Sean Byars

Antagonistic Pleiotropy in Human Disease

Sean G Byars, Konstantinos Voskarides

Journal article  |  2019  |  Journal of Molecular Evolution

Between the 1930s and 1950s, scientists developed key principles of population genetics to try and explain the aging process. Almo..

Do gender and psychosocial job stressors modify the relationship between disability and sickness absence: An investigation using 12 waves of a longitudinal cohort.

Allison Milner, Zoe Aitken, Sean Byars, Peter Butterworth, Anne Kavanagh

Journal article  |  2019  |  Scandinavian Journal of Work, Environment & Health

Objectives A considerable proportion of the working population reports a disability. These workers may be at risk of adverse outco..

Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury

Prue M Pereira-Fantini, Boyuan Pang, Sean G Byars, Regina B Oakley, Elizabeth J Perkins, Peter A Dargaville, Peter G Davis, Shuai Nie, Nicholas A Williamson, Vera Ignjatovic, David G Tingay

Journal article  |  2019  |  American Journal of Respiratory Cell and Molecular Biology

The development of regional lung injury in the preterm lung is not well understood. This study aimed to characterize time-dependen..

Genes that improved fitness also cost modern humans: evidence for genes with antagonistic effects on longevity and disease

Sean G Byars, Konstantinos Voskarides

Journal article  |  2019  |  Evolution, Medicine, and Public Health

Limitations to the Association of Risk of Airway Disease With Removal of Adenoids and Tonsils in Children Reply

Sean G Byars, Stephen C Stearns, Jacobus J Boomsma

Journal article  |  2018  |  JAMA Otolaryngology–Head & Neck Surgery

CIRCULAR RNA EXPRESSION IS RESET BY BRIEF ANTIHYPERTENSIVE TREATMENT IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR)

Priscilla Prestes, Nathan De Vries, Sean Byars, Andrew Allen, Stephen Harrap, Fadi Charchar

Conference Proceedings  |  2018  |  JOURNAL OF HYPERTENSION

ANGIOTENSIN CONVERTING ENZYME INHIBITORS EPIGENETICALLY ATENUATE TELOMERE SHORTENING

Nathan De Vries, Priscilla Prestes, Mukesh Raipuria, Sean Byars, Andrew Allen, Stephen Harrap, Fadi Charchar

Conference Proceedings  |  2018  |  Journal of Hypertension

Plasma proteomics reveals gestational age-specific responses to mechanical ventilation and identifies the mechanistic pathways that initiate preterm lung injury

Prue M Pereira-Fantini, Sean G Byars, Karen E McCall, Elizabeth J Perkins, Regina B Oakley, RL Dellaca, Peter A Dargaville, Peter G Davis, Vera Ignjatovic, David G Tingay

Journal article  |  2018  |  Scientific Reports

Association of Long-term Risk of Respiratory, Allergic, and Infectious Diseases With Removal of Adenoids and Tonsils in Childhood

Sean G Byars, Stephen C Stearns, Jacobus J Boomsma

Journal article  |  2018  |  JAMA Otolaryngology-Head and Neck Surgery

Genome-Wide Association Studies and Risk Scores for Coronary Artery Disease: Sex Biases

Sean G Byars, Mike Inouye

Book Chapter  |  2018  |  Advances in Experimental Medicine and Biology

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation

Artika P Nath, Scott C Ritchie, Sean G Byars, Liam G Fearnley, Aki S Havulinna, Anni Joensuu, Antti J Kangas, Pasi Soininen, Annika Wennerstrom, Lili Milani, Andres Metspalu, Satu Mannisto, Peter Wurtz, Johannes Kettunen, Emma Raitoharju, Mika Kahonen, Markus Juonala, Aarno Palotie, Mika Ala-Korpela, Samuli Ripatti, et al.

Journal article  |  2017  |  Genome Biology

Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

Francine Z Marques, Priscilla R Prestes, Sean G Byars, Scott C Ritchie, Peter Wurtz, Sheila K Patel, Scott A Booth, Indrajeetsinh Rana, Yosuke Minoda, Stuart P Berzins, Claire L Curl, James R Bell, Bryan Wai, Piyush M Srivastava, Antti J Kangas, Pasi Soininen, Saku Ruohonen, Mika Kahonen, Terho Lehtimaki, Emma Raitoharju, et al.

Journal article  |  2017  |  Journal of the American Heart Association

Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy

Sean G Byars, Qin Qin Huang, Lesley-Ann Gray, Andrew Bakshi, Samuli Ripatti, Gad Abraham, Stephen C Stearns, Michael Inouye

Journal article  |  2017  |  PLOS Genetics

Unravelling the metabolic impact of SBS-associated microbial dysbiosis: Insights from the piglet short bowel syndrome model

Prue M Pereira-Fantini, Sean G Byars, James Pitt, Susan Lapthorne, Fiona Fouhy, Paul D Cotter, Julie E Bines

Journal article  |  2017  |  Scientific Reports

Genomic prediction of coronary heart disease

Gad Abraham, Aki S Havulinna, Oneil G Bhalala, Sean G Byars, Alysha M De Livera, Laxman Yetukuri, Emmi Tikkanen, Markus Perola, Heribert Schunkert, Eric J Sijbrands, Aarno Palotie, Nilesh J Samani, Veikko Salomaa, Samuli Ripatti, Michael Inouye

Journal article  |  2016  |  European Heart Journal

Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems

Le Shu, Yuqi Zhao, Zeyneb Kurt, Sean Geoffrey Byars, Taru Tukiainen, Johannes Kettunen, Luz D Orozco, Matteo Pellegrini, Aldons J Lusis, Samuli Ripatti, Bin Zhang, Michael Inouye, Ville-Petteri Makinen, Xia Yang

Journal article  |  2016  |  BMC Genomics

Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy

Sean Byars, Qin Qin Huang, Lesley-Ann Gray, Samuli Ripatti, Gad Abraham, Stephen Stearns, Michael Inouye

Journal article  |  2016

Abstract Traditional genome-wide scans for positive selection have mainly uncovered selective sweeps associated with monogenic tra..

Mergeomics: integration of diverse genomics resources to identify pathogenic perturbations to biological systems

Le Shu, Yuqi Zhao, Zeyneb Kurt, Sean Geoffrey Byars, Taru Tukiainen, Johannes Kettunen, Samuli Ripatti, Bin Zhang, Michael Inouye, Ville-Petteri Makinen, Xia Yang

Journal article  |  2016

Mergeomics is a computational pipeline (http://mergeomics.research.idre.ucla.edu/Download/Package/) that integrates multidimension..

Opposite differential risks for autism and schizophrenia based on maternal age, paternal age, and parental age differences

Sean G Byars, Jacobus J Boomsma

Journal article  |  2016  |  Evolution, Medicine, and Public Health

Opposite risk patterns for autism and schizophrenia are associated with normal variation in birth size: phenotypic support for hypothesized diametric gene-dosage effects

Sean G Byars, Stephen C Stearns, Jacobus J Boomsma

Journal article  |  2014  |  Proceedings of the Royal Society B: Biological Sciences

Parent-Offspring Conflict and the Persistence of Pregnancy-Induced Hypertension in Modern Humans

Birgitte Hollegaard, Sean G Byars, Jacob Lykke, Jacobus J Boomsma

Journal article  |  2013  |  PLoS ONE

Commentary: Haldanes and trends in phenotypic change in humans

Sean G Byars

Journal article  |  2013  |  International Journal of Epidemiology

Genetic links between post-reproductive lifespan and family size in Framingham.

Xiaofei Wang, Sean G Byars, Stephen C Stearns

Journal article  |  2013  |  Evolution, Medicine, and Public Health

BACKGROUND AND OBJECTIVES: Is there a trade-off between children ever born (CEB) and post-reproductive lifespan in humans? Here, w..

Constraints on the coevolution of contemporary human males and females

Stephen C Stearns, Diddahally R Govindaraju, Douglas Ewbank, Sean G Byars

Journal article  |  2012  |  Proceedings of the Royal Society B: Biological Sciences

Erratum: Measuring selection in contemporary human populations (Nature Reviews Genetics (2010) 11 (611-622))

SC Stearns, SG Byars, DR Govindaraju, D Ewbank

Journal article  |  2011  |  Nature Reviews Genetics

Measuring selection in contemporary human populations

Stephen C Stearns, Sean G Byars, Diddahally R Govindaraju, Douglas Ewbank

Journal article  |  2010  |  Nature Reviews Genetics

Natural selection in a contemporary human population

Sean G Byars, Douglas Ewbank, Diddahally R Govindaraju, Stephen C Stearns

Conference Proceedings  |  2010  |  Proceedings of the National Academy of Sciences

LACK OF STRONG LOCAL ADAPTATION IN THE ALPINE FORB CRASPEDIA LAMICOLA IN SOUTHEASTERN AUSTRALIA

Sean G Byars, Ary A Hoffmann

Journal article  |  2009  |  International Journal of Plant Sciences

Effect of altitude on the genetic structure of an Alpine grass, Poa hiemata

Sean G Byars, Yvonne Parsons, Ary A Hoffmann

Journal article  |  2009  |  Annals of Botany

Local adaptation and cogradient selection in the alpine plant, Poa hiemata, along a narrow altitudinal gradient

Sean G Byars, Warwick Papst, Ary A Hoffmann

Journal article  |  2007  |  Evolution

Intracellular freezing and survival in the freeze tolerant alpine cockroach Celatoblatta quinquemaculata

MR Worland, DA Wharton, SG Byars

Journal article  |  2004  |  Journal of Insect Physiology