Josie Iaria

Activin and BMP Signalling in Human Testicular Cancer Cell Lines, and a Role for the Nucleocytoplasmic Transport Protein Importin-5 in Their Crosstalk

Karthika Radhakrishnan, Michael Luu, Josie Iaria, Jessie M Sutherland, Eileen A McLaughlin, Hong-Jian Zhu, Kate L Loveland

Journal article  |  2023  |  Cells

Testicular germ cell tumours (TGCTs) are the most common malignancy in young men. Originating from foetal testicular germ cells th..

Fast Quantitation of TGF-β Signaling Using Adenoviral Reporter.

Adilson Fonseca Teixeira, Josie Iaria, Hong-Jian Zhu

Journal article  |  2022  |  Methods Mol Biol

The transforming growth factor-β (TGF-β) is a multifunctional cytokine critical for embryogenesis and tissue homeostasis. Alterati..

Reactivation of BMP signaling by suboptimal concentrations of MEK inhibitor and FK506 reduces organ-specific breast cancer metastasis

Jiang Ren, Yanhong Wang, Thomas Ware, Josephine Iaria, Peter ten Dijke, Hong-Jian Zhu

Journal article  |  2020  |  CANCER LETTERS

TGFβ-SMAD3 signaling is a major driving force for cancer metastasis, while BMP-SMAD1/5 signaling can counteract this response. Ana..

Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression

Jiang Ren, Marcel Smid, Josephine Iaria, Daniela CF Salvatori, Hans van Dam, Hong Jian Zhu, John WM Martens, Peter ten Dijke

Journal article  |  2019  |  BREAST CANCER RESEARCH

BACKGROUND: Bone morphogenetic proteins (BMPs) have been reported to maintain epithelial integrity and to antagonize the transform..

Live Cell Imaging of the TGF-beta/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System

Hao Chen, Thomas MB Ware, Josephine Iaria, Hong-Jian Zhu

Journal article  |  2018  |  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Transforming Growth Factor β (TGF-β) signaling regulates many important functions required for cellular homeostasis and is commonl..

Ras enhances TGF-beta signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1

Sheng Liu, Josephine Iaria, Richard J Simpson, Hong-Jian Zhu

Journal article  |  2018  |  CELL COMMUNICATION AND SIGNALING

BACKGROUND: Transformation by oncogene Ras overcomes TGF-β mediated growth inhibition in epithelial cells. However, it cooperates ..

Single live cell TGF-beta signalling imaging: breast cancer cell motility and migration is driven by sub-populations of cells with dynamic TGF-beta-Smad3 activity

Rodney B Luwor, Dulani Hakmana, Josephine Iaria, Thao V Nheu, Richard J Simpson, Hong-Jian Zhu

Journal article  |  2015  |  MOLECULAR CANCER

BACKGROUND: Metastasis is a process where only a small subset of cells is capable of successfully migrating to and propagating at ..

Targeting Stat3 and Smad7 to restore TGF-beta cytostatic regulation of tumor cells in vitro and in vivo

RB Luwor, B Baradaran, LE Taylor, J Iaria, TV Nheu, N Amiry, CM Hovens, B Wang, AH Kaye, H-J Zhu

Journal article  |  2013  |  ONCOGENE

Transforming Growth Factor-β (TGF-β) and Epidermal Growth Factor (EGF) signaling pathways are both independently implicated as key..

New reagents for improved in vitro and in vivo examination of TGF-beta signalling

Rodney B Luwor, Bo Wang, Thao V Nheu, Josephine Iaria, Evelyn Tsantikos, Margaret L Hibbs, Oliver M Sieber, Hong-Jian Zhu

Journal article  |  2011  |  GROWTH FACTORS

Transforming growth factor-β (TGF-β) signalling controls many aspects of cell behaviour and is implicated as a key regulator in tu..

Epidermal growth factor receptor: Association of extracellular domain negatively regulates intracellular kinase activation in the absence of ligand

HJ Zhu, J Iaria, S Orchard, F Walker, AW Burgess

Journal article  |  2003  |  GROWTH FACTORS

The epidermal growth factor receptor (EGFR) plays an important role in many types of human cancers. Receptor amplification, autocr..