Belinda Michell

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides

Stefan J Hermans, David B Ascher, Nancy C Hancock, Jessica K Holien, Belinda J Michell, Siew Yeen Chai, Craig J Morton, Michael W Parker

Journal article  |  2015  |  Protein Science

Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health

Michael A Gorman, Christine A Seers, Belinda J Michell, Susanne C Feil, N Laila Huq, Keith J Cross, Eric C Reynolds, Michael W Parker

Journal article  |  2015  |  Protein Science

Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase

Nicholas A Veldhuis, Valentina A Valova, Ann P Gaeth, Nickless Palstra, Katherine M Hannan, Belinda J Michell, Leonard E Kelly, Ian Jennings, Bruce E Kemp, Richard B Pearson, Phillip J Robinson, James Camakaris

Journal article  |  2009  |  International Journal of Biochemistry and Cell Biology

AMPK-independent pathways regulate skeletal muscle fatty acid oxidation

Nicolas Dzamko, Jonathan D Schertzer, James G Ryall, Rohan Steel, S Lance Macaulay, Sheena Wee, Zhi-Ping Chen, Belinda J Michell, Jonathan S Oakhill, Matthew J Watt, Sebastian Beck Jorgensen, Gordon S Lynch, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2008  |  Journal of Physiology

AMP-activated protein kinase subunit interactions - beta 1 :gamma 1 association requires beta 1 Thr-263 and Tyr-267

Tristan J Iseli, Jonathan S Oakhill, Michael F Bailey, Sheena Wee, Mark Walter, Bryce J van Denderen, Laura A Castelli, Frosa Katsis, Lee A Witters, David Stapleton, S Lance Macaulay, Belinda J Michell, Bruce E Kemp

Journal article  |  2008  |  Journal of Biological Chemistry

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

Gregory R Steinberg, Belinda J Michell, Bryce JW van Denderen, Matthew J Watt, Andrew L Carey, Barbara C Fam, Sofianos Andrikopoulos, Joseph Proietto, Cem Z Gorgun, David Carling, Gokhan S Hotamisligil, Mark A Febbraio, Thomas W Kay, Bruce E Kemp

Journal article  |  2006  |  Cell Metabolism

Differential calcineurin signalling activity and regeneration efficacy in diaphragm and limb muscles of dystrophic mdx mice

Nicole Stupka, Belinda J Michell, Bruce E Kemp, Gordon S Lynch

Journal article  |  2006  |  Neuromuscular Disorders

AMP-activated protein kinase beta subunit tethers alpha and gamma Subunits via its C-terminal sequence (186-270)

TJ Iseli, M Walter, BJW van Denderen, F Katsis, LA Witters, BE Kemp, BJ Michell, D Stapleton

Journal article  |  2005  |  Journal of Biological Chemistry

Effect of exercise on protein kinase C activity and localization in human skeletal muscle

AJ Rose, BJ Michell, BE Kemp, M Hargreaves

Journal article  |  2004  |  Journal of Physiology

AMPK beta subunit targets metabolic stress sensing to glycogen

G Polekhina, A Gupta, BJ Michell, B van Denderen, S Murthy, SC Feil, IG Jennings, DJ Campbell, LA Witters, MW Parker, BE Kemp, D Stapleton

Journal article  |  2003  |  Current Biology

AMP-activated protein kinase, super metabolic regulator

BE Kemp, D Stapleton, DJ Campbell, ZP Chen, S Murthy, M Walter, A Gupta, JJ Adams, F Katsis, B van Denderen, IG Jennings, T Iseli, BJ Michell, LA Witters

Journal article  |  2003  |  Biochemical Society Transactions

Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635

BJ Michell, MB Harris, ZP Chen, H Ju, VJ Venema, MA Blackstone, W Huang, RC Venema, BE Kemp

Journal article  |  2002  |  Journal of Biological Chemistry

Shear stress stimulates phosphorylation of eNOS at Ser635 by a protein kinase A-dependent mechanism

YC Boo, J Hwang, M Sykes, BJ Michell, BE Kemp, H Lum, H Jo

Journal article  |  2002  |  American Journal of Physiology - Heart and Circulatory Physiology

Progressive increase in human skeletal muscle AMPK alpha 2 activity and ACC phosphorylation during exercise

TJ Stephens, ZP Chen, BJ Canny, BJ Michell, BE Kemp, GK McConell

Journal article  |  2002  |  American Journal of Physiology - Endocrinology and Metabolism

Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme

D Fulton, J Fontana, G Sowa, JP Gratton, M Lin, KX Li, B Michell, BE Kemp, D Rodman, WC Sessa

Journal article  |  2002  |  Journal of Biological Chemistry

Cellular stress regulates the nucleocytoplasmic distribution of the protein-tyrosine phosphatase TCPTP

MHC Lam, BJ Michell, MT Fodero-Tavoletti, BE Kemp, NK Tonks, T Tiganis

Journal article  |  2001  |  Journal of Biological Chemistry

Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase

BJ Michell, ZP Chen, T Tiganis, D Stapleton, F Katsis, DA Power, AT Sim, BE Kemp

Journal article  |  2001  |  Journal of Biological Chemistry

Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation

MB Harris, H Ju, VJ Venema, HY Liang, R Zou, BJ Michell, ZP Chen, BE Kemp, RC Venema

Journal article  |  2001  |  Journal of Biological Chemistry

AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation.

ZP Chen, GK McConell, BJ Michell, RJ Snow, BJ Canny, BE Kemp

Journal article  |  2000  |  American Journal of Physiology-Endocrinology and Metabolism

AMP-activated protein kinase (AMPK) is a metabolic stress-sensing protein kinase responsible for coordinating metabolism and energ..

Expression of the AMP-activated protein kinase beta 1 and beta 2 subunits in skeletal muscle

ZP Chen, J Heierhorst, RJ Mann, KI Mitchelhill, BJ Michell, LA Witters, GS Lynch, BE Kemp, D Stapleton

Journal article  |  1999  |  FEBS Letters

The Akt kinase signals directly to endothelial nitric oxide synthase

BJ Michell, JE Griffiths, KI Mitchelhill, I Rodriguez-Crespo, T Tiganis, S Bozinovski, PRO de Montellano, BE Kemp, RB Pearson

Journal article  |  1999  |  Current Biology

Structural basis of autoregulation of phenylalanine hydroxylase.

B Kobe, IG Jennings, CM House, BJ Michell, KE Goodwill, BD Santarsiero, RC Stevens, RG Cotton, BE Kemp

Journal article  |  1999  |  Nature Structural Biology

Phenylalanine hydroxylase converts phenylalanine to tyrosine, a rate-limiting step in phenylalanine catabolism and protein and neu..

AMP-activated protein kinase phosphorylation of endothelial NO synthase.

ZP Chen, KI Mitchelhill, BJ Michell, D Stapleton, I Rodriguez-Crespo, LA Witters, DA Power, PR Ortiz de Montellano, BE Kemp

Journal article  |  1999  |  FEBS Letters

The AMP-activated protein kinase (AMPK) in rat skeletal and cardiac muscle is activated by vigorous exercise and ischaemic stress...

Dealing with energy demand: the AMP-activated protein kinase.

BE Kemp, KI Mitchelhill, D Stapleton, BJ Michell, ZP Chen, LA Witters

Journal article  |  1999  |  Trends in Biochemical Sciences

The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes...

Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit.

KI Mitchelhill, BJ Michell, CM House, D Stapleton, J Dyck, J Gamble, C Ullrich, LA Witters, BE Kemp

Journal article  |  1997  |  Journal of Biological Chemistry

The AMP-activated protein kinase (AMPK) consists of catalytic alpha and noncatalytic beta and gamma subunits and is responsible fo..

AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.

D Stapleton, E Woollatt, KI Mitchelhill, JK Nicholl, CS Fernandez, BJ Michell, LA Witters, DA Power, GR Sutherland, BE Kemp

Journal article  |  1997  |  FEBS Letters

The AMP-activated protein kinase (AMPK) consists of catalytic alpha and non-catalytic, beta and gamma (38 kDa) subunits and is res..

Regulation and crystallization of phosphorylated and dephosphorylated forms of truncated dimeric phenylalanine hydroxylase

B Kobe, IG Jennings, CM House, SC Feil, BJ Michell, T Tiganis, MW Parker, RGH Cotton, BE Kemp

Journal article  |  1997  |  Protein Science

Isoform-specific purification and substrate specificity of the 5'-AMP-activated protein kinase.

BJ Michell, D Stapleton, KI Mitchelhill, CM House, F Katsis, LA Witters, BE Kemp

Journal article  |  1996  |  Journal of Biological Chemistry

The 5'-AMP-activated protein kinase (AMPK) mediates several cellular responses to metabolic stress. Rat liver contains at least tw..

Mammalian AMP-activated protein kinase subfamily.

D Stapleton, KI Mitchelhill, G Gao, J Widmer, BJ Michell, T Teh, CM House, CS Fernandez, T Cox, LA Witters, BE Kemp

Journal article  |  1996  |  Journal of Biological Chemistry

The mammalian 5'-AMP-activated protein kinase (AMPK) is related to a growing family of protein kinases in yeast and plants that ar..

Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase.

D Stapleton, G Gao, BJ Michell, J Widmer, K Mitchelhill, T Teh, CM House, LA Witters, BE Kemp

Journal article  |  1994  |  Journal of Biological Chemistry

The 5'-AMP-activated protein kinase is responsible for the regulation of fatty acid synthesis by phosphorylation and inactivation ..

Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase.

KI Mitchelhill, D Stapleton, G Gao, C House, B Michell, F Katsis, LA Witters, BE Kemp

Journal article  |  1994  |  Journal of Biological Chemistry

The AMP-activated protein kinase is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carbox..