Damian Purcell

Evolutionary rate of SARS-CoV-2 increases during zoonotic infection of farmed mink

Ashleigh F Porter, Damian FJ Purcell, Benjamin P Howden, Sebastian Duchene

Journal article  |  2023  |  VIRUS EVOLUTION

To investigate genetic signatures of adaptation to the mink host, we characterised the evolutionary rate heterogeneity in mink-ass..

Protocol for production and expression of chimeric bovine-human monoclonal antibodies.

Behnaz Heydarchi, Damian FJ Purcell

Journal article  |  2022  |  STAR Protoc

We describe herein a protocol for production of chimeric bovine-human monoclonal antibodies (mAbs) from vaccinated cows. The genes..

Heparin Inhibits SARS-CoV-2 Replication in Human Nasal Epithelial Cells

Leo Yi Yang Lee, Randy Suryadinata, Conor McCafferty, Vera Ignjatovic, Damian FJ Purcell, Phil Robinson, Craig J Morton, Michael W Parker, Gary P Anderson, Paul Monagle, Kanta Subbarao, Jessica A Neil

Journal article  |  2022  |  VIRUSES-BASEL

SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Vaccination, supported by social and public health measures, has prove..

Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2

Phillip Pymm, Samuel J Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P Cooney, Kathryn C Davidson, Ebene R Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L Grimley, Damian FJ Purcell, Stephen J Kent, Adam K Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W Chung, Kanta Subbarao, et al.

Journal article  |  2022  |  ISCIENCE

The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monocl..

Surface Inactivation of Highly Mutated SARS-CoV-2 Variants of Concern: Alpha, Delta, and Omicron

Valentin A Bobrin, Sung-Po R Chen, Carlos Fitzgerald Grandes Reyes, Tim Smith, Damian FJ Purcell, Jason Armstrong, Julie L McAuley, Michael J Monteiro

Journal article  |  2022  |  BIOMACROMOLECULES

Continued SARS-CoV-2 transmission among the human population has meant the evolution of the virus to produce variants of increased..

Nonhuman primate models for evaluation of SARS-CoV-2 vaccines

Jessica A Neil, Maryanne Griffith, Dale I Godfrey, Damian FJ Purcell, Georgia Deliyannis, David Jackson, Steve Rockman, Kanta Subbarao, Terry Nolan

Journal article  |  2022  |  EXPERT REVIEW OF VACCINES

INTRODUCTION: Evaluation of immunogenicity and efficacy in animal models provide critical data in vaccine development. Nonhuman pr..

Broad and ultra-potent cross-clade neutralization of HIV-1 by a vaccine-induced CD4 binding site bovine antibody

Behnaz Heydarchi, Danielle S Fong, Hongmei Gao, Natalia A Salazar-Quiroz, Jack M Edwards, Christopher A Gonelli, Samantha Grimley, Turgut E Aktepe, Charlene Mackenzie, William J Wales, Marit J van Gils, Albert Cupo, Isabelle Rouiller, Paul R Gooley, John P Moore, Rogier W Sanders, David Montefiori, Ashish Sethi, Damian FJ Purcell

Journal article  |  2022  |  CELL REPORTS MEDICINE

Human immunodeficiency virus type 1 (HIV-1) vaccination of cows has elicited broadly neutralizing antibodies (bNAbs). In this stud..

Detection of Chimeric Cellular: HIV mRNAs Generated Through Aberrant Splicing in HIV-1 Latently Infected Resting CD4 T Cells

Michelle Y-H Lee, Georges Khoury, Moshe Olshansky, Secondo Sonza, Glen P Carter, James McMahon, Timothy P Stinear, Stephen J Turner, Sharon R Lewin, Damian FJ Purcell

Journal article  |  2022  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

Latent HIV-1 provirus in infected individuals on suppressive therapy does not always remain transcriptionally silent. Both HIV-1 L..

The Efficacy of Common Household Cleaning Agents for SARS-CoV-2 Infection Control

Catarina F Almeida, Damian FJ Purcell, Dale I Godfrey, Julie L McAuley

Journal article  |  2022  |  VIRUSES-BASEL

The COVID-19 pandemic caused by SARS-CoV-2 is having devastating effects on a global scale. Since common household disinfectants a..

De novo design of CRISPR-Cas13b enables efficient silencing of SARS-CoV-2 variants and tumour pathogenic RNAs with near single-base precision

Wenxin Hu, Wei Zhao, Amit Kumar, Gurjeet Jagjeet Singh, Shijiao Qi, Josh Casan, Carolyn Shembery, Danielle Fong, Jennifer M Zerbato, Jori Symons, Rajeev Rudraraju, Damian Purcell, Michelle Haber, Ilia Voskoboinik, Paul G Ekert, Sharon Lewin, Joseph Trapani, Mohamed Fareh

Conference Proceedings  |  2022  |  Pathology