Sandra Luza Cornejo

Perturbed iron biology in the prefrontal cortex of people with schizophrenia

Amit Lotan, Sandra Luza, Carlos M Opazo, Scott Ayton, Darius JR Lane, Serafino Mancuso, Avril Pereira, Suresh Sundram, Cynthia Shannon Weickert, Chad Bousman, Christos Pantelis, Ian P Everall, Ashley I Bush

Journal article  |  2023  |  MOLECULAR PSYCHIATRY

Despite loss of grey matter volume and emergence of distinct cognitive deficits in young adults diagnosed with schizophrenia, curr..

In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia

Parsa Ravanfar, Warda T Syeda, Mahesh Jayaram, R Jarrett Rushmore, Bradford Moffat, Alexander P Lin, Amanda E Lyall, Antonia H Merritt, Negin Yaghmaie, Liliana Laskaris, Sandra Luza, Carlos M Opazo, Benny Liberg, M Mallar Chakravarty, Gabriel A Devenyi, Patricia Desmond, Vanessa L Cropley, Nikos Makris, Martha E Shenton, Ashley Bush, et al.

Journal article  |  2022  |  SCHIZOPHRENIA

Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia pathology. Iron can also generate oxidat..

The ubiquitin proteasome system and schizophrenia

Sandra Luza, Carlos M Opazo, Chad A Bousman, Christos Pantelis, Ashley I Bush, Ian P Everall

Journal article  |  2020  |  LANCET PSYCHIATRY

The ubiquitin-proteasome system is a master regulator of neural development and the maintenance of brain structure and function. I..

Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia

Hannah Meiklejohn, Md Shaki Mostaid, Sandra Luza, Serafino G Mancuso, Dali Kang, Sonny Atherton, Debora A Rothmond, Cynthia Shannon Weickert, Carlos M Opazo, Christos Pantelis, Ashley I Bush, Ian P Everall, Chad A Bousman

Journal article  |  2019  |  JOURNAL OF PSYCHIATRIC RESEARCH

A number of recent studies have suggested the ubiquitin proteasome system (UPS) in schizophrenia is dysfunctional. The purpose of ..

Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia

Chad A Bousman, Sandra Luza, Serafino G Mancuso, Dali Kang, Carlos M Opazo, Md Shaki Mostaid, Vanessa Cropley, Patrick McGorry, Cynthia Shannon Weickert, Christos Pantelis, Ashley I Bush, Ian P Everall

Journal article  |  2019  |  SCIENTIFIC REPORTS

Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation ..

UBIQUITINATED PROTEINS ARE ELEVATED IN THE BLOOD AND BRAIN OF INDIVIDUALS WITH SCHIZOPHRENIA

Chad Bousman, Sandra Luza, Serafino Mancuso, Dali Kang, Md Shaki Mostaid, Vanessa Cropley, Cynthia Shannon Weickert, Carlos Opazo, Christos Pantelis, Ashley Bush, Ian Paul Everall

Conference Proceedings  |  2019  |  EUROPEAN NEUROPSYCHOPHARMACOLOGY

Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons

Patricio A Castro, Alejandra Ramirez, Fernando J Sepulveda, Christian Peters, Humberto Fierro, Javier Waldron, Sandra Luza, Jorge Fuentealba, Francisco J Munoz, Giancarlo V De Ferrari, Ashley I Bush, Luis G Aguayo, Carlos M Opazo

Journal article  |  2014  |  FRONTIERS IN AGING NEUROSCIENCE

Extracellular and intracellular copper and zinc regulate synaptic activity and plasticity, which may impact brain functionality an..

Biphasic effects of copper on neurotransmission in rat hippocampal neurons

Christian Peters, Braulio Munoz, Fernando J Sepulveda, Juan Urrutia, Mauricio Quiroz, Sandra Luza, Giancarlo V De Ferrari, Luis G Aguayo, Carios Opazo

Journal article  |  2011  |  JOURNAL OF NEUROCHEMISTRY

The importance of copper in the CNS is well documented, but the mechanisms related to its brain functions are poorly understood. C..

Actinic cheilitis: epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2.

I Gina Rojas, Alejandra Martínez, Ursula Brethauer, Patricia Grez, Roger Yefi, Sandra Luza, Francisco J Marchesani

Journal article  |  2009  |  Oral Oncol

Cyclooxygenase-2 (COX-2) is overexpressed in various types of human malignancies, including oral cancers. Recent studies have show..

The influence of mast cell mediators on migration of SW756 cervical carcinoma cells.

M Isolde Rudolph, Yadira Boza, Roger Yefi, Sandra Luza, Edilia Andrews, Alicia Penissi, Pablo Garrido, I Gina Rojas

Journal article  |  2008  |  J Pharmacol Sci

The role of mast cell mediators on cervical cancer cell migration was assessed using an in vitro assay of scratch wound healing on..