David Finkelstein

alpha-Synuclein E46K Mutation and Involvement of Oxidative Stress in a Drosophila Model of Parkinson's Disease

Samaneh Reiszadeh Jahromi, SR Ramesh, David I Finkelstein, Mohammad Haddadi

Journal article  |  2021  |  PARKINSONS DISEASE

Parkinson's disease (PD) is an age-associated neurodegenerative condition in which some genetic variants are known to increase dis..

Analysis of morphological and neurochemical changes in subthalamic nucleus neurons in response to a unilateral 6-OHDA lesion of the substantia nigra in adult rats

Katayoun Sedaghat, Andrew L Gundlach, David Finkelstein

Journal article  |  2021  |  IBRO NEUROSCIENCE REPORTS

Background: Subthalamic nucleus (STN) neurons undergo changes in their pattern of activity and morphology during the clinical cour..

The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease

Rachel M McQuade, Lewis M Singleton, Hongyi Wu, Sophie Lee, Remy Constable, Madeleine Di Natale, Mitchell T Ringuet, Joel P Berger, Jessica Kauhausen, Clare L Parish, David Finkelstein, John B Furness, Shanti Diwakarla

Journal article  |  2021  |  SCIENTIFIC REPORTS

Parkinson's disease (PD) is associated with neuronal damage in the brain and gut. This work compares changes in the enteric nervou..

Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology

Shalini S Rao, Larissa Lago, Irene Volitakis, Jay J Shukla, Gawain McColl, David I Finkelstein, Paul A Adlard

Journal article  |  2021  |  NEUROTHERAPEUTICS

The accumulation of neurofibrillary tangles (NFTs), which is composed of abnormally hyperphosphorylated tau aggregates, is the cla..

Fibrillar alpha-synuclein toxicity depends on functional lysosomes

Stephanie J Guiney, Paul A Adlard, Peng Lei, Celeste H Mawal, Ashley Bush, David Finkelstein, Scott Ayton

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Neurodegeneration in Parkinson's disease (PD) can be recapitulated in animals by administration of α-synuclein pre-formed fibrils ..

An intact membrane is essential for small extracellular vesicle-induced modulation of alpha-synuclein fibrillization

Cathryn L Ugalde, Shane E Gordon, Mitch Shambrook, Amirmohammad Nasiri Kenari, Bradley M Coleman, Matthew A Perugini, Victoria A Lawson, David I Finkelstein, Andrew F Hill

Journal article  |  2020  |  JOURNAL OF EXTRACELLULAR VESICLES

The misfolding and fibrillization of the protein, α-synuclein (αsyn), is associated with neurodegenerative disorders referred to a..

Reduced striatal vesicular monoamine transporter 2 in REM sleep behavior disorder: imaging prodromal parkinsonism

Leah C Beauchamp, Victor L Villemagne, David Finkelstein, Vincent Dore, Ashley Bush, Kevin J Barnham, Christopher C Rowe

Journal article  |  2020  |  SCIENTIFIC REPORTS

Motor deficits in parkinsonism are caused by degeneration of dopaminergic nigral neurons. The success of disease-modifying therapi..

Therapeutic applications of chelating drugs in iron metabolic disorders of the brain and retina

Ali Shahandeh, Bang V Bui, David I Finkelstein, Christine TO Nguyen

Journal article  |  2020  |  JOURNAL OF NEUROSCIENCE RESEARCH

Iron is essential for normal cellular function, however, excessive accumulation of iron in neural tissue has been implicated in bo..

PrPSc Oligomerization Appears Dynamic, Quickly Engendering Inherent M1000 Acute Synaptotoxicity

Simote T Foliaki, Victoria Lewis, Abu MT Islam, Matteo Senesi, David Finkelstein, Laura J Ellett, Victoria A Lawson, Paul A Adlard, Blaine R Roberts, Steven J Collins

Journal article  |  2020  |  BIOPHYSICAL JOURNAL

Prion diseases are neurodegenerative disorders pathogenically linked to cellular prion protein (PrPC) misfolding into abnormal con..

Investigation of nerve pathways mediating colorectal dysfunction in Parkinson's disease model produced by lesion of nigrostriatal dopaminergic neurons

Xin-yi Chai, Shanti Diwakarla, Ruslan V Pustovit, Rachel M McQuade, Madeleine Di Natale, Charlotte M Ermine, Clare L Parish, David I Finkelstein, John B Furness

Journal article  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Gastrointestinal (GI) dysfunction, including constipation, is a common non-motor symptom of Parkinson's disease (PD). ..