Gayle Davey

CD8( ) T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Lauren E Holz, Julia E Prier, David Freestone, Thiago M Steiner, Kieran English, Darryl N Johnson, Vanessa Mollard, Anton Cozijnsen, Gayle M Davey, Dale Godfrey, Katsuyuki Yui, Laura K Mackay, Mireille H Lahoud, Irina Caminschi, Geoffrey McFadden, Patrick Bertolino, Daniel Fernandez-Ruiz, William R Heath

Journal article  |  2018  |  Cell Reports

IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection

Kylie R James, Megan SF Soon, Ismail Sebina, Daniel Fernandez-Ruiz, Gayle Davey, Urijah N Liligeto, Arya Sheela Nair, Lily G Fogg, Chelsea L Edwards, Shannon E Best, Lianne IM Lansink, Kate Schroder, Jane AC Wilson, Rebecca Austin, Andreas Suhrbier, Steven W Lane, Geoffrey R Hill, Christian R Engwerda, William R Heath, Ashraful Haque

Journal article  |  2018  |  The Journal of Immunology

Development of a Novel CD4( ) TCR Transgenic Line That Reveals a Dominant Role for CD8( ) Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria

Daniel Fernandez-Ruiz, Lei Shong Lau, Nazanin Ghazanfari, Claerwen M Jones, Wei Yi Ng, Gayle M Davey, Dorothee Berthold, Lauren Holz, Yu Kato, Matthias H Enders, Ganchimeg Bayarsaikhan, Sanne H Hendriks, Lianne IM Lansink, Jessica A Engel, Megan SF Soon, Kylie R James, Anton Cozijnsen, Vanessa Mollard, Alessandro D Uboldi, Christopher J Tonkin, et al.

Journal article  |  2017  |  The Journal of Immunology

Liver-Resident Memory CD8( ) T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

Daniel Fernandez-Ruiz, Wei Yi Ng, Lauren E Holz, Joel Z Ma, Ali Zaid, Yik Chun Wong, Lei Shong Lau, Vanessa Mollard, Anton Cozijnsen, Nicholas Collins, Jessica Li, Gayle M Davey, Yu Kato, Sapna Devi, Roghieh Skandari, Michael Pauley, Jonathan H Manton, Dale I Godfrey, Asolina Braun, Szun Szun Tay, et al.

Journal article  |  2016  |  Immunity

T cell help amplifies innate signals in CD8 DC for optimal CD8 T cell priming

M Greyer, PG Whitney, AT Stock, GM Davey, C Tebartz, A Bachem, JD Mintern, RA Strugnell, SJ Turner, T Gebhardt, M O'Keeffe, WR Heath, S Bedoui

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Using a "prime-and-trap" vaccine strategy to generate liver TRM and protect mice form malaria liver-stage infection

WY Ng, D Fernandez-Ruiz, J Ma, A Zaid, YC Wong, LS Lau, V Mollard, A Cozijnsen, N Collins, J Li, GM Davey, L Holz, SS Tay, PS Tan, DG Bowen, F Koch-Nolte, R Bjoern, FR Carbone, BS Crabb, M Lahoud, et al.

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

T Cell Help Amplifies Innate Signals in CD8( ) DCs for Optimal CD8( ) T Cell Priming

Marie Greyer, Paul G Whitney, Angus T Stock, Gayle M Davey, Christina Tebartz, Annabell Bachem, Justine D Mintern, Richard A Strugnell, Stephen J Turner, Thomas Gebhardt, Meredith O'Keeffe, William R Heath, Sammy Bedoui

Journal article  |  2016  |  Cell Reports

Targeting Antigen to Clec9A Primes Follicular Th Cell Memory Responses Capable of Robust Recall

Yu Kato, Ali Zaid, Gayle M Davey, Scott N Mueller, Stephen L Nutt, Dimitra Zotos, David M Tarlinton, Ken Shortman, Mireille H Lahoud, William R Heath, Irina Caminschi

Journal article  |  2015  |  The Journal of Immunology

CD8( ) T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria

Lei Shong Lau, Daniel Fernandez-Ruiz, Vanessa Mollard, Angelika Sturm, Michelle A Neller, Anton Cozijnsen, Julia L Gregory, Gayle M Davey, Claerwen M Jones, Yi-Hsuan Lin, Ashraful Haque, Christian R Engwerda, Catherine Q Nie, Diana S Hansen, Kenneth M Murphy, Anthony T Papenfuss, John J Miles, Scott R Burrows, Tania de Koning-Ward, Geoffrey I McFadden, et al.

Journal article  |  2014  |  PLoS Pathogens

Identification of a MHC I-restricted epitope of DsRed in C57BL/6 mice

Gayle M Davey, Scott N Mueller, Catherine van Vliet, Michelle Gigowski, Ali Zaid, Brooke Davies, Francis R Carbone, William R Heath

Journal article  |  2013  |  Molecular Immunology

Breakdown in Repression of IFN-gamma mRNA Leads to Accumulation of Self-Reactive Effector CD8( ) T Cells

Pheh-Ping Chang, Sau K Lee, Xin Hu, Gayle Davey, Guowen Duan, Jae-Ho Cho, Guna Karupiah, Jonathan Sprent, William R Heath, Edward M Bertram, Carola G Vinuesa

Journal article  |  2012  |  Journal of Immunology

Proteomic and Metabolomic Analyses of Mitochondrial Complex I-deficient Mouse Model Generated by Spontaneous B2 Short Interspersed Nuclear Element (SINE) Insertion into NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4 (Ndufs4) Gene

Dillon W Leong, Jasper C Komen, Chelsee A Hewitt, Estelle Arnaud, Matthew McKenzie, Belinda Phipson, Melanie Bahlo, Adrienne Laskowski, Sarah A Kinkel, Gayle M Davey, William R Heath, Anne K Voss, Rene P Zahedi, James J Pitt, Roman Chrast, Albert Sickmann, Michael T Ryan, Gordon K Smyth, David R Thorburn, Hamish S Scott

Journal article  |  2012  |  Journal of Biological Chemistry

Blood-Stage Plasmodium berghei Infection Generates a Potent, Specific CD8( ) T-Cell Response Despite Residence Largely in Cells Lacking MHC I Processing Machinery

Lei Shong Lau, Daniel Fernandez Ruiz, Gayle M Davey, Tania F de Koning-Ward, Anthony T Papenfuss, Francis R Carbone, Andrew G Brooks, Brendan S Crabb, William R Heath

Journal article  |  2011  |  Journal of Infectious Diseases

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance

Francois-Xavier Hubert, Sarah A Kinkel, Gayle M Davey, Belinda Phipson, Scott N Mueller, Adrian Liston, Anna I Proietto, Ping ZF Cannon, Simon Forehan, Gordon K Smyth, Li Wu, Christopher C Goodnow, Francis R Carbone, Hamish S Scott, William R Heath

Journal article  |  2011  |  Blood

Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype

Mireille H Lahoud, Fatma Ahmet, Susie Kitsoulis, Soo San Wan, David Vremec, Chin-Nien Lee, Belinda Phipson, Wei Shi, Gordon K Smyth, Andrew M Lew, Yu Kato, Scott N Mueller, Gayle M Davey, William R Heath, Ken Shortman, Irina Caminschi

Journal article  |  2011  |  Journal of Immunology

Murine CD8 alpha DCs and human BDCA3 DCs produce large amounts of IFN-lambda in response to poly IC and DNA viruses

Henning Lauterbach, Barbara Bathke, Stefanie Gilles, Claudia Traidl-Hoffmann, Christian Luber, Gyoergy Fejer, Marina Freudenberg, Gayle Davey, David Vremec, Axel Kallies, Li Wu, Ken Shortman, Paul Chaplin, Mark Suter, Meredith O'Keeffe, Hubertus Hochrein

Journal article  |  2011  |  JOURNAL OF IMMUNOLOGY

Mouse CD8 alpha( ) DCs and human BDCA3( ) DCs are major producers of IFN-lambda in response to poly IC

Henning Lauterbach, Barbara Bathke, Stefanie Gilles, Claudia Traidl-Hoffmann, Christian A Luber, Gyoergy Fejer, Marina A Freudenberg, Gayle M Davey, David Vremec, Axel Kallies, Li Wu, Ken Shortman, Paul Chaplin, Mark Suter, Meredith O'Keeffe, Hubertus Hochrein

Journal article  |  2010  |  Journal of Experimental Medicine

Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells

Rachel J Lundie, Louise J Young, Gayle M Davey, Jose A Villadangos, Francis R Carbone, William R Heath, Brendan S Crabb

Journal article  |  2010  |  European Journal of Immunology

Cutting Edge: Priming of CD8 T Cell Immunity to Herpes Simplex Virus Type 1 Requires Cognate TLR3 Expression In Vivo

Gayle M Davey, Magdalena Wojtasiak, Anna I Proietto, Francis R Carbone, William R Heath, Sammy Bedoui

Journal article  |  2010  |  Journal of Immunology

SOCS1 negatively regulates the production of Foxp3( ) CD4( ) T cells in the thymus

Yifan Zhan, Gayle M Davey, Kate L Graham, Hiu Kiu, Nadine L Dudek, Thomas WH Kay, Andrew M Lew

Journal article  |  2009  |  Immunology and Cell Biology

The molecular signature of CD8( ) T cells undergoing deletional tolerance

Ian A Parish, Sudha Rao, Gordon K Smyth, Torsten Juelich, Gareth S Denyer, Gayle M Davey, Andreas Strasser, William R Heath

Journal article  |  2009  |  Blood

Transience of MHC Class I-restricted antigen presentation after influenza A virus infection

Justine D Mintern, Sammy Bedoui, Gayle M Davey, Jessica M Moffat, Peter C Doherty, Stephen J Turner

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance

Ian A Parish, Jason Waithman, Gayle M Davey, Gabrielle T Belz, Justine D Mintern, Christian Kurts, Robyn M Sutherland, Francis R Carbone, William R Heath

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

Equivalent stimulation of naive and memory CD8 T cells by DNA vaccination: a dendritic cell-dependent process

Sammy Bedoui, Gayle M Davey, Andrew M Lew, William R Heath

Journal article  |  2009  |  Immunology and Cell Biology

Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants

PJ White, F Anastasopoulos, JE Church, C-Y Kuo, BJ Boyd, PLC Hickey, L Sze Tu, P Burns, AM Lew, WR Heath, GM Davey, CW Pouton

Journal article  |  2008  |  Vaccine

The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

Irina Caminschi, Anna I Proietto, Fatma Ahmet, Susie Kitsoulis, Joo Shin Teh, Jennifer CY Lo, Alexandra Rizzitelli, Li Wu, David Vremec, Serani LH van Dommelen, Ian K Campbell, Eugene Maraskovsky, Hal Braley, Gayle M Davey, Patricia Mottram, Nicholas van De Velde, Kent Jensen, Andrew M Lew, Mark D Wright, William R Heath, et al.

Journal article  |  2008  |  Blood

Blood-stage Plasmodium infection induces CD8( ) T lymphocytes to parasite-expressed antigens, largely regulated by CD8 alpha( ) dendritic cells

Rachel J Lundie, Tania F de Koning-Ward, Gayle M Davey, Catherine Q Nie, Diana S Hansen, Lei Shong Lau, Justine D Mintern, Gabrielle T Belz, Louis Schofield, Francis R Carbone, Jose A Villadangos, Brendan S Crabb, William R Heath

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

Cutting edge: Enhanced IL-2 signaling can convert self-specific T cell response from tolerance to autoinimunity

Jason Waithman, Thomas Gebhardt, Gayle M Davey, William R Heath, Francis R Carbone

Journal article  |  2008  |  Journal of Immunology

Induction of antigen-specific T cell responses following blood-stage Plasmodium infection occurs mainly via CD8 alpha dendritic cells but is short-lived.

Rachel J Lundie, Tania F de Koning-Ward, Gayle M Davey, Catherine Q Nie, Diana S Hansen, Louis Schofield, Gabrielle T Belz, Francis R Carbone, Jose A Villadangos, Brendan S Crabb, William R Heath

Conference Proceedings  |  2008  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells

Irina Caminschi, Fatma Ahmet, Klaus Heger, Jason Brady, Stephen L Nutt, David Vremec, Suzanne Pietersz, Mireille H Lahoud, Louis Schofi Eld, Diana S Hansen, Meredith O'Keeffe, Mark J Smyth, Sammy Bedoui, Gayle M Davey, Jose A Villadangos, William R Heath, Ken Shortman

Journal article  |  2007  |  Journal of Experimental Medicine

The dominant role of CD8( ) dendritic cells in cross-presentation is not dictated by antigen capture

Petra Schnorrer, Georg MN Behrens, Nicholas S Wilson, Joanne L Pooley, Christopher M Smith, Dima EI-Sukkari, Gayle Davey, Fiona Kupresanin, Ming Li, Eugene Maraskovsky, Gabrielle T Belz, Francis R Carbone, Ken Shortman, William R Heath, Jose A Villadangos

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America

SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated dinflammation

GM Davey, WR Heath, R Starr

Journal article  |  2006  |  Tissue Antigens

Antigen presentation in rodent malaria

RJ Lundie, TF De Koning-Ward, GM Davey, GT Belz, NS Wilson, L Young, JA Villadangos, WR Heath, BS Crabb

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

Self tolerance to organ-specific antigens

WR Heath, IA Parish, J Waithman, GM Davey, GT Belz, FR Carbone

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

SOCS-1 deficiency results in IL-15 dependent proliferation of antigen naive CD8 T cells

GM Davey, AL Cornish, JT Burghardt, WS Alexander, FR Carbone, CD Surh, R Starr, WR Heath

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential

GM Davey, R Starr, AL Cornish, JT Burghardt, WS Alexander, FR Carbone, CD Surh, WR Heath

Journal article  |  2005  |  Journal of Experimental Medicine

Cutting edge: TLR ligands are not sufficient to break cross-tolerance to self-antigens

EE Hamilton-Williams, A Lang, D Benke, GM Davey, KH Wiesmuller, C Kurts

Journal article  |  2005  |  Journal of Immunology

Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice

M Pellegrini, P Bouillet, M Robati, GT Belz, GM Davey, A Strasser

Journal article  |  2004  |  Journal of Experimental Medicine

Interleukin (IL)-7 receptor (R) signaling is essential for T and B lymphopoiesis by promoting proliferation, differentiation, and ..

Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice

M Pellegrini, P Bouillet, M Robati, GT Belz, GM Davey, A Strasser

Journal article  |  2004  |  J. Exp. Med.

Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens

WR Heath, GT Belz, GMN Behrens, CM Smith, SP Forehan, IA Parish, GM Davey, NS Wilson, FR Carbone, JA Villadangos

Journal article  |  2004  |  Immunological Reviews

Helper requirements for generation of effector CTL to islet beta cell antigens

GMN Behrens, M Li, GM Davey, J Allison, RA Flavell, FR Carbone, WR Heath

Journal article  |  2004  |  Journal of Immunology

Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells

AL Cornish, MM Chong, GM Davey, R Darwiche, NA Nicola, DJ Hilton, TW Kay, R Starr, WS Alexander

Journal article  |  2003  |  Journal of Biological Chemistry

Suppressor of cytokine signaling-1 has IFn-gamma-independent actions in T cell homeostasis

AL Cornish, GM Davey, D Metcalf, JF Purton, JE Corbin, CJ Greenhalgh, R Darwiche, L Wu, NA Nicola, DI Godfrey, WR Heath, DJ Hilton, WS Alexander, R Starr

Journal article  |  2003  |  Journal of Immunology

Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by bim

GM Davey, C Kurts, JFAP Miller, P Bouillet, A Strasser, AG Brooks, FR Carbone, WR Heath

Journal article  |  2002  |  Journal of Experimental Medicine

Cutting edge: Precursor frequency affects the helper dependence of cytotoxic T cells

JD Mintern, GM Davey, GT Belz, FR Carbone, WR Heath

Journal article  |  2002  |  Journal of Immunology

Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity

A Hanninen, NR Martinez, GM Davey, WR Heath, LC Harrison

Journal article  |  2002  |  Journal of Clinical Investigation

Kidney protection against autoreactive CD8( ) T cells distinct from immunoprivilege and sequestration

C Kurts, I Klebba, GM Davey, KM Koch, JFAP Miller, WR Heath, J Floege

Journal article  |  2001  |  Kidney International

Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo

M Li, GM Davey, RM Sutherland, C Kurts, AM Lew, C Hirst, FR Carbone, WR Heath

Journal article  |  2001  |  Journal of Immunology

A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4( ) and CD8( ) T cells

E Blanas, GM Davey, FR Carbone, WR Heath

Journal article  |  2000  |  The Journal of Immunology

Cytotoxic T lymphocytes and cross-priming

WR Heath, SMR Clarke, GM Davey, C Kurts, AM Lew, M Li, J Mintern, RM Sutherland, FR Carbone, JFAP Miller

Journal article  |  2000  |  Immunologist

The use of carboxyfluorescein diacetate succinimidyl ester to determine the site, duration and cell type responsible for antigen presentation in vivo

J Mintern, M Li, GM Davey, E Blanas, C Kurts, FR Carbone, WR Heath

Journal article  |  1999  |  Immunology and Cell Biology

CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose

C Kurts, RM Sutherland, G Davey, M Li, AM Lew, E Blanas, FR Carbone, JFAP Miller, WR Heath

Journal article  |  1999  |  Proceedings of the National Academy of Sciences

Thymic shared antigen-2: a novel cell surface marker associated with T cell differentiation and activation.

SP Berzins, GM Davey, ES Randle-Barrett, MA Malin, BJ Classon, S Fraser, RL Boyd

Journal article  |  1999  |  Journal of Immunology

Thymic shared Ag-2 (TSA-2) is a 28-kDa, glycophosphatidylinitosol-linked cell surface molecule expressed on various T cell and thy..

Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

GM Davey, SL Schober, BT Endrizzi, AK Dutcher, SC Jameson, KA Hogquist

Journal article  |  1998  |  The Journal of Experimental Medicine

During T cell development, thymocytes which are tolerant to self-peptides but reactive to foreign peptides are selected. The curre..

Characterization of the AKR thymic microenvironment and its influence on thymocyte differentiation and lymphoma development.

GM Davey, CL Tucek-Szabo, RL Boyd

Journal article  |  1996  |  Leukemia Research

The thymic stroma has long been implicated in AKR thymic leukaemia. In this study an extensive panel of monoclonal antibodies was ..