Dr Xie is currently a senior statistician at the Melbourne EpiCentre, University of Melbourne. Dr Xie is also an Honorary Professor of School of Public Health, Xinxiang Medical University (China).
Dr Xie is also Statistical Editor of the Cochrane Library (ACE group) and a reviewer for over 10 peer-reviewed international journals. Dr. Xie holds a Bachelor degree in Medicine (MD, 1996) Masters’ in Public Health (MPH, 1999) and a PhD in Epidemiology and Biostatistics (2003). Dr Xie has accumulated some 20 years of experience and leadership skills in the fields of biostatistics, research and teaching. As a biostatistician and methodologist, Dr Xie has been involved in studies with a wide variety of different content areas, designs and settings. Her major area of expertise is in modelling the impact of chronic illness (diabetes, CVD) on public health and individual wellbeing. She also has experience and special interest in design and analysis of randomised controlled trials. To date, in total Dr Xie has been an Principle Investigator (PI) or Chief Investigator (CI) on over 20 research national/international competitive grants to the value of over $5 million (>AU$2.0 million and 3.0 million RMB) from the NHMRC, ARC (Australia), China National Science Foundation (CNSF, China), and The Medical Research Council (MRC, UK). In the past 10 years, she has published more than 75 papers in high quality international journals, including BMJ, JAMA Ophthalmology, Nature Communications, Ophthalmology, Journal of Diabetes & Metabolism, Stroke, American Journal of Kidney Diseases, American Journal of Ophthalmology, and Obesity. Her papers have been cited 1488 times in the past five years. Dr. Xie’s current research focuses on four major related themes: 1. Development, validation and refinement of risk prediction model and evaluation of new biomarkers for risk prediction using novel statistical modelling approaches for accelerating the translation of public health research into general practice. 2. Design, develop, and implement complex sampling plans and subsequently analyze resulting complex survey respondent data. 3. Analysis of Genome-Wide Association Studies (GWAS). 4. Evidence-Based Medicine: Meta-analysis She has more than 10 years’ experience in a research & teaching related role providing statistical analysis support. She has supervised and co-supervised 13 Master/PhD students. Dr Xie works with colleagues in Australia and internationally from a range of disciplines including public health, ophthalmology, public health, and health economics. Some key collaborators include Professor Ecosse Lamoureux (DukeNUS Medical School, Singapore), Professor Hugh R Taylor (Harold Mitchell Chair of Indigenous Eye Health, School of Population Health, Melbourne University), Professor Carol Brayne (Director of the Institute of Public Health, the University of Cambridge), and Professor Dongsheng Hu (Dean of College of Public Health, Shenzhen University, China). Dr Xie regularly provides Statistical training sessions at the Melbourne Epicentre, the University of Melbourne to update staffs and students on our research findings using new statistical skills. She has also developed and delivered numerous short courses and workshops, locally and internationally on topics such as critical appraisal, sample size, survey design, meta-analysis, analysis of longitudinal data, multi-level modelling and data analysis and writing.Dr Xie is a Statistical Editor of the Cochrane Library, Consultant of the Global Fund on AIDS in Henan Province, China, and a member of the China Medical Statistics. She is a member of the NHMRC Research Translation Faculty and passionate about translating research into practice.
Find out more about Sophia Xie's experience
Sophia Xie's highlights
Sophia Xie's selected work
Genome-wide association meta-analysis of corneal curvature identifies novel loci and share..
Integrated Depression Management: A Trial Of A New Model Of Care In A Low Vision Rehabilit..
High vision-related quality of life indices reduce the odds of depressive symptoms in aged..
Integrated Depression Management: A Trial Of A New Model Of Care In A Low Vision Rehabilit..
Displaying the 3 most recent projects by Sophia Xie.
Displaying the 93 most recent scholarly works by Sophia Xie.
Selective laser trabeculoplasty versus topical medication as initial glaucoma treatment: the glaucoma initial treatment study randomised clinical trial.
Ghee Soon Ang, Eva K Fenwick, Marios Constantinou, Alfred Tau Liang Gan, Ryan Eyn Kidd Man, Robert J Casson, Eric A Finkelstein, Ivan Goldberg, Paul R Healey, Konrad Pesudovs, Sutha Sanmugasundram, Jing Xie, Rachel McIntosh, Jonathan Jackson, Anthony P Wells, Andrew White, Keith Martin, Mark J Walland, Jonathan G Crowston, Ecosse Luc Lamoureux
Journal article | 2020 | British Journal of Ophthalmology
BACKGROUND/AIMS: To determine if selective laser trabeculoplasty (SLT) is superior to topical medication as a first-line treatment..
Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error
Qiao Fan, Alfred Pozarickij, Nicholas YQ Tan, Xiaobo Guo, Virginie JM Verhoeven, Veronique Vitart, Jeremy A Guggenheim, Masahiro Miyake, J Willem L Tideman, Anthony P Khawaja, Liang Zhang, Stuart MacGregor, Rene Hoehn, Peng Chen, Ginevra Biino, Juho Wedenoja, Seyed Ehsan Saffari, Milly S Tedja, Jing Xie, Carla Lanca, et al.
Journal article | 2020 | Communications Biology
Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and b..
High vision-related quality of life indices reduce the odds of depressive symptoms in aged care facilities
Gwyneth Rees, Marita McCabe, Jing Xie, Marios Constantinou, Alfred Gan, Edith Holloway, Ryan EK Man, Jonathon Jackson, Eva K Fenwick, Ecosse Lamoureux
Journal article | 2019 | Aging & Mental Health
Prevalence of glaucoma in the Australian National Eye Health Survey
Stuart Keel, Jing Xie, Joshua Foreman, Pei Ying Lee, Mostafa Alwan, Eamonn T Fahy, Peter van Wijngaarden, Jennifer C Fan Gaskin, Ghee Soon Ang, Jonathan G Crowston, Hugh R Taylor, Mohamed Dirani
Journal article | 2019 | British Journal of Ophthalmology
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases (vol 9, 1864, 2018)
Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, Rene Hoehn, Henriet Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polasek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, et al.
Journal article | 2019 | Nature Communications
Improving eye care in residential aged care facilities using the Residential Ocular Care (ROC) model: study protocol for a multicentered, prospective, customized, and cluster randomized controlled trial in Australia
Edith E Holloway, Marios Constantinou, Jing Xie, Eva K Fenwick, Eric A Finkelstein, Ryan EK Man, Michael Coote, Jonathan Jackson, Gwyn Rees, Ecosse L Lamoureux
Journal article | 2018 | Trials
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error
Milly S Tedja, Robert Wojciechowski, Pirro G Hysi, Nicholas Eriksson, Nicholas A Furlotte, Virginie JM Verhoeven, Adriana I Iglesias, Magda A Meester-Smoor, Stuart W Tompson, Qiao Fan, Anthony P Khawaja, Ching-Yu Cheng, Rene Hoehn, Kenji Yamashiro, Adam Wenocur, Clare Grazal, Toomas Haller, Andres Metspalu, Juho Wedenoja, Jost B Jonas, et al.
Journal article | 2018 | Nature Genetics
Prevalence and Causes of Unilateral Vision Impairment and Unilateral Blindness in Australia The National Eye Health Survey
Joshua Foreman, Jing Xie, Stuart Keel, Ghee Soon Ang, Pei Ying Lee, Rupert Bourne, Jonathan G Crowston, Hugh R Taylor, Mohamed Dirani
Journal article | 2018 | JAMA Ophthalmology
A genome-wide association study of corneal astigmatism: The CREAM Consortium
Rupal L Shah, Qing Li, Wanting Zhao, Milly S Tedja, J Willem L Tideman, Anthony P Khawaja, Qiao Fan, Seyhan Yazar, Katie M Williams, Virginie JM Verhoeven, Jing Xie, Ya Xing Wang, Moritz Hess, Stefan Nickels, Karl J Lackner, Olavi Parssinen, Juho Wedenoja, Ginevra Biino, Maria Pina Concas, Andre Uitterlinden, et al.
Journal article | 2018 | Molecular Vision
In Vivo Laser Confocal Microscopy Using the HRT-Rostock Cornea Module: Diversity and Diagnostic Implications in Patients with Uveitis
Lyndell L Lim, Jing Xie, Chyn C Chua, Tiffany Wong, Lani T Hoang, Matthias D Becker, Eric B Suhler, James T Rosenbaum, Friederike Mackensen
Journal article | 2018 | Ocular Immunology and Inflammation
Pupil Dilation May Affect Retinal Vessel Caliber Measures
Jie Jin Wang, Yuan Shi, Jing Xie, Ava G Tan, Lauren AB Hogdson, Sharon Lee, Meredith Wickens, Victoria F Cosatto, Kristina Kairaitis, Richard Lindley, Lyndell L Lim, Paul Mitchell, John R Wheatley, Terence C Amis
Journal article | 2018 | Ophthalmic Epidemiology
The Prevalence and Causes of Vision Loss in Indigenous and Non-Indigenous Australians
Joshua Foreman, Jing Xie, Stuart Keel, Peter van Wijngaarden, Sukhpal Singh Sandhu, Ghee Soon, Jennifer Fan Gaskin, Jonathan Crowston, Rupert Bourne, Hugh R Taylor, Mohamed Dirani
Journal article | 2017 | Ophthalmology
Combined poor diabetes control indicators are associated with higher risks of diabetic retinopathy and macular edema than poor glycemic control alone
Eva K Fenwick, Jing Xie, Ryan EK Man, Charumathi Sabanayagam, Lyndell Lim, Gwyn Rees, Tien Y Wong, Ecosse L Lamoureux
Journal article | 2017 | PLOS ONE
Problem-solving therapy for adults with diabetic retinopathy and diabetesspecific distress: a pilot randomized controlled trial
Gwyneth Rees, Fleur O'Hare, Marian Saeed, Bronwyn Sudholz, Bonnie A Sturrock, Jing Xie, Jane Speight, Ecosse L Lamoureux
Journal article | 2017 | BMJ Open Diabetes Research & Care
Assessment of the psychometric properties of the Chinese Impact of Vision Impairment questionnaire in a population-based study: findings from the Singapore Chinese Eye Study
Eva K Fenwick, Peng Guan Ong, Charumathi Sabanayagam, Gwyn Rees, Jing Xie, Edith Holloway, Ching-Yu Cheng, Tien Y Wong, Blanche Lim, Pok Chien Tan, Ecosse L Lamoureux
Journal article | 2016 | Quality of Life Research
Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error
Qiao Fan, Virginie JM Verhoeven, Robert Wojciechowski, Veluchamy A Barathi, Pirro G Hysi, Jeremy A Guggenheim, Rene Hoehn, Veronique Vitart, Anthony P Khawaja, Kenji Yamashiro, S Mohsen Hosseini, Terho Lehtimaki, Yi Lu, Toomas Haller, Jing Xie, Cecile Delcourt, Mario Pirastu, Juho Wedenoja, Puya Gharahkhani, Cristina Venturini, et al.
Journal article | 2016 | Nature Communications
Comparing the effectiveness of selective laser trabeculoplasty with topical medication as initial treatment (the Glaucoma Initial Treatment Study): study protocol for a randomised controlled trial
Ecosse L Lamoureux, Rachel Mcintosh, Marios Constantinou, Eva K Fenwick, Jing Xie, Robert Casson, Eric Finkelstein, Ivan Goldberg, Paul Healey, Ravi Thomas, Ghee Soon Ang, Konrad Pesudovs, Jonathan Crowston
Journal article | 2015 | Trials
The Influence of Coping on Vision-Related Quality of Life in Patients With Low Vision: A Prospective Longitudinal Study
Bonnie A Sturrock, Jing Xie, Edith E Holloway, Ecosse L Lamoureux, Jill E Keeffe, Eva K Fenwick, Gwyneth Rees
Journal article | 2015 | Investigative Ophthalmology and Visual Science
The Influence of Coping on Vision-Related Quality of Life (VRQoL) in Patients with Low Vision: A Prospective Longitudinal Study.
Bonnie A Sturrock, Jing Xie, Edith Eva Holloway, Ecosse L Lamoureux, Jill E Keeffe, Eva Fenwick, Gwyneth Rees
Journal article | 2015 | Investigative Opthalmology & Visual Science
PURPOSE: To determine the longitudinal impact of specific coping strategies on vision-related quality of life (VRQoL) in patients ..
A randomised controlled trial of a self-management programme for low vision implemented in low vision rehabilitation services
Gwyneth Rees, Jing Xie, Peggy P Chiang, Melanie F Larizza, Manjula Marella, Jennifer B Hassell, Jill E Keeffe, Ecosse L Lamoureux
Journal article | 2015 | PATIENT EDUCATION AND COUNSELING
Decreased Retinal Capillary Flow Is Not a Mediator of the Protective Myopia-Diabetic Retinopathy Relationship
Ryan Eyn Kidd Man, Muhammad Bayu Sasongko, Jing Xie, William J Best, Jonathan E Noonan, Tiffany Ching Shen Lo, Jie Jin Wang, Chi D Luu, Ecosse L Lamoureux
Journal article | 2014 | Investigative Ophthalmology & Visual Science
Retinal vascular caliber and the development of hypertension: a meta-analysis of individual participant data
Jie Ding, Khin Lay Wai, Kevin McGeechan, M Kamran Ikram, Ryo Kawasaki, Jing Xie, Ronald Klein, Barbara BK Klein, Mary Frances Cotch, Jie Jin Wang, Paul Mitchell, Jonathan E Shaw, Kayama Takamasa, A Richey Sharrett, Tien Y Wong
Journal article | 2014 | JOURNAL OF HYPERTENSION
Axial Length, Retinal Function, and Oxygen Consumption: A Potential Mechanism for a Lower Risk of Diabetic Retinopathy in Longer Eyes
Ryan Eyn Kidd Man, Ecosse L Lamoureux, Yamna Taouk, Jing Xie, Muhammad Bayu Sasongko, William J Best, Jonathan E Noonan, Ryo Kawasaki, Jie Jin Wang, Chi D Luu
Journal article | 2013 | Investigative Ophthalmology and Visual Science
Integrated Depression Management: A Proposed Trial of a New Model of Care in a Low Vision Rehabilitation Setting
Gwyneth Rees, David Mellor, Edith E Holloway, Bonnie A Sturrock, Mark T Hegel, Robin Casten, Jing Xie, Eric Finkelstein, Ecosse Lamoureux, Jill E Keeffe
Journal article | 2013 | Ophthalmic Epidemiology
Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error
Dwight Stambolian, Robert Wojciechowski, Konrad Oexle, Mario Pirastu, Xiaohui Li, Leslie J Raffel, Mary Frances Cotch, Emily Y Chew, Barbara Klein, Ronald Klein, Tien Y Wong, Claire L Simpson, Caroline CW Klaver, Cornelia M van Duijn, Virginie JM Verhoeven, Paul N Baird, Veronique Vitart, Andrew D Paterson, Paul Mitchell, Seang Mei Saw, et al.
Journal article | 2013 | Human Molecular Genetics
Genetic Loci for Retinal Arteriolar Microcirculation
Xueling Sim, Richard A Jensen, M Kamran Ikram, Mary Frances Cotch, Xiaohui Li, Stuart MacGregor, Jing Xie, Albert Vernon Smith, Eric Boerwinkle, Paul Mitchell, Ronald Klein, Barbara EK Klein, Nicole L Glazer, Thomas Lumley, Barbara McKnight, Bruce M Psaty, Paulus TVM de Jong, Albert Hofman, Fernando Rivadeneira, Andre G Uitterlinden, et al.
Journal article | 2013 | PLoS One
Genetic Association of Refractive Error and Axial Length with 15q14 but Not 15q25 in the Blue Mountains Eye Study Cohort
Maria Schache, Andrea J Richardson, Paul Mitchell, Jie Jin Wang, Elena Rochtchina, Ananth C Viswanathan, Tien Y Wong, Seang Mei Saw, Fotis Topouzis, Jing Xie, Xueling Sim, Elizabeth C Holliday, John Attia, Rodney J Scott, Paul N Baird
Journal article | 2013 | Ophthalmology
Insights into the Genetic Architecture of Early Stage Age-Related Macular Degeneration: A Genome-Wide Association Study Meta-Analysis
Elizabeth G Holliday, Albert V Smith, Belinda K Cornes, Gabrielle HS Buitendijk, Richard A Jensen, Xueling Sim, Thor Aspelund, Tin Aung, Paul N Baird, Eric Boerwinkle, Ching Yu Cheng, Cornelia M van Duijn, Gudny Eiriksdottir, Vilmundur Gudnason, Tamara Harris, Alex W Hewitt, Michael Inouye, Fridbert Jonasson, Barbara EK Klein, Lenore Launer, et al.
Journal article | 2013 | PLoS One
Association between Three Genetic Variants of the Perilipin Gene (PLIN) and Glucose Metabolism: Results from a Replication Study among Chinese Adults and a Meta-Analysis
Dahai Yu, Chunyang Li, Jing Xie, Guoheng Xu, Yanyan Li, Jiyan Liu, Bing Chen, Jingjing Pan, Minghui Shen, Liming Yang, Dongsheng Hu
Journal article | 2013 | Endocrine Research
Assessing disutility associated with diabetic retinopathy, diabetic macular oedema and associated visual impairment using the Vision and Quality of Life Index
Eva K Fenwick, Jing Xie, Konrad Pesudovs, Julie Ratcliffe, Peggy PC Chiang, Robert P Finger, Ecosse L Lamoureux
Journal article | 2012 | Clinical and Experimental Optometry
Delay to Treatment and Visual Outcomes in Patients Treated With Anti-Vascular Endothelial Growth Factor for Age-Related Macular Degeneration
Jonathan H Lim, Sanjeewa S Wickremasinghe, Jing Xie, Devinder S Chauhan, Paul N Baird, Luba D Robman, Gregory Hageman, Robyn H Guymer
Journal article | 2012 | American Journal of Ophthalmology
Methodology and early findings of the Diabetes Management Project: a cohort study investigating the barriers to optimal diabetes care in diabetic patients with and without diabetic retinopathy
Ecosse Luc Lamoureux, Eva Fenwick, Jing Xie, Annie Mcauley, Theona Nicolaou, Melanie Larizza, Gwyn Rees, Salmaan Qureshi, Tien Yin Wong, Rehab Benarous, Mohamed Dirani
Journal article | 2012 | Clinical and Experimental Ophthalmology
Retinal microvascular calibre and risk of incident diabetes: The multi-ethnic study of atherosclerosis
Joanne Wen Yee Yau, Jing Xie, Ecosse Lamoureux, Ronald Klein, Barbara EK Klein, Mary Frances Cotch, Alain G Bertoni, Steven Shea, Tien Y Wong
Journal article | 2012 | Diabetes Research and Clinical Practice
The Impact of Diabetic Retinopathy and Diabetic Macular Edema on Health-Related Quality of Life in Type 1 and Type 2 Diabetes
Eva K Fenwick, Jing Xie, Julie Ratcliffe, Konrad Pesudovs, Robert P Finger, Tien Y Wong, Ecosse L Lamoureux
Journal article | 2012 | Investigative Ophthalmology and Visual Science
Retinal Arteriolar Narrowing and Subsequent Development of CKD Stage 3: The Multi-Ethnic Study of Atherosclerosis (MESA)
Joanne Wen Yee Yau, Jing Xie, Ryo Kawasaki, Holly Kramer, Michael Shlipak, Ronald Klein, Barbara Klein, Mary Frances Cotch, Tien Yin Wong
Journal article | 2011 | American Journal of Kidney Diseases
Variants in the APOE Gene Are Associated with Improved Outcome after Anti-VEGF Treatment for Neovascular AMD
Sanjeewa S Wickremasinghe, Jing Xie, Jonathan Lim, Devinder S Chauhan, Luba Robman, Andrea J Richardson, Gregory Hageman, Paul N Baird, Robyn Guymer
Journal article | 2011 | Investigative Ophthalmology and Visual Science
Glaucomatous optic neuropathy evaluation project: a standardized internet system for assessing skills in optic disc examination
Yu Xiang G Kong, Michael A Coote, Evelyn C O'Neill, Lulu U Gurria, Jing Xie, David Garway-Heath, Felipe A Medeiros, Jonathan G Crowston
Journal article | 2011 | Clinical and Experimental Ophthalmology
Honours, Awards and Fellowships
Analysis of the sex ratio in Henan province (Second prize)
Aging trend and Well-off Society Construction in Henan province (Third prize)
Medicine - Royal Melbourne Hospital
Association for Research in Vision and Ophthalmology
Global Fund on AIDS in Henan Province
Henan Population Association
China Medical Statistics Association
Doctor of Philosophy
Master of Public Health (MPH)
Xi'an Jiaotong University
Doctor of Medicine