Nicholas Clemons

Inhibition of BMP2 and BMP4 Represses Barrett's Esophagus While Enhancing the Regeneration of Squamous Epithelium in Preclinical Models.

Ana CP Correia, Danielle Straub, Matthew Read, Sanne JM Hoefnagel, Salvador Romero-Pinedo, Ana C Abadía-Molina, Nicholas J Clemons, Kenneth Wang, Silvia Calpe, Wayne Phillips, Kausilia K Krishnadath

Journal article  |  2023  |  Cell Mol Gastroenterol Hepatol

BACKGROUND & AIMS: Barrett's esophagus is considered to be a metaplastic lesion that predisposes for esophageal adenocarcinoma. De..

ASO Visual Abstract: Tumor-Infiltrating Neutrophils after Neoadjuvant Therapy are Associated with Poor Prognosis in Esophageal Cancer

Carlos S Cabalag, Owen WJ Prall, John Ciciulla, Laurence A Galea, Niko Thio, Madawa Jayawardana, Trishe YM Leong, Julia Milne, Kenji M Fujihara, Lynn Chong, Michael W Hii, Gisela Mir Arnau, Paul J Neeson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Journal article  |  2022  |  ANNALS OF SURGICAL ONCOLOGY

Tumor-Infiltrating Neutrophils after Neoadjuvant Therapy are Associated with Poor Prognosis in Esophageal Cancer

Carlos S Cabalag, Owen WJ Prall, John Ciciulla, Laurence A Galea, Niko Thio, Madawa Jayawardana, Trishe YM Leong, Julia V Milne, Kenji M Fujihara, Lynn Chong, Michael W Hii, Gisela Mir Arnau, Paul J Neeson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Journal article  |  2022  |  ANNALS OF SURGICAL ONCOLOGY

BACKGROUND: In esophageal cancer (EC), there is a paucity of knowledge regarding the interplay between the tumor immune microenvir..

ASO Author Reflections: Are Tumor-Infiltrating Neutrophils Drivers of Metastatic Disease in Esophageal Cancer Patients Treated with Neoadjuvant Therapy?

Carlos S Cabalag, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Journal article  |  2022  |  ANNALS OF SURGICAL ONCOLOGY

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

Kenji M Fujihara, Bonnie Z Zhang, Thomas D Jackson, Moses O Ogunkola, Brunda Nijagal, Julia Milne, David A Sallman, Ching-Seng Ang, Iva Nikolic, Conor J Kearney, Simon J Hogg, Carlos S Cabalag, Vivien R Sutton, Sally Watt, Asuka T Fujihara, Joseph A Trapani, Kaylene J Simpson, Diana Stojanovski, Silke Leimkuhler, Sue Haupt, et al.

Journal article  |  2022  |  SCIENCE ADVANCES

The mechanism of action of eprenetapopt (APR-246, PRIMA-1MET) as an anticancer agent remains unresolved, although the clinical dev..

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells (vol 12, 709, 2021)

Sophia Ceder, Sofi E Eriksson, Ying Yu Liang, Emarndeena H Cheteh, Si Min Zhang, Kenji M Fujihara, Julie Bianchi, Vladimir JN Bykov, Lars Abrahmsen, Nicholas J Clemons, Par Nordlund, Sean G Rudd, Klas G Wiman

Journal article  |  2022  |  CELL DEATH & DISEASE

The original version of this article was unfortunately missing additional information in the legend of figure 3. The following sen..

Potential Clinical Utility of a Targeted Circulating Tumor DNA Assay in Esophageal Adenocarcinoma

Carlos S Cabalag, Michael Yates, Mariana Benitez Corrales, Paul Yeh, Stephen Q Wong, Bonnie Z Zhang, Kenji M Fujihara, Lynn Chong, Michael W Hii, Sarah-Jane Dawson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Journal article  |  2022  |  ANNALS OF SURGERY

OBJECTIVE: To explore the clinical utility of circulating tumor DNA (ctDNA) in esophageal adenocarcinoma (EAC) by developing a cos..

Targeting MDM4 as a Novel Therapeutic Approach in Prostate Cancer Independent of p53 Status

Javier Octavio Mejia-Hernandez, Dinesh Raghu, Franco Caramia, Nicholas Clemons, Kenji Fujihara, Thomas Riseborough, Amina Teunisse, Aart G Jochemsen, Lars Abrahmsen, Giovanni Blandino, Andrea Russo, Cristina Gamell, Stephen B Fox, Catherine Mitchell, Elena A Takano, David Byrne, Panimaya Jeffreena Miranda, Reem Saleh, Heather Thorne, Shahneen Sandhu, et al.

Journal article  |  2022  |  CANCERS

Metastatic prostate cancer is a lethal disease in patients incapable of responding to therapeutic interventions. Invasive prostate..

Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes

Rebecca E Hughes, Richard JR Elliott, Xiaodun Li, Alison F Munro, Ashraff Makda, Roderick N Carter, Nicholas M Morton, Kenji Fujihara, Nicholas J Clemons, Rebecca Fitzgerald, J Robert O'Neill, Ted Hupp, Neil O Carragher

Journal article  |  2022  |  ACS CHEMICAL BIOLOGY

Esophageal adenocarcinoma is of increasing global concern due to increasing incidence, a lack of effective treatments, and poor pr..

Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression

Ian Y Luk, Laura J Jenkins, Kael L Schoffer, Irvin Ng, Janson WT Tse, Dmitri Mouradov, Stanislaw Kaczmarczyk, Rebecca Nightingale, Allan D Burrows, Robin L Anderson, Diego Arango, Higinio Dopeso, Larry Croft, Mark F Richardson, Oliver M Sieber, Yang Liao, Jennifer K Mooi, Natalia Vukelic, Camilla M Reehorst, Shoukat Afshar-Sterle, et al.

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Colorectal cancers (CRCs) often display histological features indicative of aberrant differentiation but the molecular underpinnin..