Professor Eleanor Mackie is a veterinary graduate who leads the Laboratory for Bone and Muscle Cell Biology at the Parkville campus of the Melbourne Veterinary School. She has undertaken research on basic aspects of musculoskeletal development and pathology in the pharmaceutical industry, hospital-based research institutes and veterinary schools in Switzerland, the UK and Australia.
Her laboratory studies regulation of the behaviour of bone, cartilage and muscle cells during development, regeneration and pathology, with particular emphasis on the roles of extracellular matrix and proteases. Areas of current interest include the role of protease-activated receptors in a variety of contexts such as muscle-bone interactions and periodontal disease, the role of the hypertrophic chondrocyte in bone growth, and the structural basis for bone injury in racehorses.
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Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary..
Motion Trackers To Be Ued To Monitor Behavioural Changes Associated With Orthopaedic Pain ..
Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification an..
Displaying the 27 most recent projects by Eleanor Mackie.
Internal Research Grant
Displaying the 126 most recent scholarly works by Eleanor Mackie.
Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone (vol 10, 3436, 2019)
Christina Vrahnas, Martha Blank, Toby A Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwin, Nguyen Huynh, Mark R Forwood, Yifang Hu, Mika Ikegame, Keith R Bambery, Cyril Petibois, Eleanor J Mackie, Mark J Tobin, Gordon K Smyth, Jonathan S Oakhill, T John Martin, Natalie A Sims
Journal article | 2019 | Nature Communications
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs
SJ Gauci, SB Golub, L Tatarczuch, E Lee, D Chan, NC Walsh, CB Little, H Stanton, Z Lokmic, NA Sims, EJ Mackie, AJ Fosang
Journal article | 2019 | Matrix Biology
Cartilage remodelling and chondrocyte differentiation are tightly linked to angiogenesis during bone development and endochondral ..
Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
Christina Vrahnas, Martha Blank, Toby A Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwinl, Nguyen Huynh, Mark R Forwood, Yifang Hu, Mika Ikegame, Keith R Bambery, Cyril Petibois, Eleanor J Mackie, Mark J Tobin, Gordon K Smyth, Jonathan S Oakhill, T John Martin, Natalie A Sims
Journal article | 2019 | Nature Communications
Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralizatio..
Keratinocyte-specific ablation of protease-activated receptor 2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease
Nidhish Francis, Babatunde A Ayodele, Neil M O'Brien-Simpson, Walter Birchmeier, Robert N Pike, Charles N Pagel, Eleanor J Mackie
Journal article | 2018 | Cellular Microbiology
The vacuolar H ATPase V0 subunit d2 is associated with chondrocyte hypertrophy and supports chondrocyte differentiation.
Babatunde A Ayodele, Michiko Mirams, Charles N Pagel, Eleanor J Mackie
Journal article | 2017 | Bone Reports
Chondrocyte hypertrophy makes important contributions to bone development and growth. We have investigated a number of novel carti..
EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis (vol 28, pg 4482, 2014)
Stephen Tonna, Farzin M Takyar, Christina Vrahnas, Blessing Crimeen-Irwin, Patricia WM Ho, Ingrid J Poulton, Holly J Brennan, Narelle E McGregor, Elizabeth H Allan, Nguyen Huynh, Mark R Forwood, Liliana Tatarczuch, Eleanor J Mackie, T John Martin, Natalie A Sims
Journal article | 2017 | The FASEB Journal
The antiepileptic medications carbamazepine and phenytoin inhibit native sodium currents in murine osteoblasts
Sandra J Petty, Carol J Milligan, Marian Todaro, Kay L Richards, Pamuditha K Kularathna, Charles N Pagel, Chris R French, Elisa L Hill-Yardin, Terence J O'Brien, John D Wark, Eleanor J Mackie, Steven Petrou
Journal article | 2016 | Epilepsia
Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification
Stephen Tonna, Ingrid J Poulton, Farzin Taykar, Patricia WM Ho, Brett Tonkin, Blessing Crimeen-Irwin, Liliana Tatarczuch, Narelle E McGregor, Eleanor J Mackie, T John Martin, Natalie A Sims
Journal article | 2016 | Development
EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis
Stephen Tonna, Farzin M Takyar, Christina Vrahnas, Blessing Crimeen-Irwin, Patricia WM Ho, Ingrid J Poulton, Holly J Brennan, Narelle E McGregor, Elizabeth H Allan, Huynh Nguyen, Mark R Forwood, Liliana Tatarczuch, Eleanor J Mackie, T John Martin, Natalie AZ Sims
Journal article | 2014 | The FASEB Journal
Hyaluronan Synthesis and Myogenesis A REQUIREMENT FOR HYALURONAN SYNTHESIS DURING MYOGENIC DIFFERENTIATION INDEPENDENT OF PERICELLULAR MATRIX FORMATION
Liam C Hunt, Chris Gorman, Christopher Kintakas, Daniel R McCulloch, Eleanor J Mackie, Jason D White
Journal article | 2013 | Journal of Biological Chemistry
Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy
Trevor L Cameron, Katrina M Bell, Liliana Tatarczuch, Eleanor J Mackie, M Helen Rajpar, Ben T McDermott, Raymond P Boot-Handford, John F Bateman
Journal article | 2011 | PLoS One
FOCAL SUBCHONDRAL BONE ATTRITION OF THE DISTAL METACARPAL CONDYLES IN THOROUGHBRED RACEHORSES IS ASSOCIATED WITH MICROFRACTURE ACCUMULATION AND INCREASED BONE VOLUME FRACTION OF SURROUNDING BONE
E Bani Hassan, M Mirams, EJ Mackie, A Ghasem-Zadeh, RC Whitton
Conference Proceedings | 2011 | OSTEOPOROSIS INTERNATIONAL
Comprehensive Profiling of Cartilage Extracellular Matrix Formation and Maturation Using Sequential Extraction and Label-free Quantitative Proteomics
Richard Wilson, Anders F Diseberg, Lavinia Gordon, Snezana Zivkovic, Liliana Tatarczuch, Eleanor J Mackie, Jeffrey J Gorman, John F Bateman
Journal article | 2010 | Molecular and Cellular Proteomics
Proteinase-activated receptor-2 (PAR(2)) and mouse osteoblasts: Regulation of cell function and lack of specificity of PAR(2)-activating peptides
Smitha R Georgy, Charles N Pagel, David M Wong, Sutharshani Sivagurunathan, Lay H Loh, Damian E Myers, Morley D Hollenberg, Robert N Pike, Eleanor J Mackie
Journal article | 2010 | Clinical and Experimental Pharmacology and Physiology
Protease-Activated Receptor 2 Has Pivotal Roles in Cellular Mechanisms Involved in Experimental Periodontitis
David M Wong, Vivian Tam, Roselind Lam, Katrina A Walsh, Liliana Tatarczuch, Charles N Pagel, Eric C Reynolds, Neil M O'Brien-Simpson, Eleanor J Mackie, Robert N Pike
Journal article | 2010 | Infection and Immunity
Protease-Activated Receptor-1 Down-regulates the Murine Inflammatory and Humoral Response to Helicobacter pylori
Janet LK Wee, Yok-Teng Chionh, Garrett Z Ng, Stacey N Harbour, Cody Allison, Charles N Pagel, Eleanor J Mackie, Hazel M Mitchell, Richard L Ferrero, Philip Sutton
Journal article | 2010 | Gastroenterology
High Molecular Weight Gingipains from Porphyromonas gingivalis Induce Cytokine Responses from Human Macrophage-Like Cells via a Nonproteolytic Mechanism
Rebecca E Fitzpatrick, Andrea Aprico, Lakshmi C Wijeyewickrema, Charles N Pagel, David M Wong, Jan Potempa, Eleanor J Mackie, Robert N Pike
Journal article | 2009 | Journal of Innate Immunity
Myoblasts isolated from hypertrophy-responsive callipyge muscles show altered growth rates and increased resistance to serum deprivation-induced apoptosis
Lopeti T Lavulo, Kitipong Uaesoontrachoon, Michiko Mirams, Jason D White, Noelle E Cockett, Eleanor J Mackie, Charles N Pagel
Journal article | 2008 | Cells Tissues Organs
Osteopontin and skeletal muscle myoblasts: Association with muscle regeneration and regulation of myoblast function in vitro
Kitipong Uaesoontrachoon, Hyun-Jin Yoo, Elizabeth M Tudor, Robert N Pike, Eleanor J Mackie, Charles N Pagel
Journal article | 2008 | International Journal of Biochemistry and Cell Biology
Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion
A Lourbakos, J Potempa, J Travis, MR D'Andrea, P Andrade-Gordon, R Santulli, EJ Mackie, RN Pike
Journal article | 2001 | Infection and Immunity
Characterization of the receptor responsible for thrombin-induced intracellular calcium responses in osteoblast-like cells.
AL Jenkins, MD Bootman, CW Taylor, EJ Mackie, SR Stone
Journal article | 1993 | Journal of Biological Chemistry
The receptor responsible for the increase in intracellular calcium concentration ([Ca2+]i) after the addition of thrombin to the h..
Member Of Editorial Board
Editorial Board of the Journal of Biological Chemistry
Member Of Editorial Board
Editorial Board of the International Journal of Biochemistry and Cell Biology
The Royal College of Veterinary Surgeons (MRCVS)
Doctorate of Veterinary Medicine
University of Zurich
Master of Science
Iowa State University
Bachelor of Veterinary Science
University of Sydney