Damian Purcell

Water-Borne Nanocoating for Rapid Inactivation of SARS-CoV-2 and Other Viruses.

Valentin A Bobrin, Sung-Po Chen, Carlos Fitzgerald Grandes Reyes, Bing Sun, Chun Ki Ng, Youry Kim, Damian Purcell, Zhongfan Jia, Wenyi Gu, Jason W Armstrong, Julie McAuley, Michael J Monteiro

Journal article  |  2021  |  ACS Nano

The rise in coronavirus variants has resulted in surges of the disease across the globe. The mutations in the spike protein on the..

Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay

Ester Lopez, Ebene R Haycroft, Amy Adair, Francesca L Mordant, Matthew T O'Neill, Phillip Pymm, Samuel J Redmond, Wen Shi Lee, Nicholas A Gherardin, Adam K Wheatley, Jennifer A Juno, Kevin J Selva, Samantha K Davis, Samantha L Grimley, Leigh Harty, Damian FJ Purcell, Kanta Subbarao, Dale Godfrey, Stephen J Kent, Wai-Hong Tham, et al.

Journal article  |  2021  |  JCI INSIGHT

The SARS-CoV-2 receptor binding domain (RBD) is both the principal target of neutralizing antibodies and one of the most rapidly e..

SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon.

Maya Shemesh, Turgut E Aktepe, Joshua M Deerain, Julie L McAuley, Michelle D Audsley, Cassandra T David, Damian FJ Purcell, Victoria Urin, Rune Hartmann, Gregory W Moseley, Jason M Mackenzie, Gideon Schreiber, Daniel Harari

Journal article  |  2021  |  PLoS Pathog

Type I Interferons (IFN-Is) are a family of cytokines which play a major role in inhibiting viral infection. Resultantly, many vir..

Infrared Based Saliva Screening Test for COVID‐19

Bayden R Wood, Kamila Kochan, Diana E Bedolla, Natalia Salazar‐Quiroz, Samantha L Grimley, David Perez‐Guaita, Matthew J Baker, Jitraporn Vongsvivut, Mark J Tobin, Keith R Bambery, Dale Christensen, Shivani Pasricha, Anthony K Eden, Aaron Mclean, Supti Roy, Jason A Roberts, Julian Druce, Deborah A Williamson, Julie McAuley, Mike Catton, et al.

Journal article  |  2021  |  Angewandte Chemie

Infrared Based Saliva Screening Test for COVID-19

Bayden R Wood, Kamila Kochan, Diana E Bedolla, Natalia Salazar-Quiroz, Samantha L Grimley, David Perez-Guaita, Matthew J Baker, Jitraporn Vongsvivut, Mark J Tobin, Keith R Bambery, Dale Christensen, Shivani Pasricha, Anthony K Eden, Aaron Mclean, Supti Roy, Jason A Roberts, Julian Druce, Deborah A Williamson, Julie McAuley, Mike Catton, et al.

Journal article  |  2021  |  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented need for diagnostic testing that is ..

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

Mohamed Fareh, Wei Zhao, Wenxin Hu, Joshua ML Casan, Amit Kumar, Jori Symons, Jennifer M Zerbato, Danielle Fong, Ilia Voskoboinik, Paul G Ekert, Rajeev Rudraraju, Damian FJ Purcell, Sharon R Lewin, Joseph A Trapani

Journal article  |  2021  |  NATURE COMMUNICATIONS

The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approa..

Evaluation of 6 Commercial SARS-CoV-2 Serology Assays Detecting Different Antibodies for Clinical Testing and Serosurveillance.

Suellen Nicholson, Theo Karapanagiotidis, Arseniy Khvorov, Celia Douros, Francesca Mordant, Katherine Bond, Julian Druce, Deborah A Williamson, Damian Purcell, Sharon R Lewin, Sheena Sullivan, Kanta Subbarao, Mike Catton

Journal article  |  2021  |  Open Forum Infect Dis

Background: Serological testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) complements nucleic acid tests fo..

The RNA-Binding Proteins SRP14 and HMGB3 Control HIV-1 Tat mRNA Processing and Translation During HIV-1 Latency

Georges Khoury, Michelle Y Lee, Sri H Ramarathinam, James McMahon, Anthony W Purcell, Secondo Sonza, Sharon R Lewin, Damian FJ Purcell

Journal article  |  2021  |  FRONTIERS IN GENETICS

HIV-1 Tat protein is essential for virus production. RNA-binding proteins that facilitate Tat production may be absent or downregu..

Enhancement of Antibody-Dependent Cellular Cytotoxicity and Phagocytosis in Anti-HIV-1 Human-Bovine Chimeric Broadly Neutralizing Antibodies.

Jack M Edwards, Behnaz Heydarchi, Georges Khoury, Natalia A Salazar-Quiroz, Christopher A Gonelli, Bruce Wines, P Mark Hogarth, Anne B Kristensen, Matthew S Parsons, Damian FJ Purcell

Journal article  |  2021  |  J Virol

No prophylactic vaccine has provided robust protection against human immunodeficiency virus type 1 (HIV-1). Vaccine-induced broadl..

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

Jessie J-Y Chang, Daniel Rawlinson, Miranda E Pitt, George Taiaroa, Josie Gleeson, Chenxi Zhou, Francesca L Mordant, Ricardo De Paoli-Iseppi, Leon Caly, Damian FJ Purcell, Timothy P Stinear, Sarah L Londrigan, Michael B Clark, Deborah A Williamson, Kanta Subbarao, Lachlan JM Coin

Journal article  |  2021  |  CELL REPORTS

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses subgenomic RNA (sgRNA) to produce viral proteins for replication..