Carl Walkley

Genome-wide screening identifies cell cycle control as a synthetic lethal pathway with SRSF2P95H mutation.

Jane Jialu Xu, Alistair M Chalk, Iva Nikolic, Kaylene Simpson, Monique F Smeets, Carl Walkley

Journal article  |  2021  |  Blood Adv

Current strategies to target RNA splicing mutant myeloid cancers proposes targeting the remaining splicing apparatus. This approac..

Rothmund-Thomson Syndrome-Like RECQL4 Truncating Mutations Cause a Haploinsufficient Low-Bone-Mass Phenotype in Mice

Wilson Castillo-Tandazo, Ann E Frazier, Natalie A Sims, Monique F Smeets, Carl R Walkley

Journal article  |  2021  |  MOLECULAR AND CELLULAR BIOLOGY

Rothmund-Thomson Syndrome (RTS) is an autosomal recessive disorder characterized by defects in the skeletal system such as bone hy..

ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress

Diana Guallar, Alejandro Fuentes-Iglesias, Yara Souto, Cristina Ameneiro, Oscar Freire-Agulleiro, Jose Angel Pardavila, Adriana Escudero, Vera Garcia-Outeiral, Tiago Moreira, Carmen Saenz, Heng Xiong, Dongbing Liu, Shidi Xiao, Yong Hou, Kui Wu, Daniel Torrecilla, Jochen C Hartner, Miguel G Blanco, Leo J Lee, Miguel Lopez, et al.

Journal article  |  2020  |  CELL STEM CELL

RNA editing of adenosine to inosine (A to I) is catalyzed by ADAR1 and dramatically alters the cellular transcriptome, although it..

Enhancing mitochondrial function in vivo rescues MDS-like anemia induced by pRb deficiency

Taha Sen, Mayur Jain, Magnus Gram, Alexander Mattebo, Shamit Soneji, Carl R Walkley, Sofie Singbrant

Journal article  |  2020  |  EXPERIMENTAL HEMATOLOGY

Erythropoiesis is intimately coupled to cell division, and deletion of the cell cycle regulator retinoblastoma protein (pRb) cause..

DNA REPAIR AND CELL CYCLE ARE SYNTHETIC LETHAL PATHWAYS IN SRSF2P95H MUTATED CELLS

undefined Janexu, Monique Smeets, Alistair Chalk, Iva Nikolic, Kaylene Simpson, Carl Walkley

Conference Proceedings  |  2020  |  EXPERIMENTAL HEMATOLOGY

What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs

Jacki E Heraud-Farlow, Carl R Walkley

Journal article  |  2020  |  OPEN BIOLOGY

Adenosine-to-inosine (A-to-I) editing is a post-transcriptional modification of RNA which changes its sequence, coding potential a..

Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction (vol 41, pg 891, 2020)

Paul R Marshall, Qiongyi Zhao, Xiang Li, Wei Wei, Ambika Periyakaruppiah, Esmi L Zajaczkowski, Laura J Leighton, Sachithrani U Madugalle, Dean Basic, Ziqi Wang, Jiayu Yin, Wei-Siang Liau, Ankita Gupte, Carl R Walkley, Timothy W Bredy

Journal article  |  2020  |  NATURE NEUROSCIENCE

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

Therese Vu, Jasmin Straube, Amy H Porter, Megan Bywater, Axia Song, Victoria Ling, Leanne Cooper, Gabor Pali, Claudia Bruedigam, Sebastien Jacquelin, Joanne Green, Graham Magor, Andrew Perkins, Alistair M Chalk, Carl R Walkley, Florian H Heidel, Pamela Mukhopadhyay, Nicole Cloonan, Stefan Groeschel, Jan-Philipp Mallm, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during normal blood formation. Retrov..

Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction

Paul R Marshall, Qiongyi Zhao, Xiang Li, Wei Wei, Ambika Periyakaruppiah, Esmi L Zajaczkowski, Laura J Leighton, Sachithrani U Madugalle, Dean Basic, Ziqi Wang, Jiayu Yin, Wei-Siang Liau, Ankita Gupte, Carl R Walkley, Timothy W Bredy

Journal article  |  2020  |  NATURE NEUROSCIENCE

DNA forms conformational states beyond the right-handed double helix; however, the functional relevance of these noncanonical stru..

The majority of A-to-I RNA editing is not required for mammalian homeostasis

Alistair M Chalk, Scott Taylor, Jacki E Heraud-Farlow, Carl R Walkley

Journal article  |  2019  |  GENOME BIOLOGY

BACKGROUND: Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sit..