Kelly Phillips

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Iris Kramer, Maartje J Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W Steyerberg, Daniele Giardiello, Antonis C Antoniou, Paul DP Pharoah, Sander Canisius, Zumuruda Abu-Ful, Irene L Andrulis, Hoda Anton-Culver, Kristan J Aronson, Annelie Augustinsson, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, et al.

Journal article  |  2020  |  American Journal of Human Genetics

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing ..

Breast Cancer Chemoprevention: Use and Views of Australian Women and Their Clinicians.

Courtney Macdonald, Christobel M Saunders, Louise A Keogh, Morgan Hunter, Danielle Mazza, Sue-Anne McLachlan, Sandra C Jones, Stephanie Nesci, Michael L Friedlander, John L Hopper, Jon D Emery, Martha Hickey, Roger L Milne, Kelly-Anne Phillips, undefined Kathleen Cuningham Consortium for Research Into Familial Breast Cancer

Journal article  |  2020  |  Cancer Prevention Research

Guidelines endorse the use of chemoprevention for breast cancer risk reduction. This study examined the barriers and facilitators ..

Prognostic gene expression signature for high-grade serous ovarian cancer

J Millstein, T Budden, EL Goode, MS Anglesio, A Talhouk, MP Intermaggio, HS Leong, S Chen, W Elatre, B Gilks, T Nazeran, M Volchek, RC Bentley, C Wang, DS Chiu, S Kommoss, SCY Leung, J Senz, A Lum, V Chow, et al.

Journal article  |  2020  |  Annals of Oncology

BACKGROUND: Median overall survival (OS) for women with high-grade serous ovarian cancer (HGSOC) is ∼4 years, yet survival varies ..

The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation

Amy L Winship, Meaghan Griffiths, Carolina Lliberos Requesens, Urooza Sarma, Kelly-Anne Phillips, Karla J Hutt

Journal article  |  2020  |  Human Reproduction

STUDY QUESTION: What is the impact of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib, alone or in combination with che..

Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants

Daniel R Barnes, Matti A Rookus, Lesley McGuffog, Goska Leslie, Thea M Mooij, Joe Dennis, Nasim Mavaddat, Julian Adlard, Munaza Ahmed, Kristiina Aittomaki, Nadine Andrieu, Irene L Andrulis, Norbert Arnold, Banu K Arun, Jacopo Azzollini, Judith Balmana, Rosa B Barkardottir, Daniel Barrowdale, Javier Benitez, Pascaline Berthet, et al.

Journal article  |  2020  |  Genetics in Medicine

PURPOSE: We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian c..

Key steps for effective breast cancer prevention

Kara L Britt, Jack Cuzick, Kelly-Anne Phillips

Journal article  |  2020  |  Nature Reviews Cancer

Despite decades of laboratory, epidemiological and clinical research, breast cancer incidence continues to rise. Breast cancer rem..

Assessment of ovarian function as an endpoint in breast cancer clinical trials: A systematic review.

Wanyuan Cui, Prudence A Francis, Sherene Loi, Martha Hickey, Catharyn Stern, Ann H Partridge, Sibylle Loibl, Kelly-Anne Phillips

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

Haoyu Zhan, Thomas U Ahearn, Julie Lecarpentier, Daniel Barnes, Jonathan Beesley, Guanghao Qi, Xia Hang, Tracy A O'Mara, Ni Zhao, Manjeet K Bolla, Alison M Dunning, Joe Dennis, Qin Wang, Zumuruda Abu Ful, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Banu K Arun, et al.

Journal article  |  2020  |  Nature Genetics

Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1-3. To identify novel loci, w..

Considerations When Using Breast Cancer Risk Models for Women with Negative BRCA1/BRCA2 Mutation Results

Robert J MacInnis, Yuyan Liao, Julia A Knight, Roger L Milne, Alice S Whittemore, Wendy K Chung, Nicole Leoce, Richard Buchsbaum, Nur Zeinomar, Gillian S Dite, Melissa C Southey, David Goldgar, Graham G Giles, Sue-Anne McLachlan, Prue C Weideman, Stephanie Nesci, Michael L Friedlander, Gord Glendon, Irene L Andrulis, Esther M John, et al.

Journal article  |  2020  |  JNCI: Journal of the National Cancer Institute

The performance of breast cancer risk models for women with a family history but negative BRCA1 and/or BRCA2 mutation test results..

Transcriptome-wide association study of breast cancer risk by estrogen-receptor status

Helian Feng, Alexander Gusev, Bogdan Pasaniuc, Lang Wu, Jirong Long, Zomoroda Abu-full, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou, Adalgeir Arason, Volker Arndt, Kristan J Aronson, Banu K Arun, Ella Asseryanis, Paul L Auer, Jacopo Azzollini, Judith Balmana, Rosa B Barkardottir, Daniel R Barnes, et al.

Journal article  |  2020  |  Genetic Epidemiology

Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expressio..