Stuart Berzins

Thymic development of unconventional T cells: how NKT cells, MAIT cells and gamma delta T cells emerge

Daniel G Pellicci, Hui-Fern Koay, Stuart P Berzins

Journal article  |  2020  |  NATURE REVIEWS IMMUNOLOGY

T cell lineages are defined by specialized functions and differential expression of surface antigens, cytokines and transcription ..

High CD26 and Low CD94 Expression Identifies an IL-23 Responsive V delta 2( ) T Cell Subset with a MAIT Cell-like Transcriptional Profile

Kathleen M Wragg, Hyon-Xhi Tan, Anne B Kristensen, Catriona Nguyen-Robertson, Anthony D Kelleher, Matthew S Parsons, Adam K Wheatley, Stuart P Berzins, Daniel G Pellicci, Stephen J Kent, Jennifer A Juno

Journal article  |  2020  |  CELL REPORTS

Vδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit substantial heterogeneity in humans. Here,..

Foxp3( ) Tregs from Langerhans cell histiocytosis lesions co-express CD56 and have a definitively regulatory capacity

Jenee Mitchell, Jason Kelly, Egle Kvedaraite, Tatiana von Bahr Greenwood, Jan-Inge Henter, Daniel G Pellicci, Stuart P Berzins, George Kannourakis

Journal article  |  2020  |  CLINICAL IMMUNOLOGY

Langerhans cell histiocytosis (LCH) lesions contain myeloid lineage 'LCH' cells. Regulatory T cells (Tregs) are also enriched with..

A Role for MAIT Cells in Colorectal Cancer

Stuart P Berzins, Morgan E Wallace, George Kannourakis, Jason Kelly

Journal article  |  2020  |  FRONTIERS IN IMMUNOLOGY

MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associa..

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

Hui Fern Koay, Shian Su, Daniela Amann-Zalcenstein, Stephen R Daley, Iain Comerford, Carly E Whyte, Igor E Konstantinov, Yves d'Udekem, Tracey Baldwin, Peter F Hickey, Stuart P Berzins, Jeffrey YW Mak, Axel Kallies, Zhenjun Chen, Simone Nussing, Katherine Kedzierska, Laura K Mackay, Shaun R McColl, Elissa K Deenick, David P Fairlie, et al.

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

H-F Koay, S Su, D Amann-Zalcenstein, SR Daley, I Comerford, L Miosge, CE Whyte, IE Konstantinov, Y d'Udekem, T Baldwin, PF Hickey, SP Berzins, JYW Mak, Y Sontani, CM Roots, T Sidwell, A Kallies, Z Chen, S Nussing, K Kedzierska, et al.

Journal article  |  2019  |  SCIENCE IMMUNOLOGY

MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune system. These cells develop intrathymi..

Chronic inflammation and bowel cancer; are your MAITs involved?

J Kelly, G Kannourakis, D Gray, SP Berzins

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Chronically stimulated human MAIT cells are unexpectedly potent IL-13 producers

Jason Kelly, Yosuke Minoda, Tobias Meredith, Garth Cameron, Marie-Sophie Philipp, Daniel G Pellicci, Alexandra J Corbett, Christian Kurts, Daniel HD Gray, Dale Godfrey, George Kannourakis, Stuart P Berzins

Journal article  |  2019  |  IMMUNOLOGY AND CELL BIOLOGY

Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize antigens derived from riboflavin biosynthesi..

Divergent SATB1 expression across human life span and tissue compartments

Simone Nussing, Hui-Fern Koay, Sneha Sant, Thomas Loudovaris, Stuart I Mannering, Martha Lappas, Yves d'Udekem, Igor E Konstantinov, Stuart P Berzins, Guus F Rimmelzwaan, Stephen J Turner, E Bridie Clemens, Dale I Godfrey, HO Nguyen Thi, Katherine Kedzierska

Journal article  |  2019  |  IMMUNOLOGY AND CELL BIOLOGY

Special AT-rich binding protein-1 (SATB1) is a global chromatin organizer capable of activating or repressing gene transcription i..

Co-Expression of CD56 and Production of Transforming Growth Factor Beta By Foxp3 Regulatory T Cells from Langerhans Cell Histiocytosis Lesions

Jenee Mitchell, Egle Kvedaraite, Tatiana von Bahr Greenwood, Jan-Inge Henter, Daniel G Pellicci, Stuart P Berzins, George Kannourakis

Conference Proceedings  |  2018  |  BLOOD

Abstract Introduction: Langerhans cell histiocytosis (LCH) is a rare disease involving inflammatory ..