David Finkelstein

How Well Do Rodent Models of Parkinson's Disease Recapitulate Early Non-Motor Phenotypes? A Systematic Review

Tracy D Zhang, Scott C Kolbe, Leah C Beauchamp, Ella K Woodbridge, David I Finkelstein, Emma L Burrows

Journal article  |  2022  |  BIOMEDICINES

The prodromal phase of Parkinson's disease (PD) is characterised by many non-motor symptoms, and these have recently been posited ..

ATH434 Rescues Pre-motor Hyposmia in a Mouse Model of Parkinsonism

Leah C Beauchamp, Xiang M Liu, Laura J Vella, Paul A Adlard, Ashley Bush, David Finkelstein, Kevin J Barnham

Journal article  |  2022  |  NEUROTHERAPEUTICS

Hyposmia is a prevalent prodromal feature of Parkinson's disease (PD), though the neuropathology that underlies this symptom is po..

Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies.

Ichiro Kawahata, David I Finkelstein, Kohji Fukunaga

Journal article  |  2022  |  Int J Mol Sci

α-Synuclein is a protein with a molecular weight of 14.5 kDa and consists of 140 amino acids encoded by the SNCA gene. Missense mu..

Characterization of retinal function and structure in the MPTP murine model of Parkinson's disease

Katie KN Tran, Vickie HY Wong, Jeremiah KH Lim, Ali Shahandeh, Hoang Anh, David Finkelstein, Bang Bui, Christine TO Nguyen

Journal article  |  2022  |  SCIENTIFIC REPORTS

In addition to well characterized motor symptoms, visual disturbances are increasingly recognized as an early manifestation in Par..

Clinical Sphingolipids Pathway in Parkinson's Disease: From GCase to Integrated-Biomarker Discovery

Ali Esfandiary, David Isaac Finkelstein, Nicolas Hans Voelcker, David Rudd

Journal article  |  2022  |  CELLS

Alterations in the sphingolipid metabolism of Parkinson's Disease (PD) could be a potential diagnostic feature. Only around 10-15%..

Effects of Excess Iron on the Retina: Insights From Clinical Cases and Animal Models of Iron Disorders

Ali Shahandeh, Bang V Bui, David I Finkelstein, Christine TO Nguyen

Journal article  |  2022  |  FRONTIERS IN NEUROSCIENCE

Iron plays an important role in a wide range of metabolic pathways that are important for neuronal health. Excessive levels of iro..

Gastrointestinal Dysfunction in Parkinson's Disease: Current and Potential Therapeutics

Myat Noe Han, David I Finkelstein, Rachel M McQuade, Shanti Diwakarla

Journal article  |  2022  |  JOURNAL OF PERSONALIZED MEDICINE

Abnormalities in the gastrointestinal (GI) tract of Parkinson's disease (PD) sufferers were first reported over 200 years ago; how..

A Critical Analysis of Intestinal Enteric Neuron Loss and Constipation in Parkinson's Disease.

Chelsea O'Day, David Isaac Finkelstein, Shanti Diwakarla, Rachel Mai McQuade

Journal article  |  2022  |  J Parkinsons Dis

Constipation afflicts many patients with Parkinson's disease (PD) and significantly impacts on patient quality of life. PD-related..

The Placebo Response in Double-Blind Randomised Trials Evaluating Regenerative Therapies for Parkinson's Disease: A Systematic Review and Meta-Analysis

Stephen Polgar, Melissa Buultjens, Tissa Wijeratne, David Finkelstein, Sheeza Mohamed, Leila Karimi

Journal article  |  2022  |  JOURNAL OF PARKINSONS DISEASE

In the field of stem cell technologies, exciting advances are taking place leading to translational research to develop cell-based..

The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy

David Finkelstein, Jay J Shukla, Robert A Cherny, Jessica L Billings, Eiman Saleh, Nadia Stefanova, Kevin J Barnham, Paul A Adlard

Journal article  |  2022  |  JOURNAL OF PARKINSONS DISEASE

BACKGROUND: An elevation in iron levels, together with an accumulation of α-synuclein within the oligodendrocytes, are features of..