Jennifer Trieu

Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes.

Wenlan Li, Jennifer Trieu, Ronnie Blazev, Benjamin L Parker, Kate T Murphy, Kristy Swiderski, Gordon S Lynch

Journal article  |  2023  |  Am J Physiol Cell Physiol

Cancer cachexia is common in many cancers and the loss of skeletal muscle mass compromises the response to therapies and quality o..

Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy

Francesca M Alves, Kai Kysenius, Marissa K Caldow, Justin P Hardee, Jin D Chung, Jennifer Trieu, Dominic J Hare, Peter J Crouch, Scott Ayton, Ashley Bush, Gordon S Lynch, Rene Koopman

Journal article  |  2022  |  JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

BACKGROUND: Oxidative stress is implicated in the pathophysiology of Duchenne muscular dystrophy (DMD, caused by mutations in the ..

Mechanisms of chemotherapy‐induced muscle wasting in mice with cancer cachexia

Kate T Murphy, Kristy Swiderski, James G Ryall, Jonathan R Davey, Hongwei Qian, Séverine Lamon, Victoria C Foletta, Jennifer Trieu, Annabel Chee, Suzannah J Read, Timur Naim, Paul Gregorevic, Gordon S Lynch

Journal article  |  2022  |  JCSM Rapid Communications

Investigating the Potential for Sulforaphane to Attenuate Gastrointestinal Dysfunction in mdx Dystrophic Mice

Kristy Swiderski, Suzannah J Read, Audrey S Chan, Jin D Chung, Jennifer Trieu, Timur Naim, Rene Koopman, Gordon S Lynch

Journal article  |  2021  |  NUTRIENTS

Gastrointestinal (GI) dysfunction is an important, yet understudied condition associated with Duchenne muscular dystrophy (DMD), w..

Dystrophin deficiency disrupts muscle clock expression and mitochondrial quality control in mdx mice

Justin P Hardee, Marissa K Caldow, Audrey SM Chan, Stuart K Plenderleith, Jennifer Trieu, Rene Koopman, Gordon S Lynch

Journal article  |  2021  |  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Impaired oxidative capacity and mitochondrial function contribute to the dystrophic pathology in muscles of patients with Duchenne..

Phosphorylation of ERK and dystrophin S3059 protects against inflammation-associated C2C12 myotube atrophy

Kristy Swiderski, Christopher J Brock, Jennifer Trieu, Annabel Chee, Savant S Thakur, Dale M Baum, Paul Gregorevic, Kate T Murphy, Gordon S Lynch

Journal article  |  2021  |  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The dystrophin-glycoprotein complex (DGC) is a multiprotein structure required to maintain muscle fiber membrane integrity, transm..

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity

Justin P Hardee, Karen JB Martins, Paula M Miotto, James G Ryall, Stefan M Gehrig, Boris Reljic, Timur Naim, Jin D Chung, Jen Trieu, Kristy Swiderski, Ashleigh M Philp, Andrew Philp, Matthew J Watt, David A Stroud, Rene Koopman, Gregory R Steinberg, Gordon S Lynch

Journal article  |  2021  |  MOLECULAR METABOLISM

OBJECTIVES: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscul..

Defective fasting-induced PKA activation impairs adipose tissue glycogen degradation in obese Zucker rats

Marcelo Flores-Opazo, Jennifer Trieu, Timur Naim, Denisse Valladares-Ide, Hermann Zbinden-Foncea, David Stapleton

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF OBESITY

BACKGROUND: Obesity is associated with development of insulin resistance in adipose tissue (AT). Human obesity has been associated..

Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation

Kristy Swiderski, Rebecka Bindon, Jennifer Trieu, Timur Naim, Shana Schokman, Mathusi Swaminathan, Anita JL Leembruggen, Elisa L Hill-Yardin, Rene Koopman, Joel C Bornstein, Gordon S Lynch

Journal article  |  2020  |  JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND/AIMS: Patients with Duchenne muscular dystrophy exhibit significant, ongoing impairments in gastrointestinal (GI) funct..

Glycine Protects Muscle Cells From Wasting in vitro via mTORC1 Signaling

Marissa K Caldow, Daniel J Ham, Jennifer Trieu, Jin Dylan Chung, Gordon S Lynch, Rene Koopman

Journal article  |  2019  |  FRONTIERS IN NUTRITION

Glycine supplementation can protect skeletal muscles of mice from cancer-induced wasting, but the mechanisms underlying this prote..