Brent McKenzie

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis

Ian K Campbell, David Leong, Kirsten M Edwards, Veronika Rayzman, Milica Ng, Gabrielle L Goldberg, Nicholas J Wilson, Karen Scalzo-Inguanti, Charley Mackenzie-Kludas, Kate E Lawlor, Ian P Wicks, Lorena E Brown, Adriana Baz Morelli, Con Panousis, Michael J Wilson, Andrew D Nash, Brent S McKenzie, Arna E Andrews

Journal article  |  2016  |  JOURNAL OF IMMUNOLOGY

G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation an..

GM-CSF primes cardiac inflammation in a mouse model of Kawasaki disease

Angus T Stock, Jacinta A Hansen, Matthew A Sleeman, Brent S McKenzie, Ian P Wicks

Journal article  |  2016  |  JOURNAL OF EXPERIMENTAL MEDICINE

Kawasaki disease (KD) is the leading cause of pediatric heart disease in developed countries. KD patients develop cardiac inflamma..

G-CSF and Neutrophils Are Nonredundant Mediators of Murine Experimental Autoimmune Uveoretinitis (vol 186, pg 172, 2016)

Gabrielle L Goldberg, Ann L Cornish, Jane Murphy, Ee Shan Pang, Damian B D'Silva, Lyndell L Lim, Ian K Campbell, Karen Scalzo-Inguanti, Xiangting Chen, Paul G McMenamin, Eugene Maraskovsky, Brent S McKenzie, Ian P Wicks

Journal article  |  2016  |  AMERICAN JOURNAL OF PATHOLOGY

ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation

Claire Pearson, Emily E Thornton, Brent McKenzie, Anna-Lena Schaupp, Nicky Huskens, Thibault Griseri, Nathaniel West, Sim Tung, Benedict P Seddon, Holm H Uhlig, Fiona Powrie

Journal article  |  2016  |  ELIFE

Innate lymphoid cells (ILCs) contribute to host defence and tissue repair but can induce immunopathology. Recent work has revealed..

G-CSF and Neutrophils Are Nonredundant Mediators of Murine Experimental Autoimmune Uveoretinitis

Gabrielle L Goldberg, Ann L Cornish, Jane Murphy, Ee Shan Pang, Lyndell L Lim, Ian K Campbell, Karen Scalzo-Inguanti, Xiangting Chen, Paul G McMenamin, Eugene Maraskovsky, Brent S McKenzie, Ian P Wicks

Journal article  |  2016  |  AMERICAN JOURNAL OF PATHOLOGY

Granulocyte colony-stimulating factor (G-CSF) is a regulator of neutrophil production, function, and survival. Herein, we investig..

Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis

Thibault Griseri, Isabelle C Arnold, Claire Pearson, Thomas Krausgruber, Chris Schiering, Fanny Franchini, Julie Schulthess, Brent S McKenzie, Paul R Crocker, Fiona Powrie

Journal article  |  2015  |  IMMUNITY

The role of intestinal eosinophils in immune homeostasis is enigmatic and the molecular signals that drive them from protective to..

Therapeutic Effect of IVIG on Inflammatory Arthritis in Mice Is Dependent on the Fc Portion and Independent of Sialylation or Basophils

Ian K Campbell, Sylvia Miescher, Donald R Branch, Patrick J Mott, Alan H Lazarus, Dongji Han, Eugene Maraskovsky, Adrian W Zuercher, Anton Neschadim, Danila Leontyev, Brent S McKenzie, Fabian Kaesermann

Journal article  |  2014  |  JOURNAL OF IMMUNOLOGY

High-dose i.v. Ig (IVIG) is used to treat various autoimmune and inflammatory diseases; however, the mechanism of action remains u..

Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation

Thibault Griseri, Brent S McKenzie, Chris Schiering, Fiona Powrie

Journal article  |  2012  |  IMMUNITY

In interleukin-23 (IL-23)-dependent colitis, there is excessive accumulation of short-lived neutrophils and inflammatory monocytes..

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

Robert JJ O'Donoghue, Darryl A Knight, Carl D Richards, Cecilia M Prele, Hui Ling Lau, Andrew G Jarnicki, Jessica Jones, Steven Bozinovski, Ross Vlahos, Stefan Thiem, Brent S McKenzie, Bo Wang, Philip Stumbles, Geoffrey J Laurent, Robin J McAnulty, Stefan Rose-John, Hong Jian Zhu, Gary P Anderson, Matthias R Ernst, Steven E Mutsaers

Journal article  |  2012  |  EMBO MOLECULAR MEDICINE

Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive co..

Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease.

Corinne Cayatte, Barbara Joyce-Shaikh, Felix Vega, Katia Boniface, Jeffrey Grein, Erin Murphy, Wendy M Blumenschein, Smiley Chen, Maria-Christina Malinao, Beth Basham, Robert H Pierce, Edward P Bowman, Brent S McKenzie, Charles O Elson, William A Faubion, Rene de Waal Malefyt, Robert A Kastelein, Daniel Cua, Terrill K McClanahan, Maribel Beaumont

Journal article  |  2012  |  Clin Transl Gastroenterol

OBJECTIVES: Interleukin-23 (IL-23) has emerged as a new therapeutic target for the treatment of inflammatory bowel disease (IBD). ..