Belinda Michell

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides

Stefan J Hermans, David B Ascher, Nancy C Hancock, Jessica K Holien, Belinda J Michell, Siew Yeen Chai, Craig J Morton, Michael W Parker

Journal article  |  2015  |  PROTEIN SCIENCE

Insulin-regulated aminopeptidase (IRAP or oxytocinase) is a membrane-bound zinc-metallopeptidase that cleaves neuroactive peptides..

Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health

Michael A Gorman, Christine A Seers, Belinda J Michell, Susanne C Feil, N Laila Huq, Keith J Cross, Eric C Reynolds, Michael W Parker

Journal article  |  2015  |  PROTEIN SCIENCE

The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the pri..

Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase

Nicholas A Veldhuis, Valentina A Valova, Ann P Gaeth, Nickless Palstra, Katherine M Hannan, Belinda J Michell, Leonard E Kelly, Ian Jennings, Bruce E Kemp, Richard B Pearson, Phillip J Robinson, James Camakaris

Journal article  |  2009  |  INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Menkes copper-translocating P-type ATPase (ATP7A) is a critical copper transport protein functioning in systemic copper absorp..

AMPK-independent pathways regulate skeletal muscle fatty acid oxidation

Nicolas Dzamko, Jonathan D Schertzer, James G Ryall, Rohan Steel, S Lance Macaulay, Sheena Wee, Zhi-Ping Chen, Belinda J Michell, Jonathan S Oakhill, Matthew J Watt, Sebastian Beck Jorgensen, Gordon S Lynch, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2008  |  JOURNAL OF PHYSIOLOGY-LONDON

The activation of AMP-activated protein kinase (AMPK) and phosphorylation/inhibition of acetyl-CoA carboxylase 2 (ACC2) is believe..

AMP-activated protein kinase subunit interactions - beta 1 :gamma 1 association requires beta 1 Thr-263 and Tyr-267

Tristan J Iseli, Jonathan S Oakhill, Michael F Bailey, Sheena Wee, Mark Walter, Bryce J van Denderen, Laura A Castelli, Frosa Katsis, Lee A Witters, David Stapleton, S Lance Macaulay, Belinda J Michell, Bruce E Kemp

Journal article  |  2008  |  JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated protein kinase (AMPK) plays multiple roles in the body's overall metabolic balance and response to exercise, nutriti..

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

Gregory R Steinberg, Belinda J Michell, Bryce JW van Denderen, Matthew J Watt, Andrew L Carey, Barbara C Fam, Sofianos Andrikopoulos, Joseph Proietto, Cem Z Gorgun, David Carling, Gokhan S Hotamisligil, Mark A Febbraio, Thomas W Kay, Bruce E Kemp

Journal article  |  2006  |  CELL METABOLISM

Elevated levels of tumor necrosis factor (TNFalpha) are implicated in the development of insulin resistance, but the mechanisms me..

Differential calcineurin signalling activity and regeneration efficacy in diaphragm and limb muscles of dystrophic mdx mice

Nicole Stupka, Belinda J Michell, Bruce E Kemp, Gordon S Lynch

Journal article  |  2006  |  NEUROMUSCULAR DISORDERS

Calcineurin activity is essential for successful skeletal muscle regeneration in young mdx mice and in wild type mice following my..

AMP-activated protein kinase beta subunit tethers alpha and gamma Subunits via its C-terminal sequence (186-270)

TJ Iseli, M Walter, BJW van Denderen, F Katsis, LA Witters, BE Kemp, BJ Michell, D Stapleton

Journal article  |  2005  |  JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated protein kinase (AMPK) is an important metabolic stress-sensing protein kinase responsible for regulating metabolism ..

Effect of exercise on protein kinase C activity and localization in human skeletal muscle

AJ Rose, BJ Michell, BE Kemp, M Hargreaves

Journal article  |  2004  |  JOURNAL OF PHYSIOLOGY-LONDON

To investigate the effect of exercise on protein kinase C (PKC) activity and localization in human skeletal muscle, eight healthy ..

AMPK beta subunit targets metabolic stress sensing to glycogen

G Polekhina, A Gupta, BJ Michell, B van Denderen, S Murthy, SC Feil, IG Jennings, DJ Campbell, LA Witters, MW Parker, BE Kemp, D Stapleton

Journal article  |  2003  |  CURRENT BIOLOGY

AMP-activated protein kinase (AMPK) is a multisubstrate enzyme activated by increases in AMP during metabolic stress caused by exe..