Louise Purton

Sugar Rush: Supercharging Blood Cell Specification via the Inflammasome

Gavin Tjin, Louise E Purton

Journal article  |  2020  |  DEVELOPMENTAL CELL

The generation of adult hematopoietic stem and progenitor cells (HSPCs) from embryonic and induced pluripotent stem cells (iPSCs) ..

All-transretinoic acid in non-promyelocytic acute myeloid leukemia: driver lesion dependent effects on leukemic stem cells

Chi H Nguyen, Alexander M Grandits, Louise E Purton, Heinz Sill, Rotraud Wieser

Journal article  |  2020  |  CELL CYCLE

Acute myeloid leukemia (AML) is an aggressive, often fatal hematopoietic malignancy. All-trans retinoic acid (atRA), one of the fi..

Effects of chemotherapy agents used to treat pediatric acute lymphoblastic leukemia patients on bone parameters and longitudinal growth of juvenile mice

Lenny Straszkowski, Tanja Jovic, Wilson Castillo-Tandazo, David S Ritchie, Louise E Purton

Journal article  |  2020  |  EXPERIMENTAL HEMATOLOGY

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Therapies for pediatric ALL have improved such that more t..

All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia

Chi Huu Nguyen, Katharina Bauer, Hubert Hackl, Angela Schlerka, Elisabeth Koller, Anastasiya Hladik, Dagmar Stoiber, Johannes Zuber, Philipp B Staber, Andrea Hoelbl-Kovacic, Louise E Purton, Florian Grebien, Rotraud Wieser

Journal article  |  2019  |  CELL DEATH & DISEASE

Ecotropic virus integration site 1 (EVI1), whose overexpression characterizes a particularly aggressive subtype of acute myeloid l..

A population of nonneuronal GFR alpha 3-expressing cells in the bone marrow resembles nonmyelinating Schwann cells

Jenny Thai, Alanna C Green, Lincon A Stamp, Nick J Spencer, Louise E Purton, Jason Ivanusic

Journal article  |  2019  |  CELL AND TISSUE RESEARCH

Artemin is a neurotrophic factor that plays a crucial role in the regulation of neural development and regeneration and has also b..

Higher Intensity of Cell Surface Glucose-Regulated Protein 78 (csGRP78) Expression Is Seen in Patients with Early Progressive Disease/Mortality in a Cohort of Relapsed, Refractory Multiple Myeloma Patients Treated with Carfilzomib, Thalidomide and Dexamethasone

Slavisa Ninkovic, Simon Harrison, Lenny Straszkowski, Giulia Quattrocchi, Wee-Joo Chng, Louise E Purton, Quach Hang

Conference Proceedings  |  2019  |  BLOOD

Background: GRP78, an endoplasmic reticulum stress-inducible molecular chaperone, is up-regulated at times of cellular stress to l..

Cell surface glucose-regulated protein 78 (GRP78) is upregulated in plasma cells of patients with multiple myeloma compared to monoclonal gammopathy of uncertain significance

Slavisa Ninkovic, Lenny Straszkowski, Anupa Dey, Constantine Tam, Harshal Nandurkar, Simon J Harrison, Louise Purton, Hang Quach

Conference Proceedings  |  2019  |  CLINICAL LYMPHOMA MYELOMA & LEUKEMIA

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

Matthew Ku, Ruth N MacKinnon, Meaghan Wall, Nisha Narayan, Carl Walkley, Heung-Chin Cheng, Lynda J Campbell, Louise E Purton, Harshal Nandurkar

Journal article  |  2019  |  SCIENTIFIC REPORTS

Deletion of long arm of chromosome 20 [del(20q)] is the second most frequent recurrent chromosomal abnormality in hematological ma..

Mesenchymal lineage cells and their importance in B lymphocyte niches

Alanna C Green, Victoria Rudolph-Stringer, Andrew D Chantry, Joy Y Wu, Louise E Purton

Journal article  |  2019  |  BONE

Early B lymphopoiesis occurs in the bone marrow and is reliant on interactions with numerous cell types in the bone marrow microen..

Imaging methods used to study mouse and human HSC niches: Current and emerging technologies

Gavin Tjin, Eugenia Flores-Figueroa, Delfim Duarte, Lenny Straszkowski, Mark Scott, Reema A Khorshed, Louise E Purton, Cristina Lo Celso

Journal article  |  2019  |  BONE

Bone marrow contains numerous different cell types arising from hematopoietic stem cells (HSCs) and non-hematopoietic mesenchymal/..