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An integrated transcriptional switch at the beta-selection checkpoint determines T cell su..
Developing T cells form an immunological synapse for passage through the β−selection check..
Displaying the 17 most recent projects by Sarah Russell.
Displaying the 51 most recent scholarly works by Sarah Russell.
A new role for Notch in the control of polarity and asymmetric cell division of developing T cells.
Mirren Charnley, Mandy Ludford-Menting, Kim Pham, Sarah M Russell
Journal article | 2019 | Journal of Cell Science
A fundamental question in biology is how single cells can reliably produce progeny of different cell types. Notch signalling frequ..
An integrated transcriptional switch at the beta-selection checkpoint determines T cell survival, development and leukaemogenesis
Anchi S Chann, Sarah M Russell
Journal article | 2019 | Biochemical Society Transactions
In T cell development, a pivotal decision-making stage, termed β-selection, integrates a TCRβ checkpoint to coordinate survival, p..
Developing T cells form an immunological synapse for passage through the β−selection checkpoint
Amr Allam, Mirren Charnley, Kim Pham, Sarah Russell
Journal article | 2019
Abstract The β-selection checkpoint of T cell development tests whether the cell has recombined its genomic DNA to produce a funct..
The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation
Christina B Wolwer, Nathan Godde, Luke B Pase, Imogen A Elsum, Krystle YB Lim, Faruk Sacirbegovic, Carl R Walkley, Sarah Ellis, Shigeo Ohno, Fumio Matsuzaki, Sarah M Russell, Patrick O Humbert
Journal article | 2017 | PLOS ONE
Lethal giant larvae-1 deficiency enhances the CD8( ) effector T-cell response to antigen challenge in vivo
Kelly M Ramsbottom, Faruk Sacirbegovic, Edwin D Hawkins, Axel Kallies, Gabrielle T Belz, Vanessa Van Ham, Nicole M Haynes, Michael J Durrant, Patrick O Humbert, Sarah M Russell, Jane Oliaro
Journal article | 2016 | Immunology and Cell Biology
Asymmetric cell division during T cell development controls downstream fate
Pham Kim, Raz Shimoni, Mirren Charnley, Mandy J Ludford-Menting, Edwin D Hawkins, Kelly Ramsbottom, Jane Oliaro, David Izon, Stephen B Ting, Joseph Reynolds, Grant Lythe, Carmen Molina-Paris, Heather Melichar, Ellen Robey, Patrick O Humbert, Min Gu, Sarah M Russell
Journal article | 2015 | The Journal of Cell Biology
Lethal Giant Larvae 1 Tumour Suppressor Activity Is Not Conserved in Models of Mammalian T and B Cell Leukaemia
Edwin D Hawkins, Jane Oliaro, Kelly M Ramsbottom, Stephen B Ting, Faruk Sacirbegovic, Michael Harvey, Tanja Kinwell, Jacques Ghysdael, Ricky W Johnstone, Patrick O Humbert, Sarah M Russell
Journal article | 2014 | PLoS ONE
Cutting Edge: DNAX Accessory Molecule 1-Deficient CD8 T Cells Display Immunological Synapse Defects That Impair Antitumor Immunity
Kelly M Ramsbottom, Edwin D Hawkins, Raz Shimoni, Mairi McGrath, Christopher J Chan, Sarah M Russell, Mark J Smyth, Jane Oliaro
Journal article | 2014 | The Journal of Immunology
Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity
Edwin D Hawkins, Jane Oliaro, Axel Kallies, Gabrielle T Belz, Andrew Filby, Thea Hogan, Nicole Haynes, Kelly M Ramsbottom, Vanessa Van Ham, Tanja Kinwell, Benedict Seddon, Derek Davies, David Tarlinton, Andrew M Lew, Patrick O Humbert, Sarah M Russell
Journal article | 2013 | Nature Communications
Divergent lymphocyte signalling revealed by a powerful new tool for analysis of time-lapse microscopy
Kim Pham, Raz Shimoni, Mandy J Ludford-Menting, Cameron J Nowell, Pavel Lobachevsky, Ze'ev Bomzon, Min Gu, Terence P Speed, C Jane McGlade, Sarah M Russell
Journal article | 2013 | Immunology and Cell Biology
Characterization of In Vivo Dlg1 Deletion on T Cell Development and Function
Lisa A Humphries, Meredith H Shaffer, Faruk Sacirbegovic, Tamar Tomassian, Kerrie-Ann McMahon, Patrick O Humbert, Oscar Silva, June L Round, Kogo Takamiya, Richard L Huganir, Janis K Burkhardt, Sarah M Russell, M Carrie Miceli
Journal article | 2012 | PLoS One
Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2
Stephen B Ting, Eric Deneault, Kristin Hope, Sonia Cellot, Jalila Chagraoui, Nadine Mayotte, Jonas F Dorn, Jean-Philippe Laverdure, Michael Harvey, Edwin D Hawkins, Sarah M Russell, Paul S Maddox, Norman N Iscove, Guy Sauvageau
Journal article | 2012 | Blood
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice
Florian Wiede, Benjamin J Shields, Sock Hui Chew, Konstantinos Kyparissoudis, Catherine van Vliet, Sandra Galic, Michel L Tremblay, Sarah M Russell, Dale I Godfrey, Tony Tiganis
Journal article | 2011 | Journal of Clinical Investigation
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice
Katrina L Randall, Stephanie S-Y Chan, Cindy S Ma, Ivan Fung, Yan Mei, Mehmet Yabas, Andy Tan, Peter D Arkwright, Wafaa Al Suwairi, Saul Oswaldo Lugo Reyes, Marco A Yamazaki-Nakashimada, Maria de la Luz Garcia-Cruz, Joanne M Smart, Capucine Picard, Satoshi Okada, Emmanuelle Jouanguy, Jean-Laurent Casanova, Teresa Lambe, Richard J Cornall, Sarah Russell, et al.
Journal article | 2011 | Journal of Experimental Medicine
Quantifying subcellular distribution of fluorescent fusion proteins in cells migrating within tissues
Heather J Melichar, Ou Li, Paul Herzmark, Raghav K Padmanabhan, Jane Oliaro, Mandy J Ludford-Menting, Philippe Bousso, Sarah M Russell, Badrinath Roysam, Ellen A Robey
Journal article | 2011 | Immunology and Cell Biology
Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division
John T Chang, Maria L Ciocca, Ichiko Kinjyo, Vikram R Palanivel, Courtney E McClurkin, Caitlin S De Jong, Erin C Mooney, Jiyeon S Kim, Natalie C Steinel, Jane Oliaro, Catherine C Yin, Bogdan I Florea, Herman S Overkleeft, Leslie J Berg, Sarah M Russell, Gary A Koretzky, Martha S Jordan, Steven L Reiner
Journal article | 2011 | Immunity
The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts.
Mandy J Ludford-Menting, Blessing Crimeen-Irwin, Jane Oliaro, Anupama Pasam, David Williamson, Natalie Pedersen, Patricia Guillaumot, Dale Christansen, Serge Manie, Katharina Gaus, Sarah M Russell
Journal article | 2011 | Journal of Lipids
Many infectious agents utilize CD46 for infection of human cells, and therapeutic applications of CD46-binding viruses are now bei..
Asymmetric Cell Division of T Cells upon Antigen Presentation Uses Multiple Conserved Mechanisms
Jane Oliaro, Vanessa Van Ham, Faruk Sacirbegovic, Anupama Pasam, Ze'ev Bomzon, Kim Pham, Mandy J Ludford-Menting, Nigel J Waterhouse, Michael Bots, Edwin D Hawkins, Sally V Watt, Leonie A Cluse, Chris JP Clarke, David J Izon, John T Chang, Natalie Thompson, Min Gu, Ricky W Johnstone, Mark J Smyth, Patrick O Humbert, et al.
Journal article | 2010 | Journal of Immunology
Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation
Jane Oliaro, Anupama Pasam, Nigel J Waterhouse, Kylie A Browne, Mandy J Ludford-Menting, Joseph A Trapani, Sarah M Russell
Journal article | 2006 | Proceedings of the National Academy of Sciences of the United States of America
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation
MJ Ludford-Menting, J Oliaro, F Sacirbegovic, ETY Cheah, N Pedersen, SJ Thomas, A Pasam, R Iazzolino, LE Dow, NJ Waterhouse, A Murphy, S Ellis, MJ Smyth, MH Kershaw, PK Darcy, PO Humbert, SM Russell
Journal article | 2005 | Immunity
Honours, Awards and Fellowships
The Sir Peter Maccallum Department Of Oncology
University of Melbourne
Bachelor of Science (Hons)
University of Melbourne