Alexandra Corbett

RIPK3 controls MAIT cell accumulation during development but not during infection

Timothy Patton, Zhe Zhao, Xin Yi Lim, Eleanor Eddy, Huimeng Wang, Adam G Nelson, Bronte Ennis, Sidonia BG Eckle, Michael NT Souter, Troi J Pediongco, Hui-Fern Koay, Jian-Guo Zhang, Tirta M Djajawi, Cynthia Louis, Najoua Lalaoui, Nicolas Jacquelot, Andrew M Lew, Daniel G Pellicci, James McCluskey, Yifan Zhan, et al.

Journal article  |  2023  |  CELL DEATH & DISEASE

Cell death mechanisms in T lymphocytes vary according to their developmental stage, cell subset and activation status. The cell de..

T-cell receptor αβ double-negative T cells in the kidney are predominantly extravascular and increase in abundance in response to ischemia-reperfusion injury.

Sarah L Snelgrove, Olivia Susanto, Louisa Yeung, Pamela Hall, M Ursula Norman, Alexandra J Corbett, A Richard Kitching, Michael J Hickey

Journal article  |  2023  |  Immunol Cell Biol

T-cell receptor+ CD4- CD8- double-negative (DN) T cells are a population of T cells present in low abundance in blood and lymphoid..

The establishment of a cytomegalovirus -specific CD8( ) T-cell threshold by kinetic modeling for the prediction of post-hemopoietic stem cell transplant reactivation

Jing Zhang, Jinpeng Cao, Runhui Zheng, Mengqiu Yu, Zhengfang Lin, Caixia Wang, James McCluskey, Ji Yang, Zhenjun Chen, Alexandra J Corbett, Pengxing Cao, Wenjian Mo, Zhongfang Wang

Journal article  |  2022  |  ISCIENCE

The dynamic interaction between the CMV virus and host immune response remains obscure, thus hindering the diagnosis and therapeut..

CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells

Michael NT Souter, Wael Awad, Shihan Li, Troi Pediongco, Bronwyn S Meehan, Lucy J Meehan, Zehua Tian, Zhe Zhao, Huimeng Wang, Adam Nelson, Jérôme Le Nours, Yogesh Khandokar, T Praveena, Jacinta Wubben, Jie Lin, Lucy C Sullivan, George Lovrecz, Jeffrey YW Mak, Ligong Liu, Lyudmila Kostenko, et al.

Journal article  |  2022  |  Journal of Experimental Medicine

Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of riboflavin-based antigens presented by t..

Human mucosal V alpha 7.2( )CD161(hi) T cell distribution at physiologic state and in Helicobacter pylori infection

Norasate Boonpattanaporn, Thidarat Kongkaew, Panjana Sengprasert, Michael NT Souter, Narisorn Lakananurak, Rungsun Rerknimitr, Alexandra J Corbett, Rangsima Reantragoon

Journal article  |  2022  |  JOURNAL OF LEUKOCYTE BIOLOGY

Mucosal-associated invariant T (MAIT) cells are innate-like, unconventional T cells that are present in peripheral blood and mucos..

The balance of interleukin-12 and interleukin-23 determines the bias of MAIT1 versus MAIT17 responses during bacterial infection

Huimeng Wang, Adam G Nelson, Bingjie Wang, Zhe Zhao, Xin Yi Lim, Mai Shi, Lucy J Meehan, Xiaoxiao Jia, Katherine Kedzierska, Bronwyn S Meehan, Sidonia BG Eckle, Michael NT Souter, Troi J Pediongco, Jeffrey YW Mak, David P Fairlie, James McCluskey, Zhongfang Wang, Alexandra J Corbett, Zhenjun Chen

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

Mucosal-associated invariant T (MAIT) cells are a major subset of innate-like T cells mediating protection against bacterial infec..

Unconventional T Cell Immunity in the Lungs of Young Children with Cystic Fibrosis

Rebecca McElroy, Ghazal Alipour Talesh, Christopher M Harpur, Rosemary Carzino, Alexandra J Corbett, Daniel G Pellicci, Sarath Ranganathan, Philip Sutton

Journal article  |  2022  |  FRONTIERS IN BIOSCIENCE-LANDMARK

BACKGROUND: People with Cystic Fibrosis (CF) develop pulmonary inflammation, chronic infection and structural lung damage early in..

Dual TCR-alpha Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation

Sara Suliman, Lars Kjer-Nielsen, Sarah K Iwany, Kattya Lopez Tamara, Liyen Loh, Ludivine Grzelak, Katherine Kedzierska, Tonatiuh A Ocampo, Alexandra J Corbett, James McCluskey, Jamie Rossjohn, Segundo R Leon, Roger Calderon, Leonid Lecca-Garcia, Megan B Murray, D Branch Moody, Ildiko Van Rhijn

Journal article  |  2022  |  JOURNAL OF IMMUNOLOGY

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are highly abundant in human blood and tissues. Most MAIT..

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Sergio Abrignani, Richard Addo, Muebeccel Akdis, Immanuel Andrae, Francesco Andreata, Francesco Annunziato, Eduardo Arranz, Petra Bacher, Sudipto Bari, Vincenzo Barnaba, Joana Barros-Martins, Dirk Baumjohann, Cristian G Beccaria, David Bernardo, Dominic A Boardman, Jessica Borger, Chotima Boettcher, et al.

Journal article  |  2021  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and..

Molecular basis underpinning metabolite-mediated T-cell immunity

Wael Awad, Geraldine Ler, Jeffrey YW Mak, Jerome Le Nours, James McCluskey, Alexandra J Corbett, David P Fairlie, Jamie Rossjohn

Journal article  |  2021  |  ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES