David de Souza

Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal

Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L Baker, Tracy C McGarr, Christine A Wells, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast st..

EirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetii

Miku Kuba, Nitika Neha, Patrice Newton, Yi Wei Lee, Vicki Bennett-Wood, Abderrahman Hachani, David P De Souza, Brunda Nijagal, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton

Journal article  |  2020  |  Infection and Immunity

The zoonotic bacterial pathogen Coxiella burnetii is the causative agent of Q fever, a febrile illness which can cause a serious c..

A Neural basis for Octanoic acid regulation of energy balance

Vanessa R Haynes, Natalie J Michael, Marco van den Top, Fei-Yue Zhao, Russell D Brown, David De Souza, Garron T Dodd, David Spanswick, Matthew J Watt

Journal article  |  2020  |  Molecular Metabolism

OBJECTIVES: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aime..

Metabolomics Provide Sensitive Insights into the Impacts of Low Level Environmental Contamination on Fish Health-A Pilot Study

Sara M Long, Dedreia L Tull, David P De Souza, Konstantinos A Kouremenos, Saravanan Dayalan, Malcolm J McConville, Kathryn L Hassell, Vincent J Pettigrove, Marthe Monique Gagnon

Journal article  |  2020  |  Metabolites

This exploratory study aims to investigate the health of sand flathead (Platycephalus bassensis) sampled from five sites in Port P..

SdrA, an NADP(H)-regenerating enzyme, is crucial for Coxiella burnetii to resist oxidative stress and replicate intracellularly.

Mebratu A Bitew, Janine Hofmann, David P De Souza, Nadeeka K Wawegama, Hayley J Newton, Fiona M Sansom

Journal article  |  2019  |  Cellular Microbiology

Coxiella burnetii, the causative agent of the zoonotic disease Q fever, is a Gram-negative bacterium that replicates inside macrop..

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

EP Kusnadi, AS Trigos, C Cullinane, DL Goode, O Larsson, JR Devlin, KT Chan, DP De Souza, MJ McConville, GA McArthur, G Thomas, E Sanij, G Poortinga, RD Hannan, KM Hannan, J Kang, RB Pearson

Journal article  |  2019  |  bioRxiv

Abstract Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our first-i..

Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjaerg syndrome

Yilin Kang, Alexander J Anderson, Thomas Daniel Jackson, Catherine S Palmer, David P De Souza, Kenji M Fujihara, Tegan Stait, Ann E Frazier, Nicholas J Clemons, Deidreia Tull, David R Thorburn, Malcolm J McConville, Michael T Ryan, David A Stroud, Diana Stojanovski

Journal article  |  2019  |  eLife

Human Tim8a and Tim8b are members of an intermembrane space chaperone network, known as the small TIM family. Mutations in TIMM8A ..

Coxiella burnetii utilizes both glutamate and glucose during infection with glucose uptake mediated by multiple transporters

Miku Kuba, Nitika Neha, David P De Souza, Saravanan Dayalan, Joshua PM Newson, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton

Journal article  |  2019  |  BIOCHEMICAL JOURNAL

Metabolite Changes in an Estuarine Annelid Following Sublethal Exposure to a Mixture of Zinc and Boscalid

Georgia M Sinclair, Allyson L O'Brien, Michael Keough, David P de Souza, Saravanan Dayalan, Komal Kanojia, Konstantinos Kouremenos, Dedreia L Tull, Rhys A Coleman, Oliver AH Jones, Sara M Long

Journal article  |  2019  |  Metabolites

Environmental pollutants such as heavy metals and fungicides pose a serious threat to waterways worldwide. Toxicological assessmen..

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2019  |  Journal of Clinical Investigation

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells

Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, et al.

Journal article  |  2019  |  Immunity

Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..

Using metabolomics to assess the sub-lethal effects of zinc and boscalid on an estuarine polychaete worm over time

Georgia M Sinclair, Allyson L O'Brien, Michael Keough, David P De Souza, Saravanan Dayalan, Komal Kanojia, Konstantinos Kouremenos, Dedreia L Tull, Rhys A Coleman, Oliver AH Jones, Sara M Long

Journal article  |  2019  |  Metabolomics

INTRODUCTION: Zinc is a heavy metal commonly detected in urban estuaries around Australia. Boscalid is a fungicide found in estuar..

Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome

Kim R Simpfendorfer, Nancy Wang, Dedreia L Tull, David P De Souza, Amsha Nahid, Andre Mu, Dianna M Hocking, John S Pedersen, Odilia LC Wijburg, Malcolm J McConville, Richard A Strugnell

Journal article  |  2019  |  Molecular Medicine

Circadian and wake-dependent changes in human plasma polar metabolites during prolonged wakefulness: A preliminary analysis

Leilah K Grant, Suzanne Ftouni, Brunda Nijagal, David P De Souza, Dedreia Tull, Malcolm J McConville, Shantha MW Rajaratnam, Steven W Lockley, Clare Anderson

Journal article  |  2019  |  Scientific Reports

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

Hazel Tye, Chien-Hsiung Yu, Lisa A Simms, Marcel R de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S Penington, Cassandra R Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F Wockner, Adele Preaudet, Lisa A Mielke, Stephen A Wilcox, Yasunori Ogura, Sinead C Corr, Komal Kanojia, Konstantinos A Kouremenos, David P De Souza, Malcolm J McConville, Richard A Flavell, et al.

Journal article  |  2018  |  Nature Communications

Cord Blood CD8( ) T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner

Yuxia Zhang, Jovana Maksimovic, Bing Huang, David Peter De Souza, Gaetano Naselli, Huan Chen, Li Zhang, Kai Weng, Hanquan Liang, Yanhui Xu, John M Wentworth, Nicholas D Huntington, Alicia Oshlack, Sitang Gong, Axel Kallies, Peter Vuillermin, Min Yang, Leonard C Harrison

Journal article  |  2018  |  Frontiers in Immunology

Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment

Sarah A Best, David P De Souza, Ariena Kersbergen, Antonia N Policheni, Saravanan Dayalan, Dedreia Tull, Vivek Rathi, Daniel H Gray, Matthew E Ritchie, Malcolm J McConville, Kate D Sutherland

Journal article  |  2018  |  Cell Metabolism

Talaromyces marneffei simA Encodes a Fungal Cytochrome P450 Essential for Survival in Macrophages

Kylie J Boyce, David P De Souza, Saravanan Dayalan, Shivani Pasricha, Dedreia Tull, Malcolm J McConville, Alex Andrianopoulos

Journal article  |  2018  |  mSphere

De novo NAD synthesis is required for intracellular replication of Coxiella burnetii, the causative agent of the neglected zoonotic disease Q fever

MA Bitew, CA Khoo, N Neha, DP De Souza, D Tull, NK Wawegama, HJ Newton, FM Sansom

Journal article  |  2018  |  Journal of Biological Chemistry

© 2018 Bitew et al. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc. Coxiell..

Comparative Metabolomics of Mycoplasma bovis and Mycoplasma gallisepticum Reveals Fundamental Differences in Active Metabolic Pathways and Suggests Novel Gene Annotations

Y Masukagami, DP De Souza, S Dayalan, C Bowen, S O'Callaghan, K Kouremenos, B Nijagal, D Tull, KA Tivendale, PF Markham, MJ McConville, GF Browning, FM Sansom

Journal article  |  2017  |  MSYSTEMS

Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex

Yilin Kang, David A Stroud, Michael J Baker, David P De Souza, Ann E Frazier, Michael Liem, Dedreia Tull, Suresh Mathivanan, Malcolm J McConville, David R Thorburn, Michael T Ryan, Diana Stojanovski

Journal article  |  2017  |  Molecular Cell

CIRCADIAN AND WAKE-DEPENDENT CHANGES IN THE HUMAN PLASMA METABOLOME

LK Grant, S Ftouni, B Nijagal, D De Souza, SW Rajaratnam, SW Lockley, C Anderson

Conference Proceedings  |  2017  |  Sleep

MASTR-MS: a web-based collaborative laboratory information management system (LIMS) for metabolomics

Adam Hunter, Saravanan Dayalan, David De Souza, Brad Power, Rodney Lorrimar, Tamas Szabo, Nguyen Thu, Sean O'Callaghan, Jeremy Hack, James Pyke, Amsha Nahid, Roberto Barrero, Ute Roessner, Vladimir Likic, Dedreia Tull, Antony Bacic, Malcolm McConville, Matthew Bellgard

Journal article  |  2017  |  METABOLOMICS

Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis

Greg M Kowalski, Steven Hamley, Ahrathy Selathurai, Joachim Kloehn, David P De Souza, Sean O'Callaghan, Brunda Nijagal, Dedreia L Tull, Malcolm J McConville, Clinton R Bruce

Journal article  |  2016  |  Scientific Reports

Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema

Lisa M Sedger, Dedreia L Tull, Malcolm J McConville, David P De Souza, Thusitha WT Rupasinghe, Spencer J Williams, Saravanan Dayalan, Daniel Lanzer, Helen Mackie, Thomas C Lam, John Boyages

Journal article  |  2016  |  PLOS ONE

Lipidomic and metabolomic characterization of a genetically modified mouse model of the early stages of human type 1 diabetes pathogenesis

Anne Julie Overgaard, Jacquelyn M Weir, David Peter De Souza, Dedreia Tull, Claus Haase, Peter J Meikle, Flemming Pociot

Journal article  |  2016  |  Metabolomics

In vivo cardiac glucose metabolism in the high-fat fed mouse: Comparison of euglycemic-hyperinsulinemic clamp derived measures of glucose uptake with a dynamic metabolomic flux profiling approach

Greg M Kowalski, David P De Souza, Steve Risis, Micah L Burch, Steven Hamley, Joachim Kloehn, Ahrathy Selathurai, Robert S Lee-Young, Dedreia Tull, Sean O'Callaghan, Malcolm J McConville, Clinton R Bruce

Journal article  |  2015  |  Biochemical and Biophysical Research Communications

Application of dynamic metabolomics to examine in vivo skeletal muscle glucose metabolism in the chronically high-fat fed mouse

Greg M Kowalski, David P De Souza, Micah L Burch, Steven Hamley, Joachim Kloehn, Ahrathy Selathurai, Dedreia Tull, Sean O'Callaghan, Malcolm J McConville, Clinton R Bruce

Journal article  |  2015  |  Biochemical and Biophysical Research Communications

Host Reticulocytes Provide Metabolic Reservoirs That Can Be Exploited by Malaria Parasites

Anubhav Srivastava, Darren J Creek, Krystal J Evans, David De Souza, Louis Schofield, Sylke Mueller, Michael P Barrett, Malcolm J McConville, Andrew P Waters

Journal article  |  2015  |  PLOS PATHOGENS

A multi-platform metabolomics approach demonstrates changes in energy metabolism and the transsulfuration pathway in Chironomus tepperi following exposure to zinc

Sara M Long, Dedreia L Tull, Katherine J Jeppe, David P De Souza, Saravanan Dayalan, Vincent J Pettigrove, Malcolm J McConville, Ary A Hoffmann

Journal article  |  2015  |  Aquatic Toxicology

Use of C-13 Stable Isotope Labelling for Pathway and Metabolic Flux Analysis in Leishmania Parasites

Eleanor C Saunders, David R de Souza, Jennifer M Chambers, Milica Ng, James Pyke, Malcolm J McConville

Journal article  |  2015  |  Methods in Molecular Biology

Specific plasma lipid classes and phospholipid fatty acids indicative of dairy food consumption associate with insulin sensitivity

Paul John Nestel, Nora Straznicky, Natalie Ann Mellett, Gerard Wong, David Peter De Souza, Dedreia Lorraine Tull, Christopher Kenneth Barlow, Mariee Teresa Grima, Peter John Meikle

Journal article  |  2014  |  American Journal of Clinical Nutrition

Detection of Polar Metabolites Through the Use of Gas Chromatography–Mass Spectrometry

David P De Souza

Book Chapter  |  2013  |  Methods in Molecular Biology

Detection of Polar Metabolites Through the Use of Gas Chromatography-Mass Spectrometry

David P De Souza

Journal article  |  2013  |  Methods in Molecular Biology

Cross-Platform Urine Metabolomics of Experimental Hyperglycemia in Type 2 Diabetes

Liesbet Temmerman

Journal article  |  2013  |  Journal of Diabetes and Metabolism

Normalizing and Integrating Metabolomics Data

Alysha M De Livera, Daniel A Dias, David De Souza, Thusitha Rupasinghe, James Pyke, Dedreia Tull, Ute Roessner, Malcolm McConville, Terence P Speed

Journal article  |  2012  |  ANALYTICAL CHEMISTRY

Physicochemical properties and trace organic compounds in a dairy processor's aerobic bioreactor

Michael W Heaven, Karl Wild, David De Souza, Amsha Nahid, Dedreia Tull, Mark Watkins, Murray Hannah, David Nash

Journal article  |  2012  |  BIORESOURCE TECHNOLOGY

PyMS: a Python toolkit for processing of gas chromatography-mass spectrometry (GC-MS) data. Application and comparative study of selected tools

Sean O'Callaghan, David P De Souza, Andrew Isaac, Qiao Wang, Luke Hodkinson, Moshe Olshansky, Tim Erwin, Bill Appelbe, Dedreia L Tull, Ute Roessner, Antony Bacic, Malcolm J McConville, Vladimir A Likic

Journal article  |  2012  |  BMC BIOINFORMATICS

A dynamic programming approach for the alignment of signal peaks in multiple gas chromatography-mass spectrometry experiments

MD Robinson, DP De Souza, WW Keen, EC Saunders, MJ McConville, TP Speed, VA Likić

Book Chapter  |  2011

Central carbon metabolism of Leishmania parasites

Eleanor C Saunders, David P de Souza, Thomas Naderer, Marijke F Sernee, Julie E Ralton, Maria A Doyle, James I MacRae, Jenny L Chambers, Joanne Heng, Amsha Nahid, Vladimir A Likic, Malcolm J McConville

Journal article  |  2010  |  Parasitology

Profiling of polar metabolites in biological extracts using diamond hydride-based aqueous normal phase chromatography

Damien L Callahan, David De Souza, Antony Bacic, Ute Roessner

Journal article  |  2009  |  Journal of Separation Science

Oocyst wall formation and composition in coccidian parasites

Kelly Mai, Philippa A Sharman, Robert A Walker, Marilyn Katrib, David De Souza, Malcolm J McConville, Michael G Wallach, Sabina I Belli, David JP Ferguson, Nicholas C Smith

Journal article  |  2009  |  Memorias do Instituto Oswaldo Cruz

Metabolite profiling of Plasmodium falciparum.

James MacRae, David De Souza, Vladimir Likic, Sash Lopatieki, Alan Cowman, Malcolm J McConville

Conference Proceedings  |  2008  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Analysis of the Leishmania Metabolome

M MCCONVILLE, D DE SOUZA, E SAUNDERS, J PYKE, T NADERER, undefined Ellis, M SERNEE, J RALTON, V LIKIC

Book Chapter  |  2008

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability

JJ Babon, EJ McManus, SG Yao, DP DeSouza, LA Mielke, NS Sprigg, TA Willson, DJ Hilton, NA Nicola, M Baca, SE Nicholson, RS Norton

Journal article  |  2006  |  Molecular Cell

Role and regulation of glycosylation pathways in leishmania parasites

MJ McConville, F Sernee, JE Ralton, T Naderer, M Ellis, D De Souza, E Saunders, V Likic

Conference Proceedings  |  2006  |  FASEB JOURNAL

Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain

JJ Babon, SG Yao, DP DeSouza, CF Harrison, LJ Fabri, E Liepinsh, SD Scrofani, M Baca, RS Norton

Journal article  |  2005  |  FEBS Journal

Direct production of proteins with N-terminal cysteine for site-specific conjugation

IE Gentle, DP De Souza, M Baca

Journal article  |  2004  |  Bioconjugate Chemistry

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling

WD Fairlie, AD Uboldi, JE McCoubrie, CXC Wang, EF Lee, SG Yao, DP De Souza, S Mifsud, D Metcalf, NA Nicola, RS Norton, M Baca

Journal article  |  2004  |  Journal of Biological Chemistry

Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2

WD Fairlie, D De Souza, NA Nicola, M Baca

Journal article  |  2003  |  Biochemical Journal

A fusion protein system for the recombinant production of short disulfide-containing peptides

WD Fairlie, AD Uboldi, DP De Souza, GJ Hemmings, NA Nicola, M Baca

Journal article  |  2002  |  Protein Expression and Purification

SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities

D De Souza, LJ Fabri, A Nash, DJ Hilton, NA Nicola, M Baca

Journal article  |  2002  |  Biochemistry

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

DL Krebs, RT Uren, D Metcalf, S Rakar, JG Zhang, R Starr, DP De Souza, K Hanzinikolas, J Eyles, LM Connolly, RJ Simpson, NA Nicola, SE Nicholson, M Baca, DJ Hilton, WS Alexander

Journal article  |  2002  |  Molecular and Cellular Biology

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

SE Nicholson, D De Souza, LJ Fabri, J Corbin, TA Willson, JG Zhang, A Silva, M Asimakis, A Farley, AD Nash, D Metcalf, DJ Hilton, NA Nicola, M Baca

Journal article  |  2000  |  Proceedings of the National Academy of Sciences

Attempt to Detect Garlic Allyl Sulphides from Saliva after Consumption of Garlic Tablets Using GC-MS

Cathy J Watson David de Souza

Journal article  |  Journal of Microbial & Biochemical Technology