John Drago

Rapidly progressive Fronto-temporal dementia (FTD) associated with Frontotemporal lobar degeneration (FTLD) in the presence of Fused in Sarcoma (FUS) protein: a rare, sporadic, and aggressive form of FTD

Nicholas I Bradfield, Catriona McLean, John Drago, David G Darby, David Ames

Journal article  |  2017  |  International Psychogeriatrics

Amyloid-Related Memory Decline in Preclinical Alzheimer's Disease Is Dependent on APOE epsilon 4 and Is Detectable over 18-Months

Christine Thai, Yen Ying Lim, Victor L Villemagne, Simon M Laws, David Ames, Kathryn A Ellis, Stephanie R Rainey-Smith, Ralph N Martins, Colin L Masters, Christopher C Rowe, Paul Maruff

Journal article  |  2015  |  PLOS ONE

Role of alpha 4-and alpha 6-containing nicotinic receptors in the acquisition and maintenance of nicotine self-administration

Heather B Madsen, Harcharan S Koghar, Tine Pooters, Jim S Massalas, John Drago, Andrew J Lawrence

Journal article  |  2015  |  Addiction Biology

Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells

Luning Jiang, Claire O'Leary, Hyun Ah Kim, Clare L Parish, Jim Massalas, John L Waddington, Michelle E Ehrlich, Guenter Schuetz, Ilse Gantois, Andrew J Lawrence, John Drago

Journal article  |  2015  |  Neurobiology of Disease

Prenatal nicotine exposure increases hyperventilation in alpha 4-knock-out mice during mild asphyxia

Joanne Ayraam, Gary Cohen, John Drago, Peter B Frappell

Journal article  |  2015  |  Respiratory Physiology & Neurobiology

Resolving pathobiological mechanisms relating to Huntington disease: Gait, balance, and involuntary movements in mice with targeted ablation of striatal D1 dopamine receptor cells

Hyun Ah Kim, Luning Jiang, Heather Madsen, Clare L Parish, Jim Massalas, Arthur Smardencas, Claire O'Leary, Ilse Gantois, Colm O'Tuathaigh, John L Waddington, Michelle E Ehrlich, Andrew J Lawrence, John Drago

Journal article  |  2014  |  NEUROBIOLOGY OF DISEASE

Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases

Arthur Smardencas, Kerelos Rizkalla, Hyun Ah Kim, Jim Massalas, Claire O'Leary, Michelle E Ehrlich, Guenter Schuetz, Andrew J Lawrence, John Drago

Journal article  |  2013  |  BMC NEUROSCIENCE

Behavioural and Anatomical Characterization of Mutant Mice With Targeted Deletion of D-1 Dopamine Receptor-Expressing Cells: Response to Acute Morphine

Daniela Babovic, Luning Jiang, Satoshi Goto, Ilse Gantois, Guenter Schuetz, Andrew J Lawrence, John L Waddington, John Drago

Journal article  |  2013  |  Journal of Pharmacological Sciences

Constitutive and Conditional Mutant Mouse Models for Understanding Dopaminergic Regulation of Orofacial Movements: Emerging Insights and Challenges

Katsunori Tomiyama, John Drago, John L Waddington, Noriaki Koshikawa

Journal article  |  2012  |  Journal of Pharmacological Sciences

Differential Diagnosis in Alzheimer's Disease and Dementia with Lewy Bodies via VMAT2 and Amyloid Imaging

Victor L Villemagne, Nobuyuki Okamura, Svetlana Pejoska, John Drago, Rachel S Mulligan, Gael Chetelat, Graeme O'Keefe, Gareth Jones, Hank F Kung, Michael Pontecorvo, Colin L Masters, Daniel M Skovronsky, Christopher C Rowe

Journal article  |  2012  |  Neurodegenerative Diseases

Automated Assessment of Bradykinesia and Dyskinesia in Parkinson's Disease

Robert I Griffiths, Katya Kotschet, Sian Arfon, Zheng Ming Xu, William Johnson, John Drago, Andrew Evans, Peter Kempster, Sanjay Raghav, Malcolm K Horne

Journal article  |  2012  |  Journal of Parkinson's Disease

Phenotypic Disruption to Orofacial Movement Topography in Conditional Mutants With Generalized CamKIIa/Cre D1Tox Versus Striatal-Specific DARPP-32/Cre D1Tox Ablation of D1 Dopamine Receptor-Expressing Cells

Katsunori Tomiyama, Hyun Ah Kim, Anthony Kinsella, Michelle E Ehrlich, Guenter Schuetz, Noriaki Koshikawa, Andrew J Lawrence, John L Waddington, John Drago

Journal article  |  2011  |  Synapse

Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite

Wolfgang B Liedtke, Michael J McKinley, Lesley L Walker, Hao Zhang, Andreas R Pfenning, John Drago, Sarah J Hochendoner, Donald L Hilton, Andrew J Lawrence, Derek A Denton

Journal article  |  2011  |  Proceedings of the National Academy of Sciences of the United States of America

In Vivo Assessment of Vesicular Monoamine Transporter Type 2 in Dementia With Lewy Bodies and Alzheimer Disease

Victor L Villemagne, Nobuyuki Okamura, Svetlana Pejoska, John Drago, Rachel S Mulligan, Gael Chetelat, Uwe Ackermann, Graeme O'Keefe, Gareth Jones, Sylvia Gong, Henry Tochon-Danguy, Hank F Kung, Colin L Masters, Daniel M Skovronsky, Christopher C Rowe

Journal article  |  2011  |  Archives of Neurology

The Necessity of alpha 4* Nicotinic Receptors in Nicotine-Driven Behaviors: Dissociation Between Reinforcing and Motor Effects of Nicotine

Elizabeth Cahir, Katie Pillidge, John Drago, Andrew J Lawrence

Journal article  |  2011  |  Neuropsychopharmacology

Development of an In Vitro Model to Evaluate the Regenerative Capacity of Adult Brain-Derived Tyrosine Hydroxylase-Expressing Dopaminergic Neurons

Shohreh Majd, Arthur Smardencas, Clare L Parish, John Drago

Journal article  |  2011  |  Neurochemical Research

Creating a Ventral Midbrain Stem Cell Niche in an Animal Model for Parkinson's Disease

Chathurini V Fernando, David Moses, Clare L Parish, Doris Tomas, John Drago, Malcolm K Horne

Journal article  |  2010  |  Stem Cells and Development

In Vivo Measurement of Vesicular Monoamine Transporter Type 2 Density in Parkinson Disease with F-18-AV-133

Nobuyuki Okamura, Victor L Villemagne, John Drago, Svetlana Pejoska, Rajinder K Dhamija, Rachel S Mulligan, Julia R Ellis, Uwe Ackermann, Graeme O'Keefe, Gareth Jones, Hank F Kung, Michael J Pontecorvo, Daniel Skovronsky, Christopher C Rowe

Journal article  |  2010  |  Journal of Nuclear Medicine

Age-related behavioural phenotype and cellular characterisation of mice with progressive ablation of D1 dopamine receptor-expressing cells

Daniela Babovic, Luning Jiang, Ilse Gantois, Andrew J Lawrence, Vincenzo Ferreri, Guenter Schuetz, John L Waddington, John Drago

Journal article  |  2010  |  Behavioural Brain Research

Altered fast- and slow-twitch muscle fibre characteristics in female mice with a (S248F) knock-in mutation of the brain neuronal nicotinic acetylcholine receptor

David J Cannata, David I Finkelstein, Ilse Gantois, Yaroslav Teper, John Drago, Jan M West

Journal article  |  2009  |  Journal of Muscle Research and Cell Motility

SK channel function regulates the dopamine phenotype of neurons in the substantia nigra pars compacta

TD Aumann, I Gantois, K Egan, A Vais, D Tomas, J Drago, MK Horne

Journal article  |  2008  |  Experimental Neurology

Fetal striatum- and ventral mesencephalon-derived expanded neurospheres rescue dopaminergic neurons in vitro and the nigro-striatal system in vivo

D Moses, J Drago, Y Teper, I Gantois, DI Finkelstein, MK Horne

Journal article  |  2008  |  Neuroscience

Dopamine D-1 vs D-5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling

Gerard J O'Sullivan, Mark Dunleavy, Kerstin Hakansson, Mario Clementi, Anthony Kinsella, David T Croke, John Drago, Allen A Fienberg, Paul Greengard, David R Sibley, Gilberto Fisone, David C Henshall, John L Waddington

Journal article  |  2008  |  Neuropharmacology

Sprouting of dopamine terminals and altered dopamine release and uptake in Parkinsonian dyskinaesia

Joohyung Lee, Wen-Mei Zhu, Davor Stanic, David I Finkelstein, Marjorie H Horne, Jasmine Henderson, Andrew J Lawrence, Louise O'Connor, Doris Tomas, John Drago, Malcolm K Horne

Journal article  |  2008  |  Brain

Gene targeting demonstrates that alpha 4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [H-3]epibatidine binding sites and components of biphasic Rb-86( ) efflux with high and low sensitivity to stimulation by acetylcholine

Michael J Marks, Natalie M Meinerz, John Drago, Allan C Collins

Journal article  |  2007  |  Neuropharmacology

Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior

Ilse Gantois, Ke Fang, Luning Jiang, Daniela Babovic, Andrew J Lawrence, Vincenzo Ferreri, Yaroslav Teper, Bianca Jupp, Jenna Ziebell, Cristina M Morganti-Kossmann, Terence J O'Brien, Rachel Nally, Guenter Schuetz, John Waddington, Gary F Egan, John Drago

Journal article  |  2007  |  Proceedings of the National Academy of Sciences of the United States of America

Null mutation of the alpha 4 nicotinic receptor subunit increases the propensity of muscarinic-mediated neuronal bursting in mouse hippocampal slices

Christopher A Reid, Harold A Coleman, David I Finkelstein, Malcolm K Horne, John Drago

Journal article  |  2006  |  Neuropharmacology

Murine embryonic EGF-responsive ventral mesencephalic neurospheres display distinct regional specification and promote survival of dopaminergic neurons

David Moses, Yaroslav Teper, Ilse Gantois, David I Finkelstein, Malcolm K Horne, John Drago

Journal article  |  2006  |  Experimental Neurology

Comparison of ethanol preference and neurochemical measures of mesolimbic dopamine and adenosine systems across different strains of mice

JL Short, J Drago, AJ Lawrence

Journal article  |  2006  |  Alcoholism - Clinical and Experimental Research

Receptor crosstalk: Characterization of mice deficient in dopamine D-1 and adenosine A(2A) receptors

JL Short, C Ledent, J Drago, AJ Lawrence

Journal article  |  2006  |  Neuropsychopharmacology

Genetic interdependence of adenosine and dopamine receptors: Evidence from receptor knockout mice

JL Short, C Ledent, E Borrelli, J Drago, AJ Lawrence

Journal article  |  2006  |  Neuroscience

Chapter III The use of dopamine receptor knockout mice in understanding brain dopamine neurotransmission and sprouting in the nigrostriatal pathway

MK Horne, J Drago, J Nunan

Journal article  |  2005  |  Handbook of Chemical Neuroanatomy

Mice lacking the alpha 4 nicotinic receptor subunit fail to modulate dopaminergic neuronal arbors and possess impaired dopamine transporter function

CL Parish, J Nunan, DI Finkelstein, FN McNamara, JY Wong, JL Waddington, RM Brown, AJ Lawrence, MK Horne, J Drago

Journal article  |  2005  |  Molecular Pharmacology

Assessment of temperature, proximity, and course of the esophagus during radiofrequency ablation within the left atrium.

Jennifer E Cummings, Robert A Schweikert, Walid I Saliba, J David Burkhardt, Johannes Brachmann, Jens Gunther, Volker Schibgilla, Atul Verma, MarkAlain Dery, John L Drago, Fethi Kilicaslan, Andrea Natale

Journal article  |  2005  |  Circulation

BACKGROUND: Left atrioesophageal fistula is a devastating complication of atrial fibrillation ablation. There is no standard appro..

Haloperidol treatment reverses behavioural and anatomical changes in cocaine-dependent mice

CL Parish, J Drago, D Stanic, E Borrelli, DI Finkelstein, MK Horne

Journal article  |  2005  |  Neurobiology of Disease

Alternative energy sources for the ablation of arrhythmias.

Jennifer E Cummings, Antonio Pacifico, John L Drago, Fethi Kilicaslan, Andrea Natale

Journal article  |  2005  |  Pacing and Clinical Electrophysiology

Handbook of Chemical Neuroanatomy: Dopamine

M HORNE, J DRAGO, JM NUNAN

Scholarly edition  |  2005

Glial responses associated with dopaminergic striatal reinnervation following lesions of the rat substantia nigra

D Stanic, W Tripanichkul, J Drago, DI Finkelstein, MK Horn

Journal article  |  2004  |  Brain Research

Quantified assessment of terminal density and innervation.

David I Finkelstein, Davor Stanic, Clare L Parish, John Drago, Malcolm K Horne

Journal article  |  2004  |  Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]

Stereological methods allow for the determination of cell numbers, terminal densities, and, subsequently, the estimation of termin..

Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice

M Kobayashi, C Iaccarino, A Saiardi, V Heidt, Y Bozzi, R Picetti, C Vitale, H Westphal, J Drago, E Borrelli

Journal article  |  2004  |  Proceedings of the National Academy of Sciences of the United States of America

D-1-like dopamine receptor-mediated function in congenic mutants with D-1 vs. D5 receptor "knockout"

GJ O'Sullivan, JJ Clifford, K Tomiyama, N Koshikawa, J Drago, DR Sibley, DT Croke, JL Waddington

Journal article  |  2004  |  Journal of Receptors and Signal Transduction

Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice

O Salminen, KL Murphy, JM McIntosh, J Drago, MJ Marks, AC Collins, SR Grady

Journal article  |  2004  |  Molecular Pharmacology

Comparative phenotypic resolution of spontaneous D-2-like and D-1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D-2 vs. D-3 receptor "knockout"

K Tomiyama, FN McNamara, JJ Clifford, A Kinsella, J Drago, S Fuchs, DK Grandy, MJ Low, M Rubinstein, O Tighe, DT Croke, N Koshikawa, JL Waddington

Journal article  |  2004  |  Synapse

Erratum: Changes in function and ultrastructure of striatal dopaminergic terminals that regenerate following partial lesions of the Snpc (Journal of Neurochemistry (2003) 86 (329-343)

D Stanic, CL Parish, WM Zhu, EV Krstew, AJ Lawrence, J Drago, DI Finkelstein, MK Horne

Journal article  |  2003  |  Journal of Neurochemistry

Timecourse of striatal re-innervation following lesions of dopaminergic SNpc neurons of the rat

D Stanic, DI Finkelstein, DW Bourke, J Drago, MK Horne

Journal article  |  2003  |  European Journal of Neuroscience

Neurochemical changes in dopamine D1, D3 and D1/D3 receptor knockout mice

JYF Wong, JJ Clifford, JS Massalas, DI Finkelstein, MK Horne, JL Waddington, J Drago

Journal article  |  2003  |  European Journal of Pharmacology

Changes in function and ultrastructure of striatal dopaminergic terminals that regenerate following partial lesions of the SNpc

D Stanic, CL Parish, WM Zhu, EV Krstew, AJ Lawrence, J Drago, DI Finkelstein, MK Horne

Journal article  |  2003  |  Journal of Neurochemistry

Essential conservation of D1 mutant phenotype at the level of individual topographies of behaviour in mice lacking both D1 and D3 dopamine receptors.

John YF Wong, Jeremiah J Clifford, Jim S Massalas, Anthony Kinsella, John L Waddington, John Drago

Journal article  |  2003  |  Psychopharmacology

RATIONALE: In the absence of agonists and antagonists evidencing appropriate selectivities, individual and interactive properties ..

D2Dopamine receptor blockade results in sprouting of DA axons in the intact animal but prevents sprouting following nigral lesions

W Tripanichkul, D Stanic, J Drago, DI Finkelstein, MK Horne

Journal article  |  2003  |  European Journal of Neuroscience

Congenic D1A dopamine receptor mutants: ethologically based resolution of behavioural topography indicates genetic background as a determinant of knockout phenotype.

Fergal N McNamara, Jeremiah J Clifford, Orna Tighe, Anthony Kinsella, John Drago, David T Croke, John L Waddington

Journal article  |  2003  |  Neuropsychopharmacology

D(1A)-null mice were backcrossed over 14 generations into a C57BL/6 background to result in essential elimination (to <0.005%) of ..

Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive.

Tom R Hollon, Martin J Bek, Jean E Lachowicz, Marjorie A Ariano, Eva Mezey, Ramesh Ramachandran, Scott R Wersinger, Patricio Soares-da-Silva, Zhi Fang Liu, Alexander Grinberg, John Drago, W Scott Young, Heiner Westphal, Pedro A Jose, David R Sibley

Journal article  |  2002  |  The Journal of Neuroscience

Dopamine is an important transmitter in the CNS and PNS, critically regulating numerous neuropsychiatric and physiological functio..

Phenotypic, ethologically based resolution of spontaneous and D(2)-like vs D(1)-like agonist-induced behavioural topography in mice with congenic D(3) dopamine receptor "knockout".

Fergal N McNamara, Jeremiah J Clifford, Orna Tighe, Anthony Kinsella, John Drago, Sara Fuchs, David T Croke, John L Waddington

Journal article  |  2002  |  Synapse

Uncertainty as to the functional role of the D(3) dopamine receptor, due primarily to a paucity of selective agonists or antagonis..

The role of interleukin-1, interleukin-6, and glia in inducing growth of neuronal terminal arbors in mice

CL Parish, DI Finkelstein, W Tripanichkul, AR Satoskar, J Drago, MK Horne

Journal article  |  2002  |  The Journal of Neuroscience

Effects of long-term treatment with dopamine receptor agonists and antagonists on terminal arbor size

CL Parish, D Stanic, J Drago, E Borrelli, DI Finkelstein, MK Horne

Journal article  |  2002  |  European Journal of Neuroscience

Diurnal variation of c-Fos expression in subdivisions of the dorsal raphe nucleus of the Mongolian gerbil (Meriones unguiculatus).

S Janusonis, KV Fite

Journal article  |  2001  |  The Journal of Comparative Neurology

Recent studies suggest that the dorsal raphe nucleus (DRN) of the brainstem contains several subdivisions that differ both anatomi..

Nephron endowment in glial cell line-derived neurotrophic factor (GDNF) heterozygous mice.

LA Cullen-McEwen, J Drago, JF Bertram

Journal article  |  2001  |  Kidney International

BACKGROUND: The exact molecular mechanisms that regulate ureteric branching morphogenesis in the developing metanephros have not b..

Quantification of D1B(D5) receptors in dopamine D1A receptor-deficient mice.

DM Montague, CD Striplin, JS Overcash, J Drago, CP Lawler, RB Mailman

Journal article  |  2001  |  Synapse

The unavailability of selective D1A(D1) or D1B(D5) dopamine receptor ligands has prevented the direct localization of binding site..

Characterisation of central adenosine A(1) receptors and adenosine transporters in mice lacking the adenosine A(2a) receptor

BJ Snell, JL Short, J Drago, C Ledent, AJ Lawrence

Journal article  |  2000  |  Brain Research

Visualisation of AMPA binding sites in the brain of mice lacking the adenosine A(2a) receptor

BJ Snell, JL Short, J Drago, C Ledent, AJ Lawrence

Journal article  |  2000  |  Neuroscience Letters

Phenotypic characterization of an alpha(4) neuronal nicotinic acetylcholine receptor subunit knock-out mouse

SA Ross, JYF Wong, JJ Clifford, A Kinsella, JS Massalas, MK Horne, IE Scheffer, I Kola, JL Waddington, SF Berkovic, J Drago

Journal article  |  2000  |  The Journal of Neuroscience

Role of dopamine D(1) receptors for kappa-opioid-mediated locomotor activity and antinociception during the preweanling period: a study using D(1) receptor knockout mice.

PE Karper, A Nazarian, CA Crawford, J Drago, SA McDougall

Journal article  |  2000  |  Physiology & Behavior

kappa-Opioid receptor agonists both increase the locomotor activity of preweanling rats and induce antinociception. To determine w..

Spatial learning deficit in dopamine D(1) receptor knockout mice.

M El-Ghundi, PJ Fletcher, J Drago, DR Sibley, BF O'Dowd, SR George

Journal article  |  1999  |  European Journal of Pharmacology

Dopamine D(1) receptors are expressed in the hippocampus and prefrontal cortex, suggesting a role in cognition. Dopamine D(1) rece..

Erratum: Targeted expression of a toxin gene to D1 dopamine receptor neurons by Cre-mediated site-specific recombination (Journal of Neuroscience (December 1998) (9845-9857))

J Drago, P Padungchaichot, JYF Wong, AJ Lawrence, JF McManus, SH Sumarsono, AL Natoli, M Lakso, N Wreford, H Westphal, I Kola, DI Finkelstein

Journal article  |  1999  |  Journal of Neuroscience

Targeted expression of a toxin gene to D1 dopamine receptor neurons by Cre-mediated site-specific recombination

J Drago, P Padungchaichot, JYF Wong, AJ Lawrence, JF McManus, SH Sumarsono, AL Natoli, M Lakso, N Wreford, H Westphal, I Kola, DI Finkelstein

Journal article  |  1998  |  The Journal of Neuroscience

Topographical evaluation of the phenotype of spontaneous behaviour in mice with targeted gene deletion of the D1A dopamine receptor: paradoxical elevation of grooming syntax.

JJ Clifford, O Tighe, DT Croke, DR Sibley, J Drago, JL Waddington

Journal article  |  1998  |  Neuropharmacology

The phenotype of spontaneous behaviour in mice with targeted gene deletion of the DIA dopamine receptor was investigated topograph..

Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behavior.

M El-Ghundi, SR George, J Drago, PJ Fletcher, T Fan, T Nguyen, C Liu, DR Sibley, H Westphal, BF O'Dowd

Journal article  |  1998  |  European Journal of Pharmacology

The role of the dopamine D1 receptor subtype in alcohol-seeking behaviors was studied in mice genetically deficient in dopamine D1..

Action sequencing is impaired in D1A-deficient mutant mice.

HC Cromwell, KC Berridge, J Drago, MS Levine

Journal article  |  1998  |  European Journal of Neuroscience

The role of dopamine in the production of behaviour is multifarious in that it can influence different aspects of movement (e.g. m..

Dopamine receptors and dopamine transporter in brain function and addictive behaviors: insights from targeted mouse mutants.

J Drago, P Padungchaichot, D Accili, S Fuchs

Journal article  |  1998  |  Developmental Neuroscience

Recent advances in molecular biology have resulted in a number of genetically manipulated mice with defined changes at dopamine re..

Striatal excitatory amino acid receptor subunit expression in the D1A-dopamine receptor-deficient mouse.

MA Ariano, J Drago, DR Sibley, MS Levine

Journal article  |  1998  |  Developmental Neuroscience

The influence of dopamine receptor deletion on the expression and distribution of striatal excitatory amino acid (EAA) receptor su..

Behavioral analysis of multiple D1-like dopamine receptor subtypes: new agents and studies in transgenic mice with D1A receptor knockout.

JL Waddington, AM Deveney, J Clifford, O Tighe, DT Croke, DR Sibley, J Drago

Journal article  |  1998  |  Advances in Pharmacology

D1 receptors mediate dopamine action in the fetal suprachiasmatic nuclei: studies of mice with targeted deletion of the D1 dopamine receptor gene.

M Bender, J Drago, SA Rivkees

Journal article  |  1997  |  Molecular Brain Research

Studies in rodents suggest the presence of a dopaminergic system that influences the function of a biological clock in the hypotha..

Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development.

FD Porter, J Drago, Y Xu, SS Cheema, C Wassif, SP Huang, E Lee, A Grinberg, JS Massalas, D Bodine, F Alt, H Westphal

Journal article  |  1997  |  Development

We investigated the function of Lhx2, a LIM homeobox gene expressed in developing B-cells, forebrain and neural retina, by analyzi..

Effects of repeated amphetamine treatment on the locomotor activity of the dopamine D1A-deficient mouse.

CA Crawford, J Drago, JB Watson, MS Levine

Journal article  |  1997  |  NeuroReport

The role of dopamine D1A receptors in mediating amphetamine-induced sensitization was investigated using the D1A-deficient mouse. ..

Transgenic mice to study the role of dopamine receptors in cardiovascular function.

PA Jose, J Drago, D Accili, GM Eisner, RA Felder

Conference Proceedings  |  1997  |  Clinical and Experimental Hypertension

Dopamine, an intrarenal regulator of sodium transport, is important in the pathogenesis of hypertension. The transduction of D1-li..

D1-like dopaminergic activation of phosphoinositide hydrolysis is independent of D1A dopamine receptors: evidence from D1A knockout mice.

E Friedman, LQ Jin, GP Cai, TR Hollon, J Drago, DR Sibley, HY Wang

Journal article  |  1997  |  Molecular Pharmacology

Accumulated evidence suggests that dopamine and dopamine D1 agonists can activate phospholipase C in both brain and peripheral tis..

Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice.

MS Levine, KL Altemus, C Cepeda, HC Cromwell, C Crawford, MA Ariano, J Drago, DR Sibley, H Westphal

Journal article  |  1996  |  The Journal of Neuroscience

The role of D1 dopamine (DA) receptors in mediating the ability of DA to modulate responses attributable to activation of NMDA rec..

Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile

T Rankin, M Familari, E Lee, A Ginsberg, N Dwyer, J BlanchetteMackie, J Drago, H Westphal, J Dean

Journal article  |  1996  |  Development

Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension.

FE Albrecht, J Drago, RA Felder, MP Printz, GM Eisner, JE Robillard, DR Sibley, HJ Westphal, PA Jose

Journal article  |  1996  |  Journal of Clinical Investigation

Since dopamine produced by the kidney is an intrarenal regulator of sodium transport, an abnormality of the dopaminergic system ma..

Dopamine receptor signaling defects in spontaneous hypertension.

PA Jose, GM Eisner, J Drago, RM Carey, RA Felder

Journal article  |  1996  |  American Journal of Hypertension

Dopamine produced by renal proximal tubules acts as an intrarenal natriuretic factor by direct tubular action; this paracrine effe..

Erratum: (Journal of Clinical Investigation (May 15, 1996) 97:10 (2285- 2286))

FE Albrecht, J Drago, RA Felder, MP Printz, GM Eisner, JE Robillard, DR Sibley, HJ Westphal, PA Jose

Journal article  |  1996  |  Journal of Clinical Investigation

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.

SS Lee, T Pineau, J Drago, EJ Lee, JW Owens, DL Kroetz, PM Fernandez-Salguero, H Westphal, FJ Gonzalez

Journal article  |  1995  |  Molecular and Cellular Biology

To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in rodents, we disrupted the ligan..

DEFECTIVE LYMPHOID DEVELOPMENT IN MICE LACKING EXPRESSION OF THE COMMON CYTOKINE RECEPTOR-GAMMA CHAIN

XQ CAO, EW SHORES, J HULI, MR ANVER, BL KELSALL, SM RUSSELL, J DRAGO, M NOGUCHI, A GRINBERG, ET BLOOM, WE PAUL, SI KATZ, PE LOVE, WJ LEONARD

Journal article  |  1995  |  Immunity

GROWTH-FACTORS - POTENTIAL THERAPEUTIC APPLICATIONS IN NEUROLOGY

J DRAGO, TJ KILPATRICK, SA KOBLAR, PS TALMAN

Journal article  |  1994  |  Journal of Neurology, Neurosurgery & Psychiatry

L-myc and N-myc influence lineage determination in the central nervous system.

O Bernard, J Drago, H Sheng

Journal article  |  1992  |  Neuron

The N-myc and the L-myc proto-oncogenes are expressed during embryonal development mainly in the developing brain. Studies of thei..

Basic fibroblast growth factor upregulates steady-state levels of laminin B1 and B2 chain mRNA in cultured neuroepithelial cells.

J Drago, V Nurcombe, MJ Pearse, M Murphy, PF Bartlett

Journal article  |  1991  |  Experimental Cell Research

The growth of purified populations of murine neuroepithelial cells isolated from 10 day embryonic (E10) telencephalon and mesencep..

A method for the isolation of purified murine neuroepithelial cells from the developing mouse brain.

J Drago, M Murphy, KA Bailey, PF Bartlett

Journal article  |  1991  |  Journal of Neuroscience Methods

The adult mammalian central nervous system develops from the pseudostratified neuroepithelium of the neural tube. In order to stud..

Laminin through its long arm E8 fragment promotes the proliferation and differentiation of murine neuroepithelial cells in vitro.

J Drago, V Nurcombe, PF Bartlett

Journal article  |  1991  |  Experimental Cell Research

The epigenetic factors involved in regulating the proliferation and differentiation of cells of the developing mammalian central n..

Fibroblast growth factor stimulates the proliferation and differentiation of neural precursor cells in vitro.

M Murphy, J Drago, PF Bartlett

Journal article  |  1990  |  Journal of Neuroscience Research

We have developed an in vitro culture system to study the regulation of proliferation and differentiation of neural precursor cell..

Induction of the ganglioside marker A2B5 on cultured cerebellar neural cells by growth factors.

J Drago, KL Reid, PF Bartlett

Journal article  |  1989  |  Neuroscience Letters

The surface ganglioside marker A2B5 was originally detected on neurons, but has subsequently been shown to be expressed on a wide ..