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Prof

Philip Beart

Honorary
Florey Department of Neuroscience and Mental Health
neurosciences
science & technology
life sciences & biomedicine
neurosciences & neurology
brain disorders
neurological
biochemistry & molecular biology
neurodegenerative
2.1 biological and endogenous factors
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Prof

Philip Beart

 
Division
Medicine, Dentistry and Health Sciences
Philip Beart's Profile Picture
Prof

Philip Beart

 
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Projects

Displaying the 10 most recent projects from 13 for Philip Beart.

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TARGETING AUTOPHAGY TO IMPROVE PROTEIN METABOLISM IN ALS

One common feature of MND is the accumulation of protein deposits inside nerve cells which leads to their death. We have identified a potent..

2016 - 2018
Completed
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RESEARCH FELLOWSHIP

My research focuses on understanding pathobiological mechanisms in acute and chronic neurodegenerative conditions such as stroke and Parkins..

2012 - 2016
Completed
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Contributions of astrocytic TDP-43 to motoneuron disease

Motor neuron disease (MND) leads to death of nerve cells, paralysis and death. There is no cure. Mutations in the protein TDP43 cause MND. I..

2012 - 2015
Completed
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Targeting astrogliosis and brain stimulation after stroke to promote plasticity and functional recovery

2014 - 2015
Completed
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REGULATING ASTROCYTOSIS FOR APPROPRIATE DEFENCE AND REPAIR OF THE BRAIN AFTER INJURY

An inflammatory process, designed to clean up cell debris and maintain tissue integrity following brain insult, also results in an astrocyti..

2012 - 2014
Completed
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AURORA KINASE: MOLECULAR, CELLULAR AND FUNCTIONAL STUDIES DECIPHERING ITS ROLE IN STROKE INJURY

In stroke patients, oxygen deprivation indirectly induces massive nerve cell death by activating an enzyme called aurora kinase A (AURKA). W..

2012 - 2014
Completed
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AURORA KINASE: MOLECULAR, CELLULAR AND FUNCTIONAL STUDIES DECIPHERING ITS ROLE IN STROKE INJURY

In stroke patients, oxygen deprivation indirectly induces massive nerve cell death by activating an enzyme called aurora kinase A (AURKA). W..

2012 - 2014
Completed
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RESEARCH FELLOWSHIP 2007 - BEART

I am a neuroscientist employing strategies of biochemistry, pathology, pharmacology and developmental biology to examine the mechanisms of n..

2007 - 2011
Completed
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Unravelling mitochondrial contributions to neuronal injury

Mitochondria are components of cells normally providing energy for essential functions and in the energy demanding brain, under stress condi..

2008 - 2011
Completed
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Pharmacological regulation of the function of glutamate tranporters

Dysfunction of glutamate transport is implicated in the pathology of neurodegenerative conditions. Our aim is to understand how the molecule..

2008 - 2010
Completed

13

Projects

Project Types

13

Research Grant

Scholarly Works

Displaying the 10 most recent scholarly works from 286 for Philip Beart.

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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters

Stephen PH Alexander, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Laura Amarosi, Catriona MH Anderson, Philip Mark Beart, Stefan Broer, Paul A Dawson, Bruno Hagenbuch, James R Hammond, Ken-ichi Inui, Yoshikatsu Kanai, et al.

Journal article  |  2021  |  BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise..

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Neuro-nutraceuticals: Natural products nourish the brain but be aware of contrary effects

Robert J Williams, Kochupurackal P Mohanakumar, Philip M Beart

Journal article  |  2021  |  NEUROCHEMISTRY INTERNATIONAL

In this Special Issue on "Nutraceuticals: Molecular and Functional Insights into how Natural Products Nourish the Brain", the edit..

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Amyotrophic Lateral Sclerosis and Autophagy: Dysfunction and Therapeutic Targeting

Azin Amin, Nirma D Perera, Philip M Beart, Bradley J Turner, Fazel Shabanpoor

Journal article  |  2020  |  CELLS

Over the past 20 years, there has been a drastically increased understanding of the genetic basis of Amyotrophic Lateral Sclerosis..

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OBITUARY Leslie Iversen (1937-2020)

Solomon H Snyder, Bevyn Jarrott, Anthony J Turner, Philip M Beart

Journal article  |  2020  |  JOURNAL OF NEUROCHEMISTRY

This is an Obituary for Leslie Iversen (1937-2020). Les Iversen was an internationally renowned neuroscientist and pharmacologist,..

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Special Issue in Honour of Michael B Robinson

Philip M Beart

Journal article  |  2020  |  NEUROCHEMICAL RESEARCH

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Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS

Samantha K Barton, Chew L Lau, Mathew DF Chiam, Doris Tomas, Hakan Muyderman, Philip M Beare, Bradley J Turner

Journal article  |  2020  |  NEUROCHEMICAL RESEARCH

Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) caused by mutations in superoxide dismutase 1 (SOD1) is partly no..

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Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases

Olga Corti, Klas Blomgren, Angelo Poletti, Philip M Beart

Journal article  |  2020  |  JOURNAL OF NEUROCHEMISTRY

In autophagy long-lived proteins, protein aggregates or damaged organelles are engulfed by vesicles called autophagosomes prior to..

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The origins and early history of neurochemistry and its societies

Anne I Boullerne, Paul Foley, Anthony J Turner, Graham AR Johnston, Philip M Beart

Journal article  |  2019  |  JOURNAL OF NEUROCHEMISTRY

At the 2017 joint meeting of the International Society for Neurochemistry (ISN) and the European Society for Neurochemistry, 150 y..

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SLC1 family of amino acid transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Philip M Beart

Journal article  |  2019  |  IUPHAR/BPS Guide to Pharmacology CITE

The SLC1 family of sodium dependent transporters includes the plasma membrane located glutamate transporters and the neutral amino..

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Therapeutics for dementia and Alzheimer's disease: New directions for precision medicine

JA Duce, X Zhu, LH Jacobson, PM Beart

Journal article  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

This article is part of a themed section on Therapeutics for Dementia and Alzheimer's Disease: New Directions for Precision Medici..

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Scholarly Works

Keyword Analysis

Neurosciences
Expanding Knowledge
Pharmacology and Pharmaceutical Sciences
Clinical Health
Biochemistry and Cell Biology
Provision of Health and Support Services
Allied Health and Rehabilitation Science
Bioinformatics and Computational Biology
Clinical Sciences
Health Services and Systems

Credentials

Positions

Honorary

Florey Department of Neuroscience and Mental Health

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