Harry Georgiou

Decidual mesenchymal stem/stromal cells from preeclamptic patients secrete endoglin, which at high levels inhibits endothelial cell attachment in vitro

C Perera, S Zheng, MI Kokkinos, HM Georgiou, M Schoppet, PF James, SP Brennecke, B Kalionis

Journal article  |  2022  |  PLACENTA

INTRODUCTION: In preeclampsia (PE), inadequate remodelling of spiral arterioles in the decidua basalis causes oxidative stress and..

Mesenchymal Stem/Stromal Cells and Their Role in Oxidative Stress Associated with Preeclampsia

Gina D Kusuma, Harry M Georgiou, Anthony Perkins, Mohamed H Abumaree, Shaun P Brennecke, Bill Kalionis

Journal article  |  2022  |  YALE JOURNAL OF BIOLOGY AND MEDICINE

Preeclampsia (PE) is a serious medically important disorder of human pregnancy, which features de novo pregnancy-induced hypertens..

Preterm birth update in Australasia: A report of the international symposium of Preterm Birth International Collaborative-Australasia branch.

Chong Qiao, Ramkumar Menon, Ki Hoon Ahn, Shunji Suzuki, Pallavi Kshetrapal, Harry Michael Georgiou, Sam Mesiano, Nanbert Zhong

Journal article  |  2022  |  Front Pediatr

Preterm birth (PTB) is one of the most important problems that pose dilemmas for both the obstetrician and neonatologist, placing ..

Late/post-term decidual basalis-derived mesenchymal stem/stromal cells show evidence of advanced ageing and downregulation of microRNA-516b-5p

Ramin Khanabdali, Shixuan Zheng, Phillip E Melton, Harry M Georgiou, Eric Moses, Shaun P Brennecke, Bill Kalionis

Journal article  |  2021  |  PLACENTA

INTRODUCTION: The placenta is a short-lived organ, yet it shows signs of progressive ageing in the third trimester. Studies of age..

Postpartum circulating microRNA enhances prediction of future type 2 diabetes in women with previous gestational diabetes

Mugdha V Joglekar, Wilson KM Wong, Fahmida K Ema, Harry M Georgiou, Alexis Shub, Anandwardhan A Hardikar, Martha Lappas

Journal article  |  2021  |  DIABETOLOGIA

AIMS/HYPOTHESIS: Type 2 diabetes mellitus is a major cause of morbidity and death worldwide. Women with gestational diabetes melli..

Ageing in human parturition: impetus of the gestation clock in the decidua

Joan C Wijaya, Ramin Khanabdali, Harry M Georgiou, Bill Kalionis

Journal article  |  2020  |  BIOLOGY OF REPRODUCTION

Despite sharing many common features, the relationship between ageing and parturition remains poorly understood. The decidua is a ..

Decidual mesenchymal stem/stromal cell-derived extracellular vesicles ameliorate endothelial cell proliferation, inflammation, and oxidative stress in a cell culture model of preeclampsia

Shixuan Zheng, Aiwu Shi, Sophia Hill, Claire Grant, Maria I Kokkinos, Padma Murthi, Harry M Georgiou, Shaun P Brennecke, Bill Kalionis

Journal article  |  2020  |  Pregnancy Hypertension

Oxidative stress and endothelial dysfunction contribute substantially to the pathogenesis of preeclampsia (PE). Decidual mesenchym..

Functional changes in decidual mesenchymal stem/stromal cells are associated with spontaneous onset of labour

Joan C Wijaya, Ramin Khanabdali, Harry M Georgiou, Maria Kokkinos, Patrick F James, Shaun P Brennecke, Bill Kalionis

Journal article  |  2020  |  Molecular Human Reproduction

Ageing and parturition share common pathways, but their relationship remains poorly understood. Decidual cells undergo ageing as p..

94-OR: Postpartum Circulating MicroRNAs Can Predict the Development of Type 2 Diabetes in Women with Previous Gestational Diabetes

MUGDHA JOGLEKAR, WILSON K WONG, FAHMIDA KHAN EMA, HARRY M GEORGIOU, ANAND HARDIKAR, MARTHA LAPPAS

Journal article  |  2020  |  Diabetes

Type 2 diabetes (T2D) is a major cause of morbidity and death worldwide. Women with gestational diabetes mellitus (GDM) have a sev..

Preterm birth prediction in asymptomatic women at mid-gestation using a panel of novel protein biomarkers: the Prediction of PreTerm Labor (PPeTaL) study.

San Min Leow, Megan KW Di Quinzio, Zhen Long Ng, Claire Grant, Tal Amitay, Ying Wei, Moshe Hod, Penelope M Sheehan, Shaun P Brennecke, Nir Arbel, Harry M Georgiou

Journal article  |  2020  |  American Journal of Obstetrics and Gynecology MFM

BACKGROUND: Accurate prediction of spontaneous preterm labor/preterm birth in asymptomatic women remains an elusive clinical chall..