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Modular platforms for the assembly of self-adjuvanting lipopeptide-based vaccines for use ..
Utilization Of Tlr2 Agonist Pam2cys As Adjuvant To Facilitate The Development Of Staphyloc..
Geometry of a TLR2-Agonist-Based Adjuvant Can Affect the Resulting Antigen-Specific Immune..
Displaying the 7 most recent projects by Weiguang Zeng.
Internal Research Grant
Displaying the 94 most recent scholarly works by Weiguang Zeng.
Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model
Kirstie M Mangas, Andrew H Buultjens, Jessica L Porter, Sarah L Baines, Estelle Marion, Laurent Marsollier, Nicholas J Tobias, Sacha J Pidot, Kylie M Quinn, David J Price, Katherine Kedzierska, Weiguang Zeng, David C Jackson, Brendon Y Chua, Timothy P Stineara
Journal article | 2020 | Infection and Immunity
The neglected tropical disease Buruli ulcer (BU) is an infection of subcutaneous tissue with Mycobacterium ulcerans There is no ef..
Modular platforms for the assembly of self-adjuvanting lipopeptide-based vaccines for use in an out-bred population
Weiguang Zeng, Kylie J Horrocks, Amabel CL Tan, Chinn Yi Wong, Brendon Y Chua, David C Jackson
Journal article | 2020 | Vaccine
To facilitate the preparation of synthetic epitope-based self-adjuvanting vaccines capable of eliciting antibody responses in an o..
Human CD8( ) T cell cross-reactivity across influenza A, B and C viruses
Marios Koutsakos, Patricia T Illing, Thi HO Nguyen, Nicole A Mifsud, Jeremy Chase Crawford, Simone Rizzetto, Auda A Eltahla, E Bridie Clemens, Sneha Sant, Brendon Y Chua, Chinn Yi Wong, E Kaitlynn Allen, Don Teng, Pradyot Dash, David F Boyd, Ludivine Grzelak, Weiguang Zeng, Aeron C Hurt, Ian Barr, Steve Rockman, et al.
Journal article | 2019 | Nature Immunology
In Vivo Imaging of Bioluminescent Mycobacterium ulcerans: A Tool to Refine the Murine Buruli Ulcer Tail Model
Till F Omansen, Renee A Marcsisin, Brendon Y Chua, Weiguang Zeng, David C Jackson, Jessica L Porter, Ymkje Stienstra, Tjip S van der Werf, Timothy P Stinear
Journal article | 2019 | The American Journal of Tropical Medicine and Hygiene
Buruli ulcer (BU) is a neglected tropical disease caused by infection with Mycobacterium ulcerans. Unclear transmission, no availa..
The Toll-Like Receptor 2 agonist PEG-Pam(2)Cys as an immunochemoprophylactic and immunochemotherapeutic against the liver and transmission stages of malaria parasites
Medard Ernest, Carol Hunja, Yuka Arakura, Yohei Haraga, Hussein M Abkallo, Weiguang Zeng, David C Jackson, Brendon Chua, Richard Culleton
Journal article | 2018 | International Journal for Parasitology: Drugs and Drug Resistance
A lipidated bi-epitope vaccine comprising of MHC-I and MHC-II binder peptides elicits protective CD4 T cell and CD8 T cell immunity against Mycobacterium tuberculosis
Pradeep K Rai, Sathi Babu Chodisetti, Sudeep K Maurya, Sajid Nadeem, Weiguang Zeng, Ashok K Janmeja, David C Jackson, Javed N Agrewala
Journal article | 2018 | Journal of Translational Medicine
A lipidated peptide of Mycobacterium tuberculosis resuscitates the protective efficacy of BCG vaccine by evoking memory T cell immunity
Pradeep K Rai, Sathi Babu Chodisetti, Weiguang Zeng, Sajid Nadeem, Sudeep K Maurya, Susanta Pahari, Ashok K Janmeja, David C Jackson, Javed N Agrewala
Journal article | 2017 | Journal of Translational Medicine
PEGylation of a TLR2-agonist-based vaccine delivery system improves antigen trafficking and the magnitude of ensuing antibody and CD8( ) T cell responses
Toshiki Sekiya, Junya Yamagishi, John Henry V Gray, Paul G Whitney, Axel Martinelli, Weiguang Zeng, Chinn Yi Wong, Chihiro Sugimoto, David C Jackson, Brendon Y Chua
Journal article | 2017 | Biomaterials
Mycobacterium ulcerans low infectious dose and mechanical transmission support insect bites and puncturing injuries in the spread of Buruli ulcer
John R Wallace, Kirstie M Mangas, Jessica L Porter, Renee Marcsisin, Sacha J Pidot, Brian Howden, Till F Omansen, Weiguang Zeng, Jason K Axford, Paul DR Johnson, Timothy P Stinear
Journal article | 2017 | PLOS Neglected Tropical Diseases
A novel therapeutic strategy of lipidated promiscuous peptide against Mycobacterium tuberculosis by eliciting Th1 and Th17 immunity of host
Pradeep K Rai, Sathi Babu Chodisetti, Sajid Nadeem, Sudeep K Maurya, Uthaman Gowthaman, Weiguang Zeng, Ashok K Janmeja, David C Jackson, Javed N Agrewala
Journal article | 2016 | Scientific Reports
The Influenza Virus-Specific CTL Immunodominance Hierarchy in Mice Is Determined by the Relative Frequency of High-Avidity T Cells
Tania Cukalac, Jesseka Chadderton, Weiguang Zeng, Jolie G Cullen, Wan Ting Kan, Peter C Doherty, David C Jackson, Stephen J Turner, Nicole L La Gruta
Journal article | 2014 | Journal of Immunology
Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease
Julie L McAuley, Michelle D Tate, Charley J MacKenzie-Kludas, Anita Pinar, Weiguang Zeng, Andrea Stutz, Eicke Latz, Lorena E Brown, Ashley Mansell
Journal article | 2013 | PLoS Pathogens
A totally synthetic lipopeptide-based self-adjuvanting vaccine induces neutralizing antibodies against heat-stable enterotoxin from enterotoxigenic Escherichia coli
Weiguang Zeng, Kristy Azzopardi, Dianna Hocking, Chinn Yi Wong, Gorjana Robevska, Marija Tauschek, Roy M Robins-Browne, David C Jackson
Journal article | 2012 | Vaccine
Polyfunctional CD8( ) T cells are associated with the vaccination-induced control of a novel recombinant influenza virus expressing an HCV epitope
Amabel CL Tan, Emily MY Eriksson, Katherine Kedzierska, Georgia Deliyannis, Sophie A Valkenburg, Weiguang Zeng, David C Jackson
Journal article | 2012 | Antiviral Research
Affinity Thresholds for Naive CD8( ) CTL Activation by Peptides and Engineered Influenza A Viruses
Alice E Denton, Robb Wesselingh, Stephanie Gras, Carole Guillonneau, Matthew R Olson, Justine D Mintern, Weiguang Zeng, David C Jackson, Jamie Rossjohn, Philip D Hodgkin, Peter C Doherty, Stephen J Turner
Journal article | 2011 | Journal of Immunology
Promiscuous Peptide of 16 kDa Antigen Linked to Pam2Cys Protects Against Mycobacterium tuberculosis by Evoking Enduring Memory T-Cell Response
Uthaman Gowthaman, Vijender Singh, Weiguang Zeng, Shweta Jain, Kaneez F Siddiqui, Sathi Babu Chodisetti, Rama Krishna Gurram, Pankaj Parihar, Pushpa Gupta, Umesh D Gupta, David C Jackson, Javed N Agrewala
Journal article | 2011 | Journal of Infectious Diseases
A Modular Approach to Assembly of Totally Synthetic Self-adjuvanting Lipopeptide-based Vaccines Allows Conformational Epitope Building
Weiguang Zeng, Kylie J Horrocks, Gorjana Robevska, Chinn Yi Wong, Kristy Azzopardi, Marija Tauschek, Roy M Robins-Browne, David C Jackson
Journal article | 2011 | Journal of Biological Chemistry
Antigen-Driven Patterns of TCR Bias Are Shared across Diverse Outcomes of Human Hepatitis C Virus Infection
John J Miles, Duangtawan Thammanichanond, Sarah Moneer, Usha K Nivarthi, Lars Kjer-Nielsen, Samantha L Tracy, Campbell K Aitken, Rebekah M Brennan, Weiguang Zeng, Louise Marquart, David Jackson, Scott R Burrows, David S Bowden, Joseph Torresi, Margaret Hellard, Jamie Rossjohn, James McCluskey, Mandvi Bharadwaj
Journal article | 2011 | Journal of Immunology
Identification of key residues involved in fibril formation by the conserved N-terminal region of Plasmodium falciparum merozoite surface protein 2 (MSP2)
Xiaodong Yang, Christopher G Adda, Christopher A MacRaild, Andrew Low, Xuecheng Zhang, Weiguang Zeng, David C Jackson, Robin F Anders, Raymond S Norton
Journal article | 2010 | Biochimie
A phase I clinical trial of dendritic cell immunotherapy in HCV-infected individuals
Eric J Gowans, Stuart Roberts, Kathryn Jones, Irene Dinatale, Philippe A Latour, Brendan Chua, Emily MY Eriksson, Ruth Chin, Shuo Li, Dominic M Wall, Rosemary L Sparrow, Jude Moloney, Maureen Loudovaris, Rosemary Ffrench, H Miles Prince, Derek Hart, Weng Zeng, Joseph Torresi, Lorena E Brown, David C Jackson
Journal article | 2010 | Journal of Hepatology
Branched and linear lipopeptide vaccines have different effects on primary CD4( ) and CD8( ) T-cell activation but induce similar tumor-protective memory CD8( ) T-cell responses
Adriana Baz, Kathy Buttigieg, Weiguang Zeng, Michael Rizkalla, David C Jackson, Penny Groves, Anne Kelso
Journal article | 2008 | Vaccine
Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2
Hannah H Alphs, Ratish Gambhira, Balasubramanyarn Karanam, Jeffrey N Roberts, Subhashini Jagu, John T Schiller, Weiguang Zeng, David C Jackson, Richard BS Roden
Journal article | 2008 | Proceedings of the National Academy of Sciences of the United States of America
Lipopeptide Vaccines Illustrate the Potential Role of Subtype-Crossreactive T Cell Responses in the Control of Seasonal and Pandemic Influenza
L BROWN, G Deliyannis, K KEDZIERSKA, YF LAU, WC NG, W ZENG, B GILBERTSON, B LIM, JCA COBBIN, D JACKSON, S TURNER, A KELSO
Conference Proceedings | 2008 | Options for the Control of Influenza VI
Synthesis of toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccines.
Brendon Y Chua, Weiguang Zeng, David C Jackson
Journal article | 2008 | Methods in Molecular Biology
Effective Th1- and Th2-type immune responses that result in protective immunity against pathogens can be induced by self-adjuvanti..
T cell Epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the HLA class II haplotype DRB1*0301/DQBI*0201
Nadine L Dudek, Shannon Maier, Zhen-Jun Chen, Philip A Mudd, Stuart I Mannering, David C Jackson, Weiguang Zeng, Catherine L Keech, Kassie Hamlin, Zi-Jian Pan, Karen Davis-Schwarz, Jennifer Workman-Azbill, Michael Bachmann, James McCluskey, A Darise Farris
Journal article | 2007 | Arthritis and Rheumatism
Intranasal vaccination with a lipopeptide containing a conformationally constrained conserved minimal peptide, a universal T cell epitope, and a self-adjuvanting lipid protects mice from group A streptococcus challenge and reduces throat colonization
Michael R Batzloff, Jon Hartas, Weiguang Zeng, David C Jackson, Michael F Good
Journal article | 2006 | Journal of Infectious Diseases
A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses
DC Jackson, YF Lau, T Le, A Suhrbier, G Deliyannis, C Cheers, C Smith, WG Zeng, LE Brown
Journal article | 2004 | Proceedings of the National Academy of Sciences
A totally synthetic vaccine of generic structure that targets TLR2 dendritic cells and promotes either antibody or CTL responses
D JACKSON, YF LAU, undefined Le, undefined Suhrbier, G DELIYANNIS, C CHEERS, CD SMITH, W ZENG, L BROWN
Journal article | 2004 | Proceedings of the National Academy of Sciences of the United States of America
New cyclization reaction at the amino terminus of peptides and proteins.
K Rose, J Chen, M Dragovic, W Zeng, D Jeannerat, P Kamalaprija, U Burger
Journal article | 1999 | Bioconjugate Chemistry
Mild oxidation with periodate of the 1-amino-2-ol moiety of N-terminal seryl or threonyl peptides and proteins leads to a terminal..
Plasmodium falciparum polyoximes: highly immunogenic synthetic vaccines constructed by chemoselective ligation of repeat B-cell epitopes and a universal T-cell epitope of CS protein.
EH Nardin, JM Calvo-Calle, GA Oliveira, P Clavijo, R Nussenzweig, R Simon, W Zeng, K Rose
Journal article | 1998 | Vaccine
Effective immunoprophylaxis directed against the pre-erythrocytic stages of the malaria parasite requires a vaccine that can elici..
Use of Fmoc-N-(2-hydroxy-4-methoxybenzyl)amino acids in peptide synthesis.
W Zeng, PO Regamey, K Rose, Y Wang, E Bayer
Journal article | 1997 | The Journal of Peptide Research
The use of N,O-bisFmoc-N-(2-hydroxy-4-methoxybenzyl)amino acid derivatives in the synthesis of peptides with difficult sequences h..
Natural peptides as building blocks for the synthesis of large protein-like molecules with hydrazone and oxime linkages.
K Rose, W Zeng, PO Regamey, IV Chernushevich, KG Standing, HF Gaertner
Journal article | 1996 | Bioconjugate Chemistry
Methods are known for the production of synthetic protein-like molecules of nonlinear architecture with molecular masses in the 10..
1H NMR structural study of free and template-linked antigenic peptide representing the C-terminal region of the heavy chain of influenza virus hemagglutinin.
JA Wilce, W Zeng, K Rose, DJ Craik, DC Jackson
Journal article | 1996 | Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity
A 12 kDa template-assembled molecule, incorporating four oxime-linked synthetic peptides representing residues 306-328 of influenz..
Senior Research Officer Nh&Mrc
Microbiology And Immunology
Bachelor of Science
Jiangxi Medical College
Master of Science
National Institutes for Food and Drug Control
Doctor of Philosophy