Sarah Russell

A new role for Notch in the control of polarity and asymmetric cell division of developing T cells.

Mirren Charnley, Mandy Ludford-Menting, Kim Pham, Sarah M Russell

Journal article  |  2019  |  Journal of Cell Science

A fundamental question in biology is how single cells can reliably produce progeny of different cell types. Notch signalling frequ..

An integrated transcriptional switch at the beta-selection checkpoint determines T cell survival, development and leukaemogenesis

Anchi S Chann, Sarah M Russell

Journal article  |  2019  |  Biochemical Society Transactions

In T cell development, a pivotal decision-making stage, termed β-selection, integrates a TCRβ checkpoint to coordinate survival, p..

Developing T cells form an immunological synapse for passage through the β−selection checkpoint

Amr Allam, Mirren Charnley, Kim Pham, Sarah Russell

Journal article  |  2019

Abstract The β-selection checkpoint of T cell development tests whether the cell has recombined its genomic DNA to produce a funct..

Maps of variability in cell lineage trees

Damien Hicks, Terence Speed, Mohammed Yassin, Sarah Russell

Journal article  |  2019  |  PLoS Computational Biology

New approaches to lineage tracking allow the study of cell differentiation over many generations of cells during development in mu..

Maps of variability in cell lineage trees

Damien G Hicks, Terence P Speed, Mohammed Yassin, Sarah M Russell

Journal article  |  2019  |  PLOS Computational Biology

Context-Specific Mechanisms of Cell Polarity Regulation

Amr H Allam, Mirren Charnley, Sarah M Russell

Journal article  |  2018  |  Journal of Molecular Biology

Chitosan-coated amyloid fibrils increase adipogenesis of mesenchymal stem cells

Jay Gilbert, Nicholas P Reynolds, Sarah M Russell, David Haylock, Sally McArthur, Mirren Charnley, Owen G Jones

Journal article  |  2017  |  Materials Science and Engineering: C

In vitro tracking and intracellular protein distribution in immunology

Kajal Zibaei, Sarah M Russell

Journal article  |  2017  |  Immunology and Cell Biology

The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation

Christina B Wolwer, Nathan Godde, Luke B Pase, Imogen A Elsum, Krystle YB Lim, Faruk Sacirbegovic, Carl R Walkley, Sarah Ellis, Shigeo Ohno, Fumio Matsuzaki, Sarah M Russell, Patrick O Humbert

Journal article  |  2017  |  PLOS ONE

Imaging Asymmetric T Cell Division.

Mirren Charnley, Sarah M Russell

Book Chapter  |  2017  |  Methods in Molecular Biology

Asymmetric cell division (ACD) controls cell fate decisions in model organisms such as Drosophila and C. elegans and has recently ..

Mediating signaling response to actin-mediated forces Cas-L is causal in the T-cell response to forces triggered by antigen presentation

Ye Chen, Sarah M Russell

Journal article  |  2016  |  Immunology and Cell Biology

Dense small molecule labeling enables activator-dependent STORM by proximity mapping

Ye Chen, Min Gu, Peter W Gunning, Sarah M Russell

Journal article  |  2016  |  Histochemistry and Cell Biology

Polarity and asymmetric cell division in the control of lymphocyte fate decisions and function

Mohammed Yassin, Sarah M Russell

Journal article  |  2016  |  Current Opinion in Immunology

Scribble acts as an oncogene in E mu-myc-driven lymphoma

ED Hawkins, J Oliaro, KM Ramsbottom, A Newbold, PO Humbert, RW Johnstone, SM Russell

Journal article  |  2016  |  Oncogene

Lethal giant larvae-1 deficiency enhances the CD8( ) effector T-cell response to antigen challenge in vivo

Kelly M Ramsbottom, Faruk Sacirbegovic, Edwin D Hawkins, Axel Kallies, Gabrielle T Belz, Vanessa Van Ham, Nicole M Haynes, Michael J Durrant, Patrick O Humbert, Sarah M Russell, Jane Oliaro

Journal article  |  2016  |  Immunology and Cell Biology

Calcium Signaling Is Required for Erythroid Enucleation

Christina B Woelwer, Luke B Pase, Sarah M Russell, Patrick O Humbert

Journal article  |  2016  |  PLOS ONE

A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation

Christina B Woelwer, Luke B Pase, Helen B Pearson, Nathan J Goedde, Kurt Lackovic, David CS Huang, Sarah M Russell, Patrick O Humbert

Journal article  |  2015  |  PLOS ONE

Asymmetric cell division during T cell development controls downstream fate

Pham Kim, Raz Shimoni, Mirren Charnley, Mandy J Ludford-Menting, Edwin D Hawkins, Kelly Ramsbottom, Jane Oliaro, David Izon, Stephen B Ting, Joseph Reynolds, Grant Lythe, Carmen Molina-Paris, Heather Melichar, Ellen Robey, Patrick O Humbert, Min Gu, Sarah M Russell

Journal article  |  2015  |  The Journal of Cell Biology

The Scribble-Dlg-Lgl Module in Cell Polarity Regulation

Patrick O Humbert, Sarah M Russell, Lorey Smith, Helena E Richardson

Book Chapter  |  2015

Polarization of excitation light influences molecule counting in single-molecule localization microscopy

Ye Chen, Han Lin, Mandy J Ludford-Menting, Andrew H Clayton, Min Gu, Sarah M Russell

Journal article  |  2015  |  Histochemistry and Cell Biology

Normalized Polarization Ratios for the Analysis of Cell Polarity

Raz Shimoni, Kim Pham, Mohammed Yassin, Mandy J Ludford-Menting, Min Gu, Sarah M Russell

Journal article  |  2014  |  PLoS One

Polarized cells, polarized views: asymmetric cell division in hematopoietic cells

Kim Pham, Faruk Sacirbegovic, Sarah M Russell

Journal article  |  2014  |  Frontiers in Immunology

Lethal Giant Larvae 1 Tumour Suppressor Activity Is Not Conserved in Models of Mammalian T and B Cell Leukaemia

Edwin D Hawkins, Jane Oliaro, Kelly M Ramsbottom, Stephen B Ting, Faruk Sacirbegovic, Michael Harvey, Tanja Kinwell, Jacques Ghysdael, Ricky W Johnstone, Patrick O Humbert, Sarah M Russell

Journal article  |  2014  |  PLoS ONE

Cutting Edge: DNAX Accessory Molecule 1-Deficient CD8 T Cells Display Immunological Synapse Defects That Impair Antitumor Immunity

Kelly M Ramsbottom, Edwin D Hawkins, Raz Shimoni, Mairi McGrath, Christopher J Chan, Sarah M Russell, Mark J Smyth, Jane Oliaro

Journal article  |  2014  |  The Journal of Immunology

Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity

Edwin D Hawkins, Jane Oliaro, Axel Kallies, Gabrielle T Belz, Andrew Filby, Thea Hogan, Nicole Haynes, Kelly M Ramsbottom, Vanessa Van Ham, Tanja Kinwell, Benedict Seddon, Derek Davies, David Tarlinton, Andrew M Lew, Patrick O Humbert, Sarah M Russell

Journal article  |  2013  |  Nature Communications

TACTICS, an interactive platform for customized high-content bioimaging analysis

Raz Shimoni, Pham Kim, Mohammed Yassin, Min Gu, Sarah M Russell

Journal article  |  2013  |  Bioinformatics

Divergent lymphocyte signalling revealed by a powerful new tool for analysis of time-lapse microscopy

Kim Pham, Raz Shimoni, Mandy J Ludford-Menting, Cameron J Nowell, Pavel Lobachevsky, Ze'ev Bomzon, Min Gu, Terence P Speed, C Jane McGlade, Sarah M Russell

Journal article  |  2013  |  Immunology and Cell Biology

Characterization of In Vivo Dlg1 Deletion on T Cell Development and Function

Lisa A Humphries, Meredith H Shaffer, Faruk Sacirbegovic, Tamar Tomassian, Kerrie-Ann McMahon, Patrick O Humbert, Oscar Silva, June L Round, Kogo Takamiya, Richard L Huganir, Janis K Burkhardt, Sarah M Russell, M Carrie Miceli

Journal article  |  2012  |  PLoS One

Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2

Stephen B Ting, Eric Deneault, Kristin Hope, Sonia Cellot, Jalila Chagraoui, Nadine Mayotte, Jonas F Dorn, Jean-Philippe Laverdure, Michael Harvey, Edwin D Hawkins, Sarah M Russell, Paul S Maddox, Norman N Iscove, Guy Sauvageau

Journal article  |  2012  |  Blood

Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function

Ivan Fung, Sarah M Russell, Jane Oliaro

Journal article  |  2012  |  Clinical & Developmental Immunology

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

Florian Wiede, Benjamin J Shields, Sock Hui Chew, Konstantinos Kyparissoudis, Catherine van Vliet, Sandra Galic, Michel L Tremblay, Sarah M Russell, Dale I Godfrey, Tony Tiganis

Journal article  |  2011  |  Journal of Clinical Investigation

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

Katrina L Randall, Stephanie S-Y Chan, Cindy S Ma, Ivan Fung, Yan Mei, Mehmet Yabas, Andy Tan, Peter D Arkwright, Wafaa Al Suwairi, Saul Oswaldo Lugo Reyes, Marco A Yamazaki-Nakashimada, Maria de la Luz Garcia-Cruz, Joanne M Smart, Capucine Picard, Satoshi Okada, Emmanuelle Jouanguy, Jean-Laurent Casanova, Teresa Lambe, Richard J Cornall, Sarah Russell, et al.

Journal article  |  2011  |  Journal of Experimental Medicine

Quantifying subcellular distribution of fluorescent fusion proteins in cells migrating within tissues

Heather J Melichar, Ou Li, Paul Herzmark, Raghav K Padmanabhan, Jane Oliaro, Mandy J Ludford-Menting, Philippe Bousso, Sarah M Russell, Badrinath Roysam, Ellen A Robey

Journal article  |  2011  |  Immunology and Cell Biology

Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division

John T Chang, Maria L Ciocca, Ichiko Kinjyo, Vikram R Palanivel, Courtney E McClurkin, Caitlin S De Jong, Erin C Mooney, Jiyeon S Kim, Natalie C Steinel, Jane Oliaro, Catherine C Yin, Bogdan I Florea, Herman S Overkleeft, Leslie J Berg, Sarah M Russell, Gary A Koretzky, Martha S Jordan, Steven L Reiner

Journal article  |  2011  |  Immunity

The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts.

Mandy J Ludford-Menting, Blessing Crimeen-Irwin, Jane Oliaro, Anupama Pasam, David Williamson, Natalie Pedersen, Patricia Guillaumot, Dale Christansen, Serge Manie, Katharina Gaus, Sarah M Russell

Journal article  |  2011  |  Journal of Lipids

Many infectious agents utilize CD46 for infection of human cells, and therapeutic applications of CD46-binding viruses are now bei..

Super-resolution imaging and statistical analysis of CdSe/CdS Core/Shell semiconductor nanocrystals

Betty P Kouskousis, Joel van Embden, Dru Morrish, Sarah M Russell, Min Gu

Journal article  |  2010  |  Journal of Biophotonics

Asymmetric Cell Division of T Cells upon Antigen Presentation Uses Multiple Conserved Mechanisms

Jane Oliaro, Vanessa Van Ham, Faruk Sacirbegovic, Anupama Pasam, Ze'ev Bomzon, Kim Pham, Mandy J Ludford-Menting, Nigel J Waterhouse, Michael Bots, Edwin D Hawkins, Sally V Watt, Leonie A Cluse, Chris JP Clarke, David J Izon, John T Chang, Natalie Thompson, Min Gu, Ricky W Johnstone, Mark J Smyth, Patrick O Humbert, et al.

Journal article  |  2010  |  Journal of Immunology

Second harmonic generation imaging via nonlinear endomicroscopy

Hongchun Bao, Alex Boussioutas, Reynolds Jeremy, Sarah Russell, Min Gu

Journal article  |  2010  |  Optics Express

Imaging of goblet cells as a marker for intestinal metaplasia of the stomach by one-photon and two-photon fluorescence endomicroscopy

Hongchun Bao, Alex Boussioutas, Jeremy Reynolds, Sarah Russell, Min Gu

Journal article  |  2009  |  Journal of Biomedical Optics

A method for prolonged imaging of motile lymphocytes

Daniel Day, Kim Pham, Mandy J Ludford-Menting, Jane Oliaro, David Izon, Sarah M Russell, Min Gu

Journal article  |  2009  |  Immunology and Cell Biology

Upsides and downsides to polarity and asymmetric cell division in leukemia

ED Hawkins, SM Russell

Journal article  |  2008  |  Oncogene

Determination of T-cell fate by dendritic cells: a new role for asymmetric cell division?

Sarah M Russell

Journal article  |  2008  |  Immunology and Cell Biology

The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge

LE Dow, JS Kauffman, J Caddy, AS Peterson, SM Jane, SM Russell, PO Humbert

Journal article  |  2007  |  Oncogene

Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation

Jane Oliaro, Anupama Pasam, Nigel J Waterhouse, Kylie A Browne, Mandy J Ludford-Menting, Joseph A Trapani, Sarah M Russell

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America

A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation

MJ Ludford-Menting, J Oliaro, F Sacirbegovic, ETY Cheah, N Pedersen, SJ Thomas, A Pasam, R Iazzolino, LE Dow, NJ Waterhouse, A Murphy, S Ellis, MJ Smyth, MH Kershaw, PK Darcy, PO Humbert, SM Russell

Journal article  |  2005  |  Immunity

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

LE Dow, AM Brumby, R Muratore, ML Coombe, KA Sedelies, JA Trapani, SM Russell, HE Richardson, PO Humbert

Journal article  |  2003  |  Oncogene

Ligand binding determines whether CD46 is internalized by clathrin-coated pits or macropinocytosis

B Crimeen-Irwin, S Ellis, D Christiansen, MJ Ludford-Menting, J Milland, M Lanteri, BE Loveland, D Gerlier, SM Russell

Journal article  |  2003  |  Journal of Biological Chemistry

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer

P Humbert, S Russell, H Richardson

Journal article  |  2003  |  Bioessays

Spectra and lifetimes of fluorescence resonance energy transfer fluorophores under two-photon excitation

R Ashman, B Crimeen-Irwin, M Ludford-Menting, S Russell, M Gu

Journal article  |  2003  |  Scanning

The cytoplasmic tail of alpha 1,3-galactosyltransferase inhibits Golgi localization of the full-length enzyme

J Milland, SM Russell, HC Dodson, IFC McKenzie, MS Sandrin

Journal article  |  2002  |  Journal of Biological Chemistry

A functional interaction between CD46 and DLG4 - A role for DLG4 in epithelial polarization

MJ Ludford-Menting, SJ Thomas, B Crimeen, LJ Harris, BE Loveland, M Bills, S Ellis, SM Russell

Journal article  |  2002  |  Journal of Biological Chemistry