Clare Parish

Tissue Programmed Hydrogels Functionalized with GDNF Improve Human Neural Grafts in Parkinson's Disease

Cameron PJ Hunt, Vanessa Penna, Carlos W Gantner, Niamh Moriarty, Yi Wang, Stephanie Franks, Charlotte M Ermine, Isabelle R de Luzy, Chiara Pavan, Benjamin M Long, Richard J Williams, Lachlan H Thompson, David R Nisbet, Clare L Parish

Journal article  |  2021  |  ADVANCED FUNCTIONAL MATERIALS

The survival and synaptic integration of transplanted dopaminergic (DA) progenitors are essential for ameliorating motor symptoms ..

Spontaneous formation of beta-sheet nano-barrels during the early aggregation of Alzheimer's amyloid beta

Yunxiang Sun, Aleksandr Kakinen, Xulin Wan, Niamh Moriarty, Cameron PJ Hunt, Yuhuan Li, Nicholas Andrikopoulos, Aparna Nandakumar, Thomas P Davis, Clare L Parish, Yang Song, Pu Chun Ke, Feng Ding

Journal article  |  2021  |  NANO TODAY

Soluble low-molecular-weight oligomers formed during the early aggregation of amyloid peptides have been hypothesized as a major t..

Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats

Isabelle R de Luzy, Kevin CL Law, Niamh Moriarty, Cameron PJ Hunt, Jennifer C Durnall, Lachlan H Thompson, Andras Nagy, Clare L Parish

Journal article  |  2021  |  NATURE COMMUNICATIONS

Despite advancements in human pluripotent stem cells (hPSCs) differentiation protocols to generate appropriate neuronal progenitor..

FGF-MAPK signaling regulates human deep-layer corticogenesis

Carlos W Gantner, Cameron PJ Hunt, Jonathan C Niclis, Vanessa Penna, Stuart J McDougall, Lachlan H Thompson, Clare L Parish

Journal article  |  2021  |  STEM CELL REPORTS

Despite heterogeneity across the six layers of the mammalian cortex, all excitatory neurons are generated from a single founder po..

Focal Ischemic Injury to the Early Neonatal Rat Brain Models Cognitive and Motor Deficits with Associated Histopathological Outcomes Relevant to Human Neonatal Brain Injury

Brett J Kagan, Charlotte M Ermine, Stefano Frausin, Clare L Parish, Jess Nithianantharajah, Lachlan H Thompson

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neonatal arterial ischemic stroke is one of the more severe birth complications. The injury can result in extensive neurological d..

Embryonic stem cells go from bench to bedside for Parkinson's disease

Clare L Parish, Lachlan H Thompson

Journal article  |  2021  |  CELL REPORTS MEDICINE

Stem-cell-derived transplants may soon be a promising treatment option for Parkinson's disease. In preparation for clinical trial,..

The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease

Rachel M McQuade, Lewis M Singleton, Hongyi Wu, Sophie Lee, Remy Constable, Madeleine Di Natale, Mitchell T Ringuet, Joel P Berger, Jessica Kauhausen, Clare L Parish, David Finkelstein, John B Furness, Shanti Diwakarla

Journal article  |  2021  |  SCIENTIFIC REPORTS

Parkinson's disease (PD) is associated with neuronal damage in the brain and gut. This work compares changes in the enteric nervou..

An Optimized Protocol for the Generation of Midbrain Dopamine Neurons under Defined Conditions.

Carlos W Gantner, Agustín Cota-Coronado, Lachlan H Thompson, Clare L Parish

Journal article  |  2020  |  STAR Protoc

Here, we describe a xeno-free, feeder-free, and chemically defined protocol for the generation of ventral midbrain dopaminergic (v..

Ischemic Injury Does Not Stimulate Striatal Neuron Replacement Even during Periods of Active Striatal Neurogenesis

Charlotte M Ermine, Jordan L Wright, Davor Stanic, Clare L Parish, Lachlan H Thompson

Journal article  |  2020  |  ISCIENCE

Ischemic damage to the adult rodent forebrain has been widely used as a model system to study injury-induced neurogenesis, resulti..

Investigation of nerve pathways mediating colorectal dysfunction in Parkinson's disease model produced by lesion of nigrostriatal dopaminergic neurons

Xin-yi Chai, Shanti Diwakarla, Ruslan V Pustovit, Rachel M McQuade, Madeleine Di Natale, Charlotte M Ermine, Clare L Parish, David I Finkelstein, John B Furness

Journal article  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Gastrointestinal (GI) dysfunction, including constipation, is a common non-motor symptom of Parkinson's disease (PD). ..