Weiguang Zeng

Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model

Kirstie M Mangas, Andrew H Buultjens, Jessica L Porter, Sarah L Baines, Estelle Marion, Laurent Marsollier, Nicholas J Tobias, Sacha J Pidot, Kylie M Quinn, David J Price, Katherine Kedzierska, Weiguang Zeng, David C Jackson, Brendon Y Chua, Timothy P Stineara

Journal article  |  2020  |  Infection and Immunity

The neglected tropical disease Buruli ulcer (BU) is an infection of subcutaneous tissue with Mycobacterium ulcerans There is no ef..

Modular platforms for the assembly of self-adjuvanting lipopeptide-based vaccines for use in an out-bred population

Weiguang Zeng, Kylie J Horrocks, Amabel CL Tan, Chinn Yi Wong, Brendon Y Chua, David C Jackson

Journal article  |  2020  |  Vaccine

To facilitate the preparation of synthetic epitope-based self-adjuvanting vaccines capable of eliciting antibody responses in an o..

Geometry of a TLR2-Agonist-Based Adjuvant Can Affect the Resulting Antigen-Specific Immune Response

Acep R Wijayadikusumah, Weiguang Zeng, Hayley A McQuilten, Chinn Yi Wong, David C Jackson, Brendon Y Chua

Journal article  |  2019  |  Molecular Pharmaceutics

Human CD8( ) T cell cross-reactivity across influenza A, B and C viruses

Marios Koutsakos, Patricia T Illing, Thi HO Nguyen, Nicole A Mifsud, Jeremy Chase Crawford, Simone Rizzetto, Auda A Eltahla, E Bridie Clemens, Sneha Sant, Brendon Y Chua, Chinn Yi Wong, E Kaitlynn Allen, Don Teng, Pradyot Dash, David F Boyd, Ludivine Grzelak, Weiguang Zeng, Aeron C Hurt, Ian Barr, Steve Rockman, et al.

Journal article  |  2019  |  Nature Immunology

In Vivo Imaging of Bioluminescent Mycobacterium ulcerans: A Tool to Refine the Murine Buruli Ulcer Tail Model

Till F Omansen, Renee A Marcsisin, Brendon Y Chua, Weiguang Zeng, David C Jackson, Jessica L Porter, Ymkje Stienstra, Tjip S van der Werf, Timothy P Stinear

Journal article  |  2019  |  The American Journal of Tropical Medicine and Hygiene

Buruli ulcer (BU) is a neglected tropical disease caused by infection with Mycobacterium ulcerans. Unclear transmission, no availa..

The Toll-Like Receptor 2 agonist PEG-Pam(2)Cys as an immunochemoprophylactic and immunochemotherapeutic against the liver and transmission stages of malaria parasites

Medard Ernest, Carol Hunja, Yuka Arakura, Yohei Haraga, Hussein M Abkallo, Weiguang Zeng, David C Jackson, Brendon Chua, Richard Culleton

Journal article  |  2018  |  International Journal for Parasitology: Drugs and Drug Resistance

A lipidated bi-epitope vaccine comprising of MHC-I and MHC-II binder peptides elicits protective CD4 T cell and CD8 T cell immunity against Mycobacterium tuberculosis

Pradeep K Rai, Sathi Babu Chodisetti, Sudeep K Maurya, Sajid Nadeem, Weiguang Zeng, Ashok K Janmeja, David C Jackson, Javed N Agrewala

Journal article  |  2018  |  Journal of Translational Medicine

Anti-inflammatory approaches to treat contact lens discomfort: a randomized, controlled trial

Laura Elizabeth Downie, Anne Gad, Chinn Yi Wong, John Henry V Gray, Weiguang Zeng, David C Jackson, Algis J Vingrys

Conference Proceedings  |  2018  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Modulating Contact Lens Discomfort With Anti-Inflammatory Approaches: A Randomized Controlled Trial

Laura E Downie, Anne Gad, Chinn Yi Wong, John Henry V Gray, Weiguang Zeng, David C Jackson, Algis J Vingrys

Journal article  |  2018  |  Investigative Opthalmology & Visual Science

A lipidated peptide of Mycobacterium tuberculosis resuscitates the protective efficacy of BCG vaccine by evoking memory T cell immunity

Pradeep K Rai, Sathi Babu Chodisetti, Weiguang Zeng, Sajid Nadeem, Sudeep K Maurya, Susanta Pahari, Ashok K Janmeja, David C Jackson, Javed N Agrewala

Journal article  |  2017  |  Journal of Translational Medicine

PEGylation of a TLR2-agonist-based vaccine delivery system improves antigen trafficking and the magnitude of ensuing antibody and CD8( ) T cell responses

Toshiki Sekiya, Junya Yamagishi, John Henry V Gray, Paul G Whitney, Axel Martinelli, Weiguang Zeng, Chinn Yi Wong, Chihiro Sugimoto, David C Jackson, Brendon Y Chua

Journal article  |  2017  |  Biomaterials

Mycobacterium ulcerans low infectious dose and mechanical transmission support insect bites and puncturing injuries in the spread of Buruli ulcer

John R Wallace, Kirstie M Mangas, Jessica L Porter, Renee Marcsisin, Sacha J Pidot, Brian Howden, Till F Omansen, Weiguang Zeng, Jason K Axford, Paul DR Johnson, Timothy P Stinear

Journal article  |  2017  |  PLOS Neglected Tropical Diseases

Tear Interferon-Gamma as a Biomarker for Evaporative Dry Eye Disease

David Charles Jackson, Weiguang Zeng, Chinn Yi Wong, Edin Jessica Mifsud, Nicholas Andrew Williamson, Ching-Seng Ang, Algis Jonas Vingrys, Laura Elizabeth Downie

Journal article  |  2016  |  Investigative Opthalmology & Visual Science

A novel therapeutic strategy of lipidated promiscuous peptide against Mycobacterium tuberculosis by eliciting Th1 and Th17 immunity of host

Pradeep K Rai, Sathi Babu Chodisetti, Sajid Nadeem, Sudeep K Maurya, Uthaman Gowthaman, Weiguang Zeng, Ashok K Janmeja, David C Jackson, Javed N Agrewala

Journal article  |  2016  |  Scientific Reports

Chemical Synthesis of Monomeric, Dimeric and Tetrameric Forms of the Ectodomain of Influenza Matrix 2 Protein

Weiguang Zeng, Kylie J Horrocks, Amabel CL Tan, David C Jackson

Journal article  |  2016  |  European Journal of Organic Chemistry

A lipidated form of the extracellular domain of influenza M2 protein as a self-adjuvanting vaccine candidate

Weiguang Zeng, Amabel CL Tan, Kylie Horrocks, David C Jackson

Journal article  |  2015  |  Vaccine

Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2

Sophie Lees, Suzanne B Golub, Karena Last, Weiguang Zeng, David C Jackson, Philip Sutton, Amanda J Fosang

Journal article  |  2015  |  Arthritis & Rheumatology

Different Arms of the Adaptive Immune System Induced by a Combination Vaccine Work in Concert to Provide Enhanced Clearance of Influenza

Joanna CA Cobbin, Weiguang Zeng, David C Jackson, Lorena E Brown

Journal article  |  2014  |  PLoS ONE

The Influenza Virus-Specific CTL Immunodominance Hierarchy in Mice Is Determined by the Relative Frequency of High-Avidity T Cells

Tania Cukalac, Jesseka Chadderton, Weiguang Zeng, Jolie G Cullen, Wan Ting Kan, Peter C Doherty, David C Jackson, Stephen J Turner, Nicole L La Gruta

Journal article  |  2014  |  Journal of Immunology

Lipidated promiscuous peptide augments the expression of MHC-II molecules on dendritic cells and activates T cells

Uthaman Gowthaman, Pradeep K Rai, Weiguang Zeng, David C Jackson, Javed N Agrewala

Journal article  |  2013  |  Indian Journal of Medical Research

Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

Julie L McAuley, Michelle D Tate, Charley J MacKenzie-Kludas, Anita Pinar, Weiguang Zeng, Andrea Stutz, Eicke Latz, Lorena E Brown, Ashley Mansell

Journal article  |  2013  |  PLoS Pathogens

The design and proof of concept for a CD8 T cell-based vaccine inducing cross-subtype protection against influenza A virus

ACL Tan, G Deliyannis, M Bharadwaj, LE Brown, W Zeng, DC Jackson

Journal article  |  2013  |  Immunology and Cell Biology

The design and proof of concept for a CD8( ) T cell-based vaccine inducing cross-subtype protection against influenza A virus

Amabel CL Tan, Georgia Deliyannis, Mandvi Bharadwaj, Lorena E Brown, Weiguang Zeng, David C Jackson

Journal article  |  2013  |  Immunology and Cell Biology

Intranasal Administration of the TLR2 Agonist Pam2Cys Provides Rapid Protection against Influenza in Mice

Amabel CL Tan, Edin J Mifsud, Weiguang Zeng, Kathryn Edenborough, Jodie McVernon, Lorena E Brown, David C Jackson

Journal article  |  2012  |  Molecular Pharmaceutics

A totally synthetic lipopeptide-based self-adjuvanting vaccine induces neutralizing antibodies against heat-stable enterotoxin from enterotoxigenic Escherichia coli

Weiguang Zeng, Kristy Azzopardi, Dianna Hocking, Chinn Yi Wong, Gorjana Robevska, Marija Tauschek, Roy M Robins-Browne, David C Jackson

Journal article  |  2012  |  Vaccine

Herpes Simplex Virus Antigens Directly Activate NK Cells via TLR2, Thus Facilitating Their Presentation to CD4 T Lymphocytes

Min Kim, Naomi R Osborne, Weiguang Zeng, Heather Donaghy, Kay McKinnon, David C Jackson, Anthony L Cunningham

Journal article  |  2012  |  Journal of Immunology

Polyfunctional CD8( ) T cells are associated with the vaccination-induced control of a novel recombinant influenza virus expressing an HCV epitope

Amabel CL Tan, Emily MY Eriksson, Katherine Kedzierska, Georgia Deliyannis, Sophie A Valkenburg, Weiguang Zeng, David C Jackson

Journal article  |  2012  |  Antiviral Research

Chitosan-based particles as biocompatible delivery vehicles for peptide and protein-based vaccines

Brendon Y Chu, Mohammad Al Kobiasi, Weiguang Zeng, David Mainwaring, David C Jackson

Journal article  |  2012  |  Procedia in Vaccinology

Chitosan Microparticles and Nanoparticles as Biocompatible Delivery Vehicles for Peptide and Protein-Based Immunocontraceptive Vaccines

Brendon Y Chua, Mohammad Al Kobaisi, Weiguang Zeng, David Mainwaring, David C Jackson

Journal article  |  2012  |  Molecular Pharmaceutics

Electrostatic-mediated enhancement of protein antigen immunogenicity using charged TLR2-targeting lipopeptides

Brendon Y Chua, David Pejoski, Stephen J Turner, Weiguang Zeng, David C Jackson

Journal article  |  2012  |  Procedia in Vaccinology

Affinity Thresholds for Naive CD8( ) CTL Activation by Peptides and Engineered Influenza A Viruses

Alice E Denton, Robb Wesselingh, Stephanie Gras, Carole Guillonneau, Matthew R Olson, Justine D Mintern, Weiguang Zeng, David C Jackson, Jamie Rossjohn, Philip D Hodgkin, Peter C Doherty, Stephen J Turner

Journal article  |  2011  |  Journal of Immunology

Promiscuous Peptide of 16 kDa Antigen Linked to Pam2Cys Protects Against Mycobacterium tuberculosis by Evoking Enduring Memory T-Cell Response

Uthaman Gowthaman, Vijender Singh, Weiguang Zeng, Shweta Jain, Kaneez F Siddiqui, Sathi Babu Chodisetti, Rama Krishna Gurram, Pankaj Parihar, Pushpa Gupta, Umesh D Gupta, David C Jackson, Javed N Agrewala

Journal article  |  2011  |  Journal of Infectious Diseases

Precursor Frequency and Competition Dictate the HLA-A2-Restricted CD8( ) T Cell Responses to Influenza A Infection and Vaccination in HLA-A2.1 Transgenic Mice

Amabel CL Tan, Nicole L La Gruta, Weiguang Zeng, David C Jackson

Journal article  |  2011  |  Journal of Immunology

Soluble Proteins Induce Strong CD8( ) T Cell and Antibody Responses through Electrostatic Association with Simple Cationic or Anionic Lipopeptides That Target TLR2

Brendon Y Chua, David Pejoski, Stephen J Turner, Weiguang Zeng, David C Jackson

Journal article  |  2011  |  Journal of Immunology

Universal vaccination: is this premature with current vaccine approaches?

Lorena Brown, Joanna Cobbin, Deborah Middleton, Ian Barr, Weiguang Zeng, David Jackson

Journal article  |  2011  |  Influenza and Other Respiratory Viruses

A Modular Approach to Assembly of Totally Synthetic Self-adjuvanting Lipopeptide-based Vaccines Allows Conformational Epitope Building

Weiguang Zeng, Kylie J Horrocks, Gorjana Robevska, Chinn Yi Wong, Kristy Azzopardi, Marija Tauschek, Roy M Robins-Browne, David C Jackson

Journal article  |  2011  |  Journal of Biological Chemistry

Antigen-Driven Patterns of TCR Bias Are Shared across Diverse Outcomes of Human Hepatitis C Virus Infection

John J Miles, Duangtawan Thammanichanond, Sarah Moneer, Usha K Nivarthi, Lars Kjer-Nielsen, Samantha L Tracy, Campbell K Aitken, Rebekah M Brennan, Weiguang Zeng, Louise Marquart, David Jackson, Scott R Burrows, David S Bowden, Joseph Torresi, Margaret Hellard, Jamie Rossjohn, James McCluskey, Mandvi Bharadwaj

Journal article  |  2011  |  Journal of Immunology

Lipidation of intact proteins produces highly immunogenic vaccine candidates

Weiguang Zeng, Emily M Eriksson, Andrew Lew, David C Jackson

Journal article  |  2011  |  Molecular Immunology

Identification of key residues involved in fibril formation by the conserved N-terminal region of Plasmodium falciparum merozoite surface protein 2 (MSP2)

Xiaodong Yang, Christopher G Adda, Christopher A MacRaild, Andrew Low, Xuecheng Zhang, Weiguang Zeng, David C Jackson, Robin F Anders, Raymond S Norton

Journal article  |  2010  |  Biochimie

A phase I clinical trial of dendritic cell immunotherapy in HCV-infected individuals

Eric J Gowans, Stuart Roberts, Kathryn Jones, Irene Dinatale, Philippe A Latour, Brendan Chua, Emily MY Eriksson, Ruth Chin, Shuo Li, Dominic M Wall, Rosemary L Sparrow, Jude Moloney, Maureen Loudovaris, Rosemary Ffrench, H Miles Prince, Derek Hart, Weng Zeng, Joseph Torresi, Lorena E Brown, David C Jackson

Journal article  |  2010  |  Journal of Hepatology

A lipopeptide based on the M2 and HA proteins of influenza A viruses induces protective antibody

David Pejoski, Weiguang Zeng, Steven Rockman, Lorena E Brown, David C Jackson

Journal article  |  2010  |  Immunology and Cell Biology

Structural requirement for the agonist activity of the TLR2 ligand Pam2Cys

Weiguang Zeng, Emily Eriksson, Brendon Chua, Lara Grollo, David C Jackson

Journal article  |  2010  |  Amino Acids

Lipopeptide vaccines illustrate the potential role of subtype-crossreactive T cells in the control of highly virulent influenza

Wy Ching Ng, Brad Gilbertson, Bock Lim, Weiguang Zeng, David C Jackson, Lorena E Brown

Journal article  |  2009  |  Influenza and Other Respiratory Viruses

A self-adjuvanting lipopeptide-based vaccine candidate for the treatment of hepatitis C virus infection

Brendon Y Chua, Emily M Eriksson, Lorena E Brown, Weiguang Zeng, Eric J Gowans, Joseph Torresi, David C Jackson

Journal article  |  2008  |  Vaccine

Dendritic cell acquisition of epitope cargo mediated by simple cationic peptide structures

Brendon Y Chua, Emily M Eriksson, Daniel P Poole, Weiguang Zeng, David C Jackson

Journal article  |  2008  |  Peptides

Branched and linear lipopeptide vaccines have different effects on primary CD4( ) and CD8( ) T-cell activation but induce similar tumor-protective memory CD8( ) T-cell responses

Adriana Baz, Kathy Buttigieg, Weiguang Zeng, Michael Rizkalla, David C Jackson, Penny Groves, Anne Kelso

Journal article  |  2008  |  Vaccine

Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2

Hannah H Alphs, Ratish Gambhira, Balasubramanyarn Karanam, Jeffrey N Roberts, Subhashini Jagu, John T Schiller, Weiguang Zeng, David C Jackson, Richard BS Roden

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

Lipopeptide Vaccines Illustrate the Potential Role of Subtype-Crossreactive T Cell Responses in the Control of Seasonal and Pandemic Influenza

L BROWN, G Deliyannis, K KEDZIERSKA, YF LAU, WC NG, W ZENG, B GILBERTSON, B LIM, JCA COBBIN, D JACKSON, S TURNER, A KELSO

Conference Proceedings  |  2008  |  Options for the Control of Influenza VI

Synthesis of toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccines.

Brendon Y Chua, Weiguang Zeng, David C Jackson

Journal article  |  2008  |  Methods in Molecular Biology

Effective Th1- and Th2-type immune responses that result in protective immunity against pathogens can be induced by self-adjuvanti..

Synthesis of toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccines

BY Chua, W Zeng, DC Jackson

Journal article  |  2008  |  Methods in Molecular Biology

Totally synthetic peptide-based immunocontraceptive vaccines show activity in dogs of different breeds

John Walker, Souravi Ghosh, Joanne Pagnon, Caterina Colantoni, Andrea Newbold, Weiguang Zeng, David C Jackson

Journal article  |  2007  |  Vaccine

T cell Epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the HLA class II haplotype DRB1*0301/DQBI*0201

Nadine L Dudek, Shannon Maier, Zhen-Jun Chen, Philip A Mudd, Stuart I Mannering, David C Jackson, Weiguang Zeng, Catherine L Keech, Kassie Hamlin, Zi-Jian Pan, Karen Davis-Schwarz, Jennifer Workman-Azbill, Michael Bachmann, James McCluskey, A Darise Farris

Journal article  |  2007  |  Arthritis and Rheumatism

Simple branched arginine-based structures can enhance the cellular uptake of peptide cargos

Brendon Y Chua, Weiguang Zeng, David C Jackson

Journal article  |  2007  |  International Journal of Peptide Research and Therapeutics

The context of epitope presentation can influence functional quality of recalled influenza A virus-specific memory CD8( ) T cells

E Bridie Day, Weiguang Zeng, Peter C Doherty, David C Jackson, Katherine Kedzierska, Stephen J Turner

Journal article  |  2007  |  Journal of Immunology

The C-terminal pentapeptide of LHRH is a dominant B cell epitope with antigenic and biological function

Weiguang Zeng, Joanne Pagnon, David C Jackson

Journal article  |  2007  |  Molecular Immunology

A self-adjuvanting multiepitope immunogen that induces a broadly cross-reactive antibody to hepatitis C virus

Joseph Torresi, Owen M Stock, Alexandra E Fischer, Lara Grollo, Heidi Drummer, Irene Boo, Weiguang Zeng, Linda Earnest-Silveira, David C Jackson

Journal article  |  2007  |  Hepatology

Induction of neutralizing antibody responses to hepatitis C virus with synthetic peptide constructs incorporating both antibody and T-helper epitopes

Joseph Torresi, Alex Fischer, Lara Grollo, Weiguang Zeng, Heidi Drummer, David C Jackson

Journal article  |  2007  |  Immunology and Cell Biology

Comparison of lipopeptide-based immunocontraceptive vaccines containing different lipid groups

Brendon Y Chua, Weiguang Zeng, Yuk Fai Lau, David C Jackson

Journal article  |  2007  |  Vaccine

Lipid-containing mimetics of natural triggers of innate immunity as CTL-inducing influenza vaccines

Yuk Fai Lau, Georgia Deliyannis, Weiguang Zeng, Ashley Mansell, David C Jackson, Lorena E Brown

Journal article  |  2006  |  International Immunology

Intranasal vaccination with a lipopeptide containing a conformationally constrained conserved minimal peptide, a universal T cell epitope, and a self-adjuvanting lipid protects mice from group A streptococcus challenge and reduces throat colonization

Michael R Batzloff, Jon Hartas, Weiguang Zeng, David C Jackson, Michael F Good

Journal article  |  2006  |  Journal of Infectious Diseases

Intranasal vaccination with a lipopeptide containing a minimal, conserved M-protein derived peptide and a self-adjuvanting lipid induces both systemic and mucosal immune responses in mice

MR Batzloff, J Hartas, W Zeng, DC Jackson, MF Good

Journal article  |  2006  |  International Congress Series

Totally synthetic peptide-based vaccines that target dendritic cells and induce potent antibody or CTL responses

DC Jackson, BY Chua, W Zeng

Journal article  |  2006  |  International Congress Series

Intranasal lipopeptide primes lung-resident memory CD8( ) T cells for long-term pulmonary protection against influenza

G Deliyannis, K Kedzierska, YF Lau, WG Zeng, SJ Turner, DC Jackson, LE Brown

Journal article  |  2006  |  European Journal of Immunology

Exploiting information inherent in binding sites of virus-specific antibodies: design of an HCV vaccine candidate cross-reactive with multiple genotypes

Lara Grollo, Joseph Torresi, Heidi Drummer, Weiquang Zeng, Nicholas Williamson, David C Jackson

Journal article  |  2006  |  Antiviral Therapy

Identification of dominant epitopes of synthetic immunocontraceptive vaccines that induce antibodies in dogs

M Yu, WG Zeng, J Pagnon, J Walker, S Ghosh, LF Wang, DC Jackson

Journal article  |  2005  |  Vaccine

Characterisation of the antibody response to a totally synthetic immunocontraceptive peptide vaccine based on LHRH

WG Zeng, S Gauci, S Ghosh, J Walker, DC Jackson

Journal article  |  2005  |  Vaccine

Immunogenic molecules

DC JACKSON, W ZENG

Patent  |  2005

Effects on rotavirus cell binding and infection of monomeric and polymeric peptides containing alpha 2 beta 1 and alpha x beta 2 integrin ligand sequences

KL Graham, WG Zeng, Y Takada, DC Jackson, BS Coulson

Journal article  |  2004  |  Journal of Virology

A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses

DC Jackson, YF Lau, T Le, A Suhrbier, G Deliyannis, C Cheers, C Smith, WG Zeng, LE Brown

Journal article  |  2004  |  Proceedings of the National Academy of Sciences

A totally synthetic vaccine of generic structure that targets TLR2 dendritic cells and promotes either antibody or CTL responses

D JACKSON, YF LAU, undefined Le, undefined Suhrbier, G DELIYANNIS, C CHEERS, CD SMITH, W ZENG, L BROWN

Journal article  |  2004  |  Proceedings of the National Academy of Sciences of the United States of America

Dissecting the role of peptides in the immune response: Theory, practice and the application to vaccine design

AW Purcell, WG Zeng, NA Mifsud, LK Ely, WA MacDonald, DC Jackson

Journal article  |  2003  |  Journal of Peptide Science

A novel method for the rational construction of well-defined immunogens: The use of oximation to conjugate cholera toxin B subunit to a peptide-polyoxime complex

JH Chen, WG Zeng, R Offord, K Rose

Journal article  |  2003  |  Bioconjugate Chemistry

Maturation of dendritic cells with lipopeptides that represent vaccine candidates for hepatitis C virus

BY Chua, A Healy, PU Cameron, O Stock, M Rizkalla, WG Zeng, J Torresi, LE Brown, NL Fowler, EJ Gowans, DC Jackson

Journal article  |  2003  |  Immunology and Cell Biology

Highly immunogenic and totally synthetic lipopeptides as self-adjuvanting immunocontraceptive vaccines

WG Zeng, S Ghosh, YF Lau, LE Brown, DC Jackson

Journal article  |  2002  |  Journal of Immunology

Identification of antigenically active tryptic fragments of apical membrane antigen-1 (AMA1) of Plasmodium chabaudi malaria: strategies for assembly of immunologically active peptides

D Salvatore, AN Hodder, WG Zeng, LE Brown, RF Anders, DC Jackson

Journal article  |  2002  |  Vaccine

Synthetic peptide epitope-based polymers: controlling size and determining the efficiency of epitope incorporation

K Sadler, W Zeng, DC Jackson

Journal article  |  2002  |  Journal of Peptide Research

Parenteral and mucosal delivery of a novel multi-epitope M protein-based group A streptococcal vaccine construct: investigation of immunogenicity in mice

LA Dunn, DJ McMillan, M Batzloff, WG Zeng, DCJ Jackson, JA Upcroft, P Upcroft, C Olive

Journal article  |  2002  |  Vaccine

Induction of long-term memory CD8( ) T cells for recall of viral clearing responses against influenza virus

G Deliyannis, DC Jackson, NJ Ede, WG Zeng, I Hourdakis, E Sakabetis, LE Brown

Journal article  |  2002  |  Journal of Virology

The central role played by peptides in the immune response and the design of peptide-based vaccines against infectious diseases and cancer

DC Jackson, AW Purcell, CJ Fitzmaurice, W Zeng, DNJ Hart

Journal article  |  2002  |  Current Drug Targets

Assembly of synthetic peptide vaccines by chemoselective ligation of epitopes: influence of different chemical linkages and epitope orientations on biological activity

WG Zeng, S Ghosh, M Macris, J Pagnon, DC Jackson

Journal article  |  2001  |  Vaccine

Lipopeptide vaccines: a strategy for improving protective immunity against influenza

G Deliyannis, DC Jackson, L Harling-McNabb, WG Zeng, NJ Ede, I Hourdakis, M Rudd, A Kelso, LE Brown

Conference Proceedings  |  2001  |  International Congress Series

New multi-determinant strategy for a group A streptococcal vaccine designed for the Australian Aboriginal population

ER Brandt, KS Sriprakash, RI Hobb, WA Hayman, WG Zeng, MR Batzloff, DC Jackson, MF Good

Journal article  |  2000  |  Nature Medicine

Totally synthetic lipid-containing polyoxime peptide constructs are potent immunogens

WG Zeng, DC Jackson, J Murray, K Rose, LE Brown

Journal article  |  2000  |  Vaccine

New cyclization reaction at the amino terminus of peptides and proteins.

K Rose, J Chen, M Dragovic, W Zeng, D Jeannerat, P Kamalaprija, U Burger

Journal article  |  1999  |  Bioconjugate Chemistry

Mild oxidation with periodate of the 1-amino-2-ol moiety of N-terminal seryl or threonyl peptides and proteins leads to a terminal..

Preparation and properties of totally synthetic immunogens

DC Jackson, CJ Fitzmaurice, LE Brown, WG Zeng

Journal article  |  1999  |  Vaccine

Plasmodium falciparum polyoximes: highly immunogenic synthetic vaccines constructed by chemoselective ligation of repeat B-cell epitopes and a universal T-cell epitope of CS protein.

EH Nardin, JM Calvo-Calle, GA Oliveira, P Clavijo, R Nussenzweig, R Simon, W Zeng, K Rose

Journal article  |  1998  |  Vaccine

Effective immunoprophylaxis directed against the pre-erythrocytic stages of the malaria parasite requires a vaccine that can elici..

9-Hydroxy-9-(4-carboxyphenyl)xanthene - A new linker for the synthesis of peptide amides

B Henkel, W Zeng, E Bayer

Journal article  |  1997  |  Tetrahedron Letters

Use of Fmoc-N-(2-hydroxy-4-methoxybenzyl)amino acids in peptide synthesis.

W Zeng, PO Regamey, K Rose, Y Wang, E Bayer

Journal article  |  1997  |  The Journal of Peptide Research

The use of N,O-bisFmoc-N-(2-hydroxy-4-methoxybenzyl)amino acid derivatives in the synthesis of peptides with difficult sequences h..

Natural peptides as building blocks for the synthesis of large protein-like molecules with hydrazone and oxime linkages.

K Rose, W Zeng, PO Regamey, IV Chernushevich, KG Standing, HF Gaertner

Journal article  |  1996  |  Bioconjugate Chemistry

Methods are known for the production of synthetic protein-like molecules of nonlinear architecture with molecular masses in the 10..

1H NMR structural study of free and template-linked antigenic peptide representing the C-terminal region of the heavy chain of influenza virus hemagglutinin.

JA Wilce, W Zeng, K Rose, DJ Craik, DC Jackson

Journal article  |  1996  |  Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity

A 12 kDa template-assembled molecule, incorporating four oxime-linked synthetic peptides representing residues 306-328 of influenz..

Synthesis of a New Template with a Built-in Adjuvant and Its Use in Constructing Peptide Vaccine Candidates Through Polyoxime Chemistry

Weiguang Zeng, David C Jackson, Keith Rose

Journal article  |  1996  |  Journal of Peptide Science

A synthetic peptide-based polyoxime vaccine construct of high purity and activity

K Rose, WG Zeng, LE Brown, DC Jackson

Journal article  |  1995  |  Molecular Immunology

Transesterification of the benzyl ester protecting group during purification of a protected pentapeptide

W Zeng, B Hemmasi, E Bayer

Journal article  |  1992  |  Tetrahedron Letters

Solution Synthesis of Phytochelatins, Isopeptides from the Plant Kingdom

W Zeng, B Hemmasi

Journal article  |  1992  |  Liebigs Annalen der Chemie