Aung Ko Win

Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study.

undefined International Mismatch Repair Consortium

Journal article  |  2021  |  Lancet Oncol

BACKGROUND: Existing clinical practice guidelines for carriers of pathogenic variants of DNA mismatch repair genes (Lynch syndrome..

No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Study

Mev Dominguez-Valentin, John-Paul Plazzer, Julian R Sampson, Christoph Engel, Stefan Aretz, Mark A Jenkins, Lone Sunde, Inge Bernstein, Gabriel Capella, Francesc Balaguer, Finlay Macrae, Ingrid M Winship, Huw Thomas, Dafydd Gareth Evans, John Burn, Marc Greenblatt, Wouter H de Vos Tot Nederveen Cappel, Rolf H Sijmons, Maartje Nielsen, Lucio Bertario, et al.

Journal article  |  2021  |  JOURNAL OF CLINICAL MEDICINE

BACKGROUND: Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers of pathogenic changes in mism..

Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer

Alexi N Archambault, Yi Lin, Jihyoun Jeon, Tabitha A Harrison, D Timothy Bishop, Hermann Brenner, Graham Casey, Andrew T Chan, Jenny Chang-Claude, Jane C Figueiredo, Steven Gallinger, Stephen B Gruber, Marc J Gunter, Michael Hoffmeister, Mark A Jenkins, Temitope O Keku, Loic Le Marchand, Li Li, Victor Moreno, Polly A Newcomb, et al.

Journal article  |  2021  |  JNCI CANCER SPECTRUM

Background: Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus,..

DNA Methylation Signatures and the Contribution of Age-Associated Methylomic Drift to Carcinogenesis in Early-Onset Colorectal Cancer

Jihoon E Joo, Mark Clendenning, Ee Ming Wong, Christophe Rosty, Khalid Mahmood, Peter Georgeson, Ingrid M Winship, Susan G Preston, Aung Ko Win, Pierre-Antoine Dugue, Harindra Jayasekara, Dallas English, Finlay A Macrae, John L Hopper, Mark A Jenkins, Roger L Milne, Graham G Giles, Melissa C Southey, Daniel D Buchanan

Journal article  |  2021  |  CANCERS

We investigated aberrant DNA methylation (DNAm) changes and the contribution of ageing-associated methylomic drift and age acceler..

Uptake of hysterectomy and bilateral salpingooophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

Toni T Seppala, Mev Dominguez-Valentin, Emma J Crosbie, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H Sijmons, Lucio Bertario, Bernardo Bonanni, Maria G Tibiletti, Giulia M Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, et al.

Journal article  |  2021  |  EUROPEAN JOURNAL OF CANCER

PURPOSE: This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecologi..

A Meta-Analysis of Obesity and Risk of Colorectal Cancer in Patients with Lynch Syndrome: The Impact of Sex and Genetics

Matteo Lazzeroni, Federica Bellerba, Mariarosaria Calvello, Finlay Macrae, Aung Ko Win, Mark Jenkins, Davide Serrano, Monica Marabelli, Sara Cagnacci, Gianluca Tolva, Debora Macis, Sara Raimondi, Luca Mazzarella, Susanna Chiocca, Saverio Caini, Lucio Bertario, Bernardo Bonanni, Sara Gandini

Journal article  |  2021  |  NUTRIENTS

There appears to be a sex-specific association between obesity and colorectal neoplasia in patients with Lynch Syndrome (LS). We m..

The Association Between Genetic Ancestry and Asthma Risk, Across Different Ethnicities and Host Countries: A Systematic Review

J Pham, DS Bui, C Lodge, M Hew, MJ Abramson, AK Win, S Dharmage

Conference Proceedings  |  2021  |  TP65. TP065 ENVIRONMENTAL EXPOSURES AND LUNG DISEASE

Assessment of a Polygenic Risk Score for Colorectal Cancer to Predict Risk of Lynch Syndrome Colorectal Cancer

Mark A Jenkins, Daniel D Buchanan, John Lai, Enes Makalic, Gillian S Dite, Aung K Win, Mark Clendenning, Ingrid M Winship, Richard B Hayes, Jeroen R Huyghe, Ulrike Peters, Steven Gallinger, Loic Le Marchand, Jane C Figueiredo, Rish K Pai, Polly A Newcomb, James M Church, Graham Casey, John L Hopper

Journal article  |  2021  |  JNCI CANCER SPECTRUM

It was not known whether the polygenic risk scores (PRSs) that predict colorectal cancer could predict colorectal cancer for peopl..

Age dependency of the polygenic risk score for colorectal cancer Response

Editorship  |  2021  |  American Journal of Human Genetics

Germline and Tumor Sequencing as a Diagnostic Tool To Resolve Suspected Lynch Syndrome

Bernard J Pope, Mark Clendenning, Christophe Rosty, Khalid Mahmood, Peter Georgeson, Jihoon E Joo, Romy Walker, Ryan A Hutchinson, Harindra Jayasekara, Sharelle Joseland, Julia Como, Susan Preston, Amanda B Spurdle, Finlay A Macrae, Aung K Win, John L Hopper, Mark A Jenkins, Ingrid M Winship, Daniel D Buchanan

Journal article  |  2021  |  JOURNAL OF MOLECULAR DIAGNOSTICS

Patients in whom mismatch repair (MMR)-deficient cancer develops in the absence of pathogenic variants of germline MMR genes or so..