David de Souza

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.

Andre Mu, William P Klare, Sarah L Baines, CN Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D Shah, Nitika Neha, et al.

Journal article  |  2023  |  Nat Commun

Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, w..

Remodeling of Carbon Metabolism during Sulfoglycolysis in Escherichia coli

Janice W-Y Mui, David P De Souza, Eleanor C Saunders, Malcolm J McConville, Spencer J Williams

Journal article  |  2023  |  APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Sulfoquinovose (SQ) is a major metabolite in the global sulfur cycle produced by nearly all photosynthetic organisms. One of the m..

Multi-substrate metabolic tracing reveals marked heterogeneity and dependency on fatty acid metabolism in human prostate cancer.

Gio Fidelito, David P De Souza, Birunthi Niranjan, William de Nardo, Shivakumar Keerthikumar, Kristin Brown, Renea A Taylor, Matthew J Watt

Journal article  |  2022  |  Mol Cancer Res

Cancer cells undergo metabolic reprogramming to meet increased bioenergetic demands. Studies in cells and mice have highlighted th..

Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin

Geoff Harley, Marina Katerelos, Kurt Gleich, David P de Souza, Vinod K Narayana, Bruce E Kemp, David A Power, Peter F Mount

Journal article  |  2022  |  BIOMEDICINE & PHARMACOTHERAPY

BACKGROUND: Acute kidney injury (AKI) is accompanied by dysregulation of cellular energy metabolism and accumulation of intracellu..

Cystathionine-beta-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

Haoran Zhu, Keefe T Chan, Xinran Huang, Carmelo Cerra, Shaun Blake, Anna S Trigos, Dovile Anderson, Darren J Creek, David P De Souza, Xi Wang, Caiyun Fu, Metta Jana, Elaine Sanij, Richard B Pearson, Jian Kang

Journal article  |  2022  |  ELIFE

Hyperactivation of oncogenic pathways downstream of RAS and PI3K/AKT in normal cells induces a senescence-like phenotype that acts..

Lipid Metabolism Is Dysregulated in the Motor Cortex White Matter in Amyotrophic Lateral Sclerosis

Gemma L Sadler, Katherine N Lewis, Vinod K Narayana, David P De Souza, Joel Mason, Catriona McLean, David G Gonsalvez, Bradley J Turner, Samantha K Barton

Journal article  |  2022  |  METABOLITES

Lipid metabolism is profoundly dysregulated in amyotrophic lateral sclerosis (ALS), yet the lipid composition of the white matter,..

Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization

Kevin Ming-Chin Lee, Adrian A Achuthan, David P De Souza, Tanya J Lupancu, Katrina J Binger, Man KS Lee, Yangsong Xu, Malcolm J McConville, Nicole A de Weerd, Dragana Dragoljevic, Paul J Hertzog, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2022  |  CELL REPORTS

Metabolic adaptations can directly influence the scope and scale of macrophage activation and polarization. Here we explore the im..

The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis

Youming Zhu, Leu Jin, Ronghua Shi, Jinming Li, Yan Wang, Li Zhang, Chao-Zhao Liang, Vinod K Narayana, David P De Souza, Rick F Thorne, Li Rong Zhang, Xu Dong Zhang, Mian Wu

Journal article  |  2022  |  MOLECULAR CELL

Non-covalent complexes of glycolytic enzymes, called metabolons, were postulated in the 1970s, but the concept has been controvers..

Using laboratory-cultured nonbiting midge larvae (Chironomus tepperi) to identify early metabolic changes following exposure to zinc

Sara M Long, Katherine J Jeppe, Rebecca Reid, David P De Souza, Komal Kanojia, James Pyke, Sean O’Callaghan, Saravanan Dayalan, Vincent J Pettigrove, Ary A Hoffmann, Malcolm J McConville, Dedreia L Tull

Book Chapter  |  2022

A Mycoplasma gallisepticum Glycerol ABC Transporter Involved in Pathogenicity

Sara Mahdizadeh, Yumiko Masukagami, Chi-Wen Tseng, Philip F Markham, David P De Souza, Brunda Nijagal, Dedreia Tull, Liliana Tatarczuch, Glenn F Browning, Fiona M Sansom

Journal article  |  2021  |  APPLIED AND ENVIRONMENTAL MICROBIOLOGY

MalF has been shown to be required for virulence in the important avian pathogen Mycoplasma gallisepticum To characterize the func..