Sammy Bedoui

Ptpn2 and KLRG1 regulate the generation and in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner, et al.

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of..

Intracellular Staphylococcus aureus and host cell death pathways

Ye Mon Soe, Sammy Bedoui, Timothy P Stinear, Abderrahman Hachani

Journal article  |  2021  |  CELLULAR MICROBIOLOGY

Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have c..

Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response

M Isabel G Lopez Sanchez, Mark Ziemann, Annabell Bachem, Rahul Makam, Jonathan G Crowston, Carl A Pinkert, Matthew McKenzie, Sammy Bedoui, Ian A Trounce

Journal article  |  2020  |  PLOS ONE

Mitochondrial OXPHOS generates most of the energy required for cellular function. OXPHOS biogenesis requires the coordinated expre..

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  IMMUNITY

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

Sympathetic nerves control bacterial clearance

Yugeesh R Lankadeva, Clive N May, Michael J McKinley, Melanie R Neeland, Shuai Ma, Dianna M Hocking, Roy Robins-Browne, Sammy Bedoui, David GS Farmer, Simon R Bailey, Davide Martelli, Robin M McAllen

Journal article  |  2020  |  SCIENTIFIC REPORTS

A neural reflex mediated by the splanchnic sympathetic nerves regulates systemic inflammation in negative feedback fashion, but it..

Emerging connectivity of programmed cell death pathways and its physiological implications

Sammy Bedoui, Marco J Herold, Andreas Strasser

Journal article  |  2020  |  NATURE REVIEWS MOLECULAR CELL BIOLOGY

The removal of functionally dispensable, infected or potentially neoplastic cells is driven by programmed cell death (PCD) pathway..

Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit

Jessica Salmon, Izabela Todorovski, Stephin Vervoort, Kym Stanley, Conor Kearney, Luciano Martelotto, Fernando Rossello, Tim Semple, Gisela Mir-Arnau, Magnus Zethoven, Michael Bots, Eva Vidacs, Kate McArthur, Elise Gressier, Nicky de Weerd, Jens Lichte, Madison Kelly, Leonie Cluse, Simon Hogg, Paul Hertzog, et al.

Journal article  |  2020

Pharmacological inhibition of epigenetic enzymes can have therapeutic benefit, particularly against hematological malignancies. Wh..

Microbiota-derived butyrate promotes metabolism and memory potential of effector CD8( )T cells

Annabell Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Dedreia Tull, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, Axel Kallies, Malcolm McConville, Stephen J Turner, Thomas Gebhardt, Sammy Bedoui

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Dissecting the molecular mechanisms underpinning T cell help for Dendritic Cell

Elise Marie Gressier, Paul Whitney, Susanne Schmidt, Sammy Bedoui

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Prior Ablation of the Splanchnic Sympathetic Nerves Increases Plasma Inflammatory Cytokine Levels and Suppresses Bacteremia in Response to Systemically Administered E. coli in Sheep

Michael McKinley, Kaylani Almeida, Sammy Bedoui, David Farmer, Dianna Hocking, Yugeesh Lankadeva, Davide Martelli, Clive May, Roy Robins-Browne, Robin McAllen

Conference Proceedings  |  2020  |  FASEB JOURNAL