Brendan Silbert

Performance of the bispectral index and electroencephalograph derived parameters of anesthetic depth during emergence from xenon and sevoflurane anesthesia.

Steven McGuigan, David A Scott, Lisbeth Evered, Brendan Silbert, David TJ Liley

Journal article  |  2023  |  J Clin Monit Comput

Many processed EEG monitors (pEEG) are unreliable when non-GABAergic anesthetic agents are used. The primary aim of the study was ..

Examining Subjective Psychological Experiences of Postoperative Delirium in Older Cardiac Surgery Patients.

Caitlin L Cohen, Kelly J Atkins, Lisbeth A Evered, Brendan S Silbert, David A Scott

Journal article  |  2022  |  Anesth Analg

BACKGROUND: Postoperative delirium (POD) is an acute syndrome including inattention and impaired cognition that affects approximat..

Acute peri-operative neurocognitive disorders: a narrative review

L Evered, K Atkins, B Silbert, DA Scott

Journal article  |  2022  |  ANAESTHESIA

Peri-operative neurocognitive disorders are the most common complication experienced by older individuals undergoing anaesthesia a..

Comparing the effect of xenon and sevoflurane anesthesia on postoperative neural injury biomarkers: a randomized controlled trial

Steven McGuigan, Lisbeth Evered, David Scott, Brendan Silbert, Henrik Zetterberg, Kaj Blennow

Journal article  |  2022  |  MEDICAL GAS RESEARCH

General anesthesia and surgery are associated with an increase in neural injury biomarkers. Elevations of these neural injury biom..

Inflammatory Biomarker Levels After Propofol or Sevoflurane Anesthesia: A Meta-analysis

Liam J O'Bryan, Kelly J Atkins, Adam Lipszyc, David A Scott, Brendan S Silbert, Lis A Evered

Journal article  |  2022  |  ANESTHESIA AND ANALGESIA

BACKGROUND: The perioperative inflammatory response may be implicated in adverse outcomes including neurocognitive dysfunction and..

Core outcome measures for Perioperative and Anaesthetic Care (COMPAC): a modified Delphi process to develop a core outcome set for trials in perioperative care and anaesthesia

Oliver Boney, S Ramani Moonesinghe, Paul S Myles, Michael PW Grocott

Journal article  |  2021  |  BRITISH JOURNAL OF ANAESTHESIA

BACKGROUND: Outcome selection underpins clinical trial interpretation. Inconsistency in outcome selection and reporting hinders co..

Digital clock drawing test metrics in older patients before and after endoscopy with sedation: An exploratory analysis

Richard A Buckley, Kelly J Atkins, Brendan Silbert, David A Scott, Lisbeth Evered

Journal article  |  2021  |  ACTA ANAESTHESIOLOGICA SCANDINAVICA

BACKGROUND: In the postoperative period, clinically feasible instruments to monitor elderly patients' neurocognitive recovery and ..

Comparison of the Spectral Features of the Frontal Electroencephalogram in Patients Receiving Xenon and Sevoflurane General Anesthesia

Steven McGuigan, Lisbeth Evered, Brendan Silbert, David A Scott, John R Cormack, Abarna Devapalasundaram, David TJ Liley

Journal article  |  2021  |  ANESTHESIA AND ANALGESIA

BACKGROUND: Depth-of-anesthesia monitoring is often utilized for patients receiving xenon anesthesia. Processed electroencephalogr..

Impaired cognitive performance on MoCA testing at discharge in elderly patients following day endoscopy and its relationship to preoperative mild cognitive impairment

Nathan J Chua, Georgia Dimopoulos, David A Scott, Brendan S Silbert, Lisbeth A Evered

Journal article  |  2021  |  ANAESTHESIA AND INTENSIVE CARE

In patients admitted to hospital, preoperative mild cognitive impairment predicts postoperative complications. The effect of mild ..

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease

James M Roe, Didac Vidal-Pineiro, Oystein Sorensen, Andreas M Brandmaier, Sandra Duzel, Hector A Gonzalez, Rogier A Kievit, Ethan Knights, Simone Kuhn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Denise C Park, Sara Pudas, Melissa M Rundle, Kristine B Walhovd, Anders M Fjell, Rene Westerhausen

Journal article  |  2021  |  NATURE COMMUNICATIONS

Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an orga..