Heidi Drummer

Tenth Scientific Biennial Meeting of the Australasian Virology Society-AVS10 2019.

Karla J Helbig, Rowena A Bull, Rebecca Ambrose, Michael R Beard, Helen Blanchard, Till Böcking, Brendon Chua, Agathe MG Colmant, Keaton M Crosse, Damian FJ Purcell, Johanna Fraser, Joshua A Hayward, Stuart T Hamilton, Matloob Husain, Robin MacDiarmid, Jason M Mackenzie, Gregory W Moseley, Thi HO Nguyen, Miguel E Quiñones-Mateu, Karl Robinson, et al.

Journal article  |  2020  |  Viruses

The Australasian Virology Society (AVS) aims to promote, support and advocate for the discipline of virology in the Australasian r..

Enhancing the antigenicity and immunogenicity of monomeric forms of hepatitis C virus E2 for use as a preventive vaccine

Rob J Center, Irene Boo, Lilian Phu, Joey McGregor, Pantelis Poumbourios, Heidi E Drummer

Journal article  |  2020  |  Journal of Biological Chemistry

The E2 glycoprotein of hepatitis C virus (HCV) is the major target of broadly neutralizing antibodies (bNAbs) that are critical fo..

Infectious KoRV-related retroviruses circulating in Australian bats

Joshua A Hayward, Mary Tachedjian, Claudia Kohl, Adam Johnson, Megan Dearnley, Brianna Jesaveluk, Christine Langer, Philip D Solymosi, Georg Hille, Andreas Nitsche, Cecilia A Sanchez, Adam Werner, Dimitri Kontos, Gary Crameri, Glenn A Marsh, Michelle L Baker, Pantelis Poumbourios, Heidi E Drummer, Edward C Holmes, Lin-Fa Wang, et al.

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

Bats are reservoirs of emerging viruses that are highly pathogenic to other mammals, including humans. Despite the diversity and a..

B cell immunodominance in primary hepatitis C virus infection.

Nicholas A Brasher, Auda A Eltahla, Alexander Underwood, Irene Boo, Simone Rizzetto, Melanie R Walker, Chaturaka Rodrigo, Fabio Luciani, Lisa Maher, Heidi E Drummer, Nicodemus Tedla, Andrew R Lloyd, Rowena A Bull

Journal article  |  2020  |  Journal of Hepatology

BACKGROUND & AIMS: Neutralising antibodies (NAbs) play a key role in clearance of HCV. NAbs have been isolated and mapped to sever..

The case for a universal hepatitis C vaccine to achieve hepatitis C elimination

Nick Scott, David P Wilson, Alexander J Thompson, Eleanor Barnes, Manal El-Sayed, Adele Schwartz Benzaken, Heidi E Drummer, Margaret E Hellard

Journal article  |  2019  |  BMC Medicine

Conjugation of an scFab domain to the oligomeric HIV envelope protein for use in immune targeting

Hannah AD King, Christopher A Gonelli, Kirsteen M Tullett, Mireille H Lahoud, Damian FJ Purcell, Heidi E Drummer, Pantelis Poumbourios, Rob J Center

Journal article  |  2019  |  PLOS ONE

Pre-clinical evaluation of a quadrivalent HCV VLP vaccine in pigs following microneedle delivery

D Christiansen, L Earnest-Silveira, B Grubor-Bauk, DK Wijesundara, I Boo, PA Ramsland, E Vincan, HE Drummer, EJ Gowans, J Torresi

Journal article  |  2019  |  Scientific Reports

Evidence of CD4( ) T cell-mediated immune pressure on the Hepatitis C virus genome

Michaela Lucas, Pooja Deshpande, Ian James, Andri Rauch, Katja Pfafferott, Elouise Gaylard, Shahzma Merani, Anne Plauzolles, Andrew Lucas, Wyatt McDonnell, Spyros Kalams, Mark Pilkinton, Cody Chastain, Louise Barnett, Amy Prosser, Simon Mallal, Karen Fitzmaurice, Heidi Drummer, M Azim Ansari, Vincent Pedergnana, et al.

Journal article  |  2018  |  Scientific Reports

Escape of Hepatitis C Virus from Epitope I Neutralization Increases Sensitivity of Other Neutralization Epitopes

Jun Gu, Joshua Hardy, Irene Boo, Patricia Vietheer, Kathleen McCaffrey, Yousef Alhammad, Abha Chopra, Silvana Gaudieri, Pantelis Poumbourios, Fasseli Coulibaly, Heidi E Drummer

Journal article  |  2018  |  Journal of Virology

Immunological responses following administration of a genotype 1a/1b/2/3a quadrivalent HCV VLP vaccine

D Christiansen, L Earnest-Silveira, B Chua, P Meuleman, I Boo, B Grubor-Bauk, DC Jackson, ZY Keck, SKH Foung, HE Drummer, EJ Gowans, J Torresi

Journal article  |  2018  |  Scientific Reports

Distinct functions for the membrane-proximal ectodomain region (MPER) of HIV-1 gp41 in cell-free and cell-cell viral transmission and cell-cell fusion

Vani GS Narasimhulu, Anna K Bellamy-McIntyre, Annamarie E Laumaea, Chan-Sien Lay, David N Harrison, Hannah AD King, Heidi E Drummer, Pantelis Poumbourios

Journal article  |  2018  |  Journal of Biological Chemistry

Antibody Responses to a Quadrivalent Hepatitis C Viral-Like Particle Vaccine Adjuvanted with Toll-Like Receptor 2 Agonists

Dale Christiansen, Linda Earnest-Silveira, Brendon Chua, Irene Boo, Heidi E Drummer, Branka Grubor-Bauk, Eric J Gowans, David C Jackson, Joseph Torresi

Journal article  |  2018  |  Viral Immunology

The Core Domain of Hepatitis C Virus Glycoprotein E2 Generates Potent Cross-Neutralizing Antibodies in Guinea Pigs

Patricia T Vietheer, Irene Boo, Jun Gu, Kathleen McCaffrey, Stirling Edwards, Catherine Owczarek, Matthew P Hardy, Louis Fabri, Rob J Center, Pantelis Poumbourios, Heidi E Drummer

Journal article  |  2017  |  Hepatology

An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry

Kathleen McCaffrey, Irene Boo, Catherine M Owczarek, Matthew P Hardy, Matthew A Perugini, Louis Fabri, Pierre Scotney, Pantelis Poumbourios, Heidi E Drummer

Journal article  |  2017  |  Journal of Virology

A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81

J Grove, K Hu, MJ Farquhar, M Goodall, L Walker, M Jamshad, HE Drummer, RM Bill, P Balfe, JA McKeating

Journal article  |  2017  |  Wellcome Open Research

Background: Tetraspanins are small transmembrane proteins, found in all higher eukaryotes, that compartmentalize cellular membrane..

The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact

Phillipe Boeuf, Heidi E Drummer, Jack S Richards, Michelle JL Scoullar, James G Beeson

Journal article  |  2016  |  BMC Medicine

Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region

Yousef Alhammad, Jun Gu, Irene Boo, David Harrison, Kathleen McCaffrey, Patricia T Vietheer, Stirling Edwards, Charles Quinn, Fasseli Coulibaly, Pantelis Poumbourios, Heidi E Drummer

Journal article  |  2015  |  Journal of Virology

The role of a hepatitis C virus vaccine: modelling the benefits alongside direct-acting antiviral treatments

Nick Scott, Emma McBryde, Peter Vickerman, Natasha K Martin, Jack Stone, Heidi Drummer, Margaret Hellard

Journal article  |  2015  |  BMC Medicine

Longitudinal Sequence and Functional Evolution within Glycoprotein E2 in Hepatitis C Virus Genotype 3a Infection

Yousef MO Alhammad, Sanvir Maharajh, Rebecca Butcher, John-Sebastian Eden, Peter A White, Pantelis Poumbourios, Heidi E Drummer

Journal article  |  2015  |  PLOS ONE

Challenges to the development of vaccines to hepatitis C virus that elicit neutralizing antibodies

Heidi E Drummer

Journal article  |  2014  |  Frontiers in Microbiology

A Summary of the 20th International Symposium on Hepatitis C Virus and Related Viruses

Michael R Beard, Rose Ffrench, Eric J Gowans, Karla J Helbig, Nicholas M Eyre, Mark MW Douglas, Jason Grebely, Golo Ahlenstiel, Stephen Locarnini, Jacob George, Nick A Shackel, Peter A White, Alex J Thompson, Heidi E Drummer

Journal article  |  2014  |  Gastroenterology

Detection of HCV-Specific IFN-gamma Responses in HCV Antibody and HCV RNA Negative Injecting Drug Users

Jacqueline K Flynn, Rachel Sacks-Davis, Peter Higgs, Campbell Aitken, Sarah Moneer, Vijay Suppiah, Lilly Tracy, Rosemary Ffrench, Scott Bowden, Heidi Drummer, Jacob George, Mandvi Bharadwaj, Margaret Hellard

Journal article  |  2014  |  Hepatitis Monthly

High Rates of Hepatitis C Virus Reinfection and Spontaneous Clearance of Reinfection in People Who Inject Drugs: A Prospective Cohort Study

Rachel Sacks-Davis, Campbell K Aitken, Peter Higgs, Tim Spelman, Alisa E Pedrana, Scott Bowden, Mandvi Bharadwaj, Usha K Nivarthi, Vijayaprakash Suppiah, Jacob George, Jason Grebely, Heidi E Drummer, Margaret Hellard

Journal article  |  2013  |  PLoS One

Forced virus evolution reveals functional crosstalk between the disulfide bonded region and membrane proximal ectodomain region of HIV-1 gp41

Ashraf I Khasawneh, Annemarie Laumaea, David N Harrison, Anna K Bellamy-McIntyre, Heidi E Drummer, Pantelis Poumbourios

Journal article  |  2013  |  Retrovirology

Allosteric Modulation of the HIV-1 gp120-gp41 Association Site by Adjacent gp120 Variable Region 1 (V1) N-Glycans Linked to Neutralization Sensitivity

Heidi E Drummer, Melissa K Hill, Anne L Maerz, Stephanie Wood, Paul A Ramsland, Johnson Mak, Pantelis Poumbourios

Journal article  |  2013  |  PLoS Pathogens

In silico directed mutagenesis identifies the CD81/claudin-1 hepatitis C virus receptor interface

Christopher Davis, Helen J Harris, Ke Hu, Heidi E Drummer, Jane A McKeating, Jonathan GL Mullins, Peter Balfe

Journal article  |  2012  |  Cellular Microbiology

Role of Conserved Cysteine Residues in Hepatitis C Virus Glycoprotein E2 Folding and Function

Kathleen McCaffrey, Irene Boo, Kevin Tewierek, Mark L Edmunds, Pantelis Poumbourios, Heidi E Drummer

Journal article  |  2012  |  Journal of Virology

Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2

Irene Boo, Kevin teWierik, Florian Douam, Dimitri Lavillette, Pantelis Poumbourios, Heidi E Drummer

Journal article  |  2012  |  Biochemical Journal

Role for the Terminal Clasp of HIV-1 gp41 Glycoprotein in the Initiation of Membrane Fusion

Chan-Sien Lay, Louise E Ludlow, David Stapleton, Anna K Bellamy-McIntyre, Paul A Ramsland, Heidi E Drummer, Pantelis Poumbourios

Journal article  |  2011  |  Journal of Biological Chemistry

Hepatitis C Virus (HCV) Envelope Glycoproteins E1 and E2 Contain Reduced Cysteine Residues Essential for Virus Entry

Johanna Fraser, Irene Boo, Pantelis Poumbourios, Heidi E Drummer

Journal article  |  2011  |  Journal of Biological Chemistry

The variable regions of hepatitis C virus glycoprotein E2 have an essential structural role in glycoprotein assembly and virion infectivity

Kathleen McCaffrey, Hamed Gouklani, Irene Boo, Pantelis Poumbourios, Heidi E Drummer

Journal article  |  2011  |  Journal of General Virology

The SR-BI Partner PDZK1 Facilitates Hepatitis C Virus Entry

Nicholas S Eyre, Heidi E Drummer, Michael R Beard

Journal article  |  2010  |  PLoS Pathogens

Role for the disulfide-bonded region of human immunodeficiency virus type 1 gp41 in receptor-triggered activation of membrane fusion function

Anna K Bellamy-McIntyre, Severine Baer, Louise Ludlow, Heidi E Drummer, Pantelis Poumbourios

Journal article  |  2010  |  Biochemical and Biophysical Research Communications

Functional links between the fusion peptide-proximal polar segment and membrane-proximal region of human immunodeficiency virus gp41 in distinct phases of membrane fusion

Anna K Bellamy-Mclntyre, Chan-Sien Lay, Severine Baer, Anne L Maerz, Gert H Talbo, Heidi E Drummer, Pantelis Poumbourios

Journal article  |  2007  |  Journal of Biological Chemistry

Neutralizing antibodies in patients with chronic hepatitis C infection treated with (Peg)-interferon/ribavirin

Irene Boo, Alexandra E Fischer, Doug Johnson, Ruth Chin, Maxine Giourouki, Mandvi Bharadwaj, Scott Bowden, Joseph Torresi, Heidi Drummer

Journal article  |  2007  |  Journal of Clinical Virology

Identification of equine herpesvirus 3 (equine coital exanthema virus), equine gammaherpesviruses 2 and 5, equine adenoviruses 1 and 2, equine arteritis virus and equine rhinitis A virus by polymerase chain reaction

K Dynon, A Varrasso, N Ficorilli, SA Holloway, GH Reubel, F Li, CA Hartley, MJ Studdert, HE Drummer

Journal article  |  2001  |  Australian Veterinary Journal

Identification of equine herpesviruses 1 and 4 by polymerase chain reaction

A Varrasso, K Dynon, N Ficorilli, CA Hartley, MJ Studdert, HE Drummer

Journal article  |  2001  |  Australian Veterinary Journal

Equine rhinitis A virus: structural proteins and immune response

CA Hartley, N Ficorilli, K Dynon, HE Drummer, JA Huang, MJ Studdert

Journal article  |  2001  |  Journal of General Virology

Characterization of glycoprotein B of the gammaherpesvirus equine herpesvirus-2

SA Holloway, MJ Studdert, HE Drummer

Journal article  |  1998  |  Journal of General Virology