Damian Purcell

Human T-cell lymphotropic virus type-1: a lifelong persistent infection, yet never truly silent.

Ashley Hirons, Georges Khoury, Damian FJ Purcell

Journal article  |  2021  |  The Lancet Infectious Diseases

Human T-cell lymphotropic virus type-1 (HTLV-1) has a large global burden and in some key communities, such as Indigenous Australi..

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

Jessie J-Y Chang, Daniel Rawlinson, Miranda Pitt, George Taiaroa, Josie Gleeson, Chenxi Zhou, Francesca Mordant, Ricardo De Paoli-Iseppi, Leon Caly, Damian FJ Purcell, Tim Stinear, Sarah Londrigan, Michael Clark, Deborah Williamson, Kanta Subbarao, Lachlan JM Coin

Journal article  |  2020

Summary SARS-CoV-2 uses subgenomic (sg)RNA to produce viral proteins for replication and immune evasion. We applied long-read RNA ..

Mucosal IL-4R antagonist HIV vaccination with SOSIP-gp140 booster can induce high-quality cytotoxic CD4 /CD8 T cells and humoral responses in macaques.

Z Li, M Khanna, SL Grimley, P Ellenberg, CA Gonelli, Wen Shi Lee, TH Amarasena, AD Kelleher, DFJ Purcell, SJ Kent, C Ranasinghe

Journal article  |  2020  |  Scientific Reports

Inducing humoral, cellular and mucosal immunity is likely to improve the effectiveness of HIV-1 vaccine strategies. Here, we teste..

Evaluation of Serological Tests for SARS-CoV-2: Implications for Serology Testing in a Low-Prevalence Setting

Katherine Bond, Suellen Nicholson, Seok Ming Lim, Theo Karapanagiotidis, Eloise Williams, Douglas Johnson, Tuyet Hoang, Cheryll Sia, Damian Purcell, Francesca Mordant, Sharon R Lewin, Mike Catton, Kanta Subbarao, Benjamin P Howden, Deborah A Williamson

Journal article  |  2020  |  Journal of Infectious Diseases

BACKGROUND: Robust serological assays are essential for long-term control of the COVID-19 pandemic. Many recently released point-o..

Tenth Scientific Biennial Meeting of the Australasian Virology Society-AVS10 2019

Karla J Helbig, Rowena A Bull, Rebecca Ambrose, Michael R Beard, Helen Blanchard, Till Bocking, Brendon Chua, Agathe MG Colmant, Keaton M Crosse, Damian FJ Purcell, Johanna Fraser, Joshua A Hayward, Stuart T Hamilton, Matloob Husain, Robin MacDiarmid, Jason M Mackenzie, Gregory W Moseley, Thi HO Nguyen, Miguel E Quinones-Mateu, Karl Robinson, et al.

Journal article  |  2020  |  Viruses

The Australasian Virology Society (AVS) aims to promote, support and advocate for the discipline of virology in the Australasian r..

Optimization of 5-substituted thiazolyl ureas and 6-substituted imidazopyridines as potential HIV-1 latency reversing agents

William Nguyen, Jonathan Jacobson, Kate E Jarman, Timothy R Blackmore, Helene Jousset Sabroux, Sharon R Lewin, Damian F Purcell, Brad E Sleebs

Journal article  |  2020  |  European Journal of Medicinal Chemistry

A persistent latent reservoir of virus in CD4+ T cells is a major barrier to cure HIV. Activating viral transcription in latently ..

Functional properties and sequence variation of HTLV-1 p13

Maria Omsland, Micol Silic-Benussi, Ramona Moles, Sarkis Sarkis, Damian FJ Purcell, David Yurick, Georges Khoury, Donna M D'Agostino, Vincenzo Ciminale, Genoveffa Franchini

Journal article  |  2020  |  Retrovirology

Human T cell leukemia virus type-1 (HTLV-1) was the first retrovirus found to cause cancer in humans, but the mechanisms that driv..

Tat IRES modulator of tat mRNA (TIM-TAM): a conserved RNA structure that controls Tat expression and acts as a switch for HIV productive and latent infection

Georges Khoury, Charlene Mackenzie, Lilia Ayadi, Sharon R Lewin, Christiane Branlant, Damian FJ Purcell

Journal article  |  2020  |  Nucleic Acids Research

Tat protein is essential to fully activate HIV transcription and processing of viral mRNA, and therefore determines virus expressi..

Role of HTLV-1 orf-I encoded proteins in viral transmission and persistence

Sarkis Sarkis, Veronica Galli, Ramona Moles, David Yurick, Georges Khoury, Damian FJ Purcell, Genoveffa Franchini, Cynthia A Pise-Masison

Journal article  |  2019  |  Retrovirology

The human T cell leukemia virus type 1 (HTVL-1), first reported in 1980 by Robert Gallo's group, is the etiologic agent of both ca..

p30 protein: a critical regulator of HTLV-1 viral latency and host immunity

Ramona Moles, Sarkis Sarkis, Veronica Galli, Maria Omsland, Damian FJ Purcell, David Yurick, Georges Khoury, Cynthia A Pise-Masison, Genoveffa Franchini

Journal article  |  2019  |  Retrovirology

The extraordinarily high prevalence of HTLV-1 subtype C (HTLV-1C) in some isolated indigenous communities in Oceania and the sever..