David Finkelstein

Therapeutic applications of chelating drugs in iron metabolic disorders of the brain and retina.

Ali Shahandeh, Bang V Bui, David I Finkelstein, Christine TO Nguyen

Journal article  |  2020  |  Journal of Neuroscience Research

Iron is essential for normal cellular function, however, excessive accumulation of iron in neural tissue has been implicated in bo..

PrPSc Oligomerization Appears Dynamic, Quickly Engendering Inherent M1000 Acute Synaptotoxicity

Simote T Foliaki, Victoria Lewis, Abu MT Islam, Matteo Senesi, David Finkelstein, Laura J Ellett, Victoria A Lawson, Paul A Adlard, Blaine R Roberts, Steven J Collins

Journal article  |  2020  |  Biophysical Journal

Prion diseases are neurodegenerative disorders pathogenically linked to cellular prion protein (PrPC) misfolding into abnormal con..

Investigation of nerve pathways mediating colorectal dysfunction in Parkinson's disease model produced by lesion of nigrostriatal dopaminergic neurons

Xin-yi Chai, Shanti Diwakarla, Ruslan V Pustovit, Rachel M McQuade, Madeleine Di Natale, Charlotte M Ermine, Clare L Parish, David I Finkelstein, John B Furness

Journal article  |  2020  |  Neurogastroenterology & Motility

BACKGROUND: Gastrointestinal (GI) dysfunction, including constipation, is a common non-motor symptom of Parkinson's disease (PD). ..

Distribution of Parkinson's disease associated RAB39B in mouse brain tissue

Yujing Gao, Gabrielle R Wilson, Sarah EM Stephenson, Mustapha Oulad-Abdelghani, Nicolas Charlet-Berguerand, Kiymet Bozaoglu, Catriona A McLean, Paul Q Thomas, David Finkelstein, Paul Lockhart

Journal article  |  2020  |  Molecular Brain

Regional iron distribution and soluble ferroprotein profiles in the healthy human brain

Erin J McAllum, Dominic J Hare, Irene Volitakis, Catriona A McLean, Ashley I Bush, David I Finkelstein, Blaine R Roberts

Journal article  |  2020  |  Progress in Neurobiology

Iron is essential for brain development and health where its redox properties are used for a number of neurological processes. How..

The Long Isoform of Intersectin-1 Has a Role in Learning and Memory

Nakisa Malakooti, Melanie A Pritchard, Feng Chen, Yong Yu, Charlotte Sgambelloni, Paul A Adlard, David I Finkelstein

Journal article  |  2020  |  Frontiers in Behavioral Neuroscience

Down syndrome is caused by partial or total trisomy of chromosome 21 and is characterized by intellectual disability and other dis..

Characterising the brain metalloproteome in Down syndrome patients with concomitant Alzheimer's pathology

Nakisa Malakooti, Blaine Roberts, Melanie A Pritchard, Irene Volitakis, Ron C Kim, Ira T Lott, Catriona A McLean, David Finkelstein, Paul A Adlard

Journal article  |  2020  |  Metallomics

Down syndrome (DS) is a common intellectual disability, with an incidence of 1 in 700 and is caused by trisomy 21. People with DS ..

Misfolded alpha-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells

Cathryn L Ugalde, Sarah J Annesley, Shane E Gordon, Katelyn Mroczek, Matthew A Perugini, Victoria A Lawson, Paul R Fisher, David I Finkelstein, Andrew F Hill

Journal article  |  2020  |  Disease Models & Mechanisms

The misfolding and aggregation of the largely disordered protein, α-synuclein, is a central pathogenic event that occurs in the sy..

alpha-Synuclein Regulates Development and Function of Cholinergic Enteric Neurons in the Mouse Colon

M Swaminathan, C Fung, D Finkelstein, JC Bornstein, JPP Foong

Journal article  |  2019  |  Neuroscience

Alpha-Synuclein (α-Syn) is expressed in the central nervous system and the nervous system of the gut (enteric nervous system, ENS)..

Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson's disease

Shanti Diwakarla, David I Finkelstein, Remy Constable, Olivia Artaiz, Madeleine Di Natale, Rachel M McQuade, Enie Lei, Xin-yi Chai, Mitchell T Ringuet, Linda J Fothergill, Victoria A Lawson, Laura J Ellett, Joel P Berger, John B Furness

Journal article  |  2019  |  Neurogastroenterology & Motility

BACKGROUND: Chronic stress exacerbates motor deficits and increases dopaminergic cell loss in several rodent models of Parkinson's..

Migration and Differentiation of Neural Stem Cells Diverted From the Subventricular Zone by an Injectable Self-Assembling beta-Peptide Hydrogel

Sepideh Motamed, Mark P Del Borgo, Kun Zhou, Ketav Kulkarni, Peter J Crack, Tobias D Merson, Marie-Isabel Aguilar, David Finkelstein, John S Forsythe

Journal article  |  2019  |  Frontiers in Bioengineering and Biotechnology

Neural stem cells, which are confined in localised niches are unable to repair large brain lesions because of an inability to migr..

Exercise and physical activity for people with Progressive Supranuclear Palsy: a systematic review

Susan C Slade, David Finkelstein, Jennifer L McGinley, Meg E Morris

Journal article  |  2019  |  Clinical Rehabilitation

Evaluating retinal biomarkers in a mouse model of Parkinson's disease

Christine Tram Oanh Nguyen, Katie Tran, Jeremiah Kah Heng Lim, Vickie Hoi Ying Wong, Ali Shahandeh, Algis J Vingrys, Bang V Bui, David Finkelstein

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

L-3,4-dihydroxyphenylalanine (L-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease

Jessica L Billings, Sarah L Gordon, Tristan Rawling, Philip A Doble, Ashley I Bush, Paul A Adlard, David I Finkelstein, Dominic J Hare

Journal article  |  2019  |  Journal of Neurochemistry

The role of lipids in alpha-synuclein misfolding and neurotoxicity

Cathryn L Ugalde, Victoria A Lawson, David I Finkelstein, Andrew F Hill

Journal article  |  2019  |  Journal of Biological Chemistry

Neurodegeneration in the enteric nervous system in an MPTP induced model of Parkinson's disease

Laura J Ellett, David I Finkelstein, Victoria A Lawson

Conference Proceedings  |  2019  |  PRION

PBT434 Prevents alpha-synuclein Aggregation, Neuron Loss, Motor Dysfunction and Reduces Glial Cell Inclusions in a Transgenic Mouse Model of Multiple System Atrophy

David Finkelstein, Nadia Stefanova, Paul Adlard, Margaret Bradbury, David Stamler

Conference Proceedings  |  2019  |  NEUROLOGY

Early existence and biochemical evolution characterise acutely synaptotoxic PrPSc

Simote Totauhelotu Foliaki, Victoria Lewis, Abu Mohammed Taufiqual Islam, Laura Jane Ellett, Matteo Senesi, David Isaac Finkelstein, Blaine Roberts, Victoria A Lawson, Paul Anthony Adlard, Steven John Collins

Journal article  |  2019  |  PLOS Pathogens

The Down Syndrome-Associated Protein, Regulator of Calcineurin-1, is Altered in Alzheimer's Disease and Dementia with Lewy Bodies

N Malakooti, C FOWLER, I Volitakis, CA McLean, RC Kim, Ashley Bush, A REMBACH, MA PRITCHARD, DI Finkelstein, PA Adlard

Journal article  |  2019  |  Journal of Alzheimer's disease & Parkinsonism

There is a known relationship between Alzheimer's disease (AD) and Down syndrome (DS), with the latter typically developing AD-lik..

The Down Syndrome-Associated Protein, Regulator of Calcineurin-1, is Altered in Alzheimer's Disease and Dementia with Lewy Bodies.

Malakooti N, undefined AIBL Research Group, Fowler C, Volitakis I, McLean Ca, Kim Rc, Bush Ai, Rembach A, Pritchard Ma, Finkelstein DI, Adlard Pa

Journal article  |  2019  |  Journal of Alzheimer's disease & Parkinsonism

There is a known relationship between Alzheimer's disease (AD) and Down syndrome (DS), with the latter typically developing AD-lik..

Metal chaperones: a novel therapeutic strategy for brain injury?

SD Portbury, A Sedjahtera, K Perrones, C Sgambelloni, M Zhang, PJ Crack, DI Finkelstein, PA Adlard

Journal article  |  2019  |  Brain Injury

Modulating Protein Phosphatase 2A Rescues Disease Phenotype in Neurodegenerative Tauopathies

Simon McKenzie-Nickson, Jacky Chan, Keyla Perez, Lin W Hung, Lesley Cheng, Amelia Sedjahtera, Lydia Gunawan, Paul A Adlard, David J Hayne, Lachlan E McInnes, Paul S Donnelly, David Finkelstein, Andrew F Hill, Kevin J Barnham

Journal article  |  2018  |  ACS Chemical Neuroscience

Targeting metals rescues the phenotype in an animal model of tauopathy

Amelia Sedjahtera, Lydia Gunawan, Lisa Bray, Lin Wai Hung, Jack Parsons, Nobuyuki Okamura, Victor L Villemagne, Kazuhiko Yanai, Xiang M Liu, Jacky Chan, Ashley I Bush, David I Finkelstein, Kevin J Barnham, Robert A Cherny, Paul A Adlard

Journal article  |  2018  |  Metallomics

Prion acute synaptotoxicity is largely driven by protease-resistant PrPSc species

Simote Totauhelotu Foliaki, Victoria Lewis, David Isaac Finkelstein, Victoria Lawson, Harold Arthur Coleman, Matteo Senesi, Abu Mohammed Taufiqual Islam, Feng Chen, Shannon Sarros, Blaine Roberts, Paul Anthony Adlard, Steven John Collins

Journal article  |  2018  |  PLOS Pathogens

Colonic motility and permeability deficits in A53T Mice

R McQuade, P Rajasekhar, S Diwakarla, R Constable, DP Poole, JP Berger, DI Finkelstein, JB Furness

Conference Proceedings  |  2018  |  NEUROGASTROENTEROLOGY AND MOTILITY

Trehalose elevates brain zinc levels following controlled cortical impact in a mouse model of traumatic brain injury

Stuart D Portbury, Dominic J Hare, David P Bishop, David I Finkelstein, Philip A Doble, Paul A Adlard

Journal article  |  2018  |  Metallomics

Acute Neurotoxicity Models of Prion Disease

AMT Islam, PA Adlard, DI Finkelstein, V Lewis, S Biggi, E Biasini, SJ Collins

Journal article  |  2018  |  ACS Chemical Neuroscience

Trehalose improves traumatic brain injury-induced cognitive impairment

Stuart D Portbury, Dominic J Hare, David I Finkelstein, Paul A Adlard

Journal article  |  2017  |  PLOS ONE

Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease

Michael P Gotsbacher, Thomas J Telfer, Paul K Witting, Kay L Double, David I Finkelstein, Rachel Codd

Journal article  |  2017  |  Metallomics

In vivo prion models and the disconnection between transmissibility and neurotoxicity

Matteo Senesi, Victoria Lewis, Jee H Kim, Paul A Adlard, David I Finkelstein, Steven J Collins

Journal article  |  2017  |  Ageing Research Reviews

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

David I Finkelstein, Jessica L Billings, Paul A Adlard, Scott Ayton, Amelia Sedjahtera, Colin L Masters, Simon Wilkins, David M Shackleford, Susan A Charman, Wojciech Bal, Izabela A Zawisza, Ewa Kurowska, Andrew L Gundlach, Sheri Ma, Ashley I Bush, Dominic J Hare, Philip A Doble, Simon Crawford, Elisabeth CL Gautier, Jack Parsons, et al.

Journal article  |  2017  |  ACTA NEUROPATHOLOGICA COMMUNICATIONS

Age modulates the injury-induced metallomic profile in the brain

Stuart D Portbury, Dominic J Hare, Charlotte J Sgambelloni, David P Bishop, David I Finkelstein, Philip A Doble, Paul A Adlard

Journal article  |  2017  |  Metallomics

Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion

Javier Castro-Hernandez, Paul A Adlard, David I Finkelstein

Journal article  |  2017  |  Scientific Reports

Ferroptosis and cell death mechanisms in Parkinson's disease

Stephanie J Guiney, Paul A Adlard, Ashley I Bush, David I Finkelstein, Scott Ayton

Journal article  |  2017  |  NEUROCHEMISTRY INTERNATIONAL

Lithium suppression of tau induces brain iron accumulation and neurodegeneration

P Lei, S Ayton, AT Appukuttan, S Moon, JA Duce, I Volitakis, R Cherny, SJ Wood, M Greenough, G Berger, C Pantelis, P McGorry, A Yung, DI Finkelstein, AI Bush

Journal article  |  2017  |  MOLECULAR PSYCHIATRY

Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease

Dominic J Hare, Barbara Rita Cardoso, Erika P Raven, Kay L Double, David I Finkelstein, Ewa A Szymlek-Gay, Beverley-Ann Biggs

Journal article  |  2017  |  NPJ PARKINSONS DISEASE

Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer's Disease

Stuart D Portbury, Dominic J Hare, Charlotte Sgambelloni, Kali Perronnes, Ashley J Portbury, David I Finkelstein, Paul A Adlard

Journal article  |  2017  |  Journal of Alzheimer's Disease

Metals in Alzheimer's and Parkinson's Disease: Relevance to Dementia with Lewy Bodies

Erin J McAllum, David I Finkelstein

Journal article  |  2016  |  Journal of Molecular Neuroscience

Pathogenic mechanisms of prion protein, amyloid-beta and alpha-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers

Cathryn L Ugalde, David I Finkelstein, Victoria A Lawson, Andrew F Hill

Journal article  |  2016  |  Journal of Neurochemistry

Implantable amyloid hydrogels for promoting stem cell differentiation to neurons

Subhadeep Das, Kun Zhou, Dhiman Ghosh, Narendra N Jha, Pradeep K Singh, Reeba S Jacob, Claude C Bernard, David I Finkelstein, John S Forsythe, Samir K Maji

Journal article  |  2016  |  NPG Asia Materials

Type-1 Interferons Contribute to the Neuroinflammatory Response and Disease Progression of the MPTP Mouse Model of Parkinson's Disease

Bevan S Main, Moses Zhang, Kate M Brody, Scott Ayton, Tony Frugier, David Steer, David Finkelstein, Peter J Crack, Juliet M Taylor

Journal article  |  2016  |  Glia

Restoration of intestinal function in an MPTP model of Parkinson's Disease

LJ Ellett, LW Hung, R Munckton, NA Sherratt, J Culvenor, A Grubman, JB Furness, AR White, DI Finkelstein, KJ Barnham, VA Lawson

Journal article  |  2016  |  SCIENTIFIC REPORTS

N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease

Dean J Wright, Laura J Gray, David I Finkelstein, Peter J Crouch, David Pow, Terence Y Pang, Shanshan Li, Zoe M Smith, Paul S Francis, Thibault Renoir, Anthony J Hannan

Journal article  |  2016  |  Human Molecular Genetics

Graphene Functionalized Scaffolds Reduce the Inflammatory Response and Supports Endogenous Neuroblast Migration when Implanted in the Adult Brain

Kun Zhou, Sepideh Motamed, George A Thouas, Claude C Bernard, Dan Li, Helena C Parkington, Harold A Coleman, David I Finkelstein, John S Forsythe

Journal article  |  2016  |  PLOS ONE

Effects of Neonatal Iron Feeding and Chronic Clioquinol Administration on the Parkinsonian Human A53T Transgenic Mouse

Jessica L Billings, Dominic J Hare, Milawaty Nurjono, Irene Volitakis, Robert A Cherny, Ashley I Bush, Paul A Adlard, David I Finkelstein

Journal article  |  2016  |  ACS Chemical Neuroscience

Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

DI Finkelstein, DJ Hare, JL Billings, A Sedjahtera, M Nurjono, E Arthofer, S George, JG Culvenor, AI Bush, PA Adlard

Journal article  |  2016  |  ACS Chemical Neuroscience

A time-course analysis of changes in cerebral metal levels following a controlled cortical impact

Stuart D Portbury, Dominic J Hare, Charlotte Sgambelloni, David I Finkelstein, Paul A Adlard

Journal article  |  2016  |  Metallomics

Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

David I Finkelstein, Dominic J Hare, Jessica L Billings, Amelia Sedjahtera, Milawaty Nurjono, Elisa Arthofer, Sonia George, Janetta G Culvenor, Ashley I Bush, Paul A Adlard

Journal article  |  2016  |  ACS chemical neuroscience

Iron Regulates Apolipoprotein E Expression and Secretion in Neurons and Astrocytes

He Xu, Victoria M Perreau, Krista A Dent, Ashley I Bush, David I Finkelstein, Paul A Adlard

Journal article  |  2016  |  Journal of Alzheimer's Disease

Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson's substantia nigra

Scott Ayton, Peng Lei, Catriona Mclean, Ashley Bush, David Finkelstein

Journal article  |  2016  |  SIGNAL TRANSDUCTION AND TARGETED THERAPY

Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of beta-Amyloid Toxicity and Are Mediated by Tau

Xuling Li, Peng Lei, Qingzhang Tuo, Scott Ayton, Qiao-Xin Li, Steve Moon, Irene Volitakis, Rong Liu, Colin L Masters, David I Finkelstein, Ashley I Bush

Journal article  |  2015  |  NEUROTHERAPEUTICS

Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way

He Xu, Veer B Gupta, Ian J Martins, Ralph N Martins, Christopher J Fowler, Ashley I Bush, David I Finkelstein, Paul A Adlard

Journal article  |  2015  |  NEUROBIOLOGY OF DISEASE

Is early-life iron exposure critical in neurodegeneration?

Dominic J Hare, Manish Arora, Nicole L Jenkins, David I Finkelstein, Philip A Doble, Ashley I Bush

Journal article  |  2015  |  Nature Reviews Neurology

Metal chaperones prevent zinc-mediated cognitive decline

Paul A Adlard, Jacqui Parncutt, Varsha Lal, Simon James, Dominic Hare, Philip Doble, David I Finkelstein, Ashley I Bush

Journal article  |  2015  |  Neurobiology of Disease

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

Peng Lei, Scott Ayton, Ambili Thoppuvalappil Appukuttan, Irene Volitakis, Paul A Adlard, David I Finkelstein, Ashley I Bush

Journal article  |  2015  |  NEUROBIOLOGY OF DISEASE

Comparative Study of Metal Quantification in Neurological Tissue Using Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging and X-ray Fluorescence Microscopy

Katherine M Davies, Dominic J Hare, Sylvain Bohic, Simon A James, Jessica L Billings, David I Finkelstein, Philip A Doble, Kay L Double

Journal article  |  2015  |  Analytical Chemistry

Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias

Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R Williams

Journal article  |  2015  |  Movement Disorders

GSK-3 beta dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and alpha-synuclein

JJ Credle, JL George, J Wills, V Duka, K Shah, Y-C Lee, O Rodriguez, T Simkins, M Winter, D Moechars, T Steckler, J Goudreau, DI Finkelstein, A Sidhu

Journal article  |  2015  |  Cell Death & Differentiation

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of beta-Amyloid Precursor Protein

Scott Ayton, Peng Lei, Dominic J Hare, James A Duce, Jessica L George, Paul A Adlard, Catriona McLean, Jack T Rogers, Robert A Cherny, David I Finkelstein, Ashley I Bush

Journal article  |  2015  |  JOURNAL OF NEUROSCIENCE

Cell infiltration into a 3D electrospun fiber and hydrogel hybrid scaffold implanted in the brain.

Christopher J Rivet, Kun Zhou, Ryan J Gilbert, David I Finkelstein, John S Forsythe

Journal article  |  2015  |  Biomatter

Tissue engineering scaffolds are often designed without appropriate consideration for the translational potential of the material...

High Order W02-Reactive Stable Oligomers of Amyloid-beta are Produced in vivo and in vitro via Dialysis and Filtration of Synthetic Amyloid-beta Monomer

Elysia Robb, Keyla Perez, Lin W Hung, Colin L Masters, Kevin J Barnham, Robert A Cherny, Ashley I Bush, Paul A Adlard, David I Finkelstein

Journal article  |  2015  |  JOURNAL OF ALZHEIMERS DISEASE

Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging

Bence Paul, Dominic J Hare, David P Bishop, Chad Paton, Tran Nguyen Van, Nerida Cole, Megan M Niedwiecki, Erica Andreozzi, Angela Vais, Jessica L Billings, Lisa Bray, Ashley I Bush, Gawain McColl, Blaine R Roberts, Paul A Adlard, David I Finkelstein, John Hellstrom, Janet M Hergt, Jon D Woodhead, Philip A Doble

Journal article  |  2015  |  CHEMICAL SCIENCE

Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging (vol 6, pg 5383, 2015)

Bence Paul, Dominic J Hare, David P Bishop, Chad Paton, Tran Nguyen Van, Nerida Cole, Megan M Niedzwiecki, Erica Andreozzi, Angela Vais, Jessica L Billings, Lisa Bray, Ashley I Bush, Gawain McColl, Blaine R Roberts, Paul A Adlard, David I Finkelstein, John Hellstrom, Janet M Hergt, Jon D Woodhead, Philip A Doble

Journal article  |  2015  |  CHEMICAL SCIENCE

Motor and cognitive deficits in aged tau knockout mice in two background strains

Peng Lei, Scott Ayton, Steve Moon, Qihao Zhang, Irene Volitakis, David I Finkelstein, Ashley I Bush

Journal article  |  2014  |  MOLECULAR NEURODEGENERATION

Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease

Scott Ayton, Peng Lei, Paul A Adlard, Irene Volitakis, Robert A Cherny, Ashley I Bush, David I Finkelstein

Journal article  |  2014  |  MOLECULAR NEURODEGENERATION

Glia and zinc in ageing and Alzheimer's disease: a mechanism for cognitive decline?

Sara M Hancock, David I Finkelstein, Paul A Adlard

Journal article  |  2014  |  Frontiers in Aging Neuroscience

Role of metal ions in the cognitive decline of Down syndrome

Nakisa Malakooti, Melanie A Pritchard, Paul A Adlard, David I Finkelstein

Journal article  |  2014  |  Frontiers in Aging Neuroscience

Interactions of metals and Apolipoprotein E in Alzheimer's disease

He Xu, David I Finkelstein, Paul A Adlard

Journal article  |  2014  |  Frontiers in Aging Neuroscience

Therapeutic protein supplementation corrects iron export fatigue in Parkinson's disease

S Ayton, P Lei, DI Finkelstein, AI Bush

Conference Proceedings  |  2014  |  MOVEMENT DISORDERS

Effects of GDNF-Loaded Injectable Gelatin-Based Hydrogels on Endogenous Neural Progenitor Cell Migration

Deniece Fon, Aswan Al-Abboodi, Peggy PY Chan, Kun Zhou, Peter Crack, David I Finkelstein, John S Forsythe

Journal article  |  2014  |  Advanced Healthcare Materials

A novel approach to rapidly prevent age-related cognitive decline

Paul A Adlard, Amelia Sedjahtera, Lydia Gunawan, Lisa Bray, Dominic Hare, Jessica Lear, Philip Doble, Ashley I Bush, David I Finkelstein, Robert A Cherny

Journal article  |  2014  |  AGING CELL

Rescue of the Friedreich Ataxia Knockout Mutation in Transgenic Mice Containing an FXN-EGFP Genomic Reporter

Joseph P Sarsero, Timothy P Holloway, Lingli Li, David I Finkelstein, Panos A Ioannou

Journal article  |  2014  |  PLoS One

Nanofibrous scaffolds releasing a small molecule BDNF-mimetic for the re-direction of endogenous neuroblast migration in the brain

Deniece Fon, Kun Zhou, Francesca Ercole, Friederike Fehr, Silvia Marchesan, Myles R Minter, Peter J Crack, David I Finkelstein, John S Forsythe

Journal article  |  2014  |  Biomaterials

The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue

Dominic J Hare, Jessica L George, Lisa Bray, Irene Volitakis, Angela Vais, Timothy M Ryan, Robert A Cherny, Ashley I Bush, Colin L Masters, Paul A Adlard, Philip A Doble, David I Finkelstein

Journal article  |  2014  |  JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Increased Ndfip1 in the Substantia Nigra of Parkinsonian Brains Is Associated with Elevated Iron Levels

Jason Howitt, Amanda M Gysbers, Scott Ayton, Francine Carew-Jones, Ulrich Putz, David I Finkelstein, Glenda M Halliday, Seong-Seng Tan

Journal article  |  2014  |  PLoS One

A review of β-amyloid neuroimaging in Alzheimer's disease

PA Adlard, BA Tran, DI Finkelstein, PM Desmond, LA Johnston, AI Bush, GF Egan

Journal article  |  2014  |  Frontiers in Neuroscience

Alzheimer's disease (AD) is the most common cause of dementia worldwide. As advancing age is the greatest risk factor for developi..

An iron-dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

Dominic J Hare, Peng Lei, Scott Ayton, Blaine R Roberts, Rudolf Grimm, Jessica L George, David P Bishop, Alison D Beavis, Sarah J Donovan, Gawain McColl, Irene Volitakis, Colin L Masters, Paul A Adlard, Robert A Cherny, Ashley I Bush, David I Finkelstein, Philip A Doble

Journal article  |  2014  |  CHEMICAL SCIENCE

Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival

Per Holmfeldt, Jennifer Pardieck, Anjelica C Saulsberry, Satish Kumar Nandakumar, David Finkelstein, John T Gray, Derek A Persons, Shannon McKinney-Freeman

Journal article  |  2013  |  Blood

PARKINSON'S DISEASE; TOWARDS NEW DISEASE MODIFYING THERAPIES

DI Finkelstein

Conference Proceedings  |  2013  |  Clinical and Experimental Pharmacology and Physiology

Clioquinol Synergistically Augments Rescue by Zinc Supplementation in a Mouse Model of Acrodermatitis Enteropathica

Jim Geiser, Robert C De Lisle, David Finkelstein, Paul A Adlard, Ashley I Bush, Glen K Andrews

Journal article  |  2013  |  PLOS ONE

The neuroinflammatory response induced by MPTP is altered in mice lacking the type-I interferon-alpha receptor-1 (IFNAR1)

JM Taylor, BS Main, M Zhang, S Ayton, D Finkelstein, PJ Crack

Conference Proceedings  |  2013  |  MOVEMENT DISORDERS

Serotonin dysfunction in Parkinson's disease does not correlate with levodopa-induced dyskinesias

P Cheshire, S Ayton, K Bertram, H Ling, SS O'Sullivan, A Li, G Halliday, C McLean, T Revesz, DI Finkelstein, E Storey, DR Williams

Conference Proceedings  |  2013  |  MOVEMENT DISORDERS

PBT434, a novel 8-hydroxyquinazolinone, preserves nigro-striatal circuitry, improves motor performance and inhibits alpha synuclein accumulation in animal models of Parkinson's disease by modulation of iron homeostasis

DI Finkelstein, JL George, PA Adlard, CL Masters, DJ Hare, PA Doble, E Gautier, J Parsons, G Kok, P Huggins, KJ Barnham, AI Bush, RA Cherny

Conference Proceedings  |  2013  |  MOVEMENT DISORDERS

The effect of dopamine on MPTP-induced rotarod disability

Scott Ayton, Jessica L George, Paul A Adlard, Ashley I Bush, Robert A Cherny, David I Finkelstein

Journal article  |  2013  |  NEUROSCIENCE LETTERS

Intravenous Immunglobulin Binds Beta Amyloid and Modifies Its Aggregation, Neurotoxicity and Microglial Phagocytosis In Vitro

Susann Cattepoel, Alexander Schaub, Miriam Ender, Annette Gaida, Alain Kropf, Ursula Guggisberg, Marc W Nolte, Louis Fabri, Paul A Adlard, David I Finkelstein, Reinhard Bolli, Sylvia M Miescher

Journal article  |  2013  |  PLoS One

A NOVEL RELATIONSHIP BETWEEN beta-AMYLOID PROTEIN PRECURSOR AND TAU IN ALZHEIMER'S DISEASE RELATED IRON DISRUPTION

James Duce, Peng Lei, Andrew Tsatsanis, Bruce Wong, Linh Lam, Scott Ayton, Jack Rogers, David Finkelstein, Ashley Bush

Conference Proceedings  |  2013  |  AMERICAN JOURNAL OF HEMATOLOGY

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

Scott Ayton, Peng Lei, James A Duce, Bruce XW Wong, Amelia Sedjahtera, Paul A Adlard, Ashley I Bush, David I Finkelstein

Journal article  |  2013  |  ANNALS OF NEUROLOGY

Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic Function

Adam W Oaks, Maya Frankfurt, David I Finkelstein, Anita Sidhu

Journal article  |  2013  |  PLOS ONE

Amine oxidase activity of beta-amyloid precursor protein modulates systemic and local catecholamine levels

JA Duce, S Ayton, AA Miller, A Tsatsanis, LQ Lam, L Leone, JE Corbin, H Butzkueven, TJ Kilpatrick, JT Rogers, KJ Barnham, DI Finkelstein, AI Bush

Journal article  |  2013  |  Molecular Psychiatry

Metallobiology of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity

Dominic J Hare, Paul A Adlard, Philip A Doble, David I Finkelstein

Journal article  |  2013  |  Metallomics: integrated biometal science

Zinc in Alzheimer's and Parkinson's Diseases

S AYTON, DI Finkelstein, RA Cherny, AI Bush, PA Adlard

Book Chapter  |  2013

The Role of the Plasma Membrane Redox System in the Pathogenesis of Alzheimer's Disease

Sara M Hancock, David I Finkelstein, Ashley I Bush, Paul A Adlard

Book Chapter  |  2013

Type-I interferon signaling is pro-inflammatory in models of Parkinson's disease

Bevan Main, Moses Zhang, Scott Ayton, David Finkelstein, Peter Crack, Juliet Taylor

Conference Proceedings  |  2012  |  JOURNAL OF NEUROIMMUNOLOGY

Method to Impart Electro- and Biofunctionality to Neural Scaffolds Using Graphene-Polyelectrolyte Multilayers

Kun Zhou, George A Thouas, Claude C Bernard, David R Nisbet, David I Finkelstein, Dan Li, John S Forsythe

Journal article  |  2012  |  ACS Applied Materials and Interfaces

High-Resolution Elemental Bioimaging of Ca, Mn, Fe, Co, Cu, and Zn Employing LA-ICP-MS and Hydrogen Reaction Gas

Jessica Lear, Dominic J Hare, Fred Fryer, Paul A Adlard, David I Finkelstein, Philip A Doble

Journal article  |  2012  |  Analytical Chemistry

Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory

Katherine R Martin, Alicia Corlett, Daphne Dubach, Tomris Mustafa, Harold A Coleman, Helena C Parkington, Tobias D Merson, James A Bourne, Silvia Porta, Maria L Arbones, David I Finkelstein, Melanie A Pritchard

Journal article  |  2012  |  Human Molecular Genetics

Three-Dimensional Atlas of Iron, Copper, and Zinc in the Mouse Cerebrum and Brainstem

Dominic J Hare, Jason K Lee, Alison D Beavis, Amanda van Gramberg, Jessica George, Paul A Adlard, David I Finkelstein, Philip A Doble

Journal article  |  2012  |  Analytical Chemistry

The hypoxia imaging agent Cu-II(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

Lin W Hung, Victor L Villemagne, Lesley Cheng, Nicki A Sherratt, Scott Ayton, Anthony R White, Peter J Crouch, SinChun Lim, Su Ling Leong, Simon Wilkins, Jessica George, Blaine R Roberts, Chi LL Pham, Xiang Liu, Francis CK Chiu, David M Shackleford, Andrew K Powell, Colin L Masters, Ashley I Bush, Graeme O'Keefe, et al.

Journal article  |  2012  |  JOURNAL OF EXPERIMENTAL MEDICINE

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce XW Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce, Ashley I Bush

Journal article  |  2012  |  Nature Medicine

Improving acquisition times of elemental bio-imaging for quadrupole-based LA-ICP-MS

Jessica Lear, Dominc Hare, Paul Adlard, David Finkelstein, Philip Doble

Journal article  |  2012  |  Journal of Analytical Atomic Spectrometry

PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease.

Robert A Cherny, Scott Ayton, David I Finkelstein, Ashley I Bush, Gawain McColl, Stephen M Massa

Journal article  |  2012  |  Journal of Huntington's Disease

BACKGROUND: There is evidence that interaction with biologically important metals, particularly copper and iron, contributes to th..

Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (Cu-II(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

Cynthia PW Soon, Paul S Donnelly, Bradley J Turner, Lin W Hung, Peter J Crouch, Nicki A Sherratt, Jiang-Li Tan, Nastasia K-H Lim, Linh Lam, Laura Bica, SinChun Lim, James L Hickey, Julia Morizzi, Andrew Powell, David I Finkelstein, Janetta G Culvenor, Colin L Masters, James Duce, Anthony R White, Kevin J Barnham, et al.

Journal article  |  2011  |  Journal of Biological Chemistry

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

Paul A Adlard, Laura Bica, Anthony R White, Milawaty Nurjono, Gulay Filiz, Peter J Crouch, Paul S Donnelly, Roberto Cappai, David I Finkelstein, Ashley I Bush

Journal article  |  2011  |  PLOS ONE

Tau protein: Relevance to Parkinson's disease

Peng Lei, Scott Ayton, David I Finkelstein, Paul A Adlard, Colin L Masters, Ashley I Bush

Journal article  |  2010  |  International Journal of Biochemistry and Cell Biology

alpha-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced alpha-Synuclein and PINK1 Levels After Rotenone Treatment

Sonia George, Su San Mok, Milawaty Nurjono, Scott Ayton, David I Finkelstein, Colin L Masters, Qiao-Xin Li, Janetta G Culvenor

Journal article  |  2010  |  Journal of Molecular Neuroscience

Implantation of Functionalized Thermally Gelling Xyloglucan Hydrogel Within the Brain: Associated Neurite Infiltration and Inflammatory Response

David R Nisbet, Andrew E Rodda, Malcolm K Horne, John S Forsythe, David I Finkelstein

Journal article  |  2010  |  Tissue Engineering. Part A. Tissue Engineering

Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

Paul A Adlard, Jacqui M Parncutt, David I Finkelstein, Ashley I Bush

Journal article  |  2010  |  Journal of Neuroscience

Integration of functionalised injectable hydrogels for brain tissue engineering

DR Nisbet, DI Finkelstein, JS Forysthe

Journal article  |  2010  |  European Cells and Materials

Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain

Dominic J Hare, Jessica L George, Rudolph Grimm, Simon Wilkins, Paul A Adlard, Robert A Cherny, Ashley I Bush, David I Finkelstein, Philip Doble

Journal article  |  2010  |  Metallomics: integrated biometal science

Dopamine D-2 Receptor Knockout Mice Develop Features of Parkinson Disease

Rogan B Tinsley, Chris R Bye, Clare L Parish, Angela Tziotis-Vais, Sonia George, Janetta G Culvenor, Qiao-Xin Li, Colin L Masters, David I Finkelstein, Malcolm K Horne

Journal article  |  2009  |  Annals of Neurology

Neurite infiltration and cellular response to electrospun polycaprolactone scaffolds implanted into the brain

David R Nisbet, Andrew E Rodda, Malcolm K Horne, John S Forsythe, David I Finkelstein

Journal article  |  2009  |  Biomaterials

Review Paper: A Review of the Cellular Response on Electrospun Nanofibers for Tissue Engineering

DR Nisbet, JS Forsythe, W Shen, DI Finkelstein, MK Horne

Journal article  |  2009  |  Journal of Biomaterials Applications

Surface and bulk characterisation of electrospun membranes: Problems and improvements

David R Nisbet, Andrew E Rodda, David I Finkelstein, Malcolm K Horne, John S Forsythe, Wei Shen

Journal article  |  2009  |  Colloids and Surfaces B: Biointerfaces

Effect of unilateral lesion of the nigrostriatal dopamine pathway on survival and neurochemistry of parafascicular nucleus neurons in the rat - Evaluation of time-course and LGR8 expression

Katayoun Sedahat, David I Finkelstein, Andrew L Gundlach

Journal article  |  2009  |  Brain Research

Enhancing neurite outgrowth from primary neurones and neural stem cells using thermoresponsive hydrogel scaffolds for the repair of spinal cord injury

DR Nisbet, D Moses, TR Gengenbach, JS Forsythe, DI Finkelstein, MK Horne

Journal article  |  2009  |  Journal of Biomedical Materials Research Part A

Targeting the Progression of Parkinson's Disease

JL George, S Mok, D Moses, S Wilkins, AI Bush, RA Cherny, DI Finkelstein

Journal article  |  2009  |  CURRENT NEUROPHARMACOLOGY

Altered fast- and slow-twitch muscle fibre characteristics in female mice with a (S248F) knock-in mutation of the brain neuronal nicotinic acetylcholine receptor

David J Cannata, David I Finkelstein, Ilse Gantois, Yaroslav Teper, John Drago, Jan M West

Journal article  |  2009  |  Journal of Muscle Research and Cell Motility

Erratum: Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities (Human Molecular Genetic (2008) vol. 17(21) (3281-3290) 10.1093/hmg/ddn224)

Y Yu, PY Chu, DN Bowser, DJ Keating, D Dubach, I Harper, J Tkalcevic, DI Finkelstein, MA Pritchard

Journal article  |  2009  |  Human Molecular Genetics

Molecular level and microstructural characterisation of thermally sensitive chitosan hydrogels

KE Crompton, JS Forsythe, MK Horne, DI Finkelstein, RB Knott

Journal article  |  2009  |  Soft Matter

Neural tissue engineering of the CNS using hydrogels - A review (Journal of Biomedical Materials Research Part B Applied Biomaterials) (2003) 5, (293-347) DOI: 10.1002/jbm.b.31207)

DR Nisbet, KE Crompton, MK Horne, DI Finkelstein, JS Forsythe

Journal article  |  2009  |  Journal of Biomedical Materials Research - Part B Applied Biomaterials

Quantitative elemental bio-imaging of Mn, Fe, Cu and Zn in 6-hydroxydopamine induced Parkinsonism mouse models

Dominic Hare, Brian Reedy, Rudolf Grimm, Simon Wilkins, Irene Volitakis, Jessica L George, Robert A Cherny, Ashley I Bush, David I Finkelstein, Philip Doble

Journal article  |  2009  |  Metallomics: integrated biometal science

Clioquinol Protects Against Cell Death in Parkinson's Disease Models In Vivo and In Vitro

Simon Wilkins, Colin L Masters, Ashley I Bush, Robert A Cherny, David I Finkelstein

Conference Proceedings  |  2009  |  BASAL GANGLIA IX

Relaxin Family Peptides and Receptors in Mammalian Brain Anatomical Insights and Diverse Functional Possibilities

Andrew L Gundlach, Sherie Ma, Qian Sang, Pei-Juan Shen, Loretta Piccenna, Katayoun Sedaghat, Craig M Smith, Ross AD Bathgate, Andrew J Lawrence, Geoffrey W Tregear, John D Wade, David I Finkelstein, Pascal Bonaventure, Changlu Liu, Timothy W Lovenberg, Steve W Sutton

Journal article  |  2009  |  Annals of The New York Academy of Sciences

Neural Tissue Engineering of the CNS Using Hydrogels - A review (vol 5, pg 293, 2003)

David R Nisbet, Kylie E Crompton, Malcolm K Horne, David I Finkelstein, John S Forsythe

Journal article  |  2009  |  Journal of Biomedical Materials Research Part B: Applied Biomaterials

Implantation of electrospun PCL scaffolds in the brain

DR Nisbet, JS Forsythe, MK Horne, DI Finkelstein

Conference Proceedings  |  2008  |  8th World Biomaterials Congress 2008

Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities

Yong Yu, Po-Yin Chu, David N Bowser, Damien J Keating, Daphne Dubach, Ian Harper, Josephine Tkalcevic, David I Finkelstein, Melanie A Pritchard

Journal article  |  2008  |  Human Molecular Genetics

Leucine-rich repeat-containing G-protein-coupled receptor 8 in the rat brain: Enrichment in thalamic neurons and their efferent projections

K Sedaghat, PJ Shen, DI Finkelstein, JM Henderson, AL Gundlach

Journal article  |  2008  |  Neuroscience

Neural tissue engineering of the CNS using hydrogels

DR Nisbet, KE Crompton, MK Horne, DI Finkelstein, JS Forsythe

Journal article  |  2008  |  Journal of Biomedical Materials Research - Part B

Neural tissue engineering of the CNS using hydrogels

David R Nisbet, Kylie E Crompton, Malcolm K Horne, David I Finkelstein, John S Forsythe

Journal article  |  2008  |  Journal of biomedical materials research. Part B, Applied biomaterials

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial A beta

Paul A Adlard, Robert A Cherny, David I Finkelstein, Elisabeth Gautier, Elysia Robb, Mikhalina Cortes, Irene Volitakis, Xiang Liu, Jeffrey P Smith, Keyla Perez, Katrina Laughton, Qiao-Xin Li, Susan A Charman, Joseph A Nicolazzo, Simon Wilkins, Karolina Deleva, Toni Lynch, Gaik Kok, Craig W Ritchie, Rudolph E Tanzi, et al.

Journal article  |  2008  |  Neuron

Fetal striatum- and ventral mesencephalon-derived expanded neurospheres rescue dopaminergic neurons in vitro and the nigro-striatal system in vivo

D Moses, J Drago, Y Teper, I Gantois, DI Finkelstein, MK Horne

Journal article  |  2008  |  Neuroscience

Sprouting of dopamine terminals and altered dopamine release and uptake in Parkinsonian dyskinaesia

Joohyung Lee, Wen-Mei Zhu, Davor Stanic, David I Finkelstein, Marjorie H Horne, Jasmine Henderson, Andrew J Lawrence, Louise O'Connor, Doris Tomas, John Drago, Malcolm K Horne

Journal article  |  2008  |  Brain

Estrogen enhances the number of nigral dopaminergic neurons of adult male mice without affecting nigral neuroglial number and morphology

Wanida Tripanichkul, Em-Orn Jaroensuppaperch, David Isaac Finkelstein

Journal article  |  2008  |  Neuroscience Letters

17 beta-Estradiol reduces nitrotyrosine immunoreactivity and increases SOD1 and SOD2 immunoreactivity in nigral neurons in male mice following MPTP insult

Wanida Tripanichkul, Kittisak Sripanichkulchai, James A Duce, David I Finkelstein

Journal article  |  2007  |  Brain Research

Interaction of embryonic cortical neurons on nanofibrous scaffolds for neural tissue engineering

DR Nisbet, S Pattanawong, NE Ritchie, W Shen, DI Finkelstein, MK Horne, JS Forsythe

Journal article  |  2007  |  Journal of Neural Engineering

Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering

KE Crompton, JD Goud, RV Bellamkonda, TR Gengenbach, DI Finkelstein, MK Horne, JS Forsythe

Journal article  |  2007  |  Biomaterials

Metals, oxidative stress, and brain biology

D FINKELSTEIN, T LYNCH, S WILKINS, R CHERNY, A BUSH

Book Chapter  |  2007

Metals, Oxidative Stress, and Brain Biology

DI Finkelstein, T Lynch, S Wilkins, RA Cherny, AI Bush

Book Chapter  |  2007

Null mutation of the alpha 4 nicotinic receptor subunit increases the propensity of muscarinic-mediated neuronal bursting in mouse hippocampal slices

Christopher A Reid, Harold A Coleman, David I Finkelstein, Malcolm K Horne, John Drago

Journal article  |  2006  |  Neuropharmacology

The effect of surface hydrophilicity on the behavior of embryonic cortical neurons

DR Nisbet, S Pattanawong, J Nunan, W Shen, MK Horne, DI Finkelstein, JS Forsythe

Journal article  |  2006  |  Journal of Colloid and Interface Science

Inflammatory response on injection of chitosan/GP to the brain

KE Crompton, D Tomas, DI Finkelstein, M Marr, JS Forsythe, MK Horne

Journal article  |  2006  |  Journal of Materials Science: Materials in Medicine

Murine embryonic EGF-responsive ventral mesencephalic neurospheres display distinct regional specification and promote survival of dopaminergic neurons

David Moses, Yaroslav Teper, Ilse Gantois, David I Finkelstein, Malcolm K Horne, John Drago

Journal article  |  2006  |  Experimental Neurology

Estrogen down-regulates glial activation in male mice following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication

Wanida Tripanichkul, Kittisak Sripanichkulchai, David I Finkelstein

Journal article  |  2006  |  Brain Research

Morphology and gelation of thermosensitive xyloglucan hydrogels

DR Nisbet, KE Crompton, SD Hamilton, S Shirakawa, RJ Prankerd, DI Finkelstein, MK Horne, JS Forsythe

Journal article  |  2006  |  Biophysical Chemistry

Characterization of BRCA1 and BRCA2 mutations in a large United States sample.

Sining Chen, Edwin S Iversen, Tara Friebel, Dianne Finkelstein, Barbara L Weber, Andrea Eisen, Leif E Peterson, Joellen M Schildkraut, Claudine Isaacs, Beth N Peshkin, Camille Corio, Leoni Leondaridis, Gail Tomlinson, Debra Dutson, Rich Kerber, Christopher I Amos, Louise C Strong, Donald A Berry, David M Euhus, Giovanni Parmigiani

Journal article  |  2006  |  Journal of Clinical Oncology

PURPOSE: An accurate evaluation of the penetrance of BRCA1 and BRCA2 mutations is essential to the identification and clinical man..

Estrogen protects against MPTP through glial attenuation

Wanida Tripanichkul, Kittisak Sripanichkulchai, David Finkelstein

Journal article  |  2006  |  NEUROSCIENCE RESEARCH

Mice lacking the alpha 4 nicotinic receptor subunit fail to modulate dopaminergic neuronal arbors and possess impaired dopamine transporter function

CL Parish, J Nunan, DI Finkelstein, FN McNamara, JY Wong, JL Waddington, RM Brown, AJ Lawrence, MK Horne, J Drago

Journal article  |  2005  |  Molecular Pharmacology

Chronic corticotropin-releasing factor type 1 receptor antagonism with antalarmin regulates the dopaminergic system of Fawn-Hooded rats

AJ Lawrence, CL Parish, F Chen, DJ Lodge, EV Krstew, K Card, DI Finkelstein, MK Horne

Journal article  |  2005  |  Journal of Neurochemistry

Morphology and gelation of thermosensitive chitosan hydrogels

KE Crompton, RJ Prankerd, DM Paganin, TF Scott, MK Horne, DI Finkelstein, KA Gross, JS Forsythe

Journal article  |  2005  |  Biophysical Chemistry

Dopaminergic innervation of the human striatum in Parkinson's disease

M Porritt, D Stanic, D Finkelstein, P Batchelor, S Lockhart, A Hughes, R Kalnins, D Howells

Journal article  |  2005  |  Movement Disorders

Differential expression of the GABA transporters GAT-1 and GAT-3 in brains of rats, cats, monkeys and humans

DV Pow, RKP Sullivan, SM Williams, HL Scott, PR Dodd, D Finkelstein

Journal article  |  2005  |  Cell and Tissue Research

Haloperidol treatment reverses behavioural and anatomical changes in cocaine-dependent mice

CL Parish, J Drago, D Stanic, E Borrelli, DI Finkelstein, MK Horne

Journal article  |  2005  |  Neurobiology of Disease

Postural changes after lesions of the substantia nigra pars reticulata in hemiparkinsonian monkeys

JM Henderson, D Stanic, D Tomas, J Patch, MK Horne, D Bourke, DI Finkelstein

Journal article  |  2005  |  Behavioural Brain Research

Alterations in the Proportions of Skeletal Muscle Proteins following a Unilateral Lesion to the Substantia Nigra Pars Compacta of Rats

Sliwinski A, Stanic D, Finkelstein DI, Ilic M, West JM, Dooley PC

Journal article  |  2005  |  Journal of Muscle Research and Cell Motility

Alterations in the proportions of skeletal muscle proteins following a unilateral lesion to the substantia nigra pars compacta of rats

A Sliwinski, D Stanic, DI Finkelstein, M Ilic, JM West, PC Dooley

Journal article  |  2005  |  Journal of Muscle Research and Cell Motility

Glial glutamate transporter expression patterns in brains from multiple mammalian species

SM Williams, RKP Sullivan, HL Scott, DI Finkelstein, PB Colditz, BE Lingwood, PR Dodd, DV Pow

Journal article  |  2005  |  Glia

Spontaneous formation of Lewy bodies in a rodent

J Nunan, A Tsiotis-Vais, S George, CL Parish, DK Grandy, DI Finkelstein, J Drago, MK Horne

Conference Proceedings  |  2005  |  BASAL GANGLIA VIII

Morphology studies of thermosensitive chitosan hydrogels using LSCM

KE Crompton, TF Scott, DI Finkelstein, MK Horne, KA Gross, JS Forsythe

Conference Proceedings  |  2004  |  Transactions - 7th World Biomaterials Congress

Merozoite surface proteins 4 and 5 of Plasmodium knowlesi have differing cellular localisation and association with lipid rafts

CG Black, L Wang, AE Topolska, DI Finkelstein, MK Horne, AW Thomas, N Mohandas, RL Coppel

Journal article  |  2004  |  Molecular and Biochemical Parasitology

Glial responses associated with dopaminergic striatal reinnervation following lesions of the rat substantia nigra

D Stanic, W Tripanichkul, J Drago, DI Finkelstein, MK Horn

Journal article  |  2004  |  Brain Research

Quantified assessment of terminal density and innervation.

David I Finkelstein, Davor Stanic, Clare L Parish, John Drago, Malcolm K Horne

Journal article  |  2004  |  Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]

Stereological methods allow for the determination of cell numbers, terminal densities, and, subsequently, the estimation of termin..

Dopamine dynamic changes and behavioural assessment in advanced Parkinson's disease and levodopa induced dyskinesia models

WM Zhu, DI Finkelstein, KD Buxton, J Drago, MK Horne

Conference Proceedings  |  2003  |  JOURNAL OF NEUROCHEMISTRY

Changes in function and ultrastructure of striatal dopaminergic terminals that regenerate following partial lesions of the SNpc (vol 86, pg 329, 2003)

D Stanic, CL Parish, WM Zhu, EV Krstew, AJ Lawrence, J Drago, DI Finkelstein, MK Horne

Journal article  |  2003  |  Journal of Neurochemistry

Erratum: Changes in function and ultrastructure of striatal dopaminergic terminals that regenerate following partial lesions of the Snpc (Journal of Neurochemistry (2003) 86 (329-343)

D Stanic, CL Parish, WM Zhu, EV Krstew, AJ Lawrence, J Drago, DI Finkelstein, MK Horne

Journal article  |  2003  |  Journal of Neurochemistry

Modelling the relationship between continuous covariates and clinical events using isotonic regression.

Marek Ancukiewicz, Dianne M Finkelstein, David A Schoenfeld

Journal article  |  2003  |  Statistics in Medicine

In a medical study we are often interested in graphically displaying the relationship between continuous variables and clinical ev..

Timecourse of striatal re-innervation following lesions of dopaminergic SNpc neurons of the rat

D Stanic, DI Finkelstein, DW Bourke, J Drago, MK Horne

Journal article  |  2003  |  European Journal of Neuroscience

Neurochemical changes in dopamine D1, D3 and D1/D3 receptor knockout mice

JYF Wong, JJ Clifford, JS Massalas, DI Finkelstein, MK Horne, JL Waddington, J Drago

Journal article  |  2003  |  European Journal of Pharmacology

Changes in function and ultrastructure of striatal dopaminergic terminals that regenerate following partial lesions of the SNpc

D Stanic, CL Parish, WM Zhu, EV Krstew, AJ Lawrence, J Drago, DI Finkelstein, MK Horne

Journal article  |  2003  |  Journal of Neurochemistry

Neuronal nicotinic receptors: insights gained from gene knockout and knockin mutant mice

J Drago, CD McColl, MK Horne, DI Finkelstein, SA Ross

Journal article  |  2003  |  Cellular and Molecular Life Sciences (CMLS)

D-2 Dopamine receptor blockade results in sprouting of DA axons in the intact animal but prevents sprouting following nigral lesions

W Tripanichkul, D Stanic, J Drago, DI Finkelstein, MK Horne

Journal article  |  2003  |  European Journal of Neuroscience

D2Dopamine receptor blockade results in sprouting of DA axons in the intact animal but prevents sprouting following nigral lesions

W Tripanichkul, D Stanic, J Drago, DI Finkelstein, MK Horne

Journal article  |  2003  |  European Journal of Neuroscience

Electroencephalographic characterisation of pentylenetetrazole-induced seizures in mice lacking the alpha 4 subunit of the neuronal nicotinic receptor

CD McColl, MK Horne, DI Finkelstein, JYF Wong, SF Berkovic, J Drago

Journal article  |  2003  |  Neuropharmacology

The role of interleukin-1, interleukin-6, and glia in inducing growth of neuronal terminal arbors in mice

CL Parish, DI Finkelstein, W Tripanichkul, AR Satoskar, J Drago, MK Horne

Journal article  |  2002  |  The Journal of Neuroscience

Effects of long-term treatment with dopamine receptor agonists and antagonists on terminal arbor size

CL Parish, D Stanic, J Drago, E Borrelli, DI Finkelstein, MK Horne

Journal article  |  2002  |  European Journal of Neuroscience

A mouse model of spinal and bulbar muscular atrophy

P McManamny, HS Chy, DI Finkelstein, RG Craythorn, PJ Crack, I Kola, SS Cheema, MK Horne, NG Wreford, MK O'Bryan, DM de Kretser, JR Morrison

Journal article  |  2002  |  Human Molecular Genetics

Proconvulsant-induced seizures in alpha(4) nicotinic acetylcholine receptor subunit knockout mice

JYF Wong, SA Ross, C McColl, JS Massalas, E Powney, DI Finkelstein, M Clark, MK Horne, SF Berkovic, J Drago

Journal article  |  2002  |  Neuropharmacology

Comparison of the basal ganglia in rats, marmosets, macaques, baboons, and humans: Volume and neuronal number for the output, internal relay, and striatal modulating nuclei

CD Hardman, JM Henderson, DI Finkelstein, MK Horne, G Paxinos, GM Halliday

Journal article  |  2002  |  The Journal of Comparative Neurology

Behavioural effects of neurosurgery to the substantia nigra pars reticulata in parkinsonian monkeys

JM Henderson, DI Finkelstein, D Stanic, D Tomas, J Patch, D Bourke

Conference Proceedings  |  2002  |  MOVEMENT DISORDERS

The role of dopamine receptors in regulating the size of axonal arbours

DI Finkelstein, CL Parish, D Stanic, E Borrelli, J Drago, MK Horne

Conference Proceedings  |  2002  |  BASAL GANGLIA VII

Diurnal variation of c-Fos expression in subdivisions of the dorsal raphe nucleus of the Mongolian gerbil (Meriones unguiculatus).

S Janusonis, KV Fite

Journal article  |  2001  |  The Journal of Comparative Neurology

Recent studies suggest that the dorsal raphe nucleus (DRN) of the brainstem contains several subdivisions that differ both anatomi..

Projections from the substantia nigra pars reticulata to the motor thalamus of the rat: Single axon reconstructions and immunohistochemical study

HT Kha, DI Finkelstein, D Tomas, J Drago, DV Pow, MK Horne

Journal article  |  2001  |  The Journal of Comparative Neurology

The role of dopamine receptors in regulating the size of axonal arbors

CL Parish, DI Finkelstein, J Drago, E Borrelli, MK Horne

Journal article  |  2001  |  The Journal of Neuroscience

Kainate receptors, cellular signaling and excitotoxic neuronal death: New pharmacological evidence for the functional involvement of low-affinity and metabotropic kainate receptors

SF Giardina, FY Carroll, RX Moldrich, DI Finkelstein, MK Horne, AJ Lawrence, NS Cheung, PM Beart

Conference Proceedings  |  2001  |  EXCITATORY AMINO ACIDS: TEN YEARS LATER

Comparative study on the distribution patterns of P2X(1)-P2X(6) receptor immunoreactivity in the brainstem of the rat and the common marmoset (Callithrix jacchus): Association with catecholamine cell groups

ST Yao, JA Barden, DI Finkelstein, MR Bennett, AJ Lawrence

Journal article  |  2000  |  Journal of Comparative Neurology

Study of projections from the entopeduncular nucleus to the thalamus of the rat

HT Kha, DI Finkelstein, DV Pow, AJ Lawrence, MK Horne

Journal article  |  2000  |  The Journal of Comparative Neurology

Early direct and transneuronal effects in mice with targeted expression of a toxin gene to D1 dopamine receptor neurons

P Padungchaichot, JYF Wong, AL Natoli, JS Massalas, DI Finkelstein, AL Lawrence, J Drago

Journal article  |  2000  |  Neuroscience

Axonal sprouting following lesions of the rat substantia nigra

DI Finkelstein, D Stanic, CL Parish, D Tomas, K Dickson, MK Horne

Journal article  |  2000  |  Neuroscience

Sprouting of dopaminergic axons after striatal injury: Confirmation by markers not dependent on dopamine metabolism

GT Liberatore, DI Finkelstein, JYF Wong, MK Horne, MJ Porritt, GA Donnan, DW Howells

Journal article  |  1999  |  Experimental Neurology

Erratum: Targeted expression of a toxin gene to D1 dopamine receptor neurons by Cre-mediated site-specific recombination (Journal of Neuroscience (December 1998) (9845-9857))

J Drago, P Padungchaichot, JYF Wong, AJ Lawrence, JF McManus, SH Sumarsono, AL Natoli, M Lakso, N Wreford, H Westphal, I Kola, DI Finkelstein

Journal article  |  1999  |  Journal of Neuroscience

Immunohistochemistry with antibodies to the cholecystokinin-A receptor reveals a widespread distribution in rat and monkey central nervous system

LD Mercer, J Nunan, NM Jones, AJ Lawrence, NS Cheung, JFB Mercer, SD Firth, P Thompson, B Jarrott, DI Finkelstein, PM Beart

Conference Proceedings  |  1999  |  PEPTIDERGIC G PROTEIN-COUPLED RECEPTORS

Nitrergic stimulation of the locus coeruleus modulates blood pressure and heart rate in the anaesthetized rat

ST Yao, DI Finkelstein, AJ Lawrence

Journal article  |  1999  |  Neuroscience

Targeted expression of a toxin gene to D1 dopamine receptor neurons by Cre-mediated site-specific recombination

J Drago, P Padungchaichot, JYF Wong, AJ Lawrence, JF McManus, SH Sumarsono, AL Natoli, M Lakso, N Wreford, H Westphal, I Kola, DI Finkelstein

Journal article  |  1998  |  The Journal of Neuroscience

Regional distribution of low affinity kainate receptors in brain of Macaca fascicularis determined by autoradiography using [H-3](2S,4R)-4-methylglutamate

FY Carroll, DI Finkelstein, MK Horne, AJ Lawrence, D Crawford, G Paxinos, PM Beart

Journal article  |  1998  |  Neuroscience Letters

Neuronal activity in the monkey ventrolateral thalamus following perturbations of voluntary wrist movements

EG Butler, MC Harvey, DI Finkelstein, MK Horne

Journal article  |  1998  |  Experimental Brain Research

A comparison of methods used to detect changes in neuronal discharge patterns

PR Churchward, EG Butler, DI Finkelstein, TD Aumann, A Sudbury, MK Horne

Journal article  |  1997  |  Journal of Neuroscience Methods

FGF plays a subtle role in oligodendrocyte maintenance in vivo

D Harari, D Finkelstein, O Bernard

Journal article  |  1997  |  Journal of Neuroscience Research

The effects of reversible inactivation of the subthalamopallidal pathway on the behaviour of naive and hemiparkinsonian monkeys

EG Butler, DW Bourke, DI Finkelstein, MK Horne

Journal article  |  1997  |  Journal of Clinical Neuroscience

Leukemia inhibitory factor enhances the regeneration of transected rat sciatic nerve and the function of reinnervated muscle

S Tham, B Dowsing, D Finkelstein, R Donato, SS Cheema, PF Bartlett, WA Morrison

Journal article  |  1997  |  Journal of Neuroscience Research

On the distribution of cholecystokinin B receptors in monkey brain

LD Mercer, PM Beart, MK Horne, DI Finkelstein, P Carrive, G Paxinos

Journal article  |  1996  |  Brain Research

The relationship between monkey ventrolateral thalamic nucleus activity and kinematic parameters of wrist movement

EG Butler, DI Finkelstein, MC Harvey, PR Churchward, LM Forlano, MK Korne

Journal article  |  1996  |  Brain Research

Leukemia inhibitory factor is a myotrophic and neurotrophic agent that enhances the reinnervation of muscle in the rat

DI Finkelstein, PF Bartlett, MK Horne, SS Cheema

Journal article  |  1996  |  Journal of Neuroscience Research

An electron microscopic tracer study of the projections from entopeduncular nucleus to the ventrolateral nucleus of the rat

DI Finkelstein, AK Reeves, MK Horne

Journal article  |  1996  |  Neuroscience Letters

Role of leukaemia inhibitory factor (LIF) in rat peripheral nerve regeneration.

R Donato, S Cheema, D Finkelstein, P Bartlett, W Morrison

Journal article  |  1995  |  Annals of the Academy of Medicine, Singapore

The cytokine leukaemia inhibitory factor (LIF) favours the survival and growth of axons in vitro. The efficacy of this factor in t..

PROJECTIONS FROM THE LATERAL AND INTERPOSED CEREBELLAR NUCLEI TO THE THALAMUS OF THE RAT - A LIGHT AND ELECTRON-MICROSCOPIC STUDY USING SINGLE AND DOUBLE ANTEROGRADE LABELING

TD AUMANN, JA RAWSON, DI FINKELSTEIN, MK HORNE

Journal article  |  1994  |  The Journal of Comparative Neurology

NEURAL ACTIVITY IN THE MONKEY ANTERIOR VENTROLATERAL THALAMUS DURING TRAINED, BALLISTIC MOVEMENTS

LM FORLANO, MK HORNE, EG BUTLER, D FINKELSTEIN

Journal article  |  1993  |  Journal of Neurophysiology

RECOVERY OF MUSCLE AFTER DIFFERENT PERIODS OF DENERVATION AND TREATMENTS

DI FINKELSTEIN, PC DOOLEY, AR LUFF

Journal article  |  1993  |  MUSCLE & NERVE

Developmental changes in hindlimb muscles and diaphragm of sheep.

DI Finkelstein, P Andrianakis, AR Luff, DW Walker

Journal article  |  1992  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

In this study, plasma thyroxine, contractile and histochemical (adenosinetriphosphatase and NADH) characteristics of soleus (SOL),..

DEVELOPMENTAL-CHANGES IN HINDLIMB MUSCLES AND DIAPHRAGM OF SHEEP

DI FINKELSTEIN, P ANDRIANAKIS, AR LUFF, DW WALKER

Journal article  |  1992  |  AMERICAN JOURNAL OF PHYSIOLOGY

THE EFFECT OF A 6 DAY SUCROSE DIET ON ISOMETRIC CONTRACTILE CHARACTERISTICS AND HISTOCHEMISTRY OF RAT MUSCLES

DI FINKELSTEIN, MK HORNE, JA MARSHALL

Journal article  |  1992  |  Journal of Animal Physiology and Animal Nutrition

IMMUNITY TO NERVE GROWTH-FACTOR AND THE EFFECT ON MOTOR UNIT REINNERVATION IN THE RABBIT

DI FINKELSTEIN, AR LUFF, JA SCHUIJERS

Journal article  |  1992  |  AMERICAN JOURNAL OF PHYSIOLOGY

Pathological aspects of Australian Stringhalt.

RF Slocombe, PJ Huntington, SC Friend, LB Jeffcott, AR Luff, DK Finkelstein

Journal article  |  1992  |  Equine Veterinary Journal

Nine horses with clinical signs of Australian Stringhalt were killed and tissues collected for a detailed pathological study. Lesi..

Immunity to nerve growth factor and the effect on motor unit reinnervation in the rabbit.

DI Finkelstein, AR Luff, JA Schuijers

Journal article  |  1992  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

The trophic effects of nerve growth factor (NGF) on sympathetic, peripheral afferent, and other neural crest-derived cells have be..

Developmental changes in hindlimb muscles and diaphragm of sheep

DI Finkelstein, P Andrianakis, AR Luff, DW Walker

Journal article  |  1992  |  American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Immunity to nerve growth factor and the effect on motor unit reinnervation in the rabbit

DI Finkelstein, AR Luff, JA Schuijers

Journal article  |  1992  |  American Journal of Physiology - Regulatory Integrative and Comparative Physiology

EFFECTS OF THYROIDECTOMY ON DEVELOPMENT OF SKELETAL-MUSCLE IN FETAL SHEEP

DI FINKELSTEIN, P ANDRIANAKIS, AR LUFF, D WALKER

Journal article  |  1991  |  AMERICAN JOURNAL OF PHYSIOLOGY

Effects of thyroidectomy on development of skeletal muscle in fetal sheep.

DI Finkelstein, P Andrianakis, AR Luff, D Walker

Journal article  |  1991  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

The influence of the thyroid gland on the functional and histochemical development of fast- and slow-twitch skeletal muscle of fet..

Effects of thyroidectomy on development of skeletal muscle in fetal sheep

DI Finkelstein, P Andrianakis, AR Luff, D Walker

Journal article  |  1991  |  American Journal of Physiology - Regulatory Integrative and Comparative Physiology

FUNCTIONAL AND STRUCTURAL-CHANGES OF RAT PLANTARIS MOTONEURONS FOLLOWING COMPENSATORY HYPERTROPHY OF THE MUSCLE

DI FINKELSTEIN, JG LANG, AR LUFF

Journal article  |  1991  |  The Anatomical Record

AUSTRALIAN STRINGHALT - EPIDEMIOLOGICAL, CLINICAL AND NEUROLOGICAL INVESTIGATIONS

PJ HUNTINGTON, LB JEFFCOTT, SCE FRIEND, AR LUFF, DI FINKELSTEIN, RJ FLYNN

Journal article  |  1989  |  Equine Veterinary Journal

CONTRACTILE PROPERTIES OF CAT MOTOR UNITS ENLARGED BY MOTONEURON SPROUTING

DD HATCHER, AR LUFF, RA WESTERMAN, DI FINKELSTEIN

Journal article  |  1985  |  Experimental Brain Research

Functional organization of claw protrusion in the cat

RA Westerman, D Sriratana, DI Finkelstein

Journal article  |  1983  |  Experimental Brain Research

The attitudes of nursing home aides toward elderly disabled people as related to personality differences among aides - an experimental study of the effect of these variables on the efficacy of staff training

DI Finkelstein

Journal article  |  1977  |  Abstracts of Hospital Management Studies

Isoflurane in the Aged Brain: A Link to Altered Amyloid Precursor Protein Processing

Journal article  |  Journal of Parkinson’s disease & Alzheimer’s disease