Josie Iaria

Reactivation of BMP signaling by suboptimal concentrations of MEK inhibitor and FK506 reduces organ-specific breast cancer metastasis

Jiang Ren, Yanhong Wang, Thomas Ware, Josephine Iaria, Peter ten Dijke, Hong-Jian Zhu

Journal article  |  2020  |  Cancer Letters

TGFβ-SMAD3 signaling is a major driving force for cancer metastasis, while BMP-SMAD1/5 signaling can counteract this response. Ana..

Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression

Jiang Ren, Marcel Smid, Josephine Iaria, Daniela CF Salvatori, Hans van Dam, Hong Jian Zhu, John WM Martens, Peter ten Dijke

Journal article  |  2019  |  Breast Cancer Research

Live Cell Imaging of the TGF-beta/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System

Hao Chen, Thomas MB Ware, Josephine Iaria, Hong-Jian Zhu

Journal article  |  2018  |  Journal of Visualized Experiments

Ras enhances TGF-beta signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1

Sheng Liu, Josephine Iaria, Richard J Simpson, Hong-Jian Zhu

Journal article  |  2018  |  Cell Communication and Signaling

Single live cell TGF-beta signalling imaging: breast cancer cell motility and migration is driven by sub-populations of cells with dynamic TGF-beta-Smad3 activity

Rodney B Luwor, Dulani Hakmana, Josephine Iaria, Thao V Nheu, Richard J Simpson, Hong-Jian Zhu

Journal article  |  2015  |  MOLECULAR CANCER

Targeting Stat3 and Smad7 to restore TGF-beta cytostatic regulation of tumor cells in vitro and in vivo

RB Luwor, B Baradaran, LE Taylor, J Iaria, TV Nheu, N Amiry, CM Hovens, B Wang, AH Kaye, H-J Zhu

Journal article  |  2013  |  Oncogene

New reagents for improved in vitro and in vivo examination of TGF-beta signalling

Rodney B Luwor, Bo Wang, Thao V Nheu, Josephine Iaria, Evelyn Tsantikos, Margaret L Hibbs, Oliver M Sieber, Hong-Jian Zhu

Journal article  |  2011  |  Growth Factors

Epidermal growth factor receptor: Association of extracellular domain negatively regulates intracellular kinase activation in the absence of ligand

HJ Zhu, J Iaria, S Orchard, F Walker, AW Burgess

Journal article  |  2003  |  Growth Factors