John Drago

Rapidly progressive Fronto-temporal dementia (FTD) associated with Frontotemporal lobar degeneration (FTLD) in the presence of Fused in Sarcoma (FUS) protein: a rare, sporadic, and aggressive form of FTD

Nicholas I Bradfield, Catriona McLean, John Drago, David G Darby, David Ames

Journal article  |  2017  |  INTERNATIONAL PSYCHOGERIATRICS

Fronto-temporal dementia (FTD) associated with Fused in Sarcoma (FUS) protein accumulation is an uncommon cause of FTD with a dist..

Amyloid-Related Memory Decline in Preclinical Alzheimer's Disease Is Dependent on APOE epsilon 4 and Is Detectable over 18-Months

Christine Thai, Yen Ying Lim, Victor L Villemagne, Simon M Laws, David Ames, Kathryn A Ellis, Stephanie R Rainey-Smith, Ralph N Martins, Colin L Masters, Christopher C Rowe, Paul Maruff

Journal article  |  2015  |  PLOS ONE

High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cog..

Role of alpha 4-and alpha 6-containing nicotinic receptors in the acquisition and maintenance of nicotine self-administration

Heather B Madsen, Harcharan S Koghar, Tine Pooters, Jim S Massalas, John Drago, Andrew J Lawrence

Journal article  |  2015  |  ADDICTION BIOLOGY

Tobacco smoking is a major cause of death and disease and as such there is a critical need for the development of new therapeutic ..

Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells

Luning Jiang, Claire O'Leary, Hyun Ah Kim, Clare L Parish, Jim Massalas, John L Waddington, Michelle E Ehrlich, Guenter Schuetz, Ilse Gantois, Andrew J Lawrence, John Drago

Journal article  |  2015  |  NEUROBIOLOGY OF DISEASE

D1-dopamine receptors (Drd1a) are highly expressed in the deep layers of the cerebral cortex and the striatum. A number of human d..

Prenatal nicotine exposure increases hyperventilation in alpha 4-knock-out mice during mild asphyxia

Joanne Ayraam, Gary Cohen, John Drago, Peter B Frappell

Journal article  |  2015  |  RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Prenatal nicotine exposure alters breathing and ventilatory responses to stress through stimulation of nicotine acetylcholine rece..

Resolving pathobiological mechanisms relating to Huntington disease: Gait, balance, and involuntary movements in mice with targeted ablation of striatal D1 dopamine receptor cells

Hyun Ah Kim, Luning Jiang, Heather Madsen, Clare L Parish, Jim Massalas, Arthur Smardencas, Claire O'Leary, Ilse Gantois, Colm O'Tuathaigh, John L Waddington, Michelle E Ehrlich, Andrew J Lawrence, John Drago

Journal article  |  2014  |  NEUROBIOLOGY OF DISEASE

Progressive cell loss is observed in the striatum, cerebral cortex, thalamus, hypothalamus, subthalamic nucleus and hippocampus in..

Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases

Arthur Smardencas, Kerelos Rizkalla, Hyun Ah Kim, Jim Massalas, Claire O'Leary, Michelle E Ehrlich, Guenter Schuetz, Andrew J Lawrence, John Drago

Journal article  |  2013  |  BMC NEUROSCIENCE

BACKGROUND: Mice generated by a Cre/LoxP transgenic paradigm were used to model neurodegenerative basal ganglia disease of which H..

Behavioural and Anatomical Characterization of Mutant Mice With Targeted Deletion of D-1 Dopamine Receptor-Expressing Cells: Response to Acute Morphine

Daniela Babovic, Luning Jiang, Satoshi Goto, Ilse Gantois, Guenter Schuetz, Andrew J Lawrence, John L Waddington, John Drago

Journal article  |  2013  |  JOURNAL OF PHARMACOLOGICAL SCIENCES

Considerable topographic overlap exists between brain opioidergic and dopaminergic neurons. Pharmacological blockade of the dopami..

Constitutive and Conditional Mutant Mouse Models for Understanding Dopaminergic Regulation of Orofacial Movements: Emerging Insights and Challenges

Katsunori Tomiyama, John Drago, John L Waddington, Noriaki Koshikawa

Journal article  |  2012  |  JOURNAL OF PHARMACOLOGICAL SCIENCES

Among numerous mechanisms implicated in the regulation of orofacial movements, dopamine-containing neurons have received the most ..

Differential Diagnosis in Alzheimer's Disease and Dementia with Lewy Bodies via VMAT2 and Amyloid Imaging

Victor L Villemagne, Nobuyuki Okamura, Svetlana Pejoska, John Drago, Rachel S Mulligan, Gael Chetelat, Graeme O'Keefe, Gareth Jones, Hank F Kung, Michael Pontecorvo, Colin L Masters, Daniel M Skovronsky, Christopher C Rowe

Journal article  |  2012  |  NEURODEGENERATIVE DISEASES

BACKGROUND: The noninvasive evaluation of nigrostriatal dopaminergic integrity by PET can provide useful information for the diffe..