Gayle Davey

Elucidating the Motif for CpG Oligonucleotide Binding to the Dendritic Cell Receptor DEC-205 Leads to Improved Adjuvants for Liver-Resident Memory

Jessica Li, Fatma Panetta, Meredith O'Keeffe, Ingrid M Leal Rojas, Kristen J Radford, Jian-Guo Zhang, Daniel Fernandez-Ruiz, Gayle M Davey, Benjamin S Gully, Kirsteen M Tullett, Jamie Rossjohn, Richard Berry, Chin-Nien Lee, Mireille H Lahoud, William R Heath, Irina Caminschi

Journal article  |  2021  |  JOURNAL OF IMMUNOLOGY

DEC-205 is a cell-surface receptor that transports bound ligands into the endocytic pathway for degradation or release within lyso..

Ptpn2 and KLRG1 regulate the generation and in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner, et al.

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of..

Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination.

Yu Kato, Thiago M Steiner, Hae-Young Park, Rohan O Hitchcock, Ali Zaid, Jyh Liang Hor, Sapna Devi, Gayle M Davey, David Vremec, Kirsteen M Tullett, Peck S Tan, Fatma Ahmet, Scott N Mueller, Sylvie Alonso, David M Tarlinton, Hidde L Ploegh, Tsuneyasu Kaisho, Lynette Beattie, Jonathan H Manton, Daniel Fernandez-Ruiz, et al.

Journal article  |  2020  |  Journal of Immunology

Follicular dendritic cells and macrophages have been strongly implicated in presentation of native Ag to B cells. This property ha..

CD8( ) T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Lauren E Holz, Julia E Prier, David Freestone, Thiago M Steiner, Kieran English, Darryl N Johnson, Vanessa Mollard, Anton Cozijnsen, Gayle M Davey, Dale Godfrey, Katsuyuki Yui, Laura K Mackay, Mireille H Lahoud, Irina Caminschi, Geoffrey McFadden, Patrick Bertolino, Daniel Fernandez-Ruiz, William R Heath

Journal article  |  2018  |  CELL REPORTS

Liver tissue-resident memory T (Trm) cells migrate throughout the sinusoids and are capable of protecting against malaria sporozoi..

IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection

Kylie R James, Megan SF Soon, Ismail Sebina, Daniel Fernandez-Ruiz, Gayle Davey, Urijah N Liligeto, Arya Sheela Nair, Lily G Fogg, Chelsea L Edwards, Shannon E Best, Lianne IM Lansink, Kate Schroder, Jane AC Wilson, Rebecca Austin, Andreas Suhrbier, Steven W Lane, Geoffrey R Hill, Christian R Engwerda, William R Heath, Ashraful Haque

Journal article  |  2018  |  JOURNAL OF IMMUNOLOGY

Differentiation of CD4+ Th cells is critical for immunity to malaria. Several innate immune signaling pathways have been implicate..

Development of a Novel CD4( ) TCR Transgenic Line That Reveals a Dominant Role for CD8( ) Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria

Daniel Fernandez-Ruiz, Lei Shong Lau, Nazanin Ghazanfari, Claerwen M Jones, Wei Yi Ng, Gayle M Davey, Dorothee Berthold, Lauren Holz, Yu Kato, Matthias H Enders, Ganchimeg Bayarsaikhan, Sanne H Hendriks, Lianne IM Lansink, Jessica A Engel, Megan SF Soon, Kylie R James, Anton Cozijnsen, Vanessa Mollard, Alessandro D Uboldi, Christopher J Tonkin, et al.

Journal article  |  2017  |  JOURNAL OF IMMUNOLOGY

We describe an MHC class II (I-Ab)-restricted TCR transgenic mouse line that produces CD4+ T cells specific for Plasmodium species..

Liver-Resident Memory CD8( ) T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

Daniel Fernandez-Ruiz, Wei Yi Ng, Lauren E Holz, Joel Z Ma, Ali Zaid, Yik Chun Wong, Lei Shong Lau, Vanessa Mollard, Anton Cozijnsen, Nicholas Collins, Jessica Li, Gayle M Davey, Yu Kato, Sapna Devi, Roghieh Skandari, Michael Pauley, Jonathan H Manton, Dale I Godfrey, Asolina Braun, Szun Szun Tay, et al.

Journal article  |  2016  |  IMMUNITY

In recent years, various intervention strategies have reduced malaria morbidity and mortality, but further improvements probably d..

T cell help amplifies innate signals in CD8 DC for optimal CD8 T cell priming

M Greyer, PG Whitney, AT Stock, GM Davey, C Tebartz, A Bachem, JD Mintern, RA Strugnell, SJ Turner, T Gebhardt, M O'Keeffe, WR Heath, S Bedoui

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Using a "prime-and-trap" vaccine strategy to generate liver TRM and protect mice form malaria liver-stage infection

WY Ng, D Fernandez-Ruiz, J Ma, A Zaid, YC Wong, LS Lau, V Mollard, A Cozijnsen, N Collins, J Li, GM Davey, L Holz, SS Tay, PS Tan, DG Bowen, F Koch-Nolte, R Bjoern, FR Carbone, BS Crabb, M Lahoud, et al.

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

T Cell Help Amplifies Innate Signals in CD8( ) DCs for Optimal CD8( ) T Cell Priming

Marie Greyer, Paul G Whitney, Angus T Stock, Gayle M Davey, Christina Tebartz, Annabell Bachem, Justine D Mintern, Richard A Strugnell, Stephen J Turner, Thomas Gebhardt, Meredith O'Keeffe, William R Heath, Sammy Bedoui

Journal article  |  2016  |  CELL REPORTS

DCs often require stimulation from CD4(+) T cells to propagate CD8(+) T cell responses, but precisely how T cell help optimizes th..