Weiguang Zeng

Abstract 3502: AXA-042 - a novel systemic TLR2/6 agonist for anti-tumor therapy

Anna V Galkin, Francesca Mercuri, Nicholas West, Ping Zhang, Weiguang Zeng, Grant McLachlan, Michael Bettess, Ian Holmes, David Jackson, Chris Smith, Christophe Demaison, Tobias Bald, Phil Kearney

Journal article  |  2022  |  Cancer Research

Abstract Background: Treatment approaches that engage both the innate and adaptive immune response have the potenti..

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

Journal article  |  2021  |  JCI INSIGHT

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..

Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model

Pamela C Proud, Daphne Tsitoura, Robert J Watson, Brendon Y Chua, Marilyn J Aram, Kevin R Bewley, Breeze E Cavell, Rebecca Cobb, Stuart Dowall, Susan A Fotheringham, Catherine MK Ho, Vanessa Lucas, Didier Ngabo, Emma Rayner, Kathryn A Ryan, Gillian S Slack, Stephen Thomas, Nadina Wand, Paul Yeates, Christophe Demaison, et al.

Journal article  |  2021  |  EBIOMEDICINE

BACKGROUND: The novel human coronavirus SARS-CoV-2 is a major ongoing global threat with huge economic burden. Like all respirator..

Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model

Kirstie M Mangas, Andrew H Buultjens, Jessica L Porter, Sarah L Baines, Estelle Marion, Laurent Marsollier, Nicholas J Tobias, Sacha J Pidot, Kylie M Quinn, David J Price, Katherine Kedzierska, Weiguang Zeng, David C Jackson, Brendon Y Chua, Timothy P Stineara

Journal article  |  2020  |  INFECTION AND IMMUNITY

The neglected tropical disease Buruli ulcer (BU) is an infection of subcutaneous tissue with Mycobacterium ulcerans There is no ef..

Modular platforms for the assembly of self-adjuvanting lipopeptide-based vaccines for use in an out-bred population

Weiguang Zeng, Kylie J Horrocks, Amabel CL Tan, Chinn Yi Wong, Brendon Y Chua, David C Jackson

Journal article  |  2020  |  VACCINE

To facilitate the preparation of synthetic epitope-based self-adjuvanting vaccines capable of eliciting antibody responses in an o..

Geometry of a TLR2-Agonist-Based Adjuvant Can Affect the Resulting Antigen-Specific Immune Response

Acep R Wijayadikusumah, Weiguang Zeng, Hayley A McQuilten, Chinn Yi Wong, David C Jackson, Brendon Y Chua

Journal article  |  2019  |  MOLECULAR PHARMACEUTICS

Targeted delivery of otherwise nonimmunogenic antigens to Toll-like receptors (TLRs) expressed on dendritic cells (DCs) has proven..

Human CD8( ) T cell cross-reactivity across influenza A, B and C viruses

Marios Koutsakos, Patricia T Illing, Thi HO Nguyen, Nicole A Mifsud, Jeremy Chase Crawford, Simone Rizzetto, Auda A Eltahla, E Bridie Clemens, Sneha Sant, Brendon Y Chua, Chinn Yi Wong, E Kaitlynn Allen, Don Teng, Pradyot Dash, David F Boyd, Ludivine Grzelak, Weiguang Zeng, Aeron C Hurt, Ian Barr, Steve Rockman, et al.

Journal article  |  2019  |  NATURE IMMUNOLOGY

Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and infect humans, with IAV and IBV causing the m..

In Vivo Imaging of Bioluminescent Mycobacterium ulcerans: A Tool to Refine the Murine Buruli Ulcer Tail Model

Till F Omansen, Renee A Marcsisin, Brendon Y Chua, Weiguang Zeng, David C Jackson, Jessica L Porter, Ymkje Stienstra, Tjip S van der Werf, Timothy P Stinear

Journal article  |  2019  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Buruli ulcer (BU) is a neglected tropical disease caused by infection with Mycobacterium ulcerans. Unclear transmission, no availa..

The Toll-Like Receptor 2 agonist PEG-Pam(2)Cys as an immunochemoprophylactic and immunochemotherapeutic against the liver and transmission stages of malaria parasites

Medard Ernest, Carol Hunja, Yuka Arakura, Yohei Haraga, Hussein M Abkallo, Weiguang Zeng, David C Jackson, Brendon Chua, Richard Culleton

Journal article  |  2018  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

Both vaccine and therapeutic approaches to malaria are based on conventional paradigms; whole organism or single antigen epitope-b..

A lipidated bi-epitope vaccine comprising of MHC-I and MHC-II binder peptides elicits protective CD4 T cell and CD8 T cell immunity against Mycobacterium tuberculosis

Pradeep K Rai, Sathi Babu Chodisetti, Sudeep K Maurya, Sajid Nadeem, Weiguang Zeng, Ashok K Janmeja, David C Jackson, Javed N Agrewala

Journal article  |  2018  |  JOURNAL OF TRANSLATIONAL MEDICINE

BACKGROUND: The clinical trials conducted at Chingleput India suggest that BCG fails to protect against tuberculosis (TB) in TB-en..