Aung Ko Win

Genetic Variants in the Regulatory T cell-Related Pathway and Colorectal Cancer Prognosis.

Sonja Neumeyer, Xinwei Hua, Petra Seibold, Lina Jansen, Axel Benner, Barbara Burwinkel, Niels Halama, Sonja I Berndt, Amanda I Phipps, Lori C Sakoda, Robert E Schoen, Martha L Slattery, Andrew T Chan, Manish Gala, Amit D Joshi, Shuji Ogino, Mingyang Song, Esther Herpel, Hendrik Bläker, Matthias Kloor, et al.

Journal article  |  2020  |  Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better col..

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk

Minta Thomas, Lori C Sakoda, Michael Hoffmeister, Elisabeth A Rosenthal, Jeffrey K Lee, Franzel JB van Duijnhoven, Elizabeth A Platz, Anna H Wu, Christopher H Dampier, Albert de la Chapelle, Alicja Wolk, Amit D Joshi, Andrea Burnett-Hartman, Andrea Gsur, Annika Lindblom, Antoni Castells, Aung Ko Win, Bahram Namjou, Bethany Van Guelpen, Catherine M Tangen, et al.

Journal article  |  2020  |  The American Journal of Human Genetics

Accurate colorectal cancer (CRC) risk prediction models are critical for identifying individuals at low and high risk of developin..

Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.

Mev Dominguez-Valentin, Julian R Sampson, Toni T Seppälä, Sanne W Ten Broeke, John-Paul Plazzer, Sigve Nakken, Christoph Engel, Stefan Aretz, Mark A Jenkins, Lone Sunde, Inge Bernstein, Gabriel Capella, Francesc Balaguer, Huw Thomas, D Gareth Evans, John Burn, Marc Greenblatt, Eivind Hovig, Wouter H de Vos Tot Nederveen Cappel, Rolf H Sijmons, et al.

Artefact  |  2020  |  Genetics in Medicine

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Height and Colorectal and Endometrial Cancer Risk for Persons with Lynch Syndrome.

Jesca GM Brouwer, Polly A Newcomb, Tanya M Bisseling, Jane C Figueiredo, John L Hopper, Mark A Jenkins, Jan J Koornstra, Noralane M Lindor, Hans FA Vasen, Aung K Win, Ellen Kampman, Fränzel JB van Duijnhoven

Journal article  |  2020  |  American Journal of Epidemiology

Persons with Lynch syndrome (LS - carrying a pathogenic mutation in a DNA mismatch repair gene) have an increased colorectal cance..

Analysis in the Prospective Lynch Syndrome Database identifies sarcoma as part of the Lynch syndrome tumor spectrum.

Mev Dominguez-Valentin, Julian R Sampson, Pål Møller, Toni T Seppälä, undefined PLSD Collaborators

Journal article  |  2020  |  International Journal of Cancer

Potential impact of family history-based screening guidelines on the detection of early-onset colorectal cancer

Samir Gupta, Balambal Bharti, Dennis J Ahnen, Daniel D Buchanan, Iona C Cheng, Michelle Cotterchio, Jane C Figueiredo, Steven J Gallinger, Robert W Haile, Mark A Jenkins, Noralane M Lindor, Finlay A Macrae, Loic Le Marchand, Polly A Newcomb, Stephen N Thibodeau, Aung Ko Win, Maria Elena Martinez

Journal article  |  2020  |  Cancer

BACKGROUND: Initiating screening at an earlier age based on cancer family history is one of the primary recommended strategies for..

Cumulative Burden of Colorectal Cancer Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer

Alexi N Archambault, Yu-Ru Su, Jihyoun Jeon, Minta Thomas, Yi Lin, David V Conti, Aung Ko Win, Lori C Sakoda, Iris Lansdorp-Vogelaar, Elisabeth FP Peterse, Ann G Zauber, David Duggan, Andreana N Holowatyj, Jeroen R Huyghe, Hermann Brenner, Michelle Cotterchio, Stephane Bezieau, Stephanie L Schmit, Christopher K Edlund, Melissa C Southey, et al.

Journal article  |  2020  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in t..

Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk

Nikhil K Khankari, Barbara L Banbury, Maria C Borges, Philip Haycock, Demetrius Albanes, Volker Arndt, Sonja I Berndt, Stephane Bezieau, Hermann Brenner, Peter T Campbell, Graham Casey, Andrew T Chan, Jenny Chang-Claude, David V Conti, Michelle Cotterchio, Dallas R English, Jane C Figueiredo, Graham G Giles, Edward L Giovannucci, Marc J Gunter, et al.

Journal article  |  2020  |  Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: Results from epidemiologic studies examining polyunsaturated fatty acids (PUFA) and colorectal cancer risk are inconsi..

Genetic Predictors of Circulating 25-Hydroxyvitamin D and Prognosis after Colorectal Cancer.

Sonja Neumeyer, Katja Butterbach, Barbara L Banbury, Sonja I Berndt, Peter T Campbell, Rowan T Chlebowski, Andrew T Chan, Edward L Giovannucci, Amit D Joshi, Shuji Ogino, Mingyang Song, Marjorie L McCullough, Haifa Maalmi, JoAnn E Manson, Lori C Sakoda, Robert E Schoen, Martha L Slattery, Emily White, Aung K Win, Jane C Figueiredo, et al.

Journal article  |  2020  |  Cancer Epidemiology, Biomarkers and Prevention

Background: Low serum 25-hydroxyvitamin D [25(OH)D] concentrations in patients with colorectal cancer have been consistently assoc..

Germline and Tumor Whole Genome Sequencing as a Diagnostic Tool to Resolve Suspected Lynch Syndrome

Bernard Pope, Mark Clendenning, Christophe Rosty, Khalid Mahmood, Peter Georgeson, Jihoon Joo, Romy Walker, Ryan Hutchinson, Harindra Jayasekara, Sharelle Joseland, Julia Como, Susan Preston, Amanda Spurdle, Finlay Macrae, Aung Win, John Hopper, Mark Jenkins, Ingrid Winship, Daniel Buchanan

Journal article  |  2020

Abstract Background People who develop mismatch repair (MMR) deficient cancer in the absence of a germline MMR gene pathogenic var..