Paul Gregorevic

Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart.

Darnel Prakoso, Shiang Y Lim, Jeffrey R Erickson, Rachel S Wallace, Jarmon G Lees, Mitchel Tate, Helen Kiriazis, Daniel G Donner, Darren C Henstridge, Jonathan R Davey, Hongwei Qian, Minh Deo, Laura J Parry, Amy J Davidoff, Paul Gregorevic, John C Chatham, Miles J De Blasio, Rebecca H Ritchie

Journal article  |  2021  |  Cardiovascular Research

AIMS: The glucose-driven enzymatic modification of myocardial proteins by the sugar moiety, β-N-acetylglucosamine (O-GlcNAc), is i..

Dynamic Changes to the Skeletal Muscle Proteome and Ubiquitinome Induced by the E3 Ligase, ASB2β.

Craig A Goodman, Jonathan R Davey, Adam Hagg, Benjamin L Parker, Paul Gregorevic

Journal article  |  2021  |  Molecular & Cellular Proteomics

Ubiquitination is a post-translational protein modification that has been shown to have a range of effects, including regulation o..

Bone Geometry Is Altered by Follistatin-Induced Muscle Growth in Young Adult Male Mice

ASM Chan, NE McGregor, IJ Poulton, JP Hardee, EHJ Cho, TJ Martin, P Gregorevic, NA Sims, GS Lynch

Journal article  |  2021  |  JBMR Plus

TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass

Adam Hagg, Swati Kharoud, Georgia Goodchild, Craig A Goodman, Justin L Chen, Rachel E Thomson, Hongwei Qian, Paul Gregorevic, Craig A Harrison, Kelly L Walton

Journal article  |  2020  |  Frontiers in Physiology

Inhibition of myostatin- and activin-mediated SMAD2/3 signaling using ligand traps, such as soluble receptors, ligand-targeting pr..

ACTN3 genotype influences skeletal muscle mass regulation and the response to dexamethasone

Jane Seto, Kelly Roeszler, Lyra Meehan, Harrison Wood, Chrystal Tiong, Lucinda Bek, Cheryl Lee, Paul Gregorevic, Peter Houweling, Kathryn North

Conference Proceedings  |  2020  |  Neuromuscular Disorders

Integrated glycoproteomics identifies a role of N-glycosylation and galectin-1 on myogenesis and muscle development.

Ronnie Blazev, Christopher Ashwood, Jodie L Abrahams, Long H Chung, Deanne Francis, Pengyi Yang, Kevin I Watt, Hongwei Qian, Gregory A Quaife-Ryan, James E Hudson, Paul Gregorevic, Morten Thaysen-Andersen, Benjamin L Parker

Journal article  |  2020  |  Molecular & Cellular Proteomics

Many cell surface and secreted proteins are modified by the covalent addition of glycans that play an important role in the develo..

Gene therapy targeting cardiac phosphoinositide 3-kinase (p110 alpha) attenuates cardiac remodeling in type 2 diabetes

Darnel Prakoso, Miles J De Blasio, Mitchel Tate, Helen Kiriazis, Daniel G Donner, Hongwei Qian, David Nash, Minh Deo, Kate L Weeks, Laura J Parry, Paul Gregorevic, Julie R McMullen, Rebecca Helen Ritchie

Journal article  |  2020  |  AJP Heart and Circulatory Physiology

Diabetic cardiomyopathy is a distinct form of heart disease that represents a major cause of death and disability in diabetic pati..

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

Jonathan R Davey, Emma Estevez, Rachel E Thomson, Martin Whitham, Kevin I Watt, Adam Hagg, Hongwei Qian, Darren C Henstridge, Helen Ludlow, Mark P Hedger, Sean L McGee, Melinda T Coughlan, Mark A Febbraio, Paul Gregorevic

Journal article  |  2020  |  The FASEB Journal

Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating panc..

Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle

Xiuqing Han, Lisbeth Liliendal Valbjorn Moller, Estelle De Groote, Kirstine Nyvold Bojsen-Moller, Jonathan Davey, Carlos Henriquez-Olguin, Zhencheng Li, Jonas Roland Knudsen, Thomas Elbenhardt Jensen, Sten Madsbad, Paul Gregorevic, Erik Arne Richter, Lykke Sylow

Journal article  |  2019  |  Journal of Cachexia Sarcopenia and Muscle

Treatment of type 2 diabetes with the designer cytokine IC7Fc

Maria Findeisen, Tamara L Allen, Darren C Henstridge, Helene Kammoun, Amanda E Brandon, Laurie L Baggio, Kevin I Watt, Martin Pal, Lena Cron, Emma Estevez, Christine Yang, Greg M Kowalski, Liam O'Reilly, Casey Egan, Emily Sun, May Thai Le, Guy Krippner, Timothy E Adams, Robert S Lee, Joachim Groetzinger, et al.

Journal article  |  2019  |  Nature