A/Prof Walkley completed a Bachelor of Pharmacy at the University of South Australia in 1999 and a PhD at the Peter MacCallum Cancer Centre in 2003. He undertook post-doctoral training with Prof. Stuart Orkin at the Dana-Farber Cancer Centre/Children’s Hospital Boston, USA.
In 2008, A/Prof Walkley returned to Australia and co-head’s the Stem Cell Regulation Unit at St. Vincent’s Institute of Medical Research in Melbourne. His primary interests are generating models of human cancer focusing on myelodysplastic syndrome and osteosarcoma and in the roles of RNA editing in haematopoiesis.
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Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the ..
Truncating Mutations in Recq14 Cause a Low Bone Mass Phenotype, but Not Osteosarcoma
Truncating Mutations in Recql4 Cause a Low Bone Mass Phenotype, but Not Osteosarcoma
Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice
Displaying the 67 most recent scholarly works by Carl Walkley.
The majority of A-to-I RNA editing is not required for mammalian homeostasis
Alistair M Chalk, Scott Taylor, Jacki E Heraud-Farlow, Carl R Walkley
Journal article | 2019 | Genome Biology
BACKGROUND: Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sit..
Defining the functions of adenosine-to-inosine RNA editing through hematology
Jacki E Heraud-Farlow, Alistair M Chalk, Carl R Walkley
Journal article | 2019 | Current Opinion in Hematology
PURPOSE OF REVIEW: The direct modification of RNA is now understood to be widespread, evolutionarily conserved and of consequence ..
ATP-dependent helicase activity is dispensable for the physiological functions of Recql4
Wilson Castillo-Tandazo, Monique F Smeets, Vincent Murphy, Rui Liu, Charlotte Hodson, Joerg Heierhorst, Andrew J Deans, Carl R Walkley
Journal article | 2019 | PLOS Genetics
Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder characterized by skin rash (poikiloderma), skeletal dysplas..
Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly
Matthew Ku, Ruth N MacKinnon, Meaghan Wall, Nisha Narayan, Carl Walkley, Heung-Chin Cheng, Lynda J Campbell, Louise E Purton, Harshal Nandurkar
Journal article | 2019 | Scientific Reports
Murine Models of Bone Sarcomas.
Camille Jacques, Nathalie Renema, Benjamin Ory, Carl R Walkley, Agamemnon E Grigoriadis, Dominique Heymann
Journal article | 2019 | Methods in molecular biology (Clifton, N.J.)
This chapter describes the procedures for inducing bone sarcoma in mice. Two models based on inoculation of cancer cells in paraos..
mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis.
Sally K Martin, Stephen Fitter, Nadia El Khawanky, Randall H Grose, Carl R Walkley, Louise E Purton, Markus A Ruegg, Michael N Hall, Stan Gronthos, Andrew CW Zannettino
Journal article | 2018 | Scientific Reports
Skeletal osteoblasts are important regulators of B-lymphopoiesis, serving as a rich source of factors such as CXCL12 and IL-7 whic..
Srsf2(P95H) initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells
Monique F Smeets, Shuh Ying Tan, Jane Jialu Xu, Govardhan Anande, Ashwin Unnikrishnan, Alistair M Chalk, Scott R Taylor, John E Pimanda, Meaghan Wall, Louise E Purton, Carl R Walkley
Journal article | 2018 | Blood
Adar3 Is Involved in Learning and Memory in Mice
Dessislava Mladenova, Guy Barry, Lyndsey M Konen, Sandy S Pineda, Boris Guennewig, Lotta Avesson, Raphael Zinn, Nicole Schonrock, Maina Bitar, Nicky Jonkhout, Lauren Crumlish, Dominik C Kaczorowski, Andrew Gong, Mark Pinese, Gloria R Franco, Carl R Walkley, Bryce Vissel, John S Mattick
Journal article | 2018 | Frontiers in Neuroscience
Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors
Phillip P Sharp, Jean-Marc Garnier, Tamas Hatfaludi, Zhen Xu, David Segal, Kate E Jarman, Helene Jousset, Alexandra Garnham, John T Feutrill, Anthony Cuzzupe, Peter Hall, Scott Taylor, Carl R Walkley, Dean Tyler, Mark A Dawson, Peter Czabotar, Andrew F Wilks, Stefan Glaser, David CS Huang, Christopher J Burns
Journal article | 2017 | ACS Medicinal Chemistry Letters
Dynamic landscape and regulation of RNA editing in mammals
Meng How Tan, Qin Li, Raghuvaran Shanmugam, Robert Piskol, Jennefer Kohler, Amy N Young, Kaiwen Ivy Liu, Rui Zhang, Gokul R Amaswami, Kentaro Ariyoshi, Ankita Gupte, Liam P Keegan, Cyril X George, Avinash R Amu, Ni Huang, Elizabeth A Pollina, Dena S Leeman, Alessandra R Ustighi, YP Sharon Goh, Ajay C Hawla, et al.
Journal article | 2017 | Nature
Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis
Jacki E Heraud-Farlow, Alistair M Chalk, Sandra E Linder, Qin Li, Scott Taylor, Joshua M White, Lokman Pang, Brian J Liddicoat, Ankita Gupte, Jin Billy Li, Carl R Walkley
Journal article | 2017 | Genome Biology
Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress
Wei Shi, Therese Vu, Didier Boucher, Anna Biernacka, Jules Nde, Raj K Pandita, Jasmin Straube, Glen M Boyle, Fares Al-Ejeh, Purba Nag, Jessie Jeffery, Janelle L Harris, Amanda L Bain, Marta Grzelak, Magdalena Skrzypczak, Abhishek Mitra, Norbert Dojer, Nicola Crosetto, Nicole Cloonan, Olivier J Becherel, et al.
Journal article | 2017 | Blood
mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation.
Stephen Fitter, Mary P Matthews, Sally K Martin, Jianling Xie, Soo Siang Ooi, Carl R Walkley, John D Codrington, Markus A Ruegg, Michael N Hall, Christopher G Proud, Stan Gronthos, Andrew CW Zannettino
Journal article | 2017 | Molecular and Cellular Biology
The mammalian target of rapamycin complex 1 (mTORC1) is activated by extracellular factors that control bone accrual. However, the..
The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation
Christina B Wolwer, Nathan Godde, Luke B Pase, Imogen A Elsum, Krystle YB Lim, Faruk Sacirbegovic, Carl R Walkley, Sarah Ellis, Shigeo Ohno, Fumio Matsuzaki, Sarah M Russell, Patrick O Humbert
Journal article | 2017 | PLOS ONE
Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development
Thao M Nguyen, Agnieszka Arthur, Sharon Paton, Sarah Hemming, Romana Panagopoulos, John Codrington, Carl R Walkley, Andrew CW Zannettino, Stan Gronthos
Journal article | 2016 | Bone
Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis
Brian J Liddicoat, Jochen C Hartner, Robert Piskol, Gokul Ramaswami, Alistair M Chalk, Paul D Kingsley, Vijay G Sankaran, Meaghan Wall, Louise E Purton, Peter H Seeburg, James Palis, Stuart H Orkin, Jun Lu, Jin Billy Li, Carl R Walkley
Journal article | 2016 | Experimental Hematology
Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion
Sandra Capellera-Garcia, Julian Pulecio, Kishori Dhulipala, Kavitha Siva, Violeta Rayon-Estrada, Sofie Singbrant, Mikael NE Sommarin, Carl R Walkley, Shamit Soneji, Goran Karlsson, Angel Raya, Vijay G Sankaran, Johan Flygare
Journal article | 2016 | Cell Reports
PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells
Vashe Chandrakanthan, Avani Yeola, Jair C Kwan, Rema A Oliver, Qiao Qiao, Young Chan Kang, Peter Zarzour, Dominik Beck, Lies Boelen, Ashwin Unnikrishnan, Jeanette E Villanueva, Andrea C Nunez, Kathy Knezevic, Cintia Palu, Rabab Nasrallah, Michael Carnell, Alex Macmillan, Renee Whan, Yan Yu, Philip Hardy, et al.
Journal article | 2016 | Proceedings of the National Academy of Sciences
The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma
David M Wong, Lingli Li, Sabine Jurado, Ashleigh King, Rebecca Bamford, Meaghan Wall, Mannu K Walia, Gemma L Kelly, Carl R Walkley, David M Tarlinton, Andreas Strasser, Joerg Heierhorst
Journal article | 2016 | Cell Reports
Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure
Maria Askmyr, Kirby E White, Tanja Jovic, Hannah A King, Julie M Quach, Ana C Maluenda, Emma K Baker, Monique F Smeets, Carl R Walkley, Louise E Purton
Journal article | 2015 | Scientific Reports
Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma
Ankita Gupte, Emma K Baker, Soo-San Wan, Elizabeth Stewart, Amos Loh, Anang A Shelat, Cathryn M Gould, Alistair M Chalk, Scott Taylor, Kurt Lackovic, Asa Karlstroem, Anthony J Mutsaers, Jayesh Desai, Piyush B Madhamshettiwar, Andrew CW Zannettino, Chris Burns, David CS Huang, Michael A Dyer, Kaylene J Simpson, Carl R Walkley
Journal article | 2015 | Clinical Cancer Research
RAR gamma is a negative regulator of osteoclastogenesis
Alanna C Green, Ingrid J Poulton, Christina Vrahnas, Karl D Haeusler, Carl R Walkley, Joy Y Wu, T John Martin, Matthew T Gillespie, Roshantha AS Chandraratna, Julian MW Quinn, Natalie A Sims, Louise E Purton
Journal article | 2015 | The Journal of Steroid Biochemistry and Molecular Biology
BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells
Emma K Baker, Scott Taylor, Ankita Gupte, Phillip P Sharp, Mannu Walia, Nicole C Walsh, Andrew CW Zannettino, Alistair M Chalk, Christopher J Burns, Carl R Walkley
Journal article | 2015 | Scientific Reports
Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma
Emma K Baker, Scott Taylor, Ankita Gupte, Alistair M Chalk, Shreya Bhattacharya, Alanna C Green, T John Martin, Dario Strbenac, Mark D Robinson, Louise E Purton, Carl R Walkley
Journal article | 2015 | Bone
Gene expression profiling to define the cell intrinsic role of the SKI proto-oncogene in hematopoiesis and myeloid neoplasms.
Alistair M Chalk, Brian JJ Liddicoat, Carl R Walkley, Sofie Singbrant
Journal article | 2014 | Genomics Data
The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its ope..
PTHrP, its receptor, and protein kinase A activation in osteosarcoma.
Carl R Walkley, Mannu K Walia, Patricia W Ho, T John Martin
Journal article | 2014 | Molecular & Cellular Oncology
In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-depen..
The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease
Sofie Singbrant, Meaghan Wall, Jennifer Moody, Goeran Karlsson, Alistair M Chalk, Brian Liddicoat, Megan R Russell, Carl R Walkley, Stefan Karlsson
Journal article | 2014 | Haematologica
Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation
Maya Kansara, Huei San Leong, Dan Mei Lin, Sophie Popkiss, Puiyi Pang, Dale W Garsed, Carl R Walkley, Carleen Cullinane, Jason Ellul, Nicole M Haynes, Rod Hicks, Marieke L Kuijjer, Anne-Marie Cleton-Jansen, Philip W Hinds, Mark J Smyth, David M Thomas
Journal article | 2013 | Journal of Clinical Investigation
Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA
Anthony J Mutsaers, Alvin JM Ng, Emma K Baker, Megan R Russell, Alistair M Chalk, Meaghan Wall, Brain JJ Liddicoat, Patricia WM Ho, John L Slavin, Ankita Goradia, T John Martin, Louise E Purton, Ross A Dickins, Carl R Walkley
Journal article | 2013 | Bone
Hematopoietic AMPK beta 1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
Sandra Galic, Morgan D Fullerton, Jonathan D Schertzer, Sarah Sikkema, Katarina Marcinko, Carl R Walkley, David Izon, Jane Honeyman, Zhi-Ping Chen, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg
Journal article | 2011 | Journal of Clinical Investigation
Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment
Sofie Singbrant, Megan R Russell, Tanja Jovic, Brian Liddicoat, David J Izon, Louise E Purton, Natalie A Sims, T John Martin, Vijay G Sankaran, Carl R Walkley
Journal article | 2011 | Blood
A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency
Carl R Walkley, Gemma Haines Olsen, Sebastian Dworkin, Stewart A Fabb, Jeremy Swann, Grant A McArthur, Susan V Westmoreland, Pierre Chambon, David T Scadden, Louise E Purton
Journal article | 2007 | Cell
Medicine - St Vincent'S Hospital
Medicine - St Vincent'S Hospital
Bachelor of Pharmacy
University of South Australia
Doctor of Philosophy
University of Melbourne