Carl Walkley

Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2.

Julia Z Adamska, Rohit Verma, Shakti Gupta, Thomas Hagan, Florian Wimmers, Katharine Floyd, Qin Li, Erika V Valore, Yanli Wang, Meera Trisal, José G Vilches-Moure, Shankar Subramaniam, Carl R Walkley, Mehul S Suthar, Jin Billy Li, Bali Pulendran

Journal article  |  2023  |  Cell Rep

Under normal homeostatic conditions, self-double-stranded RNA (self-dsRNA) is modified by adenosine deaminase acting on RNA 1 (ADA..

Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and Sumoylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia

Peter Truong, Sylvie Shen, Swapna Joshi, Ali Afrasiabi, Ling Zhong, Mark J Raftery, Jonas Larsson, Richard B Lock, Carl R Walkley, Hamid Alinejad Rokny, Julie AI Thoms, Christopher J Jolly, John E Pimanda

Journal article  |  2022  |  Blood

Srsf2(P95H/ ) co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice

Jane Jialu Xu, Alistair M Chalk, Meaghan Wall, Wallace Y Langdon, Monique F Smeets, Carl R Walkley

Journal article  |  2022  |  LEUKEMIA

Recurrent mutations in RNA splicing proteins and epigenetic regulators contribute to the development of myelodysplastic syndrome (..

Direct identification of A-to-I editing sites with nanopore native RNA sequencing

Tram Anh Nguyen, Jia Wei Joel Heng, Pornchai Kaewsapsak, Eng Piew Louis Kok, Dominik Stanojevic, Hao Liu, Angelysia Cardilla, Albert Praditya, Zirong Yi, Mingwan Lin, Jong Ghut Ashley Aw, Yin Ying Ho, Kai Lay Esther Peh, Yuanming Wang, Qixing Zhong, Jacki Heraud-Farlow, Shifeng Xue, Bruno Reversade, Carl Walkley, Ying Swan Ho, et al.

Journal article  |  2022  |  NATURE METHODS

Inosine is a prevalent RNA modification in animals and is formed when an adenosine is deaminated by the ADAR family of enzymes. Tr..

ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis

Ting Zhang, Chaoran Yin, Aleksandr Fedorov, Liangjun Qiao, Hongliang Bao, Nazar Beknazarov, Shiyu Wang, Avishekh Gautam, Riley M Williams, Jeremy Chase Crawford, Suraj Peri, Vasily Studitsky, Amer A Beg, Paul G Thomas, Carl Walkley, Yan Xu, Maria Poptsova, Alan Herbert, Siddharth Balachandran

Journal article  |  2022  |  NATURE

Only a small proportion of patients with cancer show lasting responses to immune checkpoint blockade (ICB)-based monotherapies. Th..

Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation

Jane Jialu Xu, Alistair M Chalk, Iva Nikolic, Kaylene J Simpson, Monique F Smeets, Carl R Walkley

Journal article  |  2022  |  BLOOD ADVANCES

Current strategies to target RNA splicing mutant myeloid cancers proposes targeting the remaining splicing apparatus. This approac..

Patience is a virtue

Carl R Walkley

Journal article  |  2022  |  BLOOD

Rothmund-Thomson Syndrome-Like RECQL4 Truncating Mutations Cause a Haploinsufficient Low-Bone-Mass Phenotype in Mice

Wilson Castillo-Tandazo, Ann E Frazier, Natalie A Sims, Monique F Smeets, Carl R Walkley

Journal article  |  2021  |  MOLECULAR AND CELLULAR BIOLOGY

Rothmund-Thomson syndrome (RTS) is an autosomal recessive disorder characterized by defects in the skeletal system, such as bone h..

ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress

Diana Guallar, Alejandro Fuentes-Iglesias, Yara Souto, Cristina Ameneiro, Oscar Freire-Agulleiro, Jose Angel Pardavila, Adriana Escudero, Vera Garcia-Outeiral, Tiago Moreira, Carmen Saenz, Heng Xiong, Dongbing Liu, Shidi Xiao, Yong Hou, Kui Wu, Daniel Torrecilla, Jochen C Hartner, Miguel G Blanco, Leo J Lee, Miguel Lopez, et al.

Journal article  |  2020  |  CELL STEM CELL

RNA editing of adenosine to inosine (A to I) is catalyzed by ADAR1 and dramatically alters the cellular transcriptome, although it..

3148 – SRSF2P95H AND TET2 LOSS CO-OPERATE TO PROMOTE CHRONIC MYELOMONOCYTIC LEUKAEMIA IN VIVO

Jane xu, Meaghan Wall, Monique Smeets, Carl Walkley

Journal article  |  2020  |  Experimental Hematology