Eleanor Ager

Mechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivo.

Alexander J Stevenson, Eleanor I Ager, Martina A Proctor, Dubravka Škalamera, Andrew Heaton, David Brown, Brian G Gabrielli

Journal article  |  2018  |  Sci Rep

Successive rounds of chemical modification in three generations of benzopyran molecules have shown to select for different mechani..

Abstract 5102: TRXE-009-1 has pan-acting anticancer activity and potently inhibits colony formation of prostate cancer epithelial cell explants

Eleanor I Ager, Dominika Butler, Alex Stevenson, Eiffe Eiffe, Andrew Heaton, Brian Gabrielli, Norman J Maitland, David Brown

Conference Proceedings  |  2017  |  Cancer Research

Abstract Background: TRXE-009-1 is a novel small molecule from the super benzopyran (SBP) drug family under develop..

Regulation of colorectal cancer cell epithelial to mesenchymal transition by the renin angiotensin system

Linh Nguyen, Eleanor I Ager, Jaclyn Neo, Christopher Christophi

Journal article  |  2016  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

BACKGROUND AND AIM: Epithelial to mesenchymal transition (EMT) is implicated in tumor progression. We aimed to determine if the re..

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

Eleanor I Ager, Sergey V Kozin, Nathaniel D Kirkpatrick, Giorgio Seano, David P Kodack, Vasileios Askoxylakis, Yuhui Huang, Shom Goel, Matija Snuderl, Alona Muzikansky, Dianne M Finkelstein, Daniel T Dransfield, Laetitia Devy, Yves Boucher, Dai Fukumura, Rakesh K Jain

Journal article  |  2015  |  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

BACKGROUND: Matrix metalloproteinase (MMP) 14 may mediate tumor progression through vascular and immune-modulatory effects. METHOD..

Blockade of the renin-angiotensin system inhibits growth of colorectal cancer liver metastases in the regenerating liver

Shir Lin Koh, EI Ager, PLN Costa, C Malcontenti-Wilson, V Muralidharan, C Christophi

Journal article  |  2014  |  CLINICAL & EXPERIMENTAL METASTASIS

Partial hepatectomy (PH), the preferred option for selected patients with colorectal cancer liver metastases (CRCLM), is associate..

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression

Shom Goel, Nisha Gupta, Brian P Walcott, Matija Snuderl, Cristina T Kesler, Nathaniel D Kirkpatrick, Takahiro Heishi, Yuhui Huang, John D Martin, Eleanor Ager, Rekha Samuel, Shuhan Wang, John Yazbek, Benjamin J Vakoc, Randall T Peterson, Timothy P Padera, Dan G Duda, Dai Fukumura, Rakesh K Jain

Journal article  |  2013  |  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

BACKGROUND: The solid tumor microvasculature is characterized by structural and functional abnormality and mediates several delete..

The renin angiotensin system regulates Kupffer cells in colorectal liver metastases

Shu Wen Wen, Eleanor I Ager, Jaclyn Neo, Christopher Christophi

Journal article  |  2013  |  CANCER BIOLOGY & THERAPY

Blockade of the renin angiotensin system (RAS) can inhibit tumor growth and this may be mediated via undefined immunomodulatory ac..

Bimodal role of Kupffer cells during colorectal cancer liver metastasis

Shu Wen Wen, Eleanor I Ager, Christopher Christophi

Journal article  |  2013  |  CANCER BIOLOGY & THERAPY

Kupffer cells (KCs) are resident liver macrophages that play a crucial role in liver homeostasis and in the pathogenesis of liver ..

Blockade of the renin-angiotensin system improves the early stages of liver regeneration and liver function

Shir Lin Koh, Eleanor Ager, Cathy Malcontenti-Wilson, Vijayaragavan Muralidharan, Christopher Christophi

Journal article  |  2013  |  JOURNAL OF SURGICAL RESEARCH

BACKGROUND: Partial hepatectomy is the preferred option for selected patients with colorectal cancer liver metastases (CRCLM). Suf..

Abstract P3-12-03: Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.

DP Kodack, E Chung, H Yamashita, J Incio, A Peters, Y Song, E Ager, Y Huang, C Farrar, A Lussiez, S Goel, M Snuderl, W Kamoun, L Hiddingh, BA Tannous, D Fukumura, JA Engelman, RK Jain

Conference Proceedings  |  2012  |  Cancer Research

Abstract Brain metastases remain a serious obstacle in the treatment of patients with human epidermal growth factor..