John Drago

Preparation and Characterization of Inhalable Ivermectin Powders as a Potential COVID-19 Therapy.

Ahmed H Albariqi, Wei-Ren Ke, Dipesh Khanal, Stefanie Kalfas, Patricia Tang, Warwick J Britton, John Drago, Hak-Kim Chan

Journal article  |  2022  |  J Aerosol Med Pulm Drug Deliv

Background: Ivermectin has received worldwide attention as a potential COVID-19 treatment after showing antiviral activity against..

Pharmacokinetics and safety of inhaled ivermectin in mice as a potential COVID-19 treatment

Ahmed H Albariqi, Yuncheng Wang, Rachel Yoon Kyung Chang, Diana H Quan, Xiaonan Wang, Stefanie Kalfas, John Drago, Warwick J Britton, Hak-Kim Chan

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pharmacokinetic limitations associated with oral ivermectin may limit its success as a potential COVID-19 treatment based on in vi..

THE THERAPEUTIC POTENTIAL OF IVERMECTIN FOR COVID-19: A SYSTEMATIC REVIEW OF MECHANISMS AND EVIDENCE

Stefanie Kalfas, Kumar Visvanathan, Kim Chan, John Drago

Journal article  |  2020

ABSTRACT Introduction Ivermectin is a commonly used antihelminthic agent with over 35 years of established safety data in humans. ..

Rapidly progressive Fronto-temporal dementia (FTD) associated with Frontotemporal lobar degeneration (FTLD) in the presence of Fused in Sarcoma (FUS) protein: a rare, sporadic, and aggressive form of FTD

Nicholas I Bradfield, Catriona McLean, John Drago, David G Darby, David Ames

Journal article  |  2017  |  INTERNATIONAL PSYCHOGERIATRICS

Fronto-temporal dementia (FTD) associated with Fused in Sarcoma (FUS) protein accumulation is an uncommon cause of FTD with a dist..

Effect of APOE Genotype on Amyloid Deposition, Brain Volume, and Memory in Cognitively Normal Older Individuals

Yen Ying Lim, Robert Williamson, Simon M Laws, Victor L Villemagne, Pierrick Bourgeat, Christopher Fowler, Stephanie Rainey-Smith, Olivier Salvado, Ralph N Martins, Christopher C Rowe, Colin L Masters, Paul Maruff

Journal article  |  2017  |  JOURNAL OF ALZHEIMERS DISEASE

BACKGROUND: The association between the apolipoprotein E (APOE) ɛ4 allele and high risk of developing Alzheimer's disease (AD) dem..

Amyloid-Related Memory Decline in Preclinical Alzheimer's Disease Is Dependent on APOE epsilon 4 and Is Detectable over 18-Months

Christine Thai, Yen Ying Lim, Victor L Villemagne, Simon M Laws, David Ames, Kathryn A Ellis, Stephanie R Rainey-Smith, Ralph N Martins, Colin L Masters, Christopher C Rowe, Paul Maruff

Journal article  |  2015  |  PLOS ONE

High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cog..

Role of alpha 4-and alpha 6-containing nicotinic receptors in the acquisition and maintenance of nicotine self-administration

Heather B Madsen, Harcharan S Koghar, Tine Pooters, Jim S Massalas, John Drago, Andrew J Lawrence

Journal article  |  2015  |  ADDICTION BIOLOGY

Tobacco smoking is a major cause of death and disease and as such there is a critical need for the development of new therapeutic ..

Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells

Luning Jiang, Claire O'Leary, Hyun Ah Kim, Clare L Parish, Jim Massalas, John L Waddington, Michelle E Ehrlich, Guenter Schuetz, Ilse Gantois, Andrew J Lawrence, John Drago

Journal article  |  2015  |  NEUROBIOLOGY OF DISEASE

D1-dopamine receptors (Drd1a) are highly expressed in the deep layers of the cerebral cortex and the striatum. A number of human d..

Prenatal nicotine exposure increases hyperventilation in alpha 4-knock-out mice during mild asphyxia

Joanne Ayraam, Gary Cohen, John Drago, Peter B Frappell

Journal article  |  2015  |  RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Prenatal nicotine exposure alters breathing and ventilatory responses to stress through stimulation of nicotine acetylcholine rece..

Role of alpha4-and alpha6-containing nicotinic receptors in the acquisition & maintenance of nicotine self-administration

HB Madsen, HS Koghar, T Pooters, JS Massalas, J Drago, AJ Lawrence

Journal article  |  2014  |  JOURNAL OF NEUROCHEMISTRY

Tobacco smoking is a major cause of death and disease and as such there is a critical need for the development of new therapeutic ..