Prof. Angela Morgan is an NHMRC Practitioner Fellow and leads the Speech and Language group at the Murdoch Children's Research Institute. She is also Professor of Speech Pathology at the University of Melbourne.
Angela has over 20 years of clinical-research experience. Her career has been focused on better understanding predictors, prognostic factors and causation for childhood speech and language disorders. Her early career focused on these challenges in children with acquired brain injury, including in children with traumatic brain injury, stroke and brain tumour.In recent times, Angela's research focus has turned to better understanding biological causation for these conditions. Angela currently leads the NHMRC CRE in Speech and Language which focuses on: (i) identification of new gene pathways leading to child speech and language disorders, (ii) conducting genotype- speech phenotype studies for rare genetic syndromes leading to more targeted therapies, and (iii) elucidating the neurobiology of genetic-based speech and language disorders using quantitative brain imaging techniques. Angela and team have identified over 50% of known single genes for a debilitating speech disorder, known as childhood apraxia of speech. Her team have also characterised speech and language in children with a number of known genetic syndromes, single gene and copy number variant conditions, including: FOXP2-related speech and language disorders, Kabuki syndrome, Floating Harbor Syndrome, 16p11.2 deletion, Koolen de Vries Syndrome, GRIN2A-related speech disorder, Dravet Syndrome, Beckwith Weidemann Syndrome and Klinefelter Syndrome. As a result of her expertise in speech outcomes in these children, Angela is increasingly leading trials, or consulting on speech outcome measures for pharmacological trials in children with rare genetic conditions. At a population level, Angela leads the phenotyping arm of a large genome wide association study examining biological contributions to stuttering.Angela's research is published in well-respected cross-disciplinary journals including the British Medical Journal, Brain, Neurology, Molecular Psychiatry and Neuroscience and Biobehavioural Reviews. She also publishes in discipline specific journals to ensure her translational clinical work reaches the appropriate audience. She has also led development of a number of clinical guidelines including the NHMRC endorsed guideline for management of speech, language and swallowing in children with traumatic brain injury and the NIH affiliated Gene Review on FOXP2-related speech and language disorder.
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Building & Commercialising A Speech Diagnostic & Treatment Planning Tool (Adaapt-Assess)
Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiolo..
Displaying the 2 most recent projects by Angela Morgan.
Displaying the 159 most recent scholarly works by Angela Morgan.
Grey matter volume in developmental speech and language disorder
Lauren Pigdon, Catherine Willmott, Sheena Reilly, Gina Conti-Ramsden, Christian Gaser, Alan Connelly, Angela T Morgan
Journal article | 2019 | Brain Structure and Function
Developmental language disorder (DLD) and developmental speech disorder (DSD) are common, yet their etiologies are not well unders..
Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response
Jennifer L Johnson, Loredana Stoica, Yuwei Liu, Ping Jun Zhu, Abhisek Bhattacharya, Shelly A Buffington, Redwan Huq, N Tony Eissa, Ola Larsson, Bo T Porse, Deepti Domingo, Urwah Nawaz, Renee Carroll, Lachlan Jolly, Tom S Scerri, Hyung-Goo Kim, Amanda Brignell, Matthew J Coleman, Ruth Braden, Usha Kini, et al.
Journal article | 2019 | Neuron
In humans, disruption of nonsense-mediated decay (NMD) has been associated with neurodevelopmental disorders (NDDs) such as autism..
Recessive variants in ZNF142 cause a complex neurodevelopmental disorder with intellectual disability, speech impairment, seizures, and dystonia
Kamal Khan, Michael Zech, Angela T Morgan, David J Amor, Matej Skorvanek, Tahir N Khan, Michael S Hildebrand, Victoria E Jackson, Thomas S Scerri, Matthew Coleman, Kristin A Rigbye, Ingrid E Scheffer, Melanie Bahlo, Matias Wagner, Daniel D Lam, Riccardo Berutti, Petra Havrankova, Anna Fecikova, Tim M Strom, Vladimir Han, et al.
Journal article | 2019 | Genetics in Medicine
PURPOSE: The purpose of this study was to expand the genetic architecture of neurodevelopmental disorders, and to characterize the..
What predicts nonword repetition performance?
Lauren Pigdon, Catherine Willmott, Sheena Reilly, Gina Conti-Ramsden, Angela T Morgan
Journal article | 2019 | Child Neuropsychology
Despite the widespread use of nonword repetition in child neuropsychological research and clinical practice, the specific cognitiv..
Expansion of phenotype of DDX3X syndrome: six new cases.
Bryony Beal, Ian Hayes, Julie McGaughran, David J Amor, Christina Miteff, Victoria Jackson, Olivia van Reyk, Gopinath Subramanian, Michael S Hildebrand, Angela T Morgan, Himanshu Goel
Journal article | 2019 | Clinical Dysmorphology
Pathogenic variants in DDX3X have recently been identified to be a relatively common cause of intellectual disability in females. ..
Speech and language in bilateral perisylvian polymicrogyria: a systematic review
Ruth O Braden, Richard J Leventer, Anna Jansen, Ingrid E Scheffer, Angela T Morgan
Journal article | 2019 | Developmental Medicine & Child Neurology
AIM: We aimed to systematically review the speech production, language, and oral function phenotype of bilateral perisylvian polym..
Looking to the Future: Speech, Language, and Academic Outcomes in an Adolescent with Childhood Apraxia of Speech
Samantha J Turner, Adam P Vogel, Bronwyn Parry-Fielder, Rhonda Campbell, Ingrid E Scheffer, Angela T Morgan
Journal article | 2019 | Folia Phoniatrica et Logopaedica
OBJECTIVE: The clinical course of childhood apraxia of speech (CAS) is poorly understood. Of the few longitudinal studies in the f..
Exploring the speech and language of individuals with non-syndromic submucous cleft palate: a preliminary report
Jessica O Boyce, Katherine Sanchez, David J Amor, Sheena Reilly, Annette Da Costa, Nicky Kilpatrick, Angela T Morgan
Journal article | 2019 | International Journal of Language & Communication Disorders
BACKGROUND: Submucous cleft palate (SMCP) has a heterogeneous presentation and is often identified late or misdiagnosed. Diagnosis..
Outcome instruments in moderate-to-severe adult traumatic brain injury: recommendations for use in psychosocial research
Cynthia A Honan, Skye McDonald, Robyn Tate, Tamara Ownsworth, Leanne Togher, Jennifer Fleming, Vicki Anderson, Angela Morgan, Cathy Catroppa, Jacinta Douglas, Heather Francis, Travis Wearne, Linda Sigmundsdottir, Jennie Ponsford
Journal article | 2019 | Neuropsychological Rehabilitation
A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development
Else Eising, Amaia Carrion-Castillo, Arianna Vino, Edythe A Strand, Kathy J Jakielski, Thomas S Scerri, Michael S Hildebrand, Richard Webster, Alan Ma, Bernard Mazoyer, Clyde Francks, Melanie Bahlo, Ingrid E Scheffer, Angela T Morgan, Lawrence D Shriberg, Simon E Fisher
Journal article | 2019 | Molecular Psychiatry
Dorsal language stream anomalies in an inherited speech disorder
Frederique J Liegeois, Samantha J Turner, Angela Mayes, Alexandra F Bonthrone, Amber Boys, Libby Smith, Bronwyn Parry-Fielder, Simone Mandelstam, Megan Spencer-Smith, Melanie Bahlo, Tom S Scerri, Michael S Hildebrand, Ingrid E Scheffer, Alan Connelly, Angela T Morgan
Journal article | 2019 | Brain
Say 'ahh'… assessing structural and functional palatal issues in children.
Jessica O Boyce, Nicky Kilpatrick, Rodrigo P Teixeira, Angela T Morgan
Journal article | 2018 | Archives of disease in childhood - Education & practice edition
CASE HISTORY: A 5-year-old girl presented with a suspected palatal abnormality, first observed by her general practitioner during ..
Characterization of speech and language phenotype in children with NRXN1 deletions
Amanda Brignell, Miya St John, Amber Boys, Amanda Bruce, Carla Dinale, Lauren Pigdon, Michael S Hildebrand, David J Amor, Angela T Morgan
Journal article | 2018 | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Psychosocial functioning following moderate-to-severe pediatric traumatic brain injury: recommended outcome instruments for research and remediation studies.
Travis Wearne, Vicki Anderson, Cathy Catroppa, Angela Morgan, Jennie Ponsford, Robyn Tate, Tamara Ownsworth, Leanne Togher, Jennifer Fleming, Jacinta Douglas, Kimberley Docking, Linda Sigmundsdottir, Heather Francis, Cynthia Honan, Skye McDonald
Journal article | 2018 | Neuropsychological Rehabilitation
Psychosocial functioning is compromised following pediatric traumatic brain injury (TBI), with the past few decades witnessing a p..
Data resource profile: The Child LAnguage REpository (CLARE)
Sheena Reilly, Eileen Cini, Lisa Gold, Sharon Goldfeld, James Law, Penny Levickis, Fiona Mensah, Angela Morgan, Jan M Nicholson, Ha ND Le, Angela Pezic, Bruce Tomblin, Melissa Wake, Louise Wardrop
Journal article | 2018 | International Journal of Epidemiology
CATALISE: A Multinational and Multidisciplinary Delphi Consensus Study. Identifying Language Impairments in Children
DVM Bishop, Margaret J Snowling, Paul A Thompson, Trisha Greenhalgh, Catherine Adams, Lisa Archibald, Gillian Baird, Ann Bauer, Jude Bellair, Christopher Boyle, Elizabeth Brownlie, Glenn Carter, Becky Clark, Judy Clegg, Nancy Cohen, Gina Conti-Ramsden, Julie Dockrell, Janet Dunn, Susan Ebbels, Aoife Gallagher, et al.
Journal article | 2016 | PLOS ONE
Consensus paper on post-operative pediatric cerebellar mutism syndrome: the Iceland Delphi results
Thora Gudrunardottir, Angela T Morgan, Andrew L Lux, David A Walker, Karin S Walsh, Elizabeth M Wells, Jeffrey H Wisoff, Marianne Juhler, Jeremy D Schmahmann, Robert F Keating, Coriene Catsman-Berrevoets
Journal article | 2016 | Child's Nervous System
A highly penetrant form of childhood apraxia of speech due to deletion of 16p11.2 (vol 24, pg 302, 2016)
Evelina Fedorenko, Angela Morgan, Elizabeth Murray, Annie Cardinaux, Cristina Mei, Helen Tager-Flusberg, Simon E Fisher, Nancy Kanwisher
Journal article | 2016 | European Journal of Human Genetics
Speech and Language in a Genotyped Cohort of Individuals with Kabuki Syndrome
Angela T Morgan, Cristina Mei, Annette Da Costa, Joanne Fifer, Damien Lederer, Valerie Benoit, Margaret J McMillin, Kati J Buckingham, Michael J Bamshad, Kate Pope, Susan M White
Journal article | 2015 | American Journal of Medical Genetics Part A
Neurobehaviour between birth and 40 weeks' gestation in infants born < 30 weeks' gestation and parental psychological wellbeing: predictors of brain development and child outcomes
Alicia J Spittle, Deanne K Thompson, Nisha C Brown, Karli Treyvaud, Jeanie LY Cheong, Katherine J Lee, Carmen C Pace, Joy Olsen, Leesa G Allinson, Angela T Morgan, Marc Seal, Abbey Eeles, Fiona Judd, Lex W Doyle, Peter J Anderson
Journal article | 2014 | BMC Pediatrics
Neural Correlates of Developmental Speech and Language Disorders: Evidence from Neuroimaging.
Frédérique Liégeois, Angela Mayes, Angela Morgan
Journal article | 2014 | Current Genetics
Disorders of speech and language arise out of a complex interaction of genetic, environmental, and neural factors. Little is under..
Small Intragenic Deletion in FOXP2 Associated With Childhood Apraxia of Speech and Dysarthria
Samantha J Turner, Michael S Hildebrand, Susan Block, John Damiano, Michael Fahey, Sheena Reilly, Melanie Bahlo, Ingrid E Scheffer, Angela T Morgan
Journal article | 2013 | American Journal of Medical Genetics. Part A
Questions about the effects of interventions: examples of appraisals from different health professions
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Book Chapter | 2013
Moving Ahead: A New Centre of Research Excellence in Brain Recovery, Focusing on Psychosocial Reintegration Following Traumatic Brain Injury
Skye McDonald, Vicki Anderson, Jennie Ponsford, Robyn Tate, Leanne Togher, Angela Morgan, Jennifer Fleming, Tamara Ownsworth, Jacinta Douglas, Bruce Murdoch
Journal article | 2012 | Brain Impairment
A Cochrane review of treatment for childhood apraxia of speech (Reprinted from Cochrane Database of Systematic Reviews, 2008)
AT Morgan, AP Vogel
Journal article | 2009 | European Journal of Physical and Rehabilitation Medicine: a journal of physical medicine and rehabilitation after pathological events
Dysarthria and dysphagia following treatment for a fourth ventricle choroid plexus papilloma.
PL Cornwell, BE Murdoch, EC Ward, A Morgan
Journal article | 2003 | Journal of Clinical Neuroscience
The present case report describes the presence of a persistent dysarthria and dysphagia as a consequence of surgical intervention ..
Dysarthria and dysphagia as long-term sequelae in a child treated for posterior fossa tumour.
Petrea L Cornwell, Bruce E Murdoch, Elizabeth C Ward, Angela Morgan
Journal article | 2003 | Pediatric Rehabilitation
The current case report provides a comprehensive description of the persistent dysarthria and dysphagia evident in a 7.5 year old ..
Displaying the most recent news article by Angela Morgan.
Honours, Awards and Fellowships
Victorian Young Tall Poppy Award
National Health and Medical Research Council Achievement Award
Australian Postgraduate Award
Speech Pathology Australia
University of Queensland Medal
Harold Mitchell International Travelling Fellowship
Dean of Medical Faculty award
Research And Teaching - Speech Pathology
Audiology And Speech Pathology
The University of Queensland
The University of Queensland