Kathryn Marshall

Knocking in Multifunctional Gene Tags into SMC Complex Subunits Using Gene Editing

Paul Kalitsis, Tao Zhang, Ji Hun Kim, Christian F Nielsen, Kathryn M Marshall, Damien F Hudson

Journal article  |  2019  |  SMC COMPLEXES: METHODS AND PROTOCOLS

Condensin, a highly conserved pentameric chromosome complex, is required for the correct organization and folding of the genome. H..

Oral trivalent bismuth ions decrease, and trivalent indium or ruthenium ions increase, intestinal tumor burden in Apc(Delta 14/ ) mice

Marie Laval, Chelsea Dumesny, Mal Eutick, Graham S Baldwin, Kathryn M Marshall

Journal article  |  2018  |  METALLOMICS

Immature forms of the peptide hormone gastrin have been implicated in the development of colorectal cancer (CRC). The biological a..

Complexes of gastrin with In3 , Ru3 or Ga3 ions are not recognised by the cholecystokinin 2 receptor

Marie Laval, Kathryn M Marshall, John Sachinidis, Andrew Scott, Mal Eutick, Graham S Baldwin

Journal article  |  2017  |  JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The peptide hormone gastrin (Gamide) binds trivalent metal ions, including indium (In), ruthenium (Ru) and gallium (Ga), with high..

Condensin, master organizer of the genome

Paul Kalitsis, Tao Zhang, Kathryn M Marshall, Christian F Nielsen, Damien F Hudson

Journal article  |  2017  |  CHROMOSOME RESEARCH

A fundamental requirement in nature is for a cell to correctly package and divide its replicated genome. Condensin is a mechanical..

Retro-inverso forms of gastrin(5-12) are as biologically active as glycine-extended gastrin in vitro but not in vivo

Kathryn M Marshall, Marie Laval, Ioulia Sims, Arthur Shulkes, Graham S Baldwin

Journal article  |  2015  |  PEPTIDES

Non-amidated gastrin peptides such as glycine-extended gastrin (Ggly) are biologically active in vitro and in vivo and have been i..

Increased gastrin gene expression provides a physiological advantage to mice under hypoxic conditions

Marie Laval, Graham S Baldwin, Arthur Shulkes, Kathryn M Marshall

Journal article  |  2015  |  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hypoxia, or a low concentration of O2, is encountered in humans undertaking activities such as mountain climbing and scuba diving ..

Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo

Kathryn M Marshall, Marie Laval, Ortis Estacio, Damien F Hudson, Paul Kalitsis, Arthur Shulkes, Graham S Baldwina, Oneel Patel

Journal article  |  2015  |  METALLOMICS

Over-expression of growth factors can contribute to the development and progression of cancer, and gastrins in particular have bee..

The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo

Kathryn M Marshall, Oneel Patel, Gianni Bramante, Marie Laval, Mildred Yim, Graham S Baldwin, Arthur Shulkes

Journal article  |  2013  |  PEPTIDES

Progastrin (PG) is processed into a number of smaller peptides including amidated gastrin (Gamide), non-amidated glycine-extended ..

Glucocorticoid-mediated inhibition of angiogenic changes in human endothelial cells is not caused by reductions in cell proliferation or migration.

James J Logie, Sadaf Ali, Kathryn M Marshall, Margarete MS Heck, Brian R Walker, Patrick WF Hadoke

Journal article  |  2010  |  PLoS One

BACKGROUND: Glucocorticoid-mediated inhibition of angiogenesis is important in physiology, pathophysiology and therapy. However, t..

The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway

Oneel Patel, Kathryn M Marshall, Gianni Bramante, Graham S Baldwin, Arthur Shulkes

Journal article  |  2010  |  REGULATORY PEPTIDES

Progastrin is processed to a number of peptides including glycine-extended gastrin, amidated gastrin and the C-terminal flanking p..