David Finkelstein

An intact membrane is essential for small extracellular vesicle-induced modulation of α-synuclein fibrillization.

Cathryn L Ugalde, Shane E Gordon, Mitch Shambrook, Amirmohammad Nasiri Kenari, Bradley M Coleman, Matthew A Perugini, Victoria A Lawson, David I Finkelstein, Andrew F Hill

Journal article  |  2020  |  Journal of Extracellular Vesicles

The misfolding and fibrillization of the protein, α-synuclein (αsyn), is associated with neurodegenerative disorders referred to a..

Reduced striatal vesicular monoamine transporter 2 in REM sleep behavior disorder: imaging prodromal parkinsonism

Leah C Beauchamp, Victor L Villemagne, David Finkelstein, Vincent Dore, Ashley Bush, Kevin J Barnham, Christopher C Rowe

Journal article  |  2020  |  Scientific Reports

Motor deficits in parkinsonism are caused by degeneration of dopaminergic nigral neurons. The success of disease-modifying therapi..

Fibrillar α-synuclein toxicity depends on functional lysosomes.

Stephanie J Guiney, Paul A Adlard, Peng Lei, Celeste H Mawal, Ashley I Bush, David I Finkelstein, Scott Ayton

Journal article  |  2020  |  Journal of Biological Chemistry

Neurodegeneration in Parkinson's disease (PD) can be recapitulated in animals by administration of α-synuclein pre-formed fibrils ..

Therapeutic applications of chelating drugs in iron metabolic disorders of the brain and retina

Ali Shahandeh, Bang V Bui, David I Finkelstein, Christine TO Nguyen

Journal article  |  2020  |  Journal of Neuroscience Research

Iron is essential for normal cellular function, however, excessive accumulation of iron in neural tissue has been implicated in bo..

PrPSc Oligomerization Appears Dynamic, Quickly Engendering Inherent M1000 Acute Synaptotoxicity

Simote T Foliaki, Victoria Lewis, Abu MT Islam, Matteo Senesi, David Finkelstein, Laura J Ellett, Victoria A Lawson, Paul A Adlard, Blaine R Roberts, Steven J Collins

Journal article  |  2020  |  Biophysical Journal

Prion diseases are neurodegenerative disorders pathogenically linked to cellular prion protein (PrPC) misfolding into abnormal con..

Investigation of nerve pathways mediating colorectal dysfunction in Parkinson's disease model produced by lesion of nigrostriatal dopaminergic neurons

Xin-yi Chai, Shanti Diwakarla, Ruslan V Pustovit, Rachel M McQuade, Madeleine Di Natale, Charlotte M Ermine, Clare L Parish, David I Finkelstein, John B Furness

Journal article  |  2020  |  Neurogastroenterology & Motility

BACKGROUND: Gastrointestinal (GI) dysfunction, including constipation, is a common non-motor symptom of Parkinson's disease (PD). ..

Distribution of Parkinson's disease associated RAB39B in mouse brain tissue

Yujing Gao, Gabrielle R Wilson, Sarah EM Stephenson, Mustapha Oulad-Abdelghani, Nicolas Charlet-Berguerand, Kiymet Bozaoglu, Catriona A McLean, Paul Q Thomas, David Finkelstein, Paul Lockhart

Journal article  |  2020  |  Molecular Brain

Regional iron distribution and soluble ferroprotein profiles in the healthy human brain

Erin J McAllum, Dominic J Hare, Irene Volitakis, Catriona A McLean, Ashley I Bush, David I Finkelstein, Blaine R Roberts

Journal article  |  2020  |  Progress in Neurobiology

Iron is essential for brain development and health where its redox properties are used for a number of neurological processes. How..

The Long Isoform of Intersectin-1 Has a Role in Learning and Memory

Nakisa Malakooti, Melanie A Pritchard, Feng Chen, Yong Yu, Charlotte Sgambelloni, Paul A Adlard, David I Finkelstein

Journal article  |  2020  |  Frontiers in Behavioral Neuroscience

Down syndrome is caused by partial or total trisomy of chromosome 21 and is characterized by intellectual disability and other dis..

Characterising the brain metalloproteome in Down syndrome patients with concomitant Alzheimer's pathology

Nakisa Malakooti, Blaine Roberts, Melanie A Pritchard, Irene Volitakis, Ron C Kim, Ira T Lott, Catriona A McLean, David Finkelstein, Paul A Adlard

Journal article  |  2020  |  Metallomics

Down syndrome (DS) is a common intellectual disability, with an incidence of 1 in 700 and is caused by trisomy 21. People with DS ..