Lee Yeoh

The direct binding of Plasmodium vivax AMA1 to erythrocytes defines a RON2-independent invasion pathway.

Seong-Kyun Lee, Leanne M Low, John F Andersen, Lee M Yeoh, Paola Carolina Valenzuela Leon, Damien R Drew, Johannes SP Doehl, Eric Calvo, Louis H Miller, James G Beeson, Karthigayan Gunalan

Journal article  |  2023  |  Proc Natl Acad Sci U S A

We used a transgenic parasite in which Plasmodium falciparum parasites were genetically modified to express Plasmodium vivax apica..

Advances in Plasmodium research, an update: Highlights from the Malaria in Melbourne 2021 conference

Jack Adderley, Coralie Boulet, Kirsty McCann, Emma McHugh, Lisa J Ioannidis, Lee M Yeoh

Journal article  |  2022  |  MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The Malaria in Melbourne 2021 conference was held online in October. This conference aims to provide a platform for students and e..

RNAseq of Infected Erythrocyte Surface Antigen-Encoding Genes.

Hanh Hong Thi Nguyen, Suffian Azizan, Lee Ming Yeoh, Jingyi Tang, Michael F Duffy

Journal article  |  2022  |  Methods Mol Biol

Massive parallel sequencing technology has greatly increased the breadth and depth of transcriptomic data that can be captured fro..

Histone modifications associated with gene expression and genome accessibility are dynamically enriched at Plasmodium falciparum regulatory sequences

Jingyi Tang, Scott A Chisholm, Lee M Yeoh, Paul R Gilson, Anthony T Papenfuss, Karen P Day, Michaela Petter, Michael F Duffy

Journal article  |  2020  |  EPIGENETICS & CHROMATIN

BACKGROUND: The malaria parasite Plasmodium falciparum has an unusually euchromatic genome with poorly conserved positioning of nu..

Developments in drug design strategies for bromodomain protein inhibitors to target Plasmodium falciparum parasites.

Hanh HT Nguyen, Lee M Yeoh, Scott A Chisholm, Michael F Duffy

Journal article  |  2020  |  Expert Opin Drug Discov

Introduction: Bromodomains (BRDs) bind to acetylated lysine residues, often on histones. The BRD proteins can contribute to gene r..

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

Tuo Yang, Lee M Yeoh, Madel V Tutor, Matthew W Dixon, Paul J McMillan, Stanley C Xie, Jessica L Bridgford, David L Gillett, Michael F Duffy, Stuart A Ralph, Malcolm J McConville, Leann Tilley, Simon A Cobbold

Journal article  |  2019  |  CELL REPORTS

Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs) is associated with mutations in Kelch1..

Alternative splicing is required for stage differentiation in malaria parasites

Lee M Yeoh, Christopher D Goodman, Vanessa Mollard, Emma McHugh, V Vern Lee, Angelika Sturm, Anton Cozijnsen, Geoffrey I McFadden, Stuart A Ralph

Journal article  |  2019  |  GENOME BIOLOGY

BACKGROUND: In multicellular organisms, alternative splicing is central to tissue differentiation and identity. Unicellular protis..

Capillary electrophoretic assay of human acetyl-coenzyme A carboxylase 2

Thu H Nguyen, Grover L Waldrop, S Douglass Gilman

Journal article  |  2019  |  ELECTROPHORESIS

Human acetyl-coenzyme A carboxylase 2 catalyzes the carboxylation of acetyl coenzyme A to form malonyl coenzyme A, along with the ..

Alternative Splicing in Apicomplexan Parasites

Lee M Yeoh, V Vern Lee, Geoffrey I McFadden, Stuart A Ralph

Journal article  |  2019  |  MBIO

Alternative splicing is a widespread, essential, and complex component of gene regulation. Apicomplexan parasites have long been r..

Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates

Lee M Yeoh, Christopher D Goodman, Vanessa Mollard, Geoffrey I McFadden, Stuart A Ralph

Journal article  |  2017  |  BMC GENOMICS

BACKGROUND: The clinical symptoms of malaria are caused by the asexual replication of Plasmodium parasites in the blood of the ver..