Clare Parish

Spontaneous Formation of β-sheet Nano-barrels during the Early Aggregation of Alzheimer's Amyloid Beta.

Yunxiang Sun, Aleksandr Kakinen, Xulin Wan, Niamh Moriarty, Cameron PJ Hunt, Yuhuan Li, Nicholas Andrikopoulos, Aparna Nandakumar, Thomas P Davis, Clare L Parish, Yang Song, Pu Chun Ke, Feng Ding

Journal article  |  2021  |  Nano Today

Soluble low-molecular-weight oligomers formed during the early aggregation of amyloid peptides have been hypothesized as a major t..

Embryonic stem cells go from bench to bedside for Parkinson's disease.

Clare L Parish, Lachlan H Thompson

Journal article  |  2021  |  Cell Reports Medicine

Stem-cell-derived transplants may soon be a promising treatment option for Parkinson's disease. In preparation for clinical trial,..

The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease.

Rachel M McQuade, Lewis M Singleton, Hongyi Wu, Sophie Lee, Remy Constable, Madeleine Di Natale, Mitchell T Ringuet, Joel P Berger, Jessica Kauhausen, Clare L Parish, David I Finkelstein, John B Furness, Shanti Diwakarla

Journal article  |  2021  |  Scientific Reports

Parkinson's disease (PD) is associated with neuronal damage in the brain and gut. This work compares changes in the enteric nervou..

FGF-MAPK signaling regulates human deep-layer corticogenesis.

Carlos W Gantner, Cameron PJ Hunt, Jonathan C Niclis, Vanessa Penna, Stuart J McDougall, Lachlan H Thompson, Clare L Parish

Journal article  |  2021  |  Stem Cell Reports

Despite heterogeneity across the six layers of the mammalian cortex, all excitatory neurons are generated from a single founder po..

An Optimized Protocol for the Generation of Midbrain Dopamine Neurons under Defined Conditions.

Carlos W Gantner, Agustín Cota-Coronado, Lachlan H Thompson, Clare L Parish

Journal article  |  2020  |  STAR Protoc

Here, we describe a xeno-free, feeder-free, and chemically defined protocol for the generation of ventral midbrain dopaminergic (v..

Ischemic Injury Does Not Stimulate Striatal Neuron Replacement Even during Periods of Active Striatal Neurogenesis

Charlotte M Ermine, Jordan L Wright, Davor Stanic, Clare L Parish, Lachlan H Thompson

Journal article  |  2020  |  iScience

Ischemic damage to the adult rodent forebrain has been widely used as a model system to study injury-induced neurogenesis, resulti..

Investigation of nerve pathways mediating colorectal dysfunction in Parkinson's disease model produced by lesion of nigrostriatal dopaminergic neurons

Xin-yi Chai, Shanti Diwakarla, Ruslan V Pustovit, Rachel M McQuade, Madeleine Di Natale, Charlotte M Ermine, Clare L Parish, David I Finkelstein, John B Furness

Journal article  |  2020  |  Neurogastroenterology & Motility

BACKGROUND: Gastrointestinal (GI) dysfunction, including constipation, is a common non-motor symptom of Parkinson's disease (PD). ..

Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease

Carlos W Gantner, Isabelle R de Luzy, Jessica A Kauhausen, Niamh Moriarty, Jonathan C Niclis, Christopher R Bye, Vanessa Penna, Cameron PJ Hunt, Charlotte M Ermine, Colin W Pouton, Deniz Kirik, Lachlan H Thompson, Clare L Parish

Journal article  |  2020  |  Cell Stem Cell

Dopaminergic neurons (DAns), generated from human pluripotent stem cells (hPSCs), are capable of functionally integrating followin..

The application of human pluripotent stem cells to model the neuronal and glial components of neurodevelopmental disorders

KM Lee, ZH Hawi, HC Parkington, CL Parish, PV Kumar, JM Polo, MA Bellgrove, J Tong

Journal article  |  2020  |  Molecular Psychiatry

Cellular models of neurodevelopmental disorders provide a valuable experimental system to uncover disease mechanisms and novel the..

Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural Environment

Arianna Cembran, Kiara F Bruggeman, Richard J Williams, Clare L Parish, David R Nisbet

Journal article  |  2020  |  iScience

The brain is a complex 3-dimensional structure, the organization of which provides a local environment that directly influences th..