Teresa MacDonald

Circulating Growth Differentiation Factor 15 Is Increased Preceding Preeclampsia Diagnosis: Implications as a Disease Biomarker

Tess Cruickshank, Teresa M MacDonald, Susan P Walker, Emerson Keenan, Kirsten Dane, Anna Middleton, Valerie Kyritsis, Jenny Myers, Catherine Cluver, Roxanne Hastie, Lina Bergman, Damanpreet Garcha, Ping Cannon, Elizabeth Murray, Tuong-Vi Nguyen, Richard Hiscock, Natasha Pritchard, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2021  |  JOURNAL OF THE AMERICAN HEART ASSOCIATION

Background We investigated the biomarker potential of growth differentiation factor 15 (GDF-15), a stress response protein highly ..

Pre-Clinical Investigation of Cardioprotective Beta-Blockers as a Therapeutic Strategy for Preeclampsia

Natalie K Binder, Teresa M MacDonald, Sally A Beard, Natasha de Alwis, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article  |  2021  |  JOURNAL OF CLINICAL MEDICINE

Despite significant maternal and fetal morbidity, a treatment for preeclampsia currently remains an unmet need in clinical care. A..

Elevated Circulating and Placental SPINT2 Is Associated with Placental Dysfunction

Ciara N Murphy, Susan P Walker, Teresa M MacDonald, Emerson Keenan, Natalie J Hannan, Mary E Wlodek, Jenny Myers, Jessica F Briffa, Tania Romano, Alexandra Roddy Mitchell, Carole-Anne Whigham, Ping Cannon, Tuong-Vi Nguyen, Manju Kandel, Natasha Pritchard, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biomarkers for placental dysfunction are currently lacking. We recently identified SPINT1 as a novel biomarker; SPINT2 is a functi..

Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study

Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Susan P Walker, Teresa M MacDonald, Ping Cannon, Tuong-Vi Nguyen, Suresh Anand Sadananthan, Mya-Thway Tint, Yi Ying Ong, Loy See Ling, Peter D Gluckman, Yap-Seng Chong, Keith M Godfrey, Shiao-Yng Chan, Kok Hian Tan, Yung Seng Lee, Navin Michael, Johan G Eriksson, Mary E Wlodek

Journal article  |  2021  |  PLACENTA

Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low materna..

Circulating Tissue Factor Pathway Inhibitor (TFPI) is increased preceding preeclampsia diagnosis and in established preeclampsia

Teresa M MacDonald, Stephen Tong, Jenny Myers, Ping Cannon, Nguyen Tuong-Vi, Emerson Keenan, Elizabeth Murray, Alesia Harper, Natasha Pritchard, Natalie J Hannan, Kirsten M Dane, Anna L Middleton, Valerie P Kyritsis, Susan P Walker, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2021  |  PLACENTA

INTRODUCTION: Tissue Factor Pathway Inhibitor (TFPI) is a part of the extrinsic coagulation pathway, and highly expressed in the p..

Reduced growth velocity from the mid-trimester is associated with placental insufficiency in fetuses born at a normal birthweight.

Lucy M Kennedy, Stephen Tong, Alice J Robinson, Richard J Hiscock, Lisa Hui, Kirsten M Dane, Anna L Middleton, Susan P Walker, Teresa M MacDonald

Journal article  |  2020  |  BMC Med

BACKGROUND: Fetal growth restriction (FGR) due to placental insufficiency is a major risk factor for stillbirth. While small-for-g..

MicroRNAs 363 and 149 are differentially expressed in the maternal circulation preceding a diagnosis of preeclampsia

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Richard Hiscock, Natalie J Hannan, Natasha Pritchard, Ping Cannon, Vi Nguyen Tuong, Manisha Miranda, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2020  |  SCIENTIFIC REPORTS

Preeclampsia is a pregnancy complication associated with angiogenic dysbalance, maternal endothelial dysfunction and end-organ inj..

Appropriate-for-gestational-age infants who exhibit reduced antenatal growth velocity display postnatal catch-up growth

Emma J McLaughlin, Richard J Hiscock, Alice J Robinson, Lisa Hui, Stephen Tong, Kirsten M Dane, Anna L Middleton, Susan P Walker, Teresa M MacDonald

Journal article  |  2020  |  PLOS ONE

BACKGROUND: Postnatally, small-for-gestational-age (SGA; birthweight 20 customised estimated fetal weight centiles), and AGA-NG to..

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

Tu'uhevaha J Kaitu'u-Lino, Teresa M MacDonald, Ping Cannon, Nguyen Tuong-Vi, Richard J Hiscock, Nick Haan, Jenny E Myers, Roxanne Hastie, Kirsten M Dane, Anna L Middleton, Intissar Bittar, Amanda N Sferruzzi-Perri, Natasha Pritchard, Alesia Harper, Natalie J Hannan, Valerie Kyritsis, Nick Crinis, Lisa Hui, Susan P Walker, Stephen Tong

Journal article  |  2020  |  NATURE COMMUNICATIONS

Purpose To investigate the relationship between patient-reported outcome (PRO) questionnaire responses and time to late age-relate..

GDF15 is Increased in Preeclampsia and May be Regulated via Transcription Factors EGR1 and SP1.

Tess Cruickshank, Teresa M MacDonald, Susan P Walker, Natalie J Hannan, Damanpreet Singh, Ping Cannon, Alesia Harper, Murray Elizabeth, Tuong-Vi Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Conference Proceedings  |  2020  |  REPRODUCTIVE SCIENCES