David de Souza

A Mycoplasma gallisepticum Glycerol ABC Transporter Involved in Pathogenicity

Sara Mahdizadeh, Yumiko Masukagami, Chi-Wen Tseng, Philip F Markham, David P De Souza, Brunda Nijagal, Dedreia Tull, Liliana Tatarczuch, Glenn F Browning, Fiona M Sansom

Journal article  |  2021  |  APPLIED AND ENVIRONMENTAL MICROBIOLOGY

MalF has been shown to be required for virulence in the important avian pathogen Mycoplasma gallisepticum To characterize the func..

The utilisation of glutamine and glucose by a 3-D tumour model trapped in quiescence

Hannah Smith, David De Souza, Dedreia Tull, Malcolm McConville, Andrea Pellagatti, Jacqueline Boultwood, Mary Board, Richard Callaghan

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Solid tumours modify their metabolic strategy to ensure sufficient biomass and energy to maintain a high rate of proliferation. Ho..

Characterisation of putative lactate synthetic pathways of Coxiella burnetii

Janine Hofmann, Mebratu A Bitew, Miku Kuba, David P De Souza, Hayley J Newton, Fiona M Sansom

Journal article  |  2021  |  PLOS ONE

The zoonotic pathogen Coxiella burnetii, the causative agent of the human disease Q fever, is an ever-present danger to global pub..

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

Eric P Kusnadi, Anna S Trigos, Carleen Cullinane, David L Goode, Ola Larsson, Jennifer R Devlin, Keefe T Chan, David P De Souza, Malcolm J McConville, Grant A McArthur, George Thomas, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Katherine M Hannan, Jian Kang, Richard B Pearson

Journal article  |  2020  |  EMBO JOURNAL

Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our previous first-i..

Microbe-Metabolite Associations Linked to the Rebounding Murine Gut Microbiome Postcolonization with Vancomycin-Resistant Enterococcus faecium

Andre Mu, Glen P Carter, Lucy Li, Nicole S Isles, Alison F Vrbanac, James T Morton, Alan K Jarmusch, David P De Souza, Vinod K Narayana, Komal Kanojia, Brunda Nijagal, Malcolm J McConville, Rob Knight, Benjamin P Howden, Timothy P Stinear

Journal article  |  2020  |  MSYSTEMS

Vancomycin-resistant Enterococcus faecium (VREfm) is an emerging antibiotic-resistant pathogen. Strain-level investigations are be..

Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal

Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L Baker, Tracy C McGarr, Christine A Wells, et al.

Journal article  |  2020  |  Nature Communications

Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast st..

EirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetii

Miku Kuba, Nitika Neha, Patrice Newton, Yi Wei Lee, Vicki Bennett-Wood, Abderrahman Hachani, David P De Souza, Brunda Nijagal, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton

Journal article  |  2020  |  INFECTION AND IMMUNITY

The zoonotic bacterial pathogen Coxiella burnetii is the causative agent of Q fever, a febrile illness which can cause a serious c..

Microbiota-derived butyrate promotes metabolism and memory potential of effector CD8( )T cells

Annabell Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Dedreia Tull, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, Axel Kallies, Malcolm McConville, Stephen J Turner, Thomas Gebhardt, Sammy Bedoui

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

A Neural basis for Octanoic acid regulation of energy balance

Vanessa R Haynes, Natalie J Michael, Marco van den Top, Fei-Yue Zhao, Russell D Brown, David De Souza, Garron T Dodd, David Spanswick, Matthew J Watt

Journal article  |  2020  |  MOLECULAR METABOLISM

OBJECTIVES: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aime..

SdrA, an NADP(H)-regenerating enzyme, is crucial for Coxiella burnetii to resist oxidative stress and replicate intracellularly

Mebratu A Bitew, Janine Hofmann, David P De Souza, Nadeeka K Wawegama, Hayley J Newton, Fiona M Sansom

Journal article  |  2020  |  CELLULAR MICROBIOLOGY

Coxiella burnetii, the causative agent of the zoonotic disease Q fever, is a Gram-negative bacterium that replicates inside macrop..