Mandvi Bharadwaj

Broad CD8( ) T cell cross-recognition of distinct influenza A strains in humans

Emma J Grant, Tracy M Josephs, Liyen Loh, E Bridie Clemens, Sneha Sant, Mandvi Bharadwaj, Weisan Chen, Jamie Rossjohn, Stephanie Gras, Katherine Kedzierska

Journal article  |  2018  |  NATURE COMMUNICATIONS

Newly-emerged and vaccine-mismatched influenza A viruses (IAVs) result in a rapid global spread of the virus due to minimal antibo..

Lack of Heterologous Cross-reactivity toward HLA-A*02:01 Restricted Viral Epitopes Is Underpinned by Distinct alpha beta T Cell Receptor Signatures

Emma J Grant, Tracy M Josephs, Sophie A Valkenburg, Linda Wooldridge, Margaret Hellard, Jamie Rossjohn, Mandvi Bharadwaj, Katherine Kedzierska, Stephanie Gras

Journal article  |  2016  |  JOURNAL OF BIOLOGICAL CHEMISTRY

αβT cell receptor (TCR) genetic diversity is outnumbered by the quantity of pathogenic epitopes to be recognized. To provide effic..

An Extensive Antigenic Footprint Underpins Immunodominant TCR Adaptability against a Hypervariable Viral Determinant

Usha K Nivarthi, Stephanie Gras, Lars Kjer-Nielsen, Richard Berry, Isabelle S Lucet, John J Miles, Samantha L Tracy, Anthony W Purcell, David S Bowden, Margaret Hellard, Jamie Rossjohn, James McCluskey, Mandvi Bharadwaj

Journal article  |  2014  |  JOURNAL OF IMMUNOLOGY

Mutations in T cell epitopes are implicated in hepatitis C virus (HCV) persistence and can impinge on vaccine development. We rece..

Detection of HCV-Specific IFN-gamma Responses in HCV Antibody and HCV RNA Negative Injecting Drug Users

Jacqueline K Flynn, Rachel Sacks-Davis, Peter Higgs, Campbell Aitken, Sarah Moneer, Vijay Suppiah, Lilly Tracy, Rosemary Ffrench, Scott Bowden, Heidi Drummer, Jacob George, Mandvi Bharadwaj, Margaret Hellard

Journal article  |  2014  |  HEPATITIS MONTHLY

BACKGROUND: Detectable HCV-specific cellular immune responses in HCV antibody and RNA negative people who inject drugs (PWID) rais..

High Rates of Hepatitis C Virus Reinfection and Spontaneous Clearance of Reinfection in People Who Inject Drugs: A Prospective Cohort Study

Rachel Sacks-Davis, Campbell K Aitken, Peter Higgs, Tim Spelman, Alisa E Pedrana, Scott Bowden, Mandvi Bharadwaj, Usha K Nivarthi, Vijayaprakash Suppiah, Jacob George, Jason Grebely, Heidi E Drummer, Margaret Hellard

Journal article  |  2013  |  PLOS ONE

UNLABELLED: Hepatitis C virus reinfection and spontaneous clearance of reinfection were examined in a highly characterised cohort ..

Nudeoprotein of influenza A virus is a major target of immunodominant CD8( ) T-cell responses

Emma Grant, Chao Wu, Kok-Fei Chan, Sidonia Eckle, Mandvi Bharadwaj, Quan Ming Zou, Katherine Kedzierska, Weisan Chen

Journal article  |  2013  |  IMMUNOLOGY AND CELL BIOLOGY

Influenza A virus causes annual epidemics and sporadic pandemics, resulting in significant morbidity and mortality worldwide. Vacc..

The design and proof of concept for a CD8( ) T cell-based vaccine inducing cross-subtype protection against influenza A virus

Amabel CL Tan, Georgia Deliyannis, Mandvi Bharadwaj, Lorena E Brown, Weiguang Zeng, David C Jackson

Journal article  |  2013  |  IMMUNOLOGY AND CELL BIOLOGY

In this study, we examined the reactivity of human peripheral blood mononuclear cells to a panel of influenza A virus (IAV) CD8(+)..

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

Patricia T Illing, Julian P Vivian, Nadine L Dudek, Lyudmila Kostenko, Zhenjun Chen, Mandvi Bharadwaj, John J Miles, Lars Kjer-Nielsen, Stephanie Gras, Nicholas A Williamson, Scott R Burrows, Anthony W Purcell, Jamie Rossjohn, James McCluskey

Journal article  |  2012  |  NATURE

Human leukocyte antigens (HLAs) are highly polymorphic proteins that initiate immunity by presenting pathogen-derived peptides to ..

Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor

Rangsima Reantragoon, Lars Kjer-Nielsen, Onisha Patel, Zhenjun Chen, Patricia T Illing, Mugdha Bhati, Lyudmila Kostenko, Mandvi Bharadwaj, Bronwyn Meehan, Ted H Hansen, Dale I Godfrey, Jamie Rossjohn, James McCluskey

Journal article  |  2012  |  JOURNAL OF EXPERIMENTAL MEDICINE

Mucosal-associated invariant T (MAIT) cells express a semiinvariant αβ T cell receptor (TCR) that binds MHC class I-like molecule ..

Detection and characterisation of alloreactive T cells.

Mandvi Bharadwaj, Nicole A Mifsud, James McCluskey

Journal article  |  2012  |  Methods Mol Biol

T cell alloreactivity is responsible for much of the morbidity and mortality associated with tissue transplantation and graft vers..