Zhi Ling Teo

Clinical implications of prospective genomic profiling of metastatic breast cancer patients

Courtney T van Geelen, Peter Savas, Zhi Ling Teo, Stephen J Luen, Chen-Fang Weng, Yi-An Ko, Keilly S Kuykhoven, Franco Caramia, Roberto Salgado, Prudence A Francis, Sarah-Jane Dawson, Stephen B Fox, Andrew Fellowes, Sherene Loi

Journal article  |  2020  |  BREAST CANCER RESEARCH

BACKGROUND: Metastatic breast cancer remains incurable. Next-generation sequencing (NGS) offers the ability to identify actionable..

Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade

Imran G House, Peter Savas, Junyun Lai, Amanda XY Chen, Amanda J Oliver, Zhi L Teo, Kirsten L Todd, Melissa A Henderson, Lauren Giuffrida, Emma V Petley, Kevin Sek, Sherly Mardiana, Tuba N Gide, Camelia Quek, Richard A Scolyer, Georgina V Long, James S Wilmott, Sherene Loi, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  CLINICAL CANCER RESEARCH

PURPOSE: Response rates to immune checkpoint blockade (ICB; anti-PD-1/anti-CTLA-4) correlate with the extent of tumor immune infil..

Characterization of high TIL breast cancers reveals a prognostic and functionally distinct tissue-resident memory subpopulation

P Savas, B Virassamy, C Ye, A Salim, CP Mintoff, F Caramia, R Salgado, ZL Teo, S Dushyanthen, A Byrne, SJ Luen, SB Fox, TP Speed, LK Mackay, PJ Neeson, S Loi

Conference Proceedings  |  2019  |  CANCER RESEARCH

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Peter Savas, Balaji Virassamy, Chengzhong Ye, Agus Salim, Christopher P Mintoff, Franco Caramia, Roberto Salgado, David J Byrne, Zhi L Teo, Sathana Dushyanthen, Ann Byrne, Lironne Wein, Stephen J Luen, Catherine Poliness, Sophie S Nightingale, Anita S Skandarajah, David E Gyorki, Chantel M Thornton, Paul A Beavis, Stephen B Fox, et al.

Journal article  |  2018  |  NATURE MEDICINE

The quantity of tumor-infiltrating lymphocytes (TILs) in breast cancer (BC) is a robust prognostic factor for improved patient sur..

Is RNASEL:p.Glu265*a modifier of early-onset breast cancer risk for carriers of high-risk mutations?

Tu Nguyen-Dumont, Zhi L Teo, Fleur Hammet, Alexis Roberge, Maryam Mahmoodi, Helen Tsimiklis, Daniel J Park, Bernard J Pope, Andrew Lonie, Miroslav K Kapuscinski, Khalid Mahmood, David E Goldgar, Graham G Giles, Ingrid Winship, John L Hopper, Melissa C Southey

Journal article  |  2018  |  BMC CANCER

BACKGROUND: Breast cancer risk for BRCA1 and BRCA2 pathogenic mutation carriers is modified by risk factors that cluster in famili..

Combined CDK4/6 and PI3K alpha Inhibition Is Synergistic and Immunogenic in Triple-Negative Breast Cancer

Zhi Ling Teo, Stephanie Versaci, Sathana Dushyanthen, Franco Caramia, Peter Savas, Chris P Mintoff, Magnus Zethoven, Balaji Virassamy, Stephen J Luen, Grant A McArthur, Wayne A Phillips, Phillip K Darcy, Sherene Loi

Journal article  |  2017  |  CANCER RESEARCH

New treatments for triple-negative breast cancer (TNBC) are urgently needed. Despite there being little evidence of clinical activ..

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

Sathana Dushyanthen, Zhi Ling Teo, Franco Caramia, Peter Savas, Christopher P Mintoff, Balaji Virassamy, Melissa A Henderson, Stephen J Luen, Mariam Mansour, Michael H Kershaw, Joseph A Trapani, Paul J Neeson, Roberto Salgado, Grant A McArthur, Justin M Balko, Paul A Beavis, Phillip K Darcy, Sherene Loi

Journal article  |  2017  |  NATURE COMMUNICATIONS

The presence of tumor-infiltrating lymphocytes in triple-negative breast cancers is correlated with improved outcomes. Ras/MAPK pa..

Advancing Immunotherapy in Metastatic Breast Cancer

Mariam Mansour, Zhi Ling Teo, Stephen J Luen, Sherene Loi

Journal article  |  2017  |  CURRENT TREATMENT OPTIONS IN ONCOLOGY

OPINION STATEMENT: Despite many advances in the treatment of breast cancer, the development of metastatic disease remains an incur..

Gene expression analysis: Current methods

ZL Teo, P Savas, S Loi

Book Chapter  |  2017

Cancer is a genetic disease characterised by multiple heterogeneous genetic and epigenetic changes. Recent studies have identified..

Gene expression analysis: Applications

P Savas, ZL Teo, S Loi

Book Chapter  |  2017

Cancer is a highly variable, heterogeneous disease induced by the accumulation of numerous genetic and environmental factors. Unde..