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SdrA, an NADP(H)-regenerating enzyme, is crucial for Coxiella burnetii to resist oxidative..
Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomec..
Coxiella burnetii utilizes both glutamate and glucose during infection with glucose uptake..
Metabolite Changes in an Estuarine Annelid Following Sublethal Exposure to a Mixture of Zi..
Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macro..
Displaying the 47 most recent scholarly works by David de Souza.
SdrA, an NADP(H)-regenerating enzyme, is crucial for Coxiella burnetii to resist oxidative stress and replicate intracellularly.
Mebratu A Bitew, Janine Hofmann, David P De Souza, Nadeeka K Wawegama, Hayley J Newton, Fiona M Sansom
Journal article | 2019 | Cellular Microbiology
Coxiella burnetii, the causative agent of the zoonotic disease Q fever, is a Gram-negative bacterium that replicates inside macrop..
Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjaerg syndrome
Yilin Kang, Alexander J Anderson, Thomas Daniel Jackson, Catherine S Palmer, David P De Souza, Kenji M Fujihara, Tegan Stait, Ann E Frazier, Nicholas J Clemons, Deidreia Tull, David R Thorburn, Malcolm J McConville, Michael T Ryan, David A Stroud, Diana Stojanovski
Journal article | 2019 | eLife
Human Tim8a and Tim8b are members of an intermembrane space chaperone network, known as the small TIM family. Mutations in TIMM8A ..
Coxiella burnetii utilizes both glutamate and glucose during infection with glucose uptake mediated by multiple transporters
Miku Kuba, Nitika Neha, David P De Souza, Saravanan Dayalan, Joshua PM Newson, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton
Journal article | 2019 | Biochemical Journal
Metabolite Changes in an Estuarine Annelid Following Sublethal Exposure to a Mixture of Zinc and Boscalid
Georgia M Sinclair, Allyson L O'Brien, Michael Keough, David P de Souza, Saravanan Dayalan, Komal Kanojia, Konstantinos Kouremenos, Dedreia L Tull, Rhys A Coleman, Oliver AH Jones, Sara M Long
Journal article | 2019 | Metabolites
Environmental pollutants such as heavy metals and fungicides pose a serious threat to waterways worldwide. Toxicological assessmen..
Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages
David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood
Journal article | 2019 | Journal of Clinical Investigation
Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells
Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, et al.
Journal article | 2019 | Immunity
Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..
Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome
Kim R Simpfendorfer, Nancy Wang, Dedreia L Tull, David P De Souza, Amsha Nahid, Andre Mu, Dianna M Hocking, John S Pedersen, Odilia LC Wijburg, Malcolm J McConville, Richard A Strugnell
Journal article | 2019 | Molecular Medicine
Circadian and wake-dependent changes in human plasma polar metabolites during prolonged wakefulness: A preliminary analysis
Leilah K Grant, Suzanne Ftouni, Brunda Nijagal, David P De Souza, Dedreia Tull, Malcolm J McConville, Shantha MW Rajaratnam, Steven W Lockley, Clare Anderson
Journal article | 2019 | Scientific Reports
NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
Hazel Tye, Chien-Hsiung Yu, Lisa A Simms, Marcel R de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S Penington, Cassandra R Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F Wockner, Adele Preaudet, Lisa A Mielke, Stephen A Wilcox, Yasunori Ogura, Sinead C Corr, Komal Kanojia, Konstantinos A Kouremenos, David P De Souza, Malcolm J McConville, Richard A Flavell, et al.
Journal article | 2018 | Nature Communications
Cord Blood CD8( ) T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner
Yuxia Zhang, Jovana Maksimovic, Bing Huang, David Peter De Souza, Gaetano Naselli, Huan Chen, Li Zhang, Kai Weng, Hanquan Liang, Yanhui Xu, John M Wentworth, Nicholas D Huntington, Alicia Oshlack, Sitang Gong, Axel Kallies, Peter Vuillermin, Min Yang, Leonard C Harrison
Journal article | 2018 | Frontiers in Immunology
Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment
Sarah A Best, David P De Souza, Ariena Kersbergen, Antonia N Policheni, Saravanan Dayalan, Dedreia Tull, Vivek Rathi, Daniel H Gray, Matthew E Ritchie, Malcolm J McConville, Kate D Sutherland
Journal article | 2018 | Cell Metabolism
De novo NAD synthesis is required for intracellular replication of Coxiella burnetii, the causative agent of the neglected zoonotic disease Q fever
MA Bitew, CA Khoo, N Neha, DP De Souza, D Tull, NK Wawegama, HJ Newton, FM Sansom
Journal article | 2018 | Journal of Biological Chemistry
© 2018 Bitew et al. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc. Coxiell..
Comparative Metabolomics of Mycoplasma bovis and Mycoplasma gallisepticum Reveals Fundamental Differences in Active Metabolic Pathways and Suggests Novel Gene Annotations
Y Masukagami, DP De Souza, S Dayalan, C Bowen, S O'Callaghan, K Kouremenos, B Nijagal, D Tull, KA Tivendale, PF Markham, MJ McConville, GF Browning, FM Sansom
Journal article | 2017 | mSystems
Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex
Yilin Kang, David A Stroud, Michael J Baker, David P De Souza, Ann E Frazier, Michael Liem, Dedreia Tull, Suresh Mathivanan, Malcolm J McConville, David R Thorburn, Michael T Ryan, Diana Stojanovski
Journal article | 2017 | Molecular Cell
MASTR-MS: a web-based collaborative laboratory information management system (LIMS) for metabolomics
Adam Hunter, Saravanan Dayalan, David De Souza, Brad Power, Rodney Lorrimar, Tamas Szabo, Nguyen Thu, Sean O'Callaghan, Jeremy Hack, James Pyke, Amsha Nahid, Roberto Barrero, Ute Roessner, Vladimir Likic, Dedreia Tull, Antony Bacic, Malcolm McConville, Matthew Bellgard
Journal article | 2017 | Metabolomics
Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis
Greg M Kowalski, Steven Hamley, Ahrathy Selathurai, Joachim Kloehn, David P De Souza, Sean O'Callaghan, Brunda Nijagal, Dedreia L Tull, Malcolm J McConville, Clinton R Bruce
Journal article | 2016 | Scientific Reports
Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema
Lisa M Sedger, Dedreia L Tull, Malcolm J McConville, David P De Souza, Thusitha WT Rupasinghe, Spencer J Williams, Saravanan Dayalan, Daniel Lanzer, Helen Mackie, Thomas C Lam, John Boyages
Journal article | 2016 | PLOS ONE
In vivo cardiac glucose metabolism in the high-fat fed mouse: Comparison of euglycemic-hyperinsulinemic clamp derived measures of glucose uptake with a dynamic metabolomic flux profiling approach
Greg M Kowalski, David P De Souza, Steve Risis, Micah L Burch, Steven Hamley, Joachim Kloehn, Ahrathy Selathurai, Robert S Lee-Young, Dedreia Tull, Sean O'Callaghan, Malcolm J McConville, Clinton R Bruce
Journal article | 2015 | Biochemical and Biophysical Research Communications
Application of dynamic metabolomics to examine in vivo skeletal muscle glucose metabolism in the chronically high-fat fed mouse
Greg M Kowalski, David P De Souza, Micah L Burch, Steven Hamley, Joachim Kloehn, Ahrathy Selathurai, Dedreia Tull, Sean O'Callaghan, Malcolm J McConville, Clinton R Bruce
Journal article | 2015 | Biochemical and Biophysical Research Communications
A multi-platform metabolomics approach demonstrates changes in energy metabolism and the transsulfuration pathway in Chironomus tepperi following exposure to zinc
Sara M Long, Dedreia L Tull, Katherine J Jeppe, David P De Souza, Saravanan Dayalan, Vincent J Pettigrove, Malcolm J McConville, Ary A Hoffmann
Journal article | 2015 | Aquatic Toxicology
Specific plasma lipid classes and phospholipid fatty acids indicative of dairy food consumption associate with insulin sensitivity
Paul John Nestel, Nora Straznicky, Natalie Ann Mellett, Gerard Wong, David Peter De Souza, Dedreia Lorraine Tull, Christopher Kenneth Barlow, Mariee Teresa Grima, Peter John Meikle
Journal article | 2014 | American Journal of Clinical Nutrition
PyMS: a Python toolkit for processing of gas chromatography-mass spectrometry (GC-MS) data. Application and comparative study of selected tools
Sean O'Callaghan, David P De Souza, Andrew Isaac, Qiao Wang, Luke Hodkinson, Moshe Olshansky, Tim Erwin, Bill Appelbe, Dedreia L Tull, Ute Roessner, Antony Bacic, Malcolm J McConville, Vladimir A Likic
Journal article | 2012 | BMC Bioinformatics
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability
JJ Babon, EJ McManus, SG Yao, DP DeSouza, LA Mielke, NS Sprigg, TA Willson, DJ Hilton, NA Nicola, M Baca, SE Nicholson, RS Norton
Journal article | 2006 | Molecular Cell
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation
DL Krebs, RT Uren, D Metcalf, S Rakar, JG Zhang, R Starr, DP De Souza, K Hanzinikolas, J Eyles, LM Connolly, RJ Simpson, NA Nicola, SE Nicholson, M Baca, DJ Hilton, WS Alexander
Journal article | 2002 | Molecular and Cellular Biology
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
SE Nicholson, D De Souza, LJ Fabri, J Corbin, TA Willson, JG Zhang, A Silva, M Asimakis, A Farley, AD Nash, D Metcalf, DJ Hilton, NA Nicola, M Baca
Journal article | 2000 | Proceedings of the National Academy of Sciences