Sammy Bedoui

Unappreciated complexity in T cell help for dendritic cells.

Sammy Bedoui, Thomas Gebhardt

Journal article  |  2022  |  Nat Immunol

Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Jessica M Salmon, Izabela Todorovski, Kym L Stanley, Claudia Bruedigam, Conor J Kearney, Luciano G Martelotto, Fernando Rossello, Timothy Semple, Gisela Mir Arnau, Magnus Zethoven, Michael Bots, Stefan Bjelosevic, Leonie A Cluse, Peter J Fraser, Veronique Litalien, Eva Vidacs, Kate McArthur, Antony Y Matthews, Elise Gressier, Nicole A de Weerd, et al.

Journal article  |  2022  |  CANCER DISCOVERY

UNLABELLED: Pharmacologic inhibition of epigenetic enzymes can have therapeutic benefit against hematologic malignancies. In addit..

Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches

Sabrina Daehling, Ana Maria Mansilla, Konrad Knoepper, Anika Grafen, Daniel T Utzschneider, Milas Ugur, Paul G Whitney, Annabell Bachem, Panagiota Arampatzi, Fabian Imdahl, Tsuneyasu Kaisho, Dietmar Zehn, Frederick Klauschen, Natalio Garbi, Axel Kallies, Antoine-Emmanuel Saliba, Georg Gasteiger, Sammy Bedoui, Wolfgang Kastenmueller

Journal article  |  2022  |  IMMUNITY

Reinvigoration of exhausted CD8+ T (Tex) cells by checkpoint immunotherapy depends on the activation of precursors of exhausted T ..

Microbial Metabolites in the Maturation and Activation of Dendritic Cells and Their Relevance for Respiratory Immunity.

Kayla R Wilson, Elise Gressier, Malcolm J McConville, Sammy Bedoui

Journal article  |  2022  |  Front Immunol

The respiratory tract is a gateway for viruses and bacteria from the external environment to invade the human body. Critical to th..

Caspase-2 does not play a critical role in cell death induction and bacterial clearance during Salmonella infection

Sven Engel, Marcel Doerflinger, Ariane R Lee, Andreas Strasser, Marco J Herold, Sammy Bedoui, Annabell Bachem

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

CD4( ) T cell immunity to Salmonella is transient in the circulation

Newton G Peres, Nancy Wang, Paul Whitney, Sven Engel, Meghanashree M Shreenivas, Ian Comerford, Dianna M Hocking, Anna B Erazo, Irmgard Foerster, Andreas Kupz, Thomas Gebhardt, Shaun R McColl, Stephen J McSorley, Sammy Bedoui, Richard A Strugnell

Journal article  |  2021  |  PLOS PATHOGENS

While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen where protection is mediated by CD..

Protein tyrosine phosphatase non-receptor type 2 and killer cell lectin-like receptor G1 regulate the generation and function of tissue-resident memory T cells in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias Hans Enders, Moshe Olshansky, Brendan Russ, Claerwen Jones, David Gyorki, Stephen Turner, Marco Herold, Tony Tiganis, Sammy Bedoui, Thomas Gebhardt

Conference Proceedings  |  2021  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Ptpn2 and KLRG1 regulate the generation and in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner, et al.

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of..

Intracellular Staphylococcus aureus and host cell death pathways

Ye Mon Soe, Sammy Bedoui, Timothy P Stinear, Abderrahman Hachani

Journal article  |  2021  |  CELLULAR MICROBIOLOGY

Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have c..

Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response

M Isabel G Lopez Sanchez, Mark Ziemann, Annabell Bachem, Rahul Makam, Jonathan G Crowston, Carl A Pinkert, Matthew McKenzie, Sammy Bedoui, Ian A Trounce

Journal article  |  2020  |  PLOS ONE

Mitochondrial OXPHOS generates most of the energy required for cellular function. OXPHOS biogenesis requires the coordinated expre..