Mai Truong

Acetoacetate and ?-hydroxybutyrate reduce mouse embryo viability via differential metabolic and epigenetic mechanisms

Emma G Whatley, Thi T Truong, Alexandra J Harvey, David K Gardner

Journal article  |  2023  |  REPRODUCTIVE BIOMEDICINE ONLINE

RESEARCH QUESTION: Does the ketone acetoacetate (AcAc) alone, or combined with β-hydroxybutyrate (βOHB), impact mouse embryo devel..

Antioxidants in Mouse Embryo Culture and Vitrification Media Maintain an In Vivo Like Gene Expression Profile

Thi T TRUONG, Alexandra J HARVEY, David K GARDNER

Journal article  |  2022  |  Fertility & Reproduction

Background: Embryo culture and cryopreservation causes detrimental effects on blastocyst gene expression. While combined antioxida..

beta-hydroxybutyrate reduces blastocyst viability via trophectoderm-mediated metabolic aberrations in mice

Emma G Whatley, Thi T Truong, Dagmar Wilhelm, Alexandra J Harvey, David K Gardner

Journal article  |  2022  |  HUMAN REPRODUCTION

STUDY QUESTION: What is the effect of the ketone β-hydroxybutyrate (βOHB) on preimplantation mouse embryo development, metabolism,..

Antioxidant supplementation of mouse embryo culture or vitrification media support more in-vivo-like gene expression post-transfer

Thi Truong, Alexandra J Harvey, David K Gardner

Journal article  |  2022  |  REPRODUCTIVE BIOMEDICINE ONLINE

RESEARCH QUESTION: What is the effect on mouse fetal gene expression of combined antioxidants (acetyl-L-carnitine, N-acetyl-L-cyst..

O-026 Advanced Glycation Endproducts: A new player in obesity related infertility

J Hutchison, TT Truong, TA Egell, LA Salamonsen, DK Gardner, J Evans

Journal article  |  2021  |  Human Reproduction

Abstract text Globally, 39% of the adult population is overweight or obese, with the prevalence of obesity followin..

A combination of growth factors and cytokines alter preimplantation mouse embryo development, foetal development and gene expression profiles

Kathryn H Gurner, Thi T Truong, Alexandra J Harvey, David K Gardner

Journal article  |  2020  |  Molecular Human Reproduction

Within the maternal tract, the preimplantation embryo is exposed to an array of growth factors (GFs) and cytokines, most of which ..

Advanced glycation end products present in the obese uterine environment compromise preimplantation embryo development

Jennifer C Hutchison, Thi T Truong, Lois A Salamonsen, David K Gardner, Jemma Evans

Journal article  |  2020  |  REPRODUCTIVE BIOMEDICINE ONLINE

Research question Proinflammatory advanced glycation end products (AGE), highly elevated within the uterine cavity of obese women,..

Antioxidants increase blastocyst cryosurvival and viability post-vitrification

Thi T Truong, David K Gardner

Journal article  |  2020  |  HUMAN REPRODUCTION

STUDY QUESTION: What is the effect of antioxidants acetyl-L-carnitine, N-acetyl-L-cysteine and α-lipoic acid (A3) in vitrification..

ANTIOXIDANTS INCREASE BLASTOCYST CRYOSURVIVAL AND VIABILITY POST VITRIFICATION.

Thi T Truong, David Gardner

Conference Proceedings  |  2019  |  FERTILITY AND STERILITY

Culture of the Mouse Preimplantation Embryo

David K Gardner, Thi T Truong

Book Chapter  |  2019  |  Methods in Molecular Biology

The first culture media designed specifically to support development of the preimplantation mouse embryo were formulated over 50 y..