profile icon
Prof

Damian Purcell

Professor In Virology
HIV vaccines
science & technology
life sciences & biomedicine
humans
virology
hiv-1
immunology
animals
hiv infections
Damian Purcell's Profile Picture
Prof

Damian Purcell

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Molecular Virology
Damian Purcell's Profile Picture
Prof

Damian Purcell

 

Projects

Displaying the 27 most recent projects by Damian Purcell.

Project icon

Humanisation Of Broadly Neutralising Bovine Monoclonal Antibodies For Hiv Cure And Prevention

2019 - 2020
Active
Project icon

Addressing The Major Challenges In Hiv Vaccine And Cure Research

HIV remains one of the defining global health challenge of our times. 37 million people are living with HIV with 2 million new infections ea..

2019 - 2023
Active
Project icon

Antibody-Based Hiv Prevention

2018 - 2019
Completed
Project icon

Mucosal Human Immunodeficiency Virus Vaccine Late Pre-Clinical Evaluation

Despite many candidate vaccines entering clinical development for protection against HIV, none has yet been successful. This proposal centre..

2018 - 2019
Completed
Project icon

Rna Processing Mechanisms Controlling Hiv Latency

Successful HIV remission and cure, where patients can live normally without daily drug therapy and risk of transmitting infectious virus, wi..

2017 - 2019
Completed
Project icon

Vaccine-Induced Broadly Neutralising Antibodies To Hiv Env

2016 - 2017
Completed
Project icon

European Aids Vaccine Initiative 2020

A vaccine to prevent AIDS is urgently needed. The European Union recently awarded over 20 million euros to a European consortium, called EAV..

2016 - 2020
Active
Project icon

European Aids Vaccine Initiative 2020

A vaccine to prevent AIDS is urgently needed. The European Union recently awarded over 20 million euros to a European consortium, called EAV..

2016 - 2020
Active
Project icon

Novel Drugs To Drive Hiv Into Remission

Even in well-resourced countries, the ability to continue treating HIV patients for their lifetime may become unaffordable, which has focuse..

2016 - 2018
Completed
Project icon

Targeting Hiv Splicing In Latently Infected T Cells: Contributing To A Cure

2015 - 2016
Completed
Project icon

Topical Microbicide To Prevent Hiv

2014 - 2016
Completed
Project icon

Hiv Latency, Pathogenesis And Immunity

The development of cures, vaccines and better treatments for HIV/AIDS is an urgent global health priority. This team of seven groups in Sydn..

2014 - 2018
Completed
Project icon

Hiv Latency Pathogenesis And Immunity

The development of cures, vaccines and better treatments for HIV/AIDS is an urgent global health priority. This team of seven groups in Sydn..

2014 - 2018
Completed
Project icon

Hiv Latency Pathogenesis And Immunity

The development of cures, vaccines and better treatments for HIV/AIDS is an urgent global health priority. This team of seven groups in Sydn..

2014 - 2018
Completed
Project icon

Hiv Latency Pathogenesis And Immunity

The development of cures, vaccines and better treatments for HIV/AIDS is an urgent global health priority. This team of seven groups in Sydn..

2014 - 2018
Completed
Project icon

Targeting Hiv Immunogens To Immune Cells To Enhance Vaccine Efficacy

2013 - 2015
Completed
Project icon

Optimizing New Drugs Targeting Hiv-1 Viral Latency

2013 - 2014
Completed
Project icon

Drugs Targeting Tat During Hiv-1 Viral Latency

2013 - 2013
Completed
Project icon

An Advanced Flow Cytometry Facility For The Peter Doherty Institute

The establishment of a flow cytometry facility in the new Peter Doherty Institute for Infection and Immunity will enhance capacity to invest..

2011 - 2012
Completed
Project icon

Understanding Mechanisms Of Hiv Latency In Cd4+ T Cells

2011
Active
Project icon

Understanding Hiv During Silent And Productive Infection

Current combination antiviral therapy can't cure an HIV infection because long-lived T-cells carrying latent HIV DNA can rekindle the infect..

2011 - 2013
Completed
Project icon

Hiv & Hcv Vaccines And Immunopathogenesis - Support Funding

The development of vaccines and better treatments for HIV-AIDS and Hepatitis C are urgent global health priorities. This Program will undert..

2009 - 2013
Completed
Project icon

Hiv & Hcv Vaccines And Immunopathogenesis

The development of vaccines and better treatments for HIV-AIDS and Hepatitis C are urgent global health priorities. This Program will undert..

2009 - 2013
Completed
Project icon

Safety Assessment Of An Rfpv Vaccine For Hiv-1, Vir201

Project icon

Rna-Mediated Control Of Hiv Expression

Completed
Project icon

Control Of Viral Replication By Non-Coding Viral Rna

In 25 years since identified, HIV-AIDS deaths have exceeded 30 million and 40 million more are now living with HIV. The toll will soon far s..

Project icon

Ultracentrifuge And Rotors - 2004 Nhmrc Equipment Grant Allocation

nan

27

Projects

Project Types

20

Research Grant

7

Research Contracts

Scholarly Works

Displaying the 143 most recent scholarly works by Damian Purcell.

Scholarly works icon

Tat IRES modulator of tat mRNA (TIM-TAM): a conserved RNA structure that controls Tat expression and acts as a switch for HIV productive and latent infection.

Georges Khoury, Charlene Mackenzie, Lilia Ayadi, Sharon R Lewin, Christiane Branlant, Damian FJ Purcell

Journal article  |  2019  |  Nucleic Acids Research

Tat protein is essential to fully activate HIV transcription and processing of viral mRNA, and therefore determines virus expressi..

Scholarly works icon

Role of HTLV-1 orf-I encoded proteins in viral transmission and persistence.

Sarkis Sarkis, Veronica Galli, Ramona Moles, David Yurick, Georges Khoury, Damian FJ Purcell, Genoveffa Franchini, Cynthia A Pise-Masison

Journal article  |  2019  |  Retrovirology

The human T cell leukemia virus type 1 (HTVL-1), first reported in 1980 by Robert Gallo's group, is the etiologic agent of both ca..

Scholarly works icon

p30 protein: a critical regulator of HTLV-1 viral latency and host immunity.

Ramona Moles, Sarkis Sarkis, Veronica Galli, Maria Omsland, Damian FJ Purcell, David Yurick, Georges Khoury, Cynthia A Pise-Masison, Genoveffa Franchini

Journal article  |  2019  |  Retrovirology

The extraordinarily high prevalence of HTLV-1 subtype C (HTLV-1C) in some isolated indigenous communities in Oceania and the sever..

Scholarly works icon

Conjugation of an scFab domain to the oligomeric HIV envelope protein for use in immune targeting

Hannah AD King, Christopher A Gonelli, Kirsteen M Tullett, Mireille H Lahoud, Damian FJ Purcell, Heidi E Drummer, Pantelis Poumbourios, Rob J Center

Journal article  |  2019  |  PLOS ONE

Scholarly works icon

HIV-1-Based Virus-like Particles that Morphologically Resemble Mature, Infectious HIV-1 Virions

Christopher A Gonelli, Georges Khoury, Rob J Center, Damian FJ Purcell

Journal article  |  2019  |  Viruses

Scholarly works icon

Gene expression signatures of circulating human type 1, 2, and 3 innate lymphoid cells

Shuo Li, Hideaki Morita, Milena Sokolowska, Ge Tan, Tadech Boonpiyathad, Lennart Opitz, Keisuke Orimo, Stuart K Archer, Kirstin Jansen, Mimi LK Tang, Damian Purcell, Magdalena Plebanski, Cezmi A Akdis

Journal article  |  2019  |  Journal of Allergy and Clinical Immunology

Scholarly works icon

Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models

William Nguyen, Jonathan Jacobson, Kate E Jarman, Helene Jousset Sabroux, Leigh Harty, James McMahon, Sharon R Lewin, Damian F Purcell, Brad E Sleebs

Journal article  |  2019  |  Journal of Medicinal Chemistry

Scholarly works icon

Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia

Jocelyn Turpin, David Yurick, Georges Khoury, Pham Hai, Stephen Locarnini, Anat Melamed, Aviva Witkover, Kim Wilson, Damian Purcell, Charles RM Bangham, Lloyd Einsiedel

Journal article  |  2019  |  The Journal of Infectious Diseases

Scholarly works icon

Multiplex Droplet Digital PCR Assay for Quantification of Human T-Cell Leukemia Virus Type 1 Subtype c DNA Proviral Load and T Cells from Blood and Respiratory Exudates Sampled in a Remote Setting

David Yurick, Georges Khoury, Bridle Clemens, Liyen Loh, Hai Pham, Katherine Kedzierska, Lloyd Einsiedel, Damian Purcell

Journal article  |  2019  |  Journal of Clinical Microbiology

Scholarly works icon

HIV latency can be established in proliferating and nonproliferating resting CD4( ) T cells in vitro: implications for latency reversal

Michael A Moso, Jenny L Anderson, Samantha Adikari, Lachlan R Gray, Georges Khoury, Judy J Chang, Jonathan C Jacobson, Anne M Ellet, Wan-Jung Chen, Suha Saleh, John J Zaunders, Damian FJ Purcell, Paul U Camerona, Melissa J Churchill, Sharon R Lewin, Hao K Lu

Journal article  |  2019  |  AIDS

Scholarly works icon

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Georges Khoury, Damian FJ Purcell

Journal article  |  2019  |  Journal of Visualized Experiments

Scholarly works icon

HIV-1 Env Trimers Eliciting Antibody With Neutralising and Cellular-dependent Functions in Vaccinated Cows

Damian Purcell, Natalia Salazar-Quiroz, Jack Edwards, Brian Muller, Chris Gonelli, Charlene MacKenzie, Georges Khoury, David MacInnes, Behnaz Heydarchi

Conference Proceedings  |  2018  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

Scholarly works icon

HIV Neutralising Monoclonal Antibodies With Optimised Antibody Effector Functions

Behnaz Heydarchi, Jack Edwards, Christopher Gonelli, Damian Purcell

Conference Proceedings  |  2018  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

Scholarly works icon

The RNA-binding proteins, SRP14 and HMGB3 play a crucial role in controlling HIV replication and latency

G Khoury, MY Lee, S Ramarathinam, S Sonza, AW Purcell, DFJ Purcell

Conference Proceedings  |  2018  |  JOURNAL OF THE INTERNATIONAL AIDS SOCIETY

Scholarly works icon

Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics

Sri H Ramarathinam, Stephanie Gras, Sheilajen Alcantara, Amanda WS Yeung, Nicole A Mifsud, Secondo Sonza, Patricia T Illing, Elias N Glaros, Robert J Center, Shane R Thomas, Stephen J Kent, Nicola Ternette, Damian FJ Purcell, Jamie Rossjohn, Anthony W Purcell

Journal article  |  2018  |  PROTEOMICS

Scholarly works icon

HIV latency reversing agents act through Tat post translational modifications

Georges Khoury, Talia M Mota, Shuang Li, Carolin Tumpach, Michelle Y Lee, Jonathan Jacobson, Leigh Harty, Jenny L Anderson, Sharon R Lewin, Damian FJ Purcell

Journal article  |  2018  |  Retrovirology

Scholarly works icon

The Molecular Biology of HIV Latency

Georges Khoury, Gilles Darcis, Michelle Y Lee, Sophie Bouchat, Benoit Van Driessche, Damian FJ Purcell, Carine Van Lint

Journal article  |  2018  |  Advances in experimental medicine and biology

Scholarly works icon

Highlights from the HTLV-1 symposium at the 2017 Australasian HIV and AIDS Conference held jointly with the 2017 Australasian Sexual Health Conference, November 2017, Canberra, Australia

Lloyd Einsiedel, Damian Purcell, Shane Schinke, Katelin Haynes, Graham P Taylor, Fabiola Martin

Journal article  |  2018  |  Journal of virus eradication

Scholarly works icon

Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8( ) T Cell-Lineage-Specific Function

Brendan E Russ, Moshe Olshansky, Jasmine Li, Michelle LT Nguyen, Linden J Gearing, Thi HO Nguyen, Matthew R Olson, Hayley A McQuilton, Simone Nussing, Georges Khoury, Damian FJ Purcell, Paul J Hertzog, Sudha Rao, Stephen J Turner

Journal article  |  2017  |  Cell Reports

Scholarly works icon

No adverse safety or virological changes 2 years following vorinostat in HIV-infected individuals on antiretroviral therapy

Talia M Mota, Thomas A Rasmussen, Ajantha Rhodes, Surekha Tennakoon, Ashanti Dantanarayana, Fiona Wightman, Michelle Hagenauer, Janine Roney, Tim Spelman, Damian FJ Purcell, James McMahon, Jennifer F Hoy, H Miles Prince, Julian H Elliott, Sharon R Lewin

Journal article  |  2017  |  AIDS

Scholarly works icon

Differentiating founder and chronic HIV envelope sequences

John M Murray, Stephen Maher, Talia Mota, Kazuo Suzuki, Anthony D Kelleher, Rob J Center, Damian Purcell

Journal article  |  2017  |  PLOS ONE

Scholarly works icon

Trimeric gp120-specific bovine monoclonal antibodies require cysteine and aromatic residues in CDRH3 for high affinity binding to HIV Env

Behnaz Heydarchi, Rob J Center, Jonathan Bebbington, Jack Cuthbertson, Christopher Gonelli, Georges Khoury, Charlene Mackenzie, Marit Lichtfuss, Grant Rawlin, Brian Muller, Damian Purcell

Journal article  |  2017  |  mAbs

Scholarly works icon

Toxicity and in vitro activity of HIV-1 latency-reversing agents in primary CNS cells

Lachlan R Gray, Hung On, Emma Roberts, Hao K Lu, Michael A Moso, Jacqueline A Raison, Catherine Papaioannou, Wan-Jung Cheng, Anne M Ellett, Jonathan C Jacobson, Damian FJ Purcell, Steve L Wesselingh, Paul R Gorry, Sharon R Lewin, Melissa J Churchill

Journal article  |  2016  |  Journal of NeuroVirology

Scholarly works icon

Repeated Vaccination of Cows with HIV Env gp140 during Subsequent Pregnancies Elicits and Sustains an Enduring Strong Env-Binding and Neutralising Antibody Response

Behnaz Heydarchi, Rob J Center, Christopher Gonelli, Brian Muller, Charlene Mackenzie, Georges Khoury, Marit Lichtfuss, Grant Rawlin, Damian FJ Purcell

Journal article  |  2016  |  PLOS ONE

Scholarly works icon

Suppression subtractive hybridization method for the identification of a new strain of murine hepatitis virus from xenografted SCID mice

Mohammed M Islam, Brendan Toohey, Damian FJ Purcell, George Kannourakis

Journal article  |  2015  |  Archives of Virology

Scholarly works icon

Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection

Sarah L Londrigan, Michelle D Tate, Emma R Job, Jessica M Moffat, Linda M Wakim, Christopher A Gonelli, Damien FJ Purcell, Andrew G Brooks, Jose A Villadangos, Patrick C Reading, Justine D Mintern

Journal article  |  2015  |  PLOS ONE

Scholarly works icon

HISTONE DEACETYLASE INHIBITORS ALTER THE ACCUMULATION OF CELL-ASSOCIATED SPLICED HIV MRNA - IMPLICATIONS FOR REACTIVATING THE RESERVOIR

Talia M Mota, Fiona Wightman, Karey Cheong, Hao K Lu, Jenny L Anderson, Damian F Purcell, Sharon Lewin

Conference Proceedings  |  2015  |  Sexually Transmitted Infections

Scholarly works icon

DIGITAL DROPLET PCR (DDPCR) QUANTIFICATION OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-1 CLADE C IN PERIPHERAL BLOOD AND LUNG INFILTRATES OF INDIGENOUS AUSTRALIAN BRONCHIECTASIS PATIENTS

D Yurick, L Einsiedel, H Pham, G Khoury, DFJ Purcell

Conference Proceedings  |  2015  |  Sexually Transmitted Infections

Scholarly works icon

MYB Elongation Is Regulated by the Nucleic Acid Binding of NF kappa B p50 to the Intronic Stem-Loop Region

Lloyd A Pereira, Honor J Hugo, Jordane Malaterre, Huiling Xu, Secondo Sonza, Alina Cures, Damian FJ Purcell, Paul A Ramsland, Steven Gerondakis, Thomas J Gonda, Robert G Ramsay

Journal article  |  2015  |  PLOS ONE

Scholarly works icon

Towards an HIV cure: science and debate from the International AIDS Society 2013 symposium

Damian FJ Purcell, Julian H Elliott, Anna-Laura Ross, John Frater

Journal article  |  2013  |  Retrovirology

Scholarly works icon

The magnitude of HIV-1 resistance to the CCR5 antagonist maraviroc may impart a differential alteration in HIV-1 tropism for macrophages and T-cell subsets

Jacqueline K Flynn, Geza Paukovics, Miranda S Moore, Anne Ellett, Lachlan R Gray, Renee Duncan, Hamid Salimi, Becky Jubb, Mike Westby, Damian FJ Purcell, Sharon R Lewin, Benhur Lee, Melissa J Churchill, Paul R Gorry, Michael Roche

Journal article  |  2013  |  Virology

Scholarly works icon

Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naive Subjects with Progressive HIV-1 Subtype C Infection

Martin R Jakobsen, Kieran Cashin, Michael Roche, Jasminka Sterjovski, Anne Ellett, Katharina Borm, Jacqueline Flynn, Christian Erikstrup, Maelenn Gouillou, Lachlan R Gray, Nitin K Saksena, Bin Wang, Damian FJ Purcell, Per Kallestrup, Rutendo Zinyama-Gutsire, Exnevia Gomo, Henrik Ullum, Lars Ostergaard, Benhur Lee, Paul A Ramsland, et al.

Journal article  |  2013  |  PLoS One

Scholarly works icon

Utility of the Sindbis replicon system as an Env-targeted HIV vaccine

Rob J Center, Annett Miller, Adam K Wheatley, Shahan M Campbell, Carly Siebentritt, Damian FJ Purcell

Journal article  |  2013  |  Vaccine

Scholarly works icon

Gene therapy as a cure for human immunodeficiency virus

SR Lewin, DFJ Purcell, J van Lunzen

Journal article  |  2012  |  European Infectious Disease

Scholarly works icon

Biology of Mucosally Transmitted Sexual Infection-Translating the Basic Science into Novel HIV Intervention: A Workshop Summary

Damian Purcell, Anthony Cunningham, Stuart Turville, Gilda Tachedjian, Alan Landay

Journal article  |  2012  |  AIDS Research and Human Retroviruses

Scholarly works icon

Anti-HIV-1 antibody-dependent cellular cytotoxicity mediated by hyperimmune bovine colostrum IgG

Marit Kramski, Gregor F Lichtfuss, Marjon Navis, Gamze Isitman, Leia Wren, Grant Rawlin, Rob J Center, Anthony Jaworowski, Stephen J Kent, Damian FJ Purcell

Journal article  |  2012  |  European Journal of Immunology

Scholarly works icon

Hyperimmune Bovine Colostrum as a Low-Cost, Large-Scale Source of Antibodies with Broad Neutralizing Activity for HIV-1 Envelope with Potential Use in Microbicides

Marit Kramski, Rob J Center, Adam K Wheatley, Jonathan C Jacobson, Marina R Alexander, Grant Rawlin, Damian FJ Purcell

Journal article  |  2012  |  Antimicrobial Agents and Chemotherapy

Scholarly works icon

Application of a case-control study design to investigate genotypic signatures of HIV-1 transmission

Talia M Mota, John M Murray, Rob J Center, Damian FJ Purcell, James M McCaw

Journal article  |  2012  |  Retrovirology

Scholarly works icon

CD4( ) T-Cell Deficiency in HIV Patients Responding to Antiretroviral Therapy Is Associated With Increased Expression of Interferon-Stimulated Genes in CD4( ) T Cells

Sonia Fernandez, Sara Tanaskovic, Karla Helbig, Reena Rajasuriar, Marit Kramski, John M Murray, Michael Beard, Damian Purcell, Sharon R Lewin, Patricia Price, Martyn A French

Journal article  |  2011  |  The Journal of Infectious Diseases

Scholarly works icon

Intensification of Antiretroviral Therapy With Raltegravir or Addition of Hyperimmune Bovine Colostrum in HIV-Infected Patients With Suboptimal CD4( ) T-Cell Response: A Randomized Controlled Trial

Helen Byakwaga, Mark Kelly, Damian FJ Purcell, Martyn A French, Janaki Amin, Sharon R Lewin, Hila Haskelberg, Anthony D Kelleher, Roger Garsia, Mark A Boyd, David A Cooper, Sean Emery

Journal article  |  2011  |  Journal of Infectious Diseases

Scholarly works icon

Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific

Kazuo Suzuki, Takaomi Ishida, Makoto Yamagishi, Chantelle Ahlenstiel, Sanjay Swaminathan, Katharine Marks, Daniel Murray, Erin M McCartney, Michael R Beard, Marina Alexander, Damian FJ Purcell, David A Cooper, Toshiki Watanabe, Anthony D Kelleher

Journal article  |  2011  |  RNA Biology

Scholarly works icon

Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4 T cells

Suha Saleh, Fiona Wightman, Saumya Ramanayake, Marina Alexander, Nitasha Kumar, Gabriela Khoury, Candida Pereira, Damian Purcell, Paul U Cameron, Sharon R Lewin

Journal article  |  2011  |  Retrovirology

Scholarly works icon

A Brain-Derived HIV-1 Envelope Protein Clone with Utility as an Immunogen

RJ Center, J Tan, J Sterjovski, LR Gray, C Siebentritt, MJ Churchill, SM Reddy, PA Ramsland, PR Gorry, DF Purcell

Conference Proceedings  |  2011  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

Scholarly works icon

Systemic and Mucosal Vaccination of Rabbits Using Envelope Glycoproteins Derived from HIV-1 Pre-Seroconversion Strains as Novel Immunogens

S Reddy, R Center, K Suzuki, B Chua, D Jackson, P Gorry, A Kelleher, D Purcell

Conference Proceedings  |  2011  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

Scholarly works icon

Novel Sensitive Real-Time PCR for Quantification of Bacterial 16S rRNA Genes in Plasma of HIV-Infected Patients as a Marker for Microbial Translocation

M Kramski, AJ Gaeguta, GF Lichtfuss, R Rajasuriar, SM Crowe, MA French, SR Lewin, RJ Center, DFJ Purcell

Journal article  |  2011  |  Journal of Clinical Microbiology

Scholarly works icon

Induction of humoral and cellular immune responses against the HIV-1 envelope protein using gamma-retroviral virus-like particles

Tea Kirkegaard, Adam Wheatley, Jesper Melchjorsen, Shervin Bahrami, Finn S Pedersen, Robert J Center, Damian FJ Purcell, Lars Ostergaard, Mogens Duch, Martin Tolstrup

Journal article  |  2011  |  Virology Journal

Scholarly works icon

Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection

Andrew Lim, Afsana Amini, Lloyd J D'Orsogna, Reena Rajasuriar, Marit Kramski, Sharon R Lewin, Damian F Purcell, Patricia Price, Martyn A French

Journal article  |  2011  |  AIDS

Scholarly works icon

Co-Expression of miRNA Targeting the Expression of PERK, but Not PKR, Enhances Cellular Immunity from an HIV-1 Env DNA Vaccine

Adam K Wheatley, Marit Kramski, Marina R Alexander, Jesse G Toe, Rob J Center, Damian FJ Purcell

Journal article  |  2011  |  PLoS One

Scholarly works icon

Role of Adjuvants in Enhancing the Immunogenicity of HIV-1 Envelope Glycoprotein based Vaccine Immunogens

S Reddy, B Chua, M Kramski, R Center, D Jackson, D Purcell

Conference Proceedings  |  2010  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

Scholarly works icon

Efficient transcription through an intron requires the binding of an Sm-type U1 snRNP with intact stem loop II to the splice donor

Marina R Alexander, Adam K Wheatley, Rob J Center, Damian FJ Purcell

Journal article  |  2010  |  Nucleic Acids Research

Scholarly works icon

Enhanced CD4 cellular apoptosis by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with progressive HIV-1 infection

Jessica Wade, Jasminka Sterjovski, Lachlan Gray, Ichael Roche, Lisa Chiavaroli, Anne Ellett, Martin R Jakobsen, Daniel Cowley, Candida da Fonseca Pereira, Nitin Saksena, Bin Wang, Damian FJ Purcell, Ingrid Karlsson, Eva-Maria Fenyoe, Melissa Churchill, Paul R Gorry

Journal article  |  2010  |  Virology

Scholarly works icon

Induction of HIV-1 subtype B and AE-specific neutralizing antibodies in mice and macaques with DNA prime and recombinant gp140 protein boost regimens

Rob J Center, Adam K Wheatley, Shahan M Campbell, Adriana J Gaeguta, Viv Peut, Sheilajen Alcantara, Carly Siebentritt, Stephen J Kent, Damian FJ Purcell

Journal article  |  2009  |  Vaccine

Scholarly works icon

P13-03. Neutralizing antibody to HIV-1 Env from hyperimmune bovine colostrum as a mucosal microbicide strategy for preventing virus transmission

M Kramski, R Center, G Rawlin, C Siebentritt, DF Purcell

Journal article  |  2009  |  Retrovirology

Scholarly works icon

P12-01. Construction and characterization of recombinant envelope glycoproteins derived from HIV-1 pre-seroconversion strains as potential vaccine immunogens

SMR Reddy, RJ Center, K Suzuki, P Gorry, A Kelleher, DF Purcell

Journal article  |  2009  |  Retrovirology

Scholarly works icon

OA021-03. Design and development of DNA vaccines for the co-expression of micro-RNA and HIV-1 Env

AK Wheatley, MR Alexander, JG Toe, RJ Center, DF Purcell

Journal article  |  2009  |  Retrovirology

Scholarly works icon

P09-07. Balancing reversion of CTL and neutralizing antibody escape mutations within HIV-1 Env upon transmission

V Peut, S Campbell, A Gaeguta, RJ Center, S Alcantara, C Fernandez, DF Purcell, SJ Kent

Journal article  |  2009  |  Retrovirology

Scholarly works icon

Balancing Reversion of Cytotoxic T-Lymphocyte and Neutralizing Antibody Escape Mutations within Human Immunodeficiency Virus Type 1 Env upon Transmission

Viv Peut, Shahan Campbell, Adriana Gaeguta, Rob J Center, Kim Wilson, Sheilajen Alcantara, Caroline S Fernandez, Damian FJ Purcell, Stephen J Kent

Journal article  |  2009  |  Journal of Virology

Scholarly works icon

Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain (vol 83, pg 5430, 2009)

Lachlan Gray, Michael Roche, Melissa J Churchill, Jasminka Sterjovski, Anne Ellett, Pantelis Poumbourios, Shameem Sherieff, Bin Wang, Nitin Saksena, Damian FJ Purcell, Steven Wesselingh, Anthony L Cunningham, Bruce J Brew, Dana Gabuzda, Paul R Gorry

Journal article  |  2009  |  Journal of Virology

Scholarly works icon

Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain

Lachlan Gray, Michael Roche, Melissa J Churchill, Jasminka Sterjovski, Anne Ellett, Pantelis Poumbourios, Shameem Sheffief, Bin Wang, Nitin Saksena, Damian FJ Purcell, Steven Wesselingh, Anthony L Cunningham, Bruce J Brew, Dana Gabuzda, Paul R Gorry

Journal article  |  2009  |  Journal of Virology

Scholarly works icon

Characterization of the TRBP domain required for Dicer interaction and function in RNA interference

Sylvanne M Daniels, Carlos E Melendez-Pena, Robert J Scarborough, Aicha Daher, Helen S Christensen, Mohamed El Far, Damian FJ Purcell, Sebastien Laine, Anne Gatignol

Journal article  |  2009  |  BMC Molecular Biology

Scholarly works icon

Complexity of the Inoculum Determines the Rate of Reversion of SIV Gag CD8 T Cell Mutant Virus and Outcome of Infection

Liyen Loh, Jeanette C Reece, Caroline S Fernandez, Sheilajen Alcantara, Robert Center, Jane Howard, Damian FJ Purcell, Mehala Balamurali, Janka Petravic, Miles P Davenport, Stephen J Kent

Journal article  |  2009  |  PLoS Pathogens

Scholarly works icon

Does RNA interference provide new hope for control of chronic hepatitis B infection?

Rachel Wilson, Damian Purcell, Hans J Netter, Peter A Revill

Journal article  |  2009  |  Antiviral Therapy

Scholarly works icon

Balancing reversion of CTL and neutralizing antibody mutations within HIV-1 Env upon transmission

V Peut, S Campbell, A Gaeguta, RJ Center, S Alcantara, C Fernandez, DF Purcell, SJ Kent

Journal article  |  2009  |  Retrovirology

Scholarly works icon

Tissue-specific sequence alterations in the HIV-1 envelope favoring CCR5-usage contribute to persistence of dual-tropic virus in brain

Lachlan R Gray, Michael Roche, Melissa J Churchill, Jasminka Sterjovski, Anne Ellett, Pantelis Poumbourios, Shameem Sherrief, Bin Wang, Nitin Saksena, Damian FJ Purcell, Steven Wesselingh, Anthony L Cunningham, Bruce J Brew, Dana Gabuzda, Paul R Gorry

Conference Proceedings  |  2009  |  JOURNAL OF NEUROVIROLOGY

Scholarly works icon

Construction and characterization of recombinant envelope glycoproteins derived from HIV-1 pre-seroconversion strains as potential vaccine immunogens

S Mohana Rama Reddy, RJ Center, K Suzuki, P Gorry, A Kelleher, DF Purcell

Conference Proceedings  |  2009  |  RETROVIROLOGY

Scholarly works icon

Neutralizing antibody to HIV-1 Env from hyperimmune bovine colostrum as a mucosal microbicide strategy for preventing virus transmission

M Kramski, R Center, G Rawlin, C Siebentritt, DF Purcell

Conference Proceedings  |  2009  |  RETROVIROLOGY

Scholarly works icon

Design and development of DNA vaccines for the co-expression of micro-RNA and HIV-1 Env

AK Wheatley, MR Alexander, JG Toe, RJ Center, DF Purcell

Conference Proceedings  |  2009  |  Retrovirology

Scholarly works icon

Controlling HIV infection HIV co-receptor gets the finger

Anthony D Kelleher, Damian F Purcell

Journal article  |  2008  |  Immunology and Cell Biology

Scholarly works icon

Sindbis virus vectors elicit hemagglutinin-specific humoral and cellular immune responses and offer a dose-sparing strategy for vaccination

Annett Miller, Rob J Center, John Stambas, Georgia Deliyannis, Peter C Doherty, Jane L Howard, Stephen J Turner, Damian FJ Purcell

Journal article  |  2008  |  Vaccine

Scholarly works icon

Screening a Panel of Natural HIV-1 Env Variants on the Basis of Neutralization Target Exposure for Vaccine Immunogens

DF Purcell, RJ Center, J Tan, C Siebentritt, J Sterjovski, LR Gray, MJ Churchill, SM Reddy, PA Ramsland, PR Gorry

Conference Proceedings  |  2008  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

Scholarly works icon

Primary HIV-1 R5 isolates from end-stage disease display enhanced viral fitness in parallel with increased gp120 net charge

Johanna Repits, Jasminka Sterjovski, Daniel Badia-Martinez, Mattias Mild, Lachlan Gray, Melissa J Churchill, Damian FJ Purcell, Anders Karlsson, Jan Albert, Eva Maria Fenyoe, Adnane Achour, Paul R Gorry, Marianne Jansson

Journal article  |  2008  |  Virology

Scholarly works icon

Evolution of DC-SIGN use revealed by fitness studies of R5 HIV-I variants emerging during AIDS progression

Marie Borggren, Johanna Repits, Carlotta Kuylenstierna, Jasminka Sterjovski, Melissa J Churchill, Damian FJ Purcell, Anders Karlsson, Jan Albert, Paul R Gorry, Marianne Jansson

Journal article  |  2008  |  Retrovirology

Scholarly works icon

HIV-I infection induces changes in expression of cellular splicing factors that regulate alternative viral splicing and virus production in macrophages

Dinushka Dowling, Somayeh Nasr-Esfahani, Chun H Tan, Kate O'Brien, Jane L Howard, David A Jans, Damian FJ Purcell, C Martin Stoltzfus, Secondo Sonza

Journal article  |  2008  |  Retrovirology

Scholarly works icon

Virologic determinants of success after structured treatment interruptions of antiretrovirals in acute HIV-1 infection

Sharon R Lewin, John M Murray, Ajantha Solomon, Fiona Wightman, Paul U Cameron, Damian J Purcell, John J Zaunders, Pat Grey, Mark Bloch, David A Cooper, Anthony D Kelleher, Don Smith

Journal article  |  2008  |  Journal of Acquired Immune Deficiency Syndromes (JAIDS)

Scholarly works icon

Amiloride derivatives inhibit coxsackievirus B3 RNA replication

David N Harrison, Elena V Gazina, Damian F Purcell, David A Anderson, Steven Petrou

Journal article  |  2008  |  Journal of Virology

Scholarly works icon

Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS

Jasminka Sterjovski, Melissa J Churchill, Anne Ellett, Lachlan R Gray, Michael J Roche, Rebecca L Dunfee, Damian Fj Purcell, Nitin Saksena, Bin Wang, Secondo Sonza, Steven L Wesselingh, Ingrid Karlsson, Eva-Maria Fenyo, Dana Gabuzda, Anthony L Cunningham, Paul R Gorry

Journal article  |  2007  |  Retrovirology

Scholarly works icon

In vitro dimerization of human immunodeficiency virus type 1 (HIV-1) spliced RNAs

Lucile Sinck, Delphine Richer, Jane Howard, Marina Alexander, Damian FJ Purcell, Roland Marquet, Jean-Christophe Paillart

Journal article  |  2007  |  Retrovirology

Scholarly works icon

Killing kinetics of simian immunodeficiency virus-specific CD8( ) T cells: implications for HIV vaccine strategies

Erik Rollman, Miranda Z Smith, Andrew G Brooks, Damian FJ Purcell, Bartek Zuber, Ian A Ramshaw, Stephen J Kent

Journal article  |  2007  |  Journal of Immunology

Scholarly works icon

A minimal uORF within the HIV-1 vpu leader allows efficient translation initiation at the downstream env AUG

Jorg Krummheuer, Adam T Johnson, Ilona Hauber, Susanne Kammler, Jenny L Anderson, Joachim Hauber, Damian FJ Purcell, Heiner Schaal

Journal article  |  2007  |  Virology

Scholarly works icon

Oncogenic properties of HIV-Tat in colorectal cancer cells

Duy Huynh, Elizabeth Vincan, Theo Mantamadiotis, Damian Purcell, Chee-Kai Chan, Robert Ramsay

Journal article  |  2007  |  Current HIV Research

Scholarly works icon

Both linear and discontinuous ribosome scanning are used for translation initiation from bicistronic human immunodeficiency virus type 1 env mRNAs

Jenny L Anderson, Adam T Johnson, Jane L Howard, Damian FJ Purcell

Journal article  |  2007  |  Journal of Virology

Scholarly works icon

Small interfering RNAs against the TAR RNA binding protein, TRBP, a dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production

Helen S Christensen, Aicha Daher, Kaitlin J Soye, Lisa B Frankel, Marina R Alexander, Sebastien Laine, Sylvie Bannwarth, Chi L Ong, Sean WL Chung, Shahan M Campbell, Damian FJ Purcell, Anne Gatignol

Journal article  |  2007  |  Journal of Virology

Scholarly works icon

Preferential infection of dendritic cells during human immunodeficiency virus type 1 infection of blood leukocytes

Paul U Cameron, Amanda J Handley, Dean C Baylis, Ajantha E Solomon, Nicholas Bernard, Damian FJ Purcell, Sharon R Lewin

Journal article  |  2007  |  Journal of Virology

Scholarly works icon

Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers

Honor Hugo, Alina Cures, Nirosha Suraweera, Yvette Drabsch, Damian Purcell, Theo Mantamadiotis, Wayne Phillips, Alex Dobrovic, Gabriella Zupi, Thomas J Gonda, Barry Iacopetta, Robert G Ramsay

Journal article  |  2006  |  Genes, Chromosomes & Cancer

Scholarly works icon

Transcriptional activity of blood-and cerebrospinal fluid-derived nef/long-terminal repeat sequences isolated from a slow progressor infected with nef -deleted human immunodeficiency virus type 1 (HIV-1) who developed HIV-associated dementia

Melissa J Churchill, Anna Figueiredo, Daniel Cowley, Lachlan Gray, Damian FJ Purcell, John S Sullivan, Dale A McPhee, Steven L Wesselingh, Bruce J Brew, Paul R Gorry

Journal article  |  2006  |  Journal of NeuroVirology

Scholarly works icon

Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues

Melissa J Churchill, Paul R Gorry, Daniel Cowley, Luxshimi Lal, Secondo Sonza, Damian FJ Purcell, Katherine A Thompson, Dana Gabuzda, Justin C McArthur, Carlos A Pardo, Steven L Wesselingh

Journal article  |  2006  |  Journal of NeuroVirology

Scholarly works icon

Genetic and Functional Analysis of R5X4 Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Derived from Two Individuals Homozygous for the CCR5 32 Allele

L Gray, MJ Churchill, N Keane, J Sterjovski, AM Ellett, DFJ Purcell, P Poumbourios, C Kol, B Wang, NK Saksena, SL Wesselingh, P Price, M French, D Gabuzda, PR Gorry

Journal article  |  2006  |  Journal of Virology

Scholarly works icon

Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5 Delta 32 allele

L Gray, MJ Churchill, N Keane, J Sterjovski, AM Ellett, DFJ Purcell, P Poumbourios, C Kol, B Wang, NK Saksena, SL Wesselingh, P Price, M French, D Gabuzda, PR Gorry

Journal article  |  2006  |  Journal of Virology

Scholarly works icon

Fowlpox virus vaccines for HIV and SHIV clinical and pre-clinical trials

BEH Coupar, DFJ Purcell, SA Thomson, IA Ramshaw, SJ Kent, DB Boyle

Journal article  |  2006  |  Vaccine

Scholarly works icon

The effect of antigen targeting sequences on antibody responses to hepatitis E virus DNA vaccines in rats and sheep

F Li, P Loke, A Healy, MW Lightowlers, CG Gauci, DFJ Purcell, DA Anderson

Journal article  |  2006  |  Vaccine

Scholarly works icon

A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1

AD Kelleher, RL Puls, M Bebbington, D Boyle, R Ffrench, SJ Kent, S Kippax, DFJ Purcell, S Thomson, H Wand, DA Cooper, S Emery

Journal article  |  2006  |  AIDS

Scholarly works icon

Construction and expression of a Rev-dependent TNF-R1 expressing HIV-infected-cell injurious vectors

WM Shi, D Baylis, D Purcell, PU Cameron

Journal article  |  2005  |  Chinese Medical Journal

Scholarly works icon

Low TRBP levels support an innate human immunodeficiency virus type 1 resistance in astrocytes by enhancing the PKR antiviral response

CL Ong, JC Thorpe, PR Gorry, S Bannwarth, A Jaworowski, JL Howard, S Chung, S Campbell, HS Christensen, G Clerzius, AJ Mouland, A Gatignol, DFJ Purcell

Journal article  |  2005  |  Journal of Virology

Scholarly works icon

Evaluation in macaques of HIV-1 DNA vaccines containing primate CpG motifs and fowlpoxvirus vaccines co-expressing IFN gamma or IL-12

CJ Dale, R De Rose, KM Wilson, HA Croom, S Thomson, BEH Coupar, A Ramsay, DFJ Purcell, R Ffrench, M Law, S Emery, DA Cooper, IA Ramshaw, DB Boyle, SJ Kent

Journal article  |  2004  |  Vaccine

Scholarly works icon

Evaluation in macaques of HIV-1 DNA vaccines containing primate CpG motifs and fowlpoxvirus vaccines co-expressing IFN? or IL-12

C DALE, R DEROSE, K WILSON, H CROOM, S THOMSON, B COUPAR, A RAMSAY, D PURCELL, R FFRENCH, M LAW

Journal article  |  2004  |  Vaccine

Scholarly works icon

Apoptosis induced in synchronized human immunodeficiency virus type 1-infected primary peripheral blood mononuclear cells is detected after the peak of CD4 T-lymphocyte loss and is dependent on the tropism of the gp120 envelope glycoprotein

VA Lawson, KA Silburn, PR Gorry, G Paukovic, DFJ Purcell, AL Greenway, DA McPhee

Journal article  |  2004  |  Journal of Virology

Scholarly works icon

Vaccines and vaccine strategies against HIV

I Stratov, R DeRose, DFJ Purcell, SJ Kent

Journal article  |  2004  |  Current Drug Targets

Scholarly works icon

Astrocyte infection by HIV-1: Mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia

PR Gorry, C Ong, J Thorpe, S Bannwarth, KA Thompson, A Gatignol, SL Wesselingh, DFJ Purcell

Journal article  |  2003  |  Current HIV Research

Scholarly works icon

[The effect of specific virus delivering of Langerhans cell for the M-tropic HIV infection].

Wei-min Shi, Paul U Cameron, Damian JF Purcell

Journal article  |  2003  |  Zhonghua yi xue za zhi

OBJECTIVE: To observe the cellular mechanism of via skin infection of Microphage tropic (M-tropic) HIV and further differentiate t..

Scholarly works icon

Decreased neurotropism of nef long terminal repeat (nef/LTR)-deleted simian immunodeficiency virus

KA Thompson, SJ Kent, ME Gahan, DFJ Purcell, CA McLean, S Preiss, CJ Dale, SL Wesselingh

Journal article  |  2003  |  Journal of NeuroVirology

Scholarly works icon

Augment of the antigenicity of HIV-1 gp160 by Rev dependent apoptosis

WM Shi, PU Cameron, DJF Purcell

Journal article  |  2003  |  Chinese Journal of Microbiology and Immunology

Scholarly works icon

Selectively reduced tat mRNA heralds the decline in productive human immunodeficiency virus type 1 infection in monocyte-derived macrophages

S Sonza, HP Mutimer, K O'Brien, P Ellery, JL Howard, JH Axelrod, NJ Deacon, SM Crowe, DFJ Purcell

Journal article  |  2002  |  Journal of Virology

Scholarly works icon

Chimeric human papilloma virus-simian/human immunodeficiency virus virus-like-particle vaccines: Immunogenicity and protective efficacy in macaques

CJ Dale, XSS Liu, R De Rose, DFJ Purcell, J Anderson, Y Xu, GR Leggatt, IH Frazer, SJ Kent

Journal article  |  2002  |  Virology

Scholarly works icon

Evidence of recombination between 3 ' and 5 ' LTRs in macaques inoculated with SIV DNA

SJ Kent, CJ Dale, S Preiss, DFJ Purcell

Journal article  |  2002  |  AIDS Research and Human Retroviruses

Scholarly works icon

Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line

S Bannwarth, L Talakoub, F Letourneur, M Duarte, DF Purcell, J Hiscott, A Gatignol

Journal article  |  2001  |  Journal of Biological Chemistry

Scholarly works icon

Vaccination with attenuated simian immunodeficiency virus by DNA inoculation

SJ Kent, CJ Dale, S Preiss, J Mills, D Campagna, DFJ Purcell

Journal article  |  2001  |  Journal of Virology

Scholarly works icon

The CD1a CD11c Langerhans cell precursors are the most susceptible blood leucocytes for HIV infection

PU Cameron, A Handley, DC Baylis, JC Reece, SR Lewin, DF Purcell

Conference Proceedings  |  2001  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

Scholarly works icon

Two Dimerization Domains in the Trans-activation Response RNA-binding Protein (TRBP) Individually Reverse the Protein Kinase R Inhibition of HIV-1 Long Terminal Repeat Expression

Aı̈cha Daher, Michèle Longuet, Dominique Dorin, Florence Bois, Emmanuel Segeral, Sylvie Bannwarth, Pier-Luigi Battisti, Damian F Purcell, Richard Benarous, Catherine Vaquero, Eliane F Meurs, Anne Gatignol

Journal article  |  2001  |  Journal of Biological Chemistry

Scholarly works icon

Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression

A Daher, M Longuet, D Dorin, F Bois, E Segeral, S Bannwarth, PL Battisti, DF Purcell, R Benarous, C Vaquero, EF Meurs, A Gatignol

Journal article  |  2001  |  Journal of Biological Chemistry

Scholarly works icon

Attenuated and wild-type HIV-1 infections and long terminal repeat-mediated gene expression from plasmids delivered by gene gun to human skin ex vivo and macaques in vivo

SJ Kent, PU Cameron, JC Reece, PR Thompson, DFJ Purcell

Journal article  |  2001  |  Virology

Scholarly works icon

Simian immunodeficiency virus infections in vervet monkeys (Clorocebus aethiops) at an Australian zoo

AK Joy, L Vogelnest, DJ Middleton, CJ Dale, D Campagna, DFJ Purcell, SJ Kent

Journal article  |  2001  |  Australian Veterinary Journal

Scholarly works icon

nef-deleted HIV-1 inhibits phagocytosis by monocyte-derived macrophages in vitro but not by peripheral blood monocytes in vivo

K Kedzierska, J Mak, A Jaworowski, A Greenway, A Violo, HT Chan, J Hocking, D Purcell, JS Sullivan, J Mills, S Crowe

Journal article  |  2001  |  AIDS

Scholarly works icon

Monocytes harbour replication-competent, non-latent HIV-1 in patients on highly active antiretroviral therapy

S Sonza, HP Mutimer, R Oelrichs, D Jardine, K Harvey, A Dunne, DF Purcell, C Birch, SM Crowe

Journal article  |  2001  |  AIDS

Scholarly works icon

Infectivity of wild-type and deleted proviral SIV DNA.

DF Purcell, PU Cameron, J Mills, S Kent

Journal article  |  2001  |  Developments in biologicals

Live attenuated lentiviruses are potentially effective candidate HIV vaccines; however, delivery of these viruses in the field wou..

Scholarly works icon

Pathogenesis of replication competent retroviruses derived from mouse cells in immunosuppressed primates: implications for use of neoplastic cells as vaccine substrates.

DF Purcell

Journal article  |  2001  |  Developments in biologicals

T-cell lymphomas developed in three of 10 immunosuppressed rhesus macaques during early experiments using retroviral vectors to tr..

Scholarly works icon

Novel endogenous type D retroviral particles expressed at high levels in a SCID mouse thymic lymphoma

S Ristevski, DFJ Purcell, J Marshall, D Campagna, S Nouri, SP Fenton, DA McPhee, G Kannourakis

Journal article  |  1999  |  Journal of Virology

Scholarly works icon

Diminished production of human immunodeficiency virus type 1 in astrocytes results from inefficient translation of gag, env, and nef mRNAs despite efficient expression of Tat and Rev

PR Gorry, JL Howard, MJ Churchill, JL Anderson, A Cunningham, D Adrian, DA McPhee, DFJ Purcell

Journal article  |  1999  |  Journal of Virology

Scholarly works icon

Restricted HIV-1 infection of human astrocytes: potential role of nef in the regulation of virus replication.

P Gorry, D Purcell, J Howard, D McPhee

Journal article  |  1998  |  Journal of Neurovirology

A small percentage of astrocytes are consistently infected in vivo by HIV-1 and may contribute to neuropathogenesis despite a non-..

Scholarly works icon

Myopathy and spontaneous Pasteurella pneumotropica-induced abscess formation in an HIV-1 transgenic mouse model

P Dickie, P Mounts, D Purcell, G Miller, T Fredrickson, LJ Chang, MA Martin

Journal article  |  1996  |  Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Scholarly works icon

An array of murine leukemia virus-related elements is transmitted and expressed in a primate recipient of retroviral gene transfer

DFJ Purcell, CM Broscius, EF Vanin, CE Buckler, AW Nienhuis, MA Martin

Journal article  |  1996  |  Journal of Virology

Scholarly works icon

Murine retroviral vector that induces long-term expression of HIV-1 envelope protein.

K Fujita, F Maldarelli, DF Purcell, J Silver

Journal article  |  1994  |  Journal of Virological Methods

A retroviral vector was constructed that induces long-term expression of human immunodeficiency virus type 1 (HIV-1) rev, vpu and ..

Scholarly works icon

AN INTEGRATION-DEFECTIVE U5 DELETION MUTANT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERTS BY ELIMINATING ADDITIONAL LONG TERMINAL REPEAT SEQUENCES

E VICENZI, DS DIMITROV, A ENGELMAN, TS MIGONE, DFJ PURCELL, J LEONARD, G ENGLUND, MA MARTIN

Journal article  |  1994  |  Journal of Virology

Scholarly works icon

ALTERNATIVE SPLICING OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 MESSENGER-RNA MODULATES VIRAL PROTEIN EXPRESSION, REPLICATION, AND INFECTIVITY

DFJ PURCELL, MA MARTIN

Journal article  |  1993  |  Journal of Virology

Scholarly works icon

COMPLEMENT REGULATORY PROTEINS AT THE FETOMATERNAL INTERFACE DURING HUMAN PLACENTAL DEVELOPMENT - DISTRIBUTION OF CD59 BY COMPARISON WITH MEMBRANE COFACTOR PROTEIN (CD46) AND DECAY ACCELERATING FACTOR (CD55)

CH HOLMES, KL SIMPSON, H OKADA, N OKADA, SD WAINWRIGHT, DFJ PURCELL, JM HOULIHAN

Journal article  |  1992  |  European Journal of Immunology

Scholarly works icon

TISSUE-SPECIFIC AND ALLELIC EXPRESSION OF THE COMPLEMENT REGULATOR CD46 IS CONTROLLED BY ALTERNATIVE SPLICING

SM RUSSELL, RL SPARROW, IFC MCKENZIE, DFJ PURCELL

Journal article  |  1992  |  European Journal of Immunology

Scholarly works icon

STRONG ASSOCIATIONS BETWEEN RFLP AND PROTEIN POLYMORPHISMS FOR CD46

AN WILTON, RW JOHNSTONE, IFC MCKENZIE, DFJ PURCELL

Journal article  |  1992  |  Immunogenetics

Scholarly works icon

THE MOLECULAR-BASIS OF CD46 POLYMORPHIC EXPRESSION AND DEMONSTRATION OF A PROTECTIVE ROLE AGAINST LYSIS BY XENOSERA

B LOVELAND, S RUSSELL, D PURCELL, R JOHNSTONE, B THORLEY, R SPARROW, I MCKENZIE

Conference Proceedings  |  1992  |  Transplantation Proceedings

Scholarly works icon

MOLECULAR CHARACTERIZATION OF THE POLYMORPHIC EXPRESSION OF CD46 - A CELL-SURFACE MOLECULE PROTECTING CELLS FROM COMPLEMENT ATTACK

SM RUSSELL, RW JOHNSTONE, A WILTON, RL SPARROW, IFC MCKENZIE, DFJ PURCELL

Conference Proceedings  |  1992  |  Transplantation Proceedings

Scholarly works icon

HUMAN ASTROCYTES EXPRESS MEMBRANE COFACTOR PROTEIN (CD46), A REGULATOR OF COMPLEMENT ACTIVATION

DL GORDON, TA SADLON, SL WESSELINGH, SM RUSSELL, RW JOHNSTONE, DFJ PURCELL

Journal article  |  1992  |  Journal of Neuroimmunology

Scholarly works icon

IDENTIFICATION OF 4 DIFFERENT CD46 (MCP) MOLECULES WITH ANTIPEPTIDE ANTIBODIES

DFJ PURCELL, RW JOHNSTONE, IFC MCKENZIE

Journal article  |  1991  |  Biochemical and Biophysical Research Communications

Scholarly works icon

ALTERNATIVELY SPLICED RNAS ENCODE SEVERAL ISOFORMS OF CD46 (MCP), A REGULATOR OF COMPLEMENT ACTIVATION

DFJ PURCELL, SM RUSSELL, NJ DEACON, MA BROWN, DJ HOOKER, IFC MCKENZIE

Journal article  |  1991  |  Immunogenetics

Scholarly works icon

THE ISOLATION OF CDNA CLONES FOR CD48

HA VAUGHAN, MM HENNING, DFJ PURCELL, IFC MCKENZIE, MS SANDRIN

Journal article  |  1991  |  Immunogenetics

Scholarly works icon

STRONG ASSOCIATIONS BETWEEN POLYMORPHISMS FOR MEMBRANE COFACTOR PROTEIN (MCP)

AN WILTON, DW COOPER, DF PURCELL, RJ JOHNSTONE, IF MCKENZIE

Conference Proceedings  |  1991  |  CYTOGENETICS AND CELL GENETICS

Scholarly works icon

THE HUMAN CELL-SURFACE GLYCOPROTEINS HULY-M5, MEMBRANE COFACTOR PROTEIN (MCP) OF THE COMPLEMENT-SYSTEM, AND TROPHOBLAST LEUKOCYTE-COMMON (TLX) ANTIGEN, ARE CD46

DFJ PURCELL, IFC MCKENZIE, DM LUBLIN, PM JOHNSON, JP ATKINSON, TJ OGLESBY, NJ DEACON

Journal article  |  1990  |  Immunology

Scholarly works icon

HUMAN NON-LINEAGE ANTIGEN, CD46 (HULY-M5) - PURIFICATION AND PARTIAL SEQUENCING DEMONSTRATES STRUCTURAL HOMOLOGY WITH COMPLEMENT-REGULATING GLYCOPROTEINS

DFJ PURCELL, NJ DEACON, SM ANDREW, IFC MCKENZIE

Journal article  |  1990  |  Immunogenetics

Scholarly works icon

HUMAN TROPHOBLAST EXPRESSION OF RETROVIRAL-LIKE ACTIVITY AND CD46 (MEMBRANE COFACTOR PROTEIN [MCP], HULY-M5, H316 [TLX] ANTIGEN)

PM JOHNSON, JM RISK, JM MWENDA, CA HART, DFJ PURCELL, NJ DEACON

Conference Proceedings  |  1990  |  REPRODUCTIVE IMMUNOLOGY 1989

Scholarly works icon

THE HUMAN NON-LINEAGE ANTIGEN CD46 (HULY-M5) AND PRIMATE RETROVIRAL GP70 MOLECULES SHARE PROTEIN-DEFINED ANTIGENIC DETERMINANTS

DFJ PURCELL, NJ DEACON, IFC MCKENZIE

Journal article  |  1989  |  Immunology and Cell Biology

Scholarly works icon

REACTIVITY OF ANTI-HUMAN MILK-FAT GLOBULE ANTIBODIES WITH SYNTHETIC PEPTIDES

PX XING, JJ TJANDRA, K REYNOLDS, PJ MCLAUGHLIN, DFJ PURCELL, IFC MCKENZIE

Journal article  |  1989  |  Journal of Immunology

Scholarly works icon

SYNTHESIS AND ANALYSIS OF PEPTIDE TO MURINE CD4 MOLECULES

GJ CLARK, MAC LADEMANN, K REYNOLDS, MM HENNING, A KELSO, R SUTHERLAND, D PURCELL, NJ DEACON, IFC MCKENZIE

Journal article  |  1989  |  TRANSPLANTATION PROCEEDINGS

Scholarly works icon

Synthesis and analysis of peptide to murine CD4 molecules

GJ Clark, MAC Lademann, K Reynolds, MM Henning, A Kelso, R Sutherland, D Purcell, NJ Deacon, IFC McKenzie

Journal article  |  1989  |  Transplantation Proceedings

Scholarly works icon

DETECTION OF HUMAN-ANTIGEN HULYM5 EPITOPES ON MOUSE FIBROBLASTS TRANSFECTED WITH CLONED GALV ENV DNA

NJ DEACON, DFJ PURCELL, IFC MCKENZIE

Conference Proceedings  |  1986  |  JOURNAL OF CELLULAR BIOCHEMISTRY

Scholarly works icon

CROSS-REACTIVITY OF A NORMAL HUMAN CELL-SURFACE ANTIGEN WITH PRIMATE RETROVIRUS GLYCOPROTEINS

RL SPARROW, DFJ PURCELL, IFC MCKENZIE

Journal article  |  1985  |  Human Immunology

Scholarly works icon

ETHICS OF INFANTICIDE AND ABORTION

D PURCELL

Journal article  |  1982  |  Medical Journal of Australia

143

Scholarly Works

Keyword Analysis

Medical Microbiology
Clinical Health (organs, Diseases and Abnormal Conditions)
Clinical (organs, Diseases and Abnormal Conditions)
Microbiology
Immunology
Biochemistry and Cell Biology
Clinical Sciences
Expanding Knowledge
Genetics
Human Pharmaceutical Products

Credentials

Positions

Professor In Virology

Microbiology And Immunology

Education

Doctor of Philosophy

University of Melbourne

Bachelor of Science (honours)

University of Melbourne

Links