Craig Hutton obtained his BSc(Hons) and PhD degrees from the University of Adelaide before appointments at the University of California, Berkeley, the University of Melbourne and the University of Sydney. He returned to Melbourne in 2003 where he is now Professor.
His research interests include the development of new methods for the synthesis and ligation of peptides, synthesis of biologically active cyclic peptide natural products, and the development of radiolabeled peptides for PET imaging of cancer.
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Structure-Activity Relationships of cyclo(L-Tyrosyl-L-tyrosine) Derivatives Binding to Myc..
Radiosynthesis and preliminary in vivo evaluation of F-18-labelled glycosylated duramycin ..
Displaying the 27 most recent projects by Craig Hutton.
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Displaying the 117 most recent scholarly works by Craig Hutton.
Celogentin mimetics as inhibitors of tubulin polymerization
Varsha J Thombare, James A Holden, Eric C Reynolds, Neil M O'Brien-Simpson, Craig A Hutton
Journal article | 2020 | Journal of Peptide Science
Bicyclic analogues of celogentin C have been synthesized in which the side chain-side chain cross-links are replaced by thioether ..
Structure-Activity Relationships of cyclo(L-Tyrosyl-L-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct
Sunnia Rajput, Kirsty J McLean, Harshwardhan Poddar, Irwin R Selvam, Gayathri Nagalingam, James A Triccas, Colin W Levy, Andrew W Munro, Craig A Hutton
Journal article | 2019 | Journal of Medicinal Chemistry
A series of analogues of cyclo(l-tyrosyl-l-tyrosine), the substrate of the Mycobacterium tuberculosis enzyme CYP121, have been syn..
Radiosynthesis and preliminary in vivo evaluation of F-18-labelled glycosylated duramycin peptides for imaging of phosphatidylethanolamine during apoptosis
Mohammad B Haskali, Delphine Denoyer, Peter D Roselt, Rodney J Hicks, Craig A Hutton
Journal article | 2019 | MedChemComm
[18F]-Labelled duramycin derivatives incorporating hydrophilic aminogalacturonic acid moieties were prepared as tracers for in viv..
Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-Linked Peptides Using Ultraviolet Photodissociation Mass Spectrometry
Soumya Mukherjee, Mengxuan Fang, W Mei Kok, Eugene A Kapp, Varsha J Thombare, Romain Huguet, Craig A Hutton, Gavin E Reid, Blaine R Roberts
Journal article | 2019 | Analytical Chemistry
Automated preparation of clinical grade [68Ga]Ga-DOTA-CP04, a cholecystokinin-2 receptor agonist, using iPHASE MultiSyn synthesis platform.
Mohammad B Haskali, Peter D Roselt, David Binns, Amit Hetsron, Stan Poniger, Craig A Hutton, Rodney J Hicks
Journal article | 2019 | EJNMMI Radiopharmacy and Chemistry
BACKGROUND: Gallium-68 ([68Ga]Ga) labelled radiopharmaceuticals have become a valuable tool in clinical practice using Positron Em..
4-Nitrophenyl activated esters are superior synthons for indirect radiolabelling of biomolecules; A direct radiofluorination tolerance and acylation kinetics study
Mohammad Haskali, Ashleigh Farnsworth, Rodney Hicks, Peter Roselt, Craig Hutton
Conference Proceedings | 2019 | JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome
Stanley C Xie, David L Gillett, Natalie J Spillman, Christopher Tsu, Madeline R Luth, Sabine Ottilie, Sandra Duffy, Alexandra E Gould, Paul Hales, Benjamin A Seager, Carlie L Charron, Frank Bruzzese, Xiaofeng Yang, Xiansi Zhao, Shih-Chung Huang, Craig A Hutton, Jeremy N Burrows, Elizabeth A Winzeler, Vicky M Avery, Lawrence R Dick, et al.
Journal article | 2018 | Journal of Medicinal Chemistry
Unimolecular reactivity of organotrifluoroborate anions, RBF3-, and their alkali metal cluster ions, M(RBF3)(2)(-) (M = Na, K; R = CH3, CH3CH2, CH3(CH2)(3), CH3(CH2)(5), c-C3H5, C6H5, C6H5CH2, CH2CHCH2, CH2CH, C6H5CO)
Fiona LB Bathie, Chris J Bowen, Craig A Hutton, Richard AJ O'Hair
Journal article | 2018 | Rapid Communications in Mass Spectrometry
Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death
Marie-Julie Nokin, Florence Durieux, Justine Bellier, Olivier Peulen, Koji Uchida, David A Spiegel, James R Cochrane, Craig A Hutton, Vincent Castronovo, Akeila Bellahcene
Journal article | 2017 | Scientific Reports
Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry
Soumya Mukherjee, Eugene A Kapp, Amber Lothian, Anne M Roberts, Yury V Vasil'ev, Berin A Boughton, Kevin J Barnham, W Mei Kok, Craig A Hutton, Colin L Masters, Ashley I Bush, Joseph S Beckmann, Somdatta Ghosh Dey, Blaine R Roberts
Journal article | 2017 | Analytical Chemistry
Sulfonation of Tyrosine as a Method To Improve Biodistribution of Peptide-Based Radiotracers: Novel F-18-Labeled Cyclic RGD Analogues
Mohammad B Haskali, Delphine Denoyer, Wayne Noonan, Carleen Culinane, Christine Rangger, Normand Pouliot, Roland Haubner, Peter D Roselt, Rodney J Hicks, Craig A Hutton
Journal article | 2017 | Molecular Pharmaceutics
Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity
Paul R Gilson, Cyrus Tan, Kate E Jarman, Kym N Lowes, Joan M Curtis, William Nguyen, Adrian E Di Rago, Hayley E Bullen, Boris Prinz, Sandra Duffy, Jonathan B Baell, Craig A Hutton, Helene Jousset Subroux, Brendan S Crabb, Vicky M Avery, Alan F Cowman, Brad E Sleebs
Journal article | 2017 | Journal of Medicinal Chemistry
Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis
Marie-Julie Nokin, Florence Durieux, Paul Peixoto, Barbara Chiavarina, Olivier Peulen, Arnaud Blomme, Andrei Turtoi, Brunelle Costanza, Nicolas Smargiasso, Dominique Baiwir, Jean L Scheijen, Casper G Schalkwijk, Justine Leenders, Pascal De Tullio, Elettra Bianchi, Marc Thiry, Koji Uchida, David A Spiegel, James R Cochrane, Craig A Hutton, et al.
Journal article | 2016 | eLife
One-step radiosynthesis of 4-nitrophenyl 2-[F-18]fluoropropionate ([F-18]NFP); improved preparation of radiolabeled peptides for PET imaging
Mohammad B Haskali, Peter D Roselt, John A Karas, Wayne Noonan, Christian W Wichmann, Andrew Katsifis, Rodney J Hicks, Craig A Hutton
Journal article | 2013 | Journal of Labelled Compounds & Radiopharmaceuticals
Novel Conjugated Quinoline-Indoles Compromise Plasmodium falciparum Mitochondrial Function and Show Promising Antimalarial Activity
Silvia C Teguh, Nectarios Klonis, Sandra Duffy, Leonardo Lucantoni, Vicky M Avery, Craig A Hutton, Jonathan B Baell, Leann Tilley
Journal article | 2013 | Journal of Medicinal Chemistry
Oligomers, fact or artefact? SDS-PAGE induces dimerization of beta-amyloid in human brain samples
Andrew D Watt, Keyla A Perez, Alan Rembach, Nicki A Sherrat, Lin Wai Hung, Timothy Johanssen, Catriona A McLean, Woan Mei Kok, Craig A Hutton, Michelle Fodero-Tavoletti, Colin L Masters, Victor L Villemagne, Kevin J Barnham
Journal article | 2013 | Acta Neuropathologica
Synthetic dityrosine-linked beta-amyloid dimers form stable, soluble, neurotoxic oligomers
W Mei Kok, Jade M Cottam, Giuseppe D Ciccotosto, Luke A Miles, John A Karas, Denis B Scanlon, Blaine R Roberts, Michael W Parker, Roberto Cappai, Kevin J Barnham, Craig A Hutton
Journal article | 2013 | Chemical Science
The crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: Unambiguous resolution of the stereochemistry of the condensation product
Berin A Boughton, Renwick CJ Dobson, Craig A Hutton
Journal article | 2012 | Proteins - Structure, Function, and Bioinformatics
Blood-Borne Amyloid-beta Dimer Correlates with Clinical Markers of Alzheimer's Disease
Victor L Villemagne, Keyla A Perez, Kerryn E Pike, W Mei Kok, Christopher C Rowe, Anthony R White, Pierrick Bourgeat, Olivier Salvado, Justin Bedo, Craig A Hutton, Noel G Faux, Colin L Masters, Kevin J Barnham
Journal article | 2010 | Journal of Neuroscience
Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax
Jarrod E Voss, Stephen W Scally, Nicole L Taylor, Sarah C Atkinson, Michael DW Griffin, Craig A Hutton, Michael W Parker, Malcolm R Alderton, Juliet A Gerrard, Renwick CJ Dobson, Con Dogovski, Matthew A Perugini
Journal article | 2010 | Journal of Biological Chemistry
Crystallization and preliminary X-ray diffraction analysis of diaminopimelate epimerase from Escherichia coli
Lilian Hor, Renwick CJ Dobson, Con Dogovski, Craig A Hutton, Matthew A Perugini
Journal article | 2010 | Acta Crystallographica Section F - Structural Biology and Crystallization Communications
Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate
Jarrod E Voss, Stephen W Scally, Nicole L Taylor, Con Dogovski, Malcolm R Alderton, Craig A Hutton, Juliet A Gerrard, Michael W Parker, Renwick CJ Dobson, Matthew A Perugini
Journal article | 2009 | Acta Crystallographica Section F - Structural Biology and Crystallization Communications
Conserved main-chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthase
Renwick CJ Dobson, Michael DW Griffin, Sean RA Devenish, F Grant Pearce, Craig A Hutton, Juliet A Gerrard, Geoffrey B Jameson, Matthew A Perugini
Journal article | 2008 | Protein Science
Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?
Voula Mitsakos, Renwick CJ Dobson, F Grant Pearce, Sean R Devenish, Genevieve L Evans, Benjamin R Burgess, Matthew A Perugini, Juliet A Gerrard, Craig A Hutton
Journal article | 2008 | Bioorganic and Medicinal Chemistry Letters
Synthesis and molecular structure of stable derivatives of (e)- and (z)-dehydrophenylalanine
CJ Easton, CA Hutton, PD Roselt, ERT Tiekink
Journal article | 1991 | Australian Journal of Chemistry
Bromination of the phenylalanine derivative (1) affords the bromides (2) and (3), which react by stereospecific anti-elimination t..
Honours, Awards and Fellowships
FRACI - Fellow of the Royal Australian Chemical Institute
Professor And Reader
Member, Chartered Chemist
Royal Australian Chemical Institute
Doctor of Philosophy
University of Adelaide
Bachelor of Science (Honours)
University of Adelaide