology
Ag presentation by dendritic cells (DC) in vivo is essential to the initiation of primary and secondary T cell responses. We have ..
Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice
JA Westwood, WK Murray, M Trivett, A Shin, P Neeson, DP MacGregor, NM Haynes, JA Trapani, P Mayura-Guru, S Fox, S Peinert, D Honemann, HM Prince, D Ritchie, AM Scott, FE Smyth, MJ Smyth, PK Darcy, MH Kershaw
Journal article | 2008 | Gene Therapy
[F-18] fluorodeoxyglucose positron emission tomography scanning for staging, response assessment, and disease surveillance in patients with mantle cell lymphoma
Saar Gill, Max Wolf, H Miles Prince, Henry Januszewicz, David Ritchie, Rodney J Hicks, John F Seymour
Journal article | 2008 | Clinical Lymphoma & Myeloma
Glycolytic metabolism confers resistance to combined all-trans retinoic acid and arsenic trioxide-induced apoptosis in HL60rho0 cells.
Patries M Herst, Elizabeth L Hesketh, David S Ritchie, Michael V Berridge
Journal article | 2008 | Leukemia Research
Glycolytic cancers are resistant to many forms of chemotherapy and some respond poorly to differentiation therapies. Here, we inve..
In vivo tracking of dendritic cells in patients with multiple myeloma
H Miles Prince, Dominic M Wall, David Ritchie, Dirk Honemann, Simon Harrrison, Hang Quach, Mick Thompson, Rodney Hicks, Eddie Lau, Jill Davison, Maureen Loudovaris, Jude Moloney, Bruce Loveland, Jacques Bartholeyns, Andrew Katsifis, Linda Mileshkin
Journal article | 2008 | Journal of Immunotherapy
Patients with multiple myeloma treated with thalidomide: evaluation of clinical parameters, cytokines, angiogenic markers, mast cells and marrow CD57*cytotoxic T cells as predictors of outcome
Linda Mileshkin, Dirk Honemann, Peter Gambell, Melanie Trivett, Yoshihiro Hayakawa, Mark Smyth, Victoria Beshay, David Ritchie, Paul Simmons, Alvin D Milner, Jerome B Zeldis, H Miles Prince
Journal article | 2007 | Haematologica
Resting B cells suppress tumor immunity via an MHC class-II dependent mechanism.
Victoria Watt, Franca Ronchese, David Ritchie
Journal article | 2007 | Journal of Immunotherapy
Resting B cells have been variously shown to induce direct tolerance of antigen specific CD8+ T cells, induce T-cell anergy via tr..
The hyper-CVAD-rituximab chemotherapy programme followed by high-dose busulfan, melphalan and autologous stem cell transplantation produces excellent event-free survival in patients with previously untreated mantle cell lymphoma
DS Ritchie, JF Seymour, AP Grigg, AW Roberts, R Hoyt, S Thompson, J Szer, HM Prince
Journal article | 2007 | Annals of Hematology
Autologous dendritic cells pulsed with eluted peptide as immunotherapy for advanced B-cell malignancies.
David Ritchie, Ian Hermans, Jianping Yang, Julie Walton, Kate Matthews, John Carter, Michael Findlay, Peter Dady, Pisana Rawson, Franca Ronchese
Journal article | 2006 | Leukemia & Lymphoma
We have studied the feasibility, safety and efficacy of vaccination with autologous dendritic cells pulsed with eluted peptide in ..
Prospective monitoring of tumor necrosis factor alpha and interferon gamma to predict the onset of acute and chronic graft-versus-host disease after allogeneic stem cell transplantation.
David Ritchie, Janet Seconi, Catherine Wood, Julie Walton, Victoria Watt
Journal article | 2005 | Biology of Blood and Marrow Transplantation
Peripheral blood T cells were isolated from 19 allogeneic and 4 autologous stem cell transplant (SCT) recipients and assessed for ..
Early and late infectious consequences of adding rituximab to fludarabine and cyclophosphamide in patients with indolent lymphoid malignancies
Constantine S Tam, John F Seymour, Michael Brown, Philip Campbell, John Scarlett, Craig Underhill, David Ritchie, Rodney Bond, Andrew P Grigg
Journal article | 2005 | Haematologica
B-Lymphocytes activated by CD40 ligand induce an antigen-specific anti-tumour immune response by direct and indirect activation of CD8( ) T-cells.
DS Ritchie, J Yang, IF Hermans, F Ronchese
Journal article | 2004 | Scandinavian Journal of Immunology
In this report, we describe the ability of CD40-ligand (CD40L)-activated, antigen-loaded B-cells to initiate antigen-specific anti..
Nephrotic syndrome following allogeneic stem cell transplantation associated with increased production of TNF-alpha and interferon-gamma by donor T cells.
J Seconi, V Watt, DS Ritchie
Journal article | 2003 | Bone Marrow Transplantation
SUMMARY: Tumor necrosis factor-alpha (TNF-alpha) has been implicated in the immunological complications of stem cell transplantati..
Dendritic cell elimination as an assay of cytotoxic T lymphocyte activity in vivo.
DS Ritchie, IF Hermans, JM Lumsden, CB Scanga, JM Roberts, J Yang, RA Kemp, F Ronchese
Journal article | 2000 | Journal of Immunological Methods
We show in this paper that the survival of antigen-loaded dendritic cells in vivo may be used as a sensitive readout of CTL activi..
CD8 T cell-dependent elimination of dendritic cells in vivo limits the induction of antitumor immunity.
IF Hermans, DS Ritchie, J Yang, JM Roberts, F Ronchese
Journal article | 2000 | The Journal of Immunology
The fate of dendritic cells (DC) after they have initiated a T cell immune response is still undefined. We have monitored the migr..
Impaired ability of MHC class II-/- dendritic cells to provide tumor protection is rescued by CD40 ligation.
IF Hermans, DS Ritchie, A Daish, J Yang, MR Kehry, F Ronchese
Journal article | 1999 | Journal of Immunology
The contribution of CD4+ T cells to dendritic cell (DC) activation and to the induction of CD8+ T cell responses in vivo was inves..
Antigen expressed on tumor cells fails to elicit an immune response, even in the presence of increased numbers of tumor-specific cytotoxic T lymphocyte precursors.
IF Hermans, A Daish, J Yang, DS Ritchie, F Ronchese
Journal article | 1998 | Cancer Research
We have used T-cell receptor (TCR) transgenic mice to analyze the interaction of tumors with the immune system. We show that the t..
The emerging role of the dendritic cell in novel cancer therapies.
IF Hermans, P Moroni-Rawson, F Ronchese, DS Ritchie
Journal article | 1998 | The New Zealand medical journal
Research over the last two years has explored a number of possible approaches to applying dendritic cell immunotherapy to the trea..