Louise Purton

All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia

Chi Huu Nguyen, Katharina Bauer, Hubert Hackl, Angela Schlerka, Elisabeth Koller, Anastasiya Hladik, Dagmar Stoiber, Johannes Zuber, Philipp B Staber, Andrea Hoelbl-Kovacic, Louise E Purton, Florian Grebien, Rotraud Wieser

Journal article  |  2019  |  Cell Death & Disease

A population of nonneuronal GFR alpha 3-expressing cells in the bone marrow resembles nonmyelinating Schwann cells

Jenny Thai, Alanna C Green, Lincon A Stamp, Nick J Spencer, Louise E Purton, Jason Ivanusic

Journal article  |  2019  |  Cell and Tissue Research

Artemin is a neurotrophic factor that plays a crucial role in the regulation of neural development and regeneration and has also b..

Cell surface glucose-regulated protein 78 (GRP78) is upregulated in plasma cells of patients with multiple myeloma compared to monoclonal gammopathy of uncertain significance

Slavisa Ninkovic, Lenny Straszkowski, Anupa Dey, Constantine Tam, Harshal Nandurkar, Simon J Harrison, Louise Purton, Hang Quach

Conference Proceedings  |  2019  |  Clinical Lymphoma Myeloma and Leukemia

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

Matthew Ku, Ruth N MacKinnon, Meaghan Wall, Nisha Narayan, Carl Walkley, Heung-Chin Cheng, Lynda J Campbell, Louise E Purton, Harshal Nandurkar

Journal article  |  2019  |  Scientific Reports

Mesenchymal lineage cells and their importance in B lymphocyte niches

Alanna C Green, Victoria Rudolph-Stringer, Andrew D Chantry, Joy Y Wu, Louise E Purton

Journal article  |  2019  |  Bone

Imaging methods used to study mouse and human HSC niches: Current and emerging technologies

Gavin Tjin, Eugenia Flores-Figueroa, Delfim Duarte, Lenny Straszkowski, Mark Scott, Reema A Khorshed, Louise E Purton, Cristina Lo Celso

Journal article  |  2019  |  Bone

The haematopoietic stem cell niche: a new player in cardiovascular disease?

Annas Al-Sharea, Man Kit Sam Lee, Louise E Purton, Edwin D Hawkins, Andrew J Murphy

Journal article  |  2019  |  Cardiovascular Research

Haematopoiesis, the process of blood production, can be altered during the initiation or progression of many diseases. Cardiovascu..

Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal

Jane Jialu Xu, Monique F Srneets, Shuh Ying Tan, Meaghan Wall, Louise E Purton, Carl R Walkley

Journal article  |  2019  |  Experimental Hematology

Extrinsic Regulation of Hematopoietic Stem Cells and Lymphocytes by Vitamin A

Chacko Joseph, Alanna C Green, Diannita Kwang, Louise E Purton

Journal article  |  2018  |  Current Stem Cell Reports

Retinoic Acid Receptor gamma Activity in Mesenchymal Stem Cells Regulates Endochondral Bone, Angiogenesis, and B Lymphopoiesis

Alanna C Green, Victoria Rudolph-Stringer, Lenny Straszkowski, Gavin Tjin, Blessing Crimeen-Irwin, Mannu Walia, T John Martin, Natalie A Sims, Louise E Purton

Journal article  |  2018  |  Journal of Bone and Mineral Research

mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis.

Sally K Martin, Stephen Fitter, Nadia El Khawanky, Randall H Grose, Carl R Walkley, Louise E Purton, Markus A Ruegg, Michael N Hall, Stan Gronthos, Andrew CW Zannettino

Journal article  |  2018  |  Scientific Reports

Skeletal osteoblasts are important regulators of B-lymphopoiesis, serving as a rich source of factors such as CXCL12 and IL-7 whic..

Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells

Clea S Grace, Hanna KA Mikkola, Diana R Dou, Vincenzo Calvanese, Roger E Ronn, Louise E Purton

Journal article  |  2018  |  Experimental Hematology

Srsf2(P95H) initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells

Monique F Smeets, Shuh Ying Tan, Jane Jialu Xu, Govardhan Anande, Ashwin Unnikrishnan, Alistair M Chalk, Scott R Taylor, John E Pimanda, Meaghan Wall, Louise E Purton, Carl R Walkley

Journal article  |  2018  |  Blood

Investigating the role of polarity protein, SCRIB, in hematopoiesis

Novita Novita, Alysha Dew, Chad Johnson, Carl R Walkley, Louise E Purton, Patrick O Humbert, Phillip K Darcy, Sarah L Ellis

Conference Proceedings  |  2018  |  Molecular and Cellular Biology / Genetics

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

Delfim Duarte, Edwin D Hawkins, Olufolake Akinduro, Heather Ang, Katia De Filippo, Isabella Y Kong, Myriam Haltalli, Nicola Ruivo, Lenny Straszkowski, Stephin J Vervoort, Catriona McLean, Tom S Weber, Reema Khorshed, Chiara Pirillo, Andrew Wei, Saravana K Ramasamy, Anjali P Kusumbe, Ken Duffy, Ralf H Adams, Louise E Purton, et al.

Journal article  |  2018  |  Cell Stem Cell

Retinoic acid receptor signalling directly regulates osteoblast and adipocyte differentiation from mesenchymal progenitor cells

AC Green, P Kocovski, T Jovic, MK Walia, RAS Chandraratna, TJ Martin, EK Baker, LE Purton

Journal article  |  2017  |  Experimental Cell Research

T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments

Edwin D Hawkins, Delfim Duarte, Olufolake Akinduro, Reema A Khorshed, Diana Passaro, Malgorzata Nowicka, Lenny Straszkowski, Mark K Scott, Steve Rothery, Nicola Ruivo, Katie Foster, Michaela Waibel, Ricky W Johnstone, Simon J Harrison, David A Westerman, Hang Quach, John Gribben, Mark D Robinson, Louise E Purton, Dominique Bonnet, et al.

Journal article  |  2016  |  Nature

Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death

S Bhattacharya, AM Chalk, AJM Ng, TJ Martin, AC Zannettino, LE Purton, J Lu, EK Baker, CR Walkley

Journal article  |  2016  |  Oncogene

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis

Brian J Liddicoat, Jochen C Hartner, Robert Piskol, Gokul Ramaswami, Alistair M Chalk, Paul D Kingsley, Vijay G Sankaran, Meaghan Wall, Louise E Purton, Peter H Seeburg, James Palis, Stuart H Orkin, Jun Lu, Jin Billy Li, Carl R Walkley

Journal article  |  2016  |  Experimental Hematology

PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells

Vashe Chandrakanthan, Avani Yeola, Jair C Kwan, Rema A Oliver, Qiao Qiao, Young Chan Kang, Peter Zarzour, Dominik Beck, Lies Boelen, Ashwin Unnikrishnan, Jeanette E Villanueva, Andrea C Nunez, Kathy Knezevic, Cintia Palu, Rabab Nasrallah, Michael Carnell, Alex Macmillan, Renee Whan, Yan Yu, Philip Hardy, et al.

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr

Julie AI Thoms, Kathy Knezevic, Jia Jenny Liu, Elias N Glaros, Thuan Thai, Qiao Qiao, Heather Campbell, Deborah Packham, Yizhou Huang, Peter Papathanasiou, Robert Tunningley, Belinda Whittle, Amanda WS Yeung, Vashe Chandrakanthan, Luke Hesson, Vivien Chen, Jason WH Wong, Louise E Purton, Robyn L Ward, Shane R Thomas, et al.

Journal article  |  2016  |  Molecular and Cellular Biology

Retinoic Acid Receptor gamma Regulates B and T Lymphopoiesis via Nestin-Expressing Cells in the Bone Marrow and Thymic Microenvironments

Chacko Joseph, Celeste Nota, Jessica L Fletcher, Ana C Maluenda, Alanna C Green, Louise E Purton

Journal article  |  2016  |  Journal of Immunology

The role of vitamin A and retinoic acid receptor signaling in post-natal maintenance of bone

Alanna C Green, T John Martin, Louise E Purton

Journal article  |  2016  |  The Journal of Steroid Biochemistry and Molecular Biology

Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure

Maria Askmyr, Kirby E White, Tanja Jovic, Hannah A King, Julie M Quach, Ana C Maluenda, Emma K Baker, Monique F Smeets, Carl R Walkley, Louise E Purton

Journal article  |  2015  |  Scientific Reports

EphB4 Expressing Stromal Cells Exhibit an Enhanced Capacity for Hematopoietic Stem Cell Maintenance

Thao M Nguyen, Agnieszka Arthur, Romana Panagopoulos, Sharon Paton, John D Hayball, Andrew CW Zannettino, Louise E Purton, Koichi Matsuo, Stan Gronthos

Journal article  |  2015  |  STEM CELLS

RAR gamma is a negative regulator of osteoclastogenesis

Alanna C Green, Ingrid J Poulton, Christina Vrahnas, Karl D Haeusler, Carl R Walkley, Joy Y Wu, T John Martin, Matthew T Gillespie, Roshantha AS Chandraratna, Julian MW Quinn, Natalie A Sims, Louise E Purton

Journal article  |  2015  |  The Journal of Steroid Biochemistry and Molecular Biology

Myelosuppressive Therapies Significantly Increase ProInflammatory Cytokines and Directly Cause Bone Loss

Julie M Quach, Maria Askmyr, Tanja Jovic, Emma K Baker, Nicole C Walsh, Simon J Harrison, Paul Neeson, David Ritchie, Peter R Ebeling, Louise E Purton

Journal article  |  2015  |  Journal of Bone and Mineral Research

The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation

Alvin JM Ng, Mannu K Walia, Monique F Smeets, Anthony J Mutsaers, Natalie A Sims, Louise E Purton, Nicole C Walsh, T John Martin, Carl R Walkley

Journal article  |  2015  |  PLOS Genetics

Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma

Emma K Baker, Scott Taylor, Ankita Gupte, Alistair M Chalk, Shreya Bhattacharya, Alanna C Green, T John Martin, Dario Strbenac, Mark D Robinson, Louise E Purton, Carl R Walkley

Journal article  |  2015  |  Bone

Src family kinases and their role in hematological malignancies

Matthew Ku, Meaghan Wall, Ruth N MacKinnon, Carl R Walkley, Louise E Purton, Constantine Tam, David Izon, Lynda Campbell, Heung-Chin Cheng, Harshal Nandurkar

Journal article  |  2015  |  Leukemia & Lymphoma

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis

Monique F Smeets, Elisabetta DeLuca, Meaghan Wall, Julie M Quach, Alistair M Chalk, Andrew J Deans, Joerg Heierhorst, Louise E Purton, David J Izon, Carl R Walkley

Journal article  |  2014  |  Journal of Clinical Investigation

Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors

Sita R Dewamitta, Chacko Joseph, Louise E Purton, Carl R Walkley

Journal article  |  2014  |  British Journal of Haematology

Myeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells

Jacqueline E Noll, Sharon A Williams, Christine M Tong, Hongsheng Wang, Julie M Quach, Louise E Purton, Katherine Pilkington, Luen B To, Andreas Evdokiou, Stan Gronthos, Andrew CW Zannettino

Journal article  |  2014  |  Haematologica

Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies

Chacko Joseph, Julie M Quach, Carl R Walkley, Steven W Lane, Cristina Lo Celso, Louise E Purton

Journal article  |  2013  |  Cell Stem Cell

Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA

Anthony J Mutsaers, Alvin JM Ng, Emma K Baker, Megan R Russell, Alistair M Chalk, Meaghan Wall, Brain JJ Liddicoat, Patricia WM Ho, John L Slavin, Ankita Goradia, T John Martin, Louise E Purton, Ross A Dickins, Carl R Walkley

Journal article  |  2013  |  Bone

ATRA and the specific RAR alpha agonist, NRX195183, have opposing effects on the clonogenicity of pre-leukemic murine AML1-ETO bone marrow cells

LCY Chee, J Hendy, LE Purton, GA McArthur

Journal article  |  2013  |  Leukemia

The granulocyte-colony stimulating factor receptor (G-CSFR) interacts with retinoic acid receptors (RARs) in the regulation of myeloid differentiation

Lynette CY Chee, Jean Hendy, Louise E Purton, Grant A McArthur

Journal article  |  2013  |  Journal of Leukocyte Biology

Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?

JE Noll, SA Williams, LE Purton, ACW Zannettino

Journal article  |  2012  |  Blood Cancer Journal

A Novel Population of Cells Expressing Both Hematopoietic and Mesenchymal Markers Is Present in the Normal Adult Bone Marrow and Is Augmented in a Murine Model of Marrow Fibrosis

Masanobu Ohishi, Wanida Ono, Noriaki Ono, Richa Khatri, Marilena Marzia, Emma K Baker, Sierra H Root, Tremika Le-Shan Wilson, Yukihide Iwamototo, Henry M Kronenberg, Hector L Aguila, Louise E Purton, Ernestina Schipani

Journal article  |  2012  |  American Journal of Pathology

G(s)alpha enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice

Joy Y Wu, Piia Aarnisalo, Murat Bastepe, Partha Sinha, Keertik Fulzele, Martin K Selig, Min Chen, Ingrid J Poulton, Louise E Purton, Natalie A Sims, Lee S Weinstein, Henry M Kronenberg

Journal article  |  2011  |  Journal of Clinical Investigation

Taking HSCs Down a Notch in Leukemia

Carl R Walkley, David J Izon, Louise E Purton

Journal article  |  2011  |  Cell Stem Cell

Defining the Hematopoietic Stem Cell Niche: The Chicken and the Egg Conundrum

Sofie Singbrant, Maria Askmyr, Louise E Purton, Carl R Walkley

Journal article  |  2011  |  Journal of Cellular Biochemistry

Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment

Sofie Singbrant, Megan R Russell, Tanja Jovic, Brian Liddicoat, David J Izon, Louise E Purton, Natalie A Sims, T John Martin, Vijay G Sankaran, Carl R Walkley

Journal article  |  2011  |  Blood

The role of p202 in regulating hematopoietic cell proliferation and differentiation

Louise E Ludlow, Louise E Purton, Kim Klarmann, Daniel J Gough, Linda L Hii, Joseph A Trapani, Jonathan R Keller, Christopher JP Clarke, Ricky W Johnstone

Journal article  |  2008  |  Journal of Interferon and Cytokine Research