David Piedrafita

The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries)

Dhanasekaran Sakthivel, Sarah Preston, Robin B Gasser, Tatiana P Soares da Costa, Julia N Hernandez, Adam Shahine, MD Shakif-Azam, Peter Lock, Jamie Rossjohn, Matthew A Perugini, Jorge Francisco Gonzalez, Els Meeusen, David Piedrafita, Travis Beddoe

Journal article  |  2020  |  COMMUNICATIONS BIOLOGY

Galectins are a family of glycan-binding molecules with a characteristic affinity for ß-D-glycosides that mediate a variety of imp..

Will helminth co-infection modulate COVID-19 severity in endemic regions?

Richard S Bradbury, David Piedrafita, Andrew Greenhill, Siddhartha Mahanty

Journal article  |  2020  |  NATURE REVIEWS IMMUNOLOGY

Selection of multi-drug resistant influenza A and B viruses under zanamivir pressure and their replication fitness in ferrets

Ding Yuan Oh, Jacqueline Panozzo, Sophie Vitesnik, Rubaiyea Farrukee, David Piedrafita, Jennifer Mosse, Aeron C Hurt

Journal article  |  2018  |  ANTIVIRAL THERAPY

BACKGROUND: Intravenous zanamivir has been used to treat patients with severe influenza. Because the majority of cases (including ..

Immunity to Haemonchus contortus and Vaccine Development

AJ Nisbet, EN Meeusen, JF Gonzalez, DM Piedrafita

Book Chapter  |  2016  |  Advances in Parasitology

Sheep are capable of developing protective immunity to Haemonchus contortus through repeated exposure to this parasite, although t..

Discovery of novel Schistosoma japonicum antigens using a targeted protein microarray approach

Hamish EG McWilliam, Patrick Driguez, David Piedrafita, Donald P McManus, Els NT Meeusen

Journal article  |  2014  |  PARASITES & VECTORS

BACKGROUND: Novel vaccine candidates against Schistosoma japonicum are required, and antigens present in the vulnerable larval dev..

Current Status for Gastrointestinal Nematode Diagnosis in Small Ruminants: Where Are We and Where Are We Going?

Sarah Jane Margaret Preston, Mark Sandeman, Jorge Gonzalez, David Piedrafita

Journal article  |  2014  |  JOURNAL OF IMMUNOLOGY RESEARCH

Gastrointestinal nematode (GIN) parasites pose a significant economic burden particularly in small ruminant production systems. An..

The Effect of Different Adjuvants on Immune Parameters and Protection following Vaccination of Sheep with a Larval-Specific Antigen of the Gastrointestinal Nematode, Haemonchus contortus

David Piedrafita, Sarah Preston, Joanna Kemp, Michael de Veer, Jayne Sherrard, Troy Kraska, Martin Elhay, Els Meeusen

Journal article  |  2013  |  PLOS ONE

It has recently been recognised that vaccine adjuvants play a critical role in directing the nature of a vaccine induced effector ..

Identification of two allelic forms of ovine CD4 exhibiting a Ser(183)/Pro(183) polymorphism in the coding sequence of domain 3

R Boscariol, J Pleasance, DM Piedrafita, HW Raadsma, TW Spithill

Journal article  |  2006  |  VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

The ovine CD4 cDNA sequence from four sheep sources (Australian Merino, Indonesian Thin Tail, Canadian cross bred, Prealpes du sud..

DNA vaccines in sheep: CTLA-4 mediated targeting and CpG motifs enhance immunogenicity in a DNA prime/protein boost strategy

NJ Kennedy, TW Spithill, J Tennent, PR Wood, D Piedrafita

Journal article  |  2006  |  VACCINE

DNA vaccines have proven to be an efficient means of inducing immune responses in small laboratory animals; however, their efficac..

Immunology of the host-parasite relationship in fasciolosis (Fasciola hepatica and Fasciola gigantica)

D Piedrafita, HW Raadsma, R Prowse, TW Spithill

Journal article  |  2004  |  CANADIAN JOURNAL OF ZOOLOGY

The protective resolution of liver fluke (Fasciola hepatica and Fasciola gigantica) infection is a dynamic interplay between the h..